Hypothesis

34 Matching Annotations

Apr 2026
www.sciencedirect.com www.sciencedirect.com

Epithelial barrier DUOX2 serves as early immune defense in intestinal pathogen control

2
1. scibot 16 Apr 2026
  
  in Public
  
  JAX:021504
  
  DOI: 10.1016/j.mucimm.2026.04.004
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
2. scibot 16 Apr 2026
  
  in Public
  
  RRID:IMER_JAX:021504
  
  DOI: 10.1016/j.mucimm.2026.04.004
  
  Resource: RRID:IMSR_JAX:021504
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:021504
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RRIDCUR:Unresolved

RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S1933021926000413
www.sciencedirect.com www.sciencedirect.com

The gut microbiota alleviates depression by remodeling gut-brain energy metabolism

1
1. scibot 02 Apr 2026
  
  in Public
  
  RRID:IMSR_JAX:021504
  
  DOI: 10.1016/j.cmet.2026.03.002
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

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sciencedirect.com/science/article/pii/S1550413126000963
Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

VGLL4 modulates Paneth cells and sustains intestinal homeostasis

1
1. scibot 18 Mar 2026
  
  in Public
  
  JAX:021504
  
  DOI: 10.1038/s44319-026-00699-3
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC12979657/
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tachykinin signaling defines distinct populations of glia in the enteric nervous system

1
1. scibot 09 Jan 2026
  
  in Public
  
  RRID:IMSR_JAX:021504
  
  DOI: 10.1016/j.neuron.2025.11.030
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC12832054/
Nov 2025
www.sciencedirect.com www.sciencedirect.com

Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states

1
1. scibot 05 Nov 2025
  
  in Public
  
  RRID:IMSR_JAX:021504
  
  DOI: 10.1016/j.cell.2025.10.005
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

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sciencedirect.com/science/article/pii/S0092867425011341
Oct 2025
www.biorxiv.org www.biorxiv.org

Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycemic control

1
1. scibot 08 Oct 2025
  
  in Public
  
  Strain #: 021504
  
  DOI: 10.1101/2025.10.02.678294
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

biorxiv.org/content/10.1101/2025.10.02.678294v1
Sep 2025
www.sciencedirect.com www.sciencedirect.com

S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis

1
1. scibot 27 Sep 2025
  
  in Public
  
  RRID:IMSR_JAX:021504
  
  DOI: 10.1016/j.immuni.2025.09.001
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

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sciencedirect.com/science/article/pii/S1074761325004121
Jun 2025
www.sciencedirect.com www.sciencedirect.com

Comparative analysis of mouse strains for in vivo induction of reprogramming factors

1
1. scibot 25 Jun 2025
  
  in Public
  
  Jackson LaboratoryStock No: 021504
  
  DOI: 10.1016/j.celrep.2025.115879
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S2211124725006503
elifesciences.org elifesciences.org

Stratification of enterochromaffin cells by single-cell expression analysis

1
1. scibot 11 Jun 2025
  
  in Public
  
  Jackson labs, 021504
  
  DOI: 10.7554/eLife.90596.2
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

elifesciences.org/reviewed-preprints/90596v2
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Stratification of enterochromaffin cells by single-cell expression analysis

1
1. scibot 08 Apr 2025
  
  in Public
  
  JAX 021504
  
  DOI: 10.7554/eLife.90596
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11970908/
Jan 2025
www.sciencedirect.com www.sciencedirect.com

Mina53 catalyzes arginine demethylation of p53 to promote tumor growth

1
1. scibot 28 Jan 2025
  
  in Public
  
  RRID:IMSR_JAX:021504
  
  DOI: 10.1016/j.celrep.2025.115242
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S2211124725000130
www.sciencedirect.com www.sciencedirect.com

Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infection

1
1. scibot 23 Jan 2025
  
  in Public
  
  Jackson LaboratoriesStrain# 021504
  
  DOI: 10.1016/j.chom.2024.12.017
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S1931312824004840
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation

1
1. scibot 14 Nov 2024
  
  in Public
  
  021504
  
  DOI: 10.21203/rs.3.rs-2531119/v2
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @AleksanderDrozdz
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC9915899/
May 2024
www.biorxiv.org www.biorxiv.org

Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut

1
1. scibot 22 May 2024
  
  in Public
  
  021504
  
  DOI: 10.1101/2024.02.06.579180
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504 DOI:10.1101/2024.02.06.579180
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DOI:10.1101/2024.02.06.579180

RRID:IMSR_JAX:021504

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scibot

URL

biorxiv.org/content/10.1101/2024.02.06.579180v2
www.sciencedirect.com www.sciencedirect.com

Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance

1
1. scibot 14 May 2024
  
  in Public
  
  021504
  
  DOI: 10.1016/j.immuni.2024.03.023
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S1074761324001444
Apr 2024
link.springer.com link.springer.com

LSD1 drives intestinal epithelial maturation and controls small intestinal immune cell composition independent of microbiota in a murine model

1
1. scibot 24 Apr 2024
  
  in Public
  
  RRID:IMSR_JAX:021504
  
  DOI: 10.1038/s41467-024-47815-2
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

link.springer.com/article/10.1038/s41467-024-47815-2
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Colitis-induced upregulation of tumor necrosis factor receptor-2 (TNFR2) terminates epithelial regenerative signaling to restore homeostasis

1
1. scibot 23 Sep 2023
  
  in Public
  
  RRID:IMSR_JAX:21504
  
  DOI: 10.1016/j.isci.2023.107829
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10510063/
Aug 2023
www.sciencedirect.com www.sciencedirect.com

PIEZO2 in somatosensory neurons controls gastrointestinal transit

1
1. scibot 04 Aug 2023
  
  in Public
  
  JAX:021504
  
  DOI: 10.1016/j.cell.2023.07.006
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S0092867423007390
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover

1
1. scibot 27 Jul 2023
  
  in Public
  
  RRID:IMSR_JAX:021504
  
  DOI: 10.1158/2767-9764.CRC-22-0522
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10364643/
Feb 2023
www.sciencedirect.com www.sciencedirect.com

Ambient oxygen levels regulate intestinal dysbiosis and GVHD severity after allogeneic stem cell transplantation

1
1. scibot 03 Feb 2023
  
  in Public
  
  RRID:IMSR_JAX:021504
  
  DOI: 10.1016/j.immuni.2023.01.007
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S1074761323000171
Nov 2022
www.sciencedirect.com www.sciencedirect.com

The gut-to-brain axis for toxin-induced defensive responses

1
1. scibot 03 Nov 2022
  
  in Public
  
  JAX:021504
  
  DOI: 10.1016/j.cell.2022.10.001
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S0092867422013149
Jun 2022
www.mdpi.com www.mdpi.com

JAC4 Protects from X-Ray Radiation-Induced Intestinal Injury by JWA-Mediated Anti-Oxidation/Inflammation Signaling

1
1. scibot 18 Jun 2022
  
  in Public
  
  RRID:IMSR_JAX:021504
  
  DOI: 10.3390/antiox11061067
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

mdpi.com/2076-3921/11/6/1067
Apr 2022
www.sciencedirect.com www.sciencedirect.com

Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer

1
1. scibot 01 Apr 2022
  
  in Public
  
  RRID:IMSR_JAX:021504
  
  DOI: 10.1016/j.immuni.2022.03.008
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S1074761322001315
Mar 2022
www.sciencedirect.com www.sciencedirect.com

A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts

1
1. scibot 09 Mar 2022
  
  in Public
  
  JAX:021504
  
  DOI: 10.1016/j.immuni.2022.02.003
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S1074761322000838
Jan 2022
www.sciencedirect.com www.sciencedirect.com

Adaptive differentiation promotes intestinal villus recovery

1
1. scibot 11 Jan 2022
  
  in Public
  
  Cat# 021504
  
  DOI: 10.1016/j.devcel.2021.12.012
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRIDCUR:Missing RRID:IMSR_JAX:021504
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RRIDCUR:Missing

RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/abs/pii/S1534580721010327
Sep 2021
www.sciencedirect.com www.sciencedirect.com

Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis

1
1. scibot 17 Sep 2021
  
  in Public
  
  RRID:IMSR_JAX:021504
  
  DOI: 10.1016/j.stem.2021.08.007
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S1934590921003441
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

1
1. scibot 30 Jul 2021
  
  in Public
  
  Jackson Laboratory021504
  
  DOI: 10.1016/j.cell.2019.12.016
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504 RRIDCUR:Unrecognized
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RRIDCUR:Unrecognized

RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S0092867419313789
Jun 2021
www.sciencedirect.com www.sciencedirect.com

DHX15 is required to control RNA virus-induced intestinal inflammation

1
1. scibot 24 Jun 2021
  
  in Public
  
  Stock No: 021504
  
  DOI: 10.1016/j.celrep.2021.109205
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRIDCUR:Missing RRID:IMSR_JAX:021504
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RRIDCUR:Missing

RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721005544
www.sciencedirect.com www.sciencedirect.com

Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration

1
1. scibot 17 Jun 2021
  
  in Public
  
  JAX Stock No. 021504
  
  DOI: 10.1016/j.xcrm.2021.100320
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S2666379121001634
May 2021
www.sciencedirect.com www.sciencedirect.com

Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis

1
1. scibot 07 May 2021
  
  in Public
  
  RRID:IMSR_JAX:021504
  
  DOI: 10.1016/j.immuni.2020.10.014
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S1074761320304556
www.sciencedirect.com www.sciencedirect.com

The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

1
1. scibot 01 May 2021
  
  in Public
  
  JAX:021504
  
  DOI: 10.1016/j.molcel.2021.04.009
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
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  RRID:IMSR_JAX:021504
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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S1097276521003142
Apr 2021
www.cell.com www.cell.com

Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis

1
1. scibot 24 Apr 2021
  
  in Public
  
  Stock No: 021504
  
  DOI: 10.1016/j.cell.2020.08.027
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
  What is this?
  
  RRID:IMSR_JAX:021504 RRIDCUR:Missing
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RRID:IMSR_JAX:021504

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scibot

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cell.com/cell/fulltext/S0092-8674(20)31069-2
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity

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1. scibot 03 Sep 2020
  
  in Public
  
  Jackson LaboratoryCat# 021504
  
  DOI: 10.1016/j.immuni.2020.02.005
  
  Resource: (IMSR Cat# JAX_021504,RRID:IMSR_JAX:021504)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:021504
  
  What is this?
  
  RRID:IMSR_JAX:021504
Visit annotations in context

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RRID:IMSR_JAX:021504

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scibot

URL

sciencedirect.com/science/article/pii/S1074761320300765