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40 Matching Annotations

Oct 2025
www.sciencedirect.com www.sciencedirect.com

Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas

1
1. scibot 30 Oct 2025
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.celrep.2025.116487
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2211124725012586
Aug 2025
www.cell.com www.cell.com

HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes

1
1. scibot 13 Aug 2025
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.cmet.2025.07.007
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
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cell.com/cell-metabolism/fulltext/S1550-4131(25)00334-1
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma

1
1. scibot 06 Aug 2025
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1158/2159-8290.CD-24-1425
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12319406/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development

1
1. scibot 18 Jun 2025
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1158/0008-5472.CAN-24-4576
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12169444/
May 2025
www.sciencedirect.com www.sciencedirect.com

Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression

1
1. scibot 29 May 2025
  
  in Public
  
  The Jackson LaboratoryStock No: 014647
  
  DOI: 10.1016/j.celrep.2025.115734
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @areedewitt04
  
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sciencedirect.com/science/article/pii/S2211124725005054
Apr 2025
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 04 Apr 2025
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1158/0008-5472.can-24-4576
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
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52.53.155.43/d82b50f0340a265ea39586fdf6016ce1aa48cfa1/PDF-html.html
Feb 2025
www.sciencedirect.com www.sciencedirect.com

KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC

1
1. scibot 20 Feb 2025
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.xcrm.2025.101966
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2666379125000394
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma

1
1. scibot 04 Oct 2024
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1158/2767-9764.CRC-24-0120
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11444119/
Jul 2024
52.53.155.43 52.53.155.43

Cancer-associated endocrine cells participate in pancreatic carcinogenesis

1
1. scibot 25 Jul 2024
  
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  Cat#014647
  
  DOI: 10.1053/j.gastro.2024.07.016
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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52.53.155.43/00ed7388bef43fd34d4811e77f0e00ce1748f907/1-s2.0-S0016508524052259-main-html.html
www.science.org www.science.org

Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer

1
1. scibot 25 Jul 2024
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1126/science.adh4567
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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science.org/doi/10.1126/science.adh4567
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ehmt2 inactivation in pancreatic epithelial cells shapes the transcriptional landscape and inflammation response of the whole pancreas

1
1. scibot 03 Jul 2024
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.3389/fgene.2024.1412767
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11211573/
May 2024
www.biorxiv.org www.biorxiv.org

EHMT2 Inactivation in Pancreatic Epithelial Cells Shapes the Transcriptional Landscape and Inflammation Response of the Whole Pancreas

1
1. scibot 29 May 2024
  
  in Public
  
  RRID: IMSR_JAX:014647
  
  DOI: 10.1101/2024.03.14.584700
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  DOI:10.1101/2024.03.14.584700 RRID:IMSR_JAX:014647
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DOI:10.1101/2024.03.14.584700

RRID:IMSR_JAX:014647

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scibot

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biorxiv.org/content/10.1101/2024.03.14.584700v1
Feb 2024
aacrjournals.org aacrjournals.org

Nuclear GRP78 Promotes Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Ductal Adenocarcinoma

2
1. scibot 23 Feb 2024
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1158/1078-0432.CCR-23-1143
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
2. scibot 23 Feb 2024
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1158/1078-0432.CCR-23-1143
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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aacrjournals.org/clincancerres/article/29/24/5183/731660/Nuclear-GRP78-Promotes-Metabolic-Reprogramming-and
link.springer.com link.springer.com

Exosomes define a local and systemic communication network in healthy pancreas and pancreatic ductal adenocarcinoma

1
1. scibot 22 Feb 2024
  
  in Public
  
  JAX:014647
  
  DOI: 10.1038/s41467-024-45753-7
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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link.springer.com/article/10.1038/s41467-024-45753-7
Jan 2024
www.sciencedirect.com www.sciencedirect.com

Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis

1
1. scibot 25 Jan 2024
  
  in Public
  
  Pdx1creJackson laboratoryStrain No.014647
  
  DOI: 10.1016/j.celrep.2024.113703
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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sciencedirect.com/science/article/pii/S2211124724000317
www.sciencedirect.com www.sciencedirect.com

Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells

2
1. scibot 04 Jan 2024
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.devcel.2023.07.025
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
2. scibot 04 Jan 2024
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.devcel.2023.07.025
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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sciencedirect.com/science/article/pii/S1534580723003945
Dec 2023
52.53.155.43 52.53.155.43

ccr-23-1143-html.html

1
1. scibot 01 Dec 2023
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1158/1078-0432.ccr-23-1143
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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52.53.155.43/aa509a782208f9df8c6754b69c5c07021388a9c4/ccr-23-1143-html.html
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression

1
1. scibot 31 Aug 2023
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1186/s12967-023-04448-1
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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ncbi.nlm.nih.gov/pmc/articles/PMC10463307/
May 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Gender-specific changes of the gut microbiome correlate with tumor development in murine models of pancreatic cancer

1
1. scibot 31 May 2023
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.isci.2023.106841
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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ncbi.nlm.nih.gov/pmc/articles/PMC10225934/
www.sciencedirect.com www.sciencedirect.com

Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress

1
1. scibot 18 May 2023
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.isci.2023.106748
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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sciencedirect.com/science/article/pii/S2589004223008258
Nov 2022
insight.jci.org insight.jci.org

Interleukin-37 protects against acinar cell pyroptosis in acute pancreatitis

1
1. scibot 22 Nov 2022
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1172/jci.insight.161244
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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insight.jci.org/articles/view/161244
Sep 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Original research: Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression

1
1. scibot 22 Sep 2022
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1136/gutjnl-2021-324994
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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ncbi.nlm.nih.gov/pmc/articles/PMC9271144/
Jun 2022
www.sciencedirect.com www.sciencedirect.com

Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

1
1. scibot 25 Jun 2022
  
  in Public
  
  JAX:014647
  
  DOI: 10.1016/j.molcel.2022.06.005
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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sciencedirect.com/science/article/pii/S109727652200541X
Mar 2022
www.sciencedirect.com www.sciencedirect.com

Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

1
1. scibot 02 Mar 2022
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.celrep.2022.110441
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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sciencedirect.com/science/article/pii/S2211124722001681
Feb 2022
www.sciencedirect.com www.sciencedirect.com

Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer

1
1. scibot 04 Feb 2022
  
  in Public
  
  JAX:014647
  
  DOI: 10.1016/j.ccell.2022.01.003
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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sciencedirect.com/science/article/pii/S1535610822000058
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

1
1. scibot 16 Aug 2021
  
  in Public
  
  JAX:014647
  
  DOI: 10.1016/j.cell.2021.07.020
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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sciencedirect.com/science/article/pii/S0092867421008795
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 09 Aug 2021
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.ydbio.2018.11.014
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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sciencedirect.com/science/article/pii/S0012160617306875
Jul 2021
www.sciencedirect.com www.sciencedirect.com

CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells

1
1. scibot 30 Jul 2021
  
  in Public
  
  Mouse. B6.FVB-Tg(Pdx1-cre)6Tuv/J
  
  DOI: 10.1016/j.celrep.2019.08.025
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:IMSR_JAX:014647

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sciencedirect.com/science/article/pii/S2211124719310599
www.sciencedirect.com www.sciencedirect.com

Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas

1
1. scibot 30 Jul 2021
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.devcel.2018.11.001
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @Jmenke
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRIDCUR:Validated RRID:IMSR_JAX:014647
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RRID:IMSR_JAX:014647

RRIDCUR:Validated

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scibot

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sciencedirect.com/science/article/pii/S1534580718309195
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks

1
1. scibot 14 Jul 2021
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.3389/fcell.2021.681153
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647
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ncbi.nlm.nih.gov/pmc/articles/PMC8261250/
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

1
1. scibot 23 Apr 2021
  
  in Public
  
  Strain: 014647
  
  DOI: 10.1016/j.ccell.2021.02.016
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:014647
  
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  RRID:IMSR_JAX:014647 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:IMSR_JAX:014647

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scibot

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sciencedirect.com/science/article/pii/S1535610821001185
dev.biologists.org dev.biologists.org

Groucho co-repressor proteins regulate β cell development and proliferation by repressing Foxa1 in the developing mouse pancreas

1
1. scibot 12 Apr 2021
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1242/dev.192401
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
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dev.biologists.org/content/148/6/dev192401
Feb 2021
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Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas

1
1. scibot 24 Feb 2021
  
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  Stock# 014647
  
  DOI: 10.1016/j.celrep.2021.108772
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @Naa003
  
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  RRID:IMSR_JAX:014647 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S2211124721000851
Sep 2020
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Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

1
1. scibot 16 Sep 2020
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.cell.2020.03.062
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @ethanbadger
  
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  RRID:IMSR_JAX:014647 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0092867420303950
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Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

1
1. scibot 11 Sep 2020
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.cell.2020.03.008
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @ethanbadger
  
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  RRID:IMSR_JAX:014647 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0092867420302701
dev.biologists.org dev.biologists.org

Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specification

1
1. scibot 04 Sep 2020
  
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  RRID:IMSR_JAX:014647
  
  DOI: 10.1242/dev.189977
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @Naa003
  
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  RRID:IMSR_JAX:014647 RRIDCUR:Validated
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dev.biologists.org/content/147/12/dev189977
Jan 2020
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Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas

1
1. scibot 12 Jan 2020
  
  in Public
  
  RRID:IMSR_JAX:014647
  
  DOI: 10.1016/j.devcel.2018.11.001
  
  Resource: (IMSR Cat# JAX_014647,RRID:IMSR_JAX:014647)
  
  Curator: @Jmenke
  
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  RRID:IMSR_JAX:014647 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1534580718309195
Nov 2018
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PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism

1
1. scibot 05 Nov 2018
  
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  014647
  
  Curator: @Jmenke
  
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  RRID:IMSR_JAX:014647 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S1534580718305975