Hypothesis

36 Matching Annotations

May 2026
dx.doi.org dx.doi.org

Class A Scavenger receptors promote tumor progression and induce a unique macrophage phenotype in a mouse model of spontaneous breast cancer

1
1. scibot 08 May 2026
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1093/jleuko/qiag026
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
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  RRID:IMSR_JAX:022974
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dx.doi.org/10.1093/jleuko/qiag026
www.sciencedirect.com www.sciencedirect.com

Tissue tension fosters macrophage-driven lipid peroxidation-induced DNA damage

1
1. scibot 01 May 2026
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.ccell.2026.03.022
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S1535610826001765
Apr 2026
www.biorxiv.org www.biorxiv.org

Mapping breast cancer lineage in radiation and immunotherapy using the REMAP mouse

1
1. scibot 25 Apr 2026
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.64898/2026.04.15.718689
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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biorxiv.org/content/10.64898/2026.04.15.718689v1
www.nature.com www.nature.com

Catabolism of extracellular glutathione supplies cysteine to support tumours

1
1. scibot 02 Apr 2026
  
  in Public
  
  022974
  
  DOI: 10.1038/s41586-026-10268-2
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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nature.com/articles/s41586-026-10268-2
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A 3D morphogenetic blueprint for metastatic outgrowth in breast cancer

1
1. scibot 02 Apr 2026
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.cell.2026.03.009
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S009286742600276X
Mar 2026
www.sciencedirect.com www.sciencedirect.com

6-Hydroxydopamine promotes antitumor immunity through macrophage remodeling beyond sympathetic ablation

1
1. scibot 20 Mar 2026
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.neuron.2026.02.028
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S0896627326001339
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Aberrant hypothalamic neuronal activity blunts glucocorticoid diurnal rhythms in murine breast cancer

1
1. scibot 16 Dec 2025
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.neuron.2025.11.019
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com:5037/science/article/pii/S089662732500892X
Sep 2025
www.sciencedirect.com www.sciencedirect.com

Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression

1
1. scibot 25 Sep 2025
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.cmet.2025.08.012
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S1550413125003857
Jul 2025
www.sciencedirect.com www.sciencedirect.com

Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity

1
1. scibot 01 Jul 2025
  
  in Public
  
  RRID:IMSR_JAX
  
  DOI: 10.1016/j.immuni.2025.06.006
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974 RRIDCUR:Unresolved
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RRIDCUR:Unresolved

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sciencedirect.com/science/article/pii/S1074761325002754
Feb 2025
www.sciencedirect.com www.sciencedirect.com

Bidirectional activation of stem-like programs between metastatic cancer and alveolar type 2 cells within the niche

1
1. scibot 27 Feb 2025
  
  in Public
  
  Jax Strain # 022974
  
  DOI: 10.1016/j.devcel.2024.05.020
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S1534580724003381
Jan 2025
www.sciencedirect.com www.sciencedirect.com

Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-α breast cancer risk

1
1. scibot 03 Jan 2025
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.xcrm.2024.101880
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S2666379124006517
Dec 2024
www.sciencedirect.com www.sciencedirect.com

A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

1
1. scibot 24 Dec 2024
  
  in Public
  
  Jackson laboratoriesStrain 022974
  
  DOI: 10.1016/j.cell.2024.11.009
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S0092867424013266
www.sciencedirect.com www.sciencedirect.com

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity

1
1. scibot 02 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.ccell.2024.10.014
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S1535610824004021
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Loss of XIST in breast cancer activates MSN-c-Met and reprograms microglia via exosomal microRNA to promote brain metastasis

1
1. scibot 15 Nov 2024
  
  in Public
  
  B6.FVB-Tg(MMTV-PyVT)634Mul/LellJ
  
  DOI: 10.1158/0008-5472.CAN-18-1102
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @AleksanderDrozdz
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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pmc.ncbi.nlm.nih.gov/articles/PMC6072593/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Platelet Angiopoietin-1 Protects Against Murine Models of Tumor Metastasis

1
1. scibot 23 Aug 2024
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1161/ATVBAHA.124.321189
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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ncbi.nlm.nih.gov/pmc/articles/PMC11335083/
Jul 2024
www.sciencedirect.com www.sciencedirect.com

Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response

1
1. scibot 25 Jul 2024
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.celrep.2024.114532
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S2211124724008611
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Pharmacological induction of chromatin remodeling drives chemosensitization in triple-negative breast cancer

1
1. scibot 09 Apr 2024
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.xcrm.2024.101504
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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RRID:IMSR_JAX:022974

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sciencedirect.com/science/article/pii/S2666379124001733
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1

1
1. scibot 13 Oct 2023
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.cmet.2023.09.004
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S1550413123003364
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Machine learning reveals genetic modifiers of the immune microenvironment of cancer

1
1. scibot 02 Sep 2023
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.isci.2023.107576
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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ncbi.nlm.nih.gov/pmc/articles/PMC10470213/
Jun 2023
www.sciencedirect.com www.sciencedirect.com

IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy

1
1. scibot 02 Jun 2023
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.stem.2023.05.007
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S1934590923001777
Dec 2022
www.sciencedirect.com www.sciencedirect.com

Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

1
1. scibot 08 Dec 2022
  
  in Public
  
  JAX:022974
  
  DOI: 10.1016/j.cmet.2022.11.003
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S1550413122004946
Nov 2022
www.sciencedirect.com www.sciencedirect.com

CD16+ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition

1
1. scibot 16 Nov 2022
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.ccell.2022.10.015
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S1535610822005062
www.sciencedirect.com www.sciencedirect.com

Isolation of mouse mammary carcinoma-derived macrophages and cancer cells for co-culture assays

1
1. scibot 11 Nov 2022
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.xpro.2022.101833
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S2666166722007134
Oct 2022
www.sciencedirect.com www.sciencedirect.com

Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer

1
1. scibot 27 Oct 2022
  
  in Public
  
  022974
  
  DOI: 10.1016/j.immuni.2022.10.002
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S107476132200543X
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment

1
1. scibot 02 Aug 2022
  
  in Public
  
  JAX:022974
  
  DOI: 10.1016/j.immuni.2022.07.001
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S107476132200334X
May 2022
www.sciencedirect.com www.sciencedirect.com

Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

1
1. scibot 12 May 2022
  
  in Public
  
  Jackson Laboratories#022974
  
  DOI: 10.1016/j.cell.2022.04.019
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S0092867422004664
Dec 2021
www.sciencedirect.com www.sciencedirect.com

PAK5 promotes RNA helicase DDX5 sumoylation and miRNA-10b processing in a kinase-dependent manner in breast cancer

1
1. scibot 22 Dec 2021
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.celrep.2021.110127
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S2211124721016235
www.sciencedirect.com www.sciencedirect.com

NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

1
1. scibot 08 Dec 2021
  
  in Public
  
  022974
  
  DOI: 10.1016/j.cmet.2021.11.011
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974 RRIDCUR:Missing
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RRIDCUR:Missing

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sciencedirect.com/science/article/pii/S1550413121005398
Sep 2021
www.sciencedirect.com www.sciencedirect.com

Activating a collaborative innate-adaptive immune response to control metastasis

1
1. scibot 04 Sep 2021
  
  in Public
  
  Cat #022974
  
  DOI: 10.1016/j.ccell.2021.08.005
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRIDCUR:Missing RRID:IMSR_JAX:022974
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RRIDCUR:Missing

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sciencedirect.com/science/article/pii/S1535610821004451
Aug 2021
www.sciencedirect.com www.sciencedirect.com

TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

1
1. scibot 08 Aug 2021
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.ccell.2017.11.019
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S1535610817305238
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases

1
1. scibot 27 Jul 2021
  
  in Public
  
  022974
  
  DOI: 10.1016/j.chembiol.2018.10.005
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @Jmenke
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRIDCUR:Missing RRID:IMSR_JAX:022974
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RRIDCUR:Missing

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sciencedirect.com/science/article/pii/S2451945618303386
May 2021
www.sciencedirect.com www.sciencedirect.com

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

1
1. scibot 12 May 2021
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.immuni.2021.04.019
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
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  RRID:IMSR_JAX:022974
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sciencedirect.com/science/article/pii/S1074761321001813
Dec 2020
www.cell.com www.cell.com

Limiting Self-Renewal of the Basal Compartment by PKA Activation Induces Differentiation and Alters the Evolution of Mammary Tumors

1
1. scibot 11 Dec 2020
  
  in Public
  
  Tg(MMTV-PyVT)634Mul/LellJ
  
  DOI: 10.1016/j.devcel.2020.10.004
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
  Curator comments: B6.FVB-Tg(MMTV-PyVT)634Mul/LellJ Mus musculus IMSR Cat# JAX:022974
  
  What is this?
  
  RRID:IMSR_JAX:022974 RRIDCUR:Missing
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RRID:IMSR_JAX:022974

RRIDCUR:Missing

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scibot

URL

cell.com/developmental-cell/fulltext/S1534-5807(20)30794-2
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity

1
1. scibot 16 Sep 2020
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.cell.2020.02.015
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
  What is this?
  
  RRIDCUR:Validated RRID:IMSR_JAX:022974
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RRIDCUR:Validated

RRID:IMSR_JAX:022974

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scibot

URL

sciencedirect.com/science/article/pii/S0092867420301598
www.sciencedirect.com www.sciencedirect.com

Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer

1
1. scibot 16 Sep 2020
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.celrep.2020.107701
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
  What is this?
  
  RRIDCUR:Validated RRID:IMSR_JAX:022974
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RRIDCUR:Validated

RRID:IMSR_JAX:022974

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720306719
www.sciencedirect.com www.sciencedirect.com

Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression

1
1. scibot 03 Sep 2020
  
  in Public
  
  RRID:IMSR_JAX:022974
  
  DOI: 10.1016/j.devcel.2020.01.025
  
  Resource: (IMSR Cat# JAX_022974,RRID:IMSR_JAX:022974)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:022974
  
  What is this?
  
  RRIDCUR:Validated RRID:IMSR_JAX:022974
Visit annotations in context

Tags

RRIDCUR:Validated

RRID:IMSR_JAX:022974

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1534580720300575