Hypothesis

28 Matching Annotations

Jan 2026
www.biorxiv.org www.biorxiv.org

Acute deletion of PLIN5 in brown adipocytes causes mitochondrial dysfunction and cold intolerance

1
1. scibot 06 Jan 2026
  
  in Public
  
  Jackson Laboratories Stock # 024670
  
  DOI: 10.64898/2025.12.31.697198
  
  Resource: RRID:IMSR_JAX:024670
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

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biorxiv.org/content/10.64898/2025.12.31.697198v1
Jul 2025
www.biorxiv.org www.biorxiv.org

Ketone body driven lipid remodeling supports thermogenic adaptation to fasting

1
1. scibot 22 Jul 2025
  
  in Public
  
  024670
  
  DOI: 10.1101/2025.06.13.659540
  
  Resource: RRID:IMSR_JAX:024670
  
  Curator: @bandrow
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

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biorxiv.org/content/10.1101/2025.06.13.659540v1
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cold-inducible GOT1 activates the malate-aspartate shuttle in brown adipose tissue to support fuel preference for fatty acids

1
1. scibot 21 Jun 2025
  
  in Public
  
  RRID:IMSR_JAX:024670
  
  DOI: 10.1016/j.celrep.2025.115888
  
  Resource: RRID:IMSR_JAX:024670
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12294511/
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 13 Jun 2025
  
  in Public
  
  #024670
  
  DOI: 10.1210/endocr/bqaf101
  
  Resource: RRID:IMSR_JAX:024670
  
  Curator: @sjvitug
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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scibot

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52.53.155.43/ce49649a6746704578290de89c30b952911ddc36/PDF-html.html
Apr 2025
www.sciencedirect.com www.sciencedirect.com

Ceramide-induced FGF13 impairs systemic metabolic health

1
1. scibot 01 Apr 2025
  
  in Public
  
  The Jackson LaboratoryStrain: 024670
  
  DOI: 10.1016/j.cmet.2025.03.002
  
  Resource: RRID:IMSR_JAX:024670
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

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sciencedirect.com/science/article/pii/S1550413125001056
Feb 2025
www.sciencedirect.com www.sciencedirect.com

Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice

1
1. scibot 11 Feb 2025
  
  in Public
  
  Jackson Labs024670
  
  DOI: 10.1016/j.isci.2025.111903
  
  Resource: RRID:IMSR_JAX:024670
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

sciencedirect.com/science/article/pii/S2589004225001634
52.53.155.43 52.53.155.43

AQP1- A regulatory factor associated with brown adipose tissue-silencing

1
1. scibot 06 Feb 2025
  
  in Public
  
  RRID:IMSR_JAX:024670
  
  DOI: 10.1101/2024.09.23.614599
  
  Resource: RRID:IMSR_JAX:024670
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

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52.53.155.43/2dcbfaa0dcc73a4d1082a5a710760ab9fbf9ca77/2024.09.23.614599.full-html.html
Sep 2024
www.sciencedirect.com www.sciencedirect.com

m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1

1
1. scibot 10 Sep 2024
  
  in Public
  
  The Jackson Laboratory Cat_024670
  
  DOI: 10.1016/j.cmet.2024.08.006
  
  Resource: RRID:IMSR_JAX:024670
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

RRIDCUR:Unresolved

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scibot

URL

sciencedirect.com/science/article/pii/S1550413124003334
Jun 2024
www.sciencedirect.com www.sciencedirect.com

Short-term cold exposure induces persistent epigenomic memory in brown fat

1
1. scibot 22 Jun 2024
  
  in Public
  
  RRID:IMSR_JAX:024670
  
  DOI: 10.1016/j.cmet.2024.05.011
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

sciencedirect.com/science/article/pii/S1550413124001876
Apr 2024
www.sciencedirect.com www.sciencedirect.com

BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis

1
1. scibot 23 Apr 2024
  
  in Public
  
  Cat# 024670
  
  DOI: 10.1016/j.cell.2024.03.030
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

sciencedirect.com/science/article/pii/S0092867424003465
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes

1
1. scibot 10 Mar 2023
  
  in Public
  
  RRID:IMSR_JAX:024670
  
  DOI: 10.1016/j.isci.2023.106161
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9988578/
Nov 2022
www.sciencedirect.com www.sciencedirect.com

Endothelial SIRT-1 has a critical role for the maintenance of capillarization in brown adipose tissue

1
1. scibot 10 Nov 2022
  
  in Public
  
  JAX:024670
  
  DOI: 10.1016/j.isci.2022.105424
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

sciencedirect.com/science/article/pii/S2589004222016960
Aug 2022
www.sciencedirect.com www.sciencedirect.com

The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis

1
1. scibot 17 Aug 2022
  
  in Public
  
  The Jackson LaboratoryStock No. 024670
  
  DOI: 10.1016/j.cmet.2022.07.011
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

sciencedirect.com/science/article/pii/S1550413122003102
Apr 2022
www.sciencedirect.com www.sciencedirect.com

Brown adipose tissue involution associated with progressive restriction in progenitor competence

1
1. scibot 14 Apr 2022
  
  in Public
  
  The Jackson LaboratoryStock No: 024670
  
  DOI: 10.1016/j.celrep.2022.110575
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

sciencedirect.com/science/article/pii/S2211124722003199
Nov 2021
www.sciencedirect.com www.sciencedirect.com

ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue

1
1. scibot 17 Nov 2021
  
  in Public
  
  JAX: Cat#024670
  
  DOI: 10.1016/j.celrep.2021.110003
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721014819
Sep 2021
www.sciencedirect.com www.sciencedirect.com

Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism

1
1. scibot 22 Sep 2021
  
  in Public
  
  Cat#024670
  
  DOI: 10.1016/j.celrep.2021.109742
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
  What is this?
  
  RRID:IMSR_JAX:024670 RRIDCUR:Missing
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RRID:IMSR_JAX:024670

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721011955
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

1
1. scibot 29 Jul 2021
  
  in Public
  
  Jackson labs024670
  
  DOI: 10.1016/j.molcel.2019.07.023
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
  What is this?
  
  RRID:IMSR_JAX:024670 RRIDCUR:Unrecognized
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RRIDCUR:Unrecognized

RRID:IMSR_JAX:024670

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scibot

URL

sciencedirect.com/science/article/pii/S1097276519305532
Jun 2021
www.sciencedirect.com www.sciencedirect.com

Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity

1
1. scibot 26 Jun 2021
  
  in Public
  
  RRID:IMSR_JAX:024670
  
  DOI: 10.1016/j.cmet.2021.06.001
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

sciencedirect.com/science/article/pii/S1550413121002710
May 2021
www.sciencedirect.com www.sciencedirect.com

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

1
1. scibot 28 May 2021
  
  in Public
  
  JAX stock: 024670
  
  DOI: 10.1016/j.cell.2021.04.037
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
  What is this?
  
  RRID:IMSR_JAX:024670 RRIDCUR:Missing
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RRID:IMSR_JAX:024670

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S0092867421005729
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21

1
1. scibot 21 May 2021
  
  in Public
  
  RRID:IMSR_JAX:024670
  
  DOI: 10.7554/eLife.66519
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8128440/
www.sciencedirect.com www.sciencedirect.com

Progenitor-like characteristics in a subgroup of UCP1+ cells within white adipose tissue

1
1. scibot 12 May 2021
  
  in Public
  
  24670
  
  DOI: 10.1016/j.devcel.2021.02.018
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
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  RRID:IMSR_JAX:024670 RRIDCUR:Missing
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RRID:IMSR_JAX:024670

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1534580721001581
Jan 2021
www.sciencedirect.com www.sciencedirect.com

Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

1
1. scibot 22 Jan 2021
  
  in Public
  
  Stock No: 24670
  
  DOI: 10.1016/j.celrep.2020.108624
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
  What is this?
  
  RRID:IMSR_JAX:024670 RRIDCUR:Missing
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RRID:IMSR_JAX:024670

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720316132
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing

1
1. scibot 15 Sep 2020
  
  in Public
  
  RRID:IMSR_JAX:024670
  
  DOI: 10.1016/j.celrep.2019.12.043
  
  Resource: (IMSR Cat# JAX_024670,RRID:IMSR_JAX:024670)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
  What is this?
  
  RRIDCUR:Validated RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2211124719317000
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:IMSR_JAX:024670
  
  Resource used:
  
  RRID:IMSR_JAX:024670
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

sciencedirect.com/science/article/pii/S1550413118304479
www.sciencedirect.com www.sciencedirect.com

A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21

1
1. scibot 05 Nov 2018
  
  in Public
  
  024670
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:024670
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:024670 RRIDCUR:Missing
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RRID:IMSR_JAX:024670

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1550413118303954
www.sciencedirect.com www.sciencedirect.com

Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:IMSR_JAX:024670
  
  Resource used:
  
  RRID:IMSR_JAX:024670
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

sciencedirect.com/science/article/pii/S1550413118301839
www.sciencedirect.com www.sciencedirect.com

Hedgehog Pathway Drives Fusion-Negative Rhabdomyosarcoma Initiated From Non-myogenic Endothelial Progenitors

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:IMSR_JAX:024670
  
  Resource used:
  
  RRID:IMSR_JAX:024670
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:024670
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RRID:IMSR_JAX:024670

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scibot

URL

sciencedirect.com/science/article/pii/S153561081730524X
Nov 2017
www.sciencedirect.com www.sciencedirect.com

FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms

1
1. scibot 08 Nov 2017
  
  in Public
  
  024670
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:024670
  
  SciCrunch record: RRID:IMSR_JAX:024670
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:024670 RRIDCUR:Missing
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RRID:IMSR_JAX:024670

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1550413117301560