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27 Matching Annotations

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Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment

1
1. scibot 09 Apr 2026
  
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  RRID:IMSR_JAX:016961
  
  DOI: 10.1016/j.immuni.2026.03.011
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1074761326001226
Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CD38 endows local antigen-specific Treg cells with stress resilience for control of compartmentalized CNS inflammation

1
1. scibot 10 Mar 2026
  
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  JAX:016961
  
  DOI: 10.1038/s41590-025-02416-z
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
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  RRID:IMSR_JAX:016961
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pmc.ncbi.nlm.nih.gov/articles/PMC12956604/
Jan 2026
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

1
1. scibot 06 Jan 2026
  
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  01 6961
  
  DOI: 10.1002/advs.202520625
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202520625
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Opposing functions of distinct regulatory T cell subsets in colorectal cancer

1
1. scibot 16 Dec 2025
  
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  JAX:016961
  
  DOI: 10.1016/j.immuni.2025.11.014
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com:5037/science/article/pii/S1074761325005163
Nov 2025
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Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis

1
1. scibot 18 Nov 2025
  
  in Public
  
  JAX 016961
  
  DOI: 10.1016/j.celrep.2025.116557
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S2211124725013282
Sep 2025
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Glycogen synthase kinase-3 is essential for Treg development and function

1
1. scibot 12 Sep 2025
  
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  JacksonCat #016961
  
  DOI: 10.1016/j.celrep.2025.116256
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S2211124725010277
Jul 2025
www.science.org www.science.org

ATF4 drives regulatory T cell functional specification in homeostasis and obesity

1
1. scibot 25 Jul 2025
  
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  RRID:IMSR_JAX:016961
  
  DOI: 10.1126/sciimmunol.adp7193
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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science.org/doi/10.1126/sciimmunol.adp7193
elifesciences.org elifesciences.org

Layilin regulates Treg motility and suppressive capacity in skin

1
1. scibot 23 Jul 2025
  
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  #016961
  
  DOI: 10.7554/eLife.105277
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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elifesciences.org/articles/105277
Dec 2024
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Interleukin-2 receptor signaling acts as a checkpoint that influences the distribution of regulatory T cell subsets

1
1. scibot 18 Dec 2024
  
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  RRID:IMSR_JAX:016961
  
  DOI: 10.1016/j.isci.2024.111248
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S2589004224024738
Sep 2024
www.sciencedirect.com www.sciencedirect.com

Protocol to quantify the activation dynamics of tumor-associated T cells in mice by functional intravital microscopy

1
1. scibot 26 Sep 2024
  
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  RRID:IMSR_JAX:016961
  
  DOI: 10.1016/j.xpro.2024.103310
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S2666166724004751
www.sciencedirect.com www.sciencedirect.com

T-follicular regulatory cells expand to control germinal center plasma cell output but fail to curb autoreactivity

1
1. scibot 17 Sep 2024
  
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  RRID:IMSR_JAX:016961
  
  DOI: 10.1016/j.isci.2024.110887
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S2589004224021126
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Hyperactivating EZH2 to augment H3K27me3 levels in regulatory T cells enhances immune suppression by driving early effector differentiation

1
1. scibot 15 Sep 2024
  
  in Public
  
  RRID:IMSR_JAX:016961
  
  DOI: 10.1016/j.celrep.2024.114724
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S2211124724010751
Aug 2024
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Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity

1
1. scibot 19 Aug 2024
  
  in Public
  
  RRID:IMSR_JAX:016961
  
  DOI: 10.1016/j.immuni.2024.07.010
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S1074761324003595
www.biorxiv.org www.biorxiv.org

Jagged-1+ Tregs Mediate Lymphatic Remodeling in Tumour-Draining Lymph Nodes

1
1. scibot 16 Aug 2024
  
  in Public
  
  Foxp3Cre-ERT2Jag1fl/fl
  
  DOI: 10.1101/2024.06.10.598373
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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biorxiv.org/content/10.1101/2024.06.10.598373v1
Jun 2024
www.biorxiv.org www.biorxiv.org

Jagged-1+ Skin Tregs Modulate the Innate Immune Response to Wound Healing

1
1. scibot 20 Jun 2024
  
  in Public
  
  JAX:016961
  
  DOI: 10.1101/2024.06.10.598375
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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biorxiv.org/content/10.1101/2024.06.10.598375v1
Apr 2024
www.sciencedirect.com www.sciencedirect.com

CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment

1
1. scibot 30 Apr 2024
  
  in Public
  
  The Jackson LaboratoryCat# 016961
  
  DOI: 10.1016/j.immuni.2024.04.003
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S1074761324002085
Feb 2024
www.sciencedirect.com www.sciencedirect.com

Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells

2
1. scibot 29 Feb 2024
  
  in Public
  
  RRID:IMSR_JAX:016961
  
  DOI: 10.1016/j.immuni.2024.01.019
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
2. scibot 29 Feb 2024
  
  in Public
  
  RRID:IMSR_JAX:016961
  
  DOI: 10.1016/j.immuni.2024.01.019
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S1074761324000451
May 2022
www.sciencedirect.com www.sciencedirect.com

Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut

1
1. scibot 11 May 2022
  
  in Public
  
  JAX:016961
  
  DOI: 10.1016/j.celrep.2022.110773
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S221112472200537X
Mar 2022
www.sciencedirect.com www.sciencedirect.com

Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa

1
1. scibot 23 Mar 2022
  
  in Public
  
  The Jackson Laboratory016961
  
  DOI: 10.1016/j.celrep.2022.110553
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S2211124722002972
Nov 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

1
1. scibot 05 Nov 2021
  
  in Public
  
  The Jackson LaboratoryStock No: 016961
  
  DOI: 10.7554/eLife.67476
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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ncbi.nlm.nih.gov/pmc/articles/PMC8553335/
Sep 2021
www.sciencedirect.com www.sciencedirect.com

Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment

1
1. scibot 21 Sep 2021
  
  in Public
  
  Cat#016961
  
  DOI: 10.1016/j.celrep.2021.109699
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRIDCUR:Missing RRID:IMSR_JAX:016961
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RRID:IMSR_JAX:016961

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scibot

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sciencedirect.com/science/article/pii/S2211124721011463
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy

1
1. scibot 04 Aug 2021
  
  in Public
  
  JAX stock #016961
  
  DOI: 10.1016/j.immuni.2021.07.005
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRIDCUR:Missing RRID:IMSR_JAX:016961
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RRID:IMSR_JAX:016961

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sciencedirect.com/science/article/pii/S1074761321002910
Jun 2021
www.sciencedirect.com www.sciencedirect.com

A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells

1
1. scibot 22 Jun 2021
  
  in Public
  
  Cat#016961
  
  DOI: 10.1016/j.cell.2021.05.028
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961 RRIDCUR:Missing
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RRID:IMSR_JAX:016961

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sciencedirect.com/science/article/pii/S0092867421006589
www.sciencedirect.com www.sciencedirect.com

Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

1
1. scibot 22 Jun 2021
  
  in Public
  
  JAX:016961
  
  DOI: 10.1016/j.cell.2021.05.027
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S0092867421006577
May 2021
www.sciencedirect.com www.sciencedirect.com

T Cell Receptor Is Required for Differentiation, but Not Maintenance, of Intestinal CD4+ Intraepithelial Lymphocytes

1
1. scibot 15 May 2021
  
  in Public
  
  Jax: 016961
  
  DOI: 10.1016/j.immuni.2020.09.003
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961 RRIDCUR:Missing
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RRID:IMSR_JAX:016961

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sciencedirect.com/science/article/pii/S1074761320303976
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function

1
1. scibot 03 Sep 2020
  
  in Public
  
  The Jackson laboratory#016961
  
  DOI: 10.1016/j.cmet.2020.03.004
  
  Resource: (IMSR Cat# JAX_016961,RRID:IMSR_JAX:016961)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:016961
  
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  RRID:IMSR_JAX:016961
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sciencedirect.com/science/article/pii/S1550413120301194