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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

L1CAM signaling through planar cell polarity drives SOX2 expression and lung adenocarcinoma metastasis

1
1. scibot 07 Aug 2026
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1038/s41467-026-74539-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13434761/
May 2026
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Uncovering spatially resolved functional genomics with CRISPR screen sequencing

1
1. scibot 29 May 2026
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.cell.2026.04.049
  
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sciencedirect.com/science/article/pii/S0092867426005167
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Protocol to generate endothelial cell-specific knockout mouse models using Cas9/Cdh5-Cre mice coupled with sgRNA

1
1. scibot 12 May 2026
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.xpro.2026.104551
  
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sciencedirect.com/science/article/pii/S2666166726002042
Apr 2026
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Cav3.1 is a neuronal leucine sensor that mediates satiety and weight loss in response to dietary protein

1
1. scibot 24 Apr 2026
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.cmet.2026.03.017
  
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aacrjournals.org aacrjournals.org

Functional genetic screens reveal key pathways instructing the molecular phenotypes of tumor-associated macrophages

1
1. scibot 23 Apr 2026
  
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  RRID: IMSR_JAX:026175
  
  DOI: 10.1158/2326-6066.CIR-25-0488
  
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aacrjournals.org/cancerimmunolres/article/13/12/2054/768330/Functional-Genetic-Screens-Reveal-Key-Pathways
www.biorxiv.org www.biorxiv.org

Transcription Factor Subtype Governs Response and Resistance to DLL3-Directed T-Cell Engagement in Small Cell Lung Cancer

1
1. scibot 16 Apr 2026
  
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  026175
  
  DOI: 10.64898/2026.04.02.715020
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
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biorxiv.org/content/10.64898/2026.04.02.715020v1
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A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina

1
1. scibot 10 Apr 2026
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.neuron.2026.03.022
  
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sciencedirect.com/science/article/pii/S0896627326002138
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A GABAergic network from AVP- to VIP-neurons in the suprachiasmatic nucleus sets the timing of circadian behavior rhythms

1
1. scibot 08 Apr 2026
  
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  JAX:026175
  
  DOI: 10.1371/journal.pbio.3003706
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12991363/
54.241.53.176 54.241.53.176

2026.03.16.712002.full-html.html

1
1. scibot 02 Apr 2026
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.64898/2026.03.16.712002
  
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54.241.53.176/b75aac600dedc1ddfbc19681fd816355be3e6d3d/2026.03.16.712002.full-html.html
Feb 2026
www.sciencedirect.com www.sciencedirect.com

Glomerular basement membrane structural integrity dictates trans-tissue deposition of laminin in the kidney

1
1. scibot 19 Feb 2026
  
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  Jackson Laboratory026175
  
  DOI: 10.1016/j.celrep.2026.117006
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
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sciencedirect.com/science/article/pii/S2211124726000847
Dec 2025
onlinelibrary.wiley.com onlinelibrary.wiley.com

Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability

1
1. scibot 11 Dec 2025
  
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  Jackson Laboratory, catalog no. 026175
  
  DOI: 10.1002/glia.70103
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
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onlinelibrary.wiley.com/doi/10.1002/glia.70103
Nov 2025
54.241.53.176 54.241.53.176

1-s2.0-S2589004225025167-main-html.html

1
1. scibot 29 Nov 2025
  
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  JAX:026175
  
  DOI: 10.1016/j.isci.2025.114255
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
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54.241.53.176/e754a7c154db613430ded36c0576582291572395/1-s2.0-S2589004225025167-main-html.html
elifesciences.org elifesciences.org

Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing

1
1. scibot 11 Nov 2025
  
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  Stock No. 026175, Jackson Laboratory
  
  DOI: 10.7554/eLife.107298
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
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elifesciences.org/articles/107298
Aug 2025
www.biorxiv.org www.biorxiv.org

L1CAM signaling through planar cell polarity generates SOX2+ metastatic progenitors in lung adenocarcinoma

1
1. scibot 27 Aug 2025
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1101/2025.08.22.671773
  
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biorxiv.org/content/10.1101/2025.08.22.671773v1
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Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer

1
1. scibot 27 Aug 2025
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.devcel.2025.07.023
  
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sciencedirect.com/science/article/pii/S153458072500499X
Jul 2025
52.53.155.43 52.53.155.43

matienzo-et-al-2025-adipocyte-specific-modulation-of-11β-hsd-enzymes-for-the-treatment-of-obesity-in-male-mice-html.html

1
1. scibot 19 Jul 2025
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.6084/m9.figshare.29333861
  
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52.53.155.43/0eec343059498565fba813ed54e166140d5ee93f/matienzo-et-al-2025-adipocyte-specific-modulation-of-11β-hsd-enzymes-for-the-treatment-of-obesity-in-male-mice-html.html
elifesciences.org elifesciences.org

Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing

1
1. scibot 16 Jul 2025
  
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  Stock No 026175
  
  DOI: 10.7554/eLife.107298.1
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
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elifesciences.org/reviewed-preprints/107298
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EED Maintains the Small Cell Lung Cancer Neuroendocrine Phenotype and Drives Lung Cancer Histological Transformation

1
1. scibot 15 Jul 2025
  
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  Jackson No. 026175
  
  DOI: 10.1101/2025.07.07.663486
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
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biorxiv.org/content/10.1101/2025.07.07.663486v1
www.embopress.org www.embopress.org

FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons | The EMBO Journal

1
1. scibot 15 Jul 2025
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1038/s44318-025-00503-3
  
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embopress.org/doi/full/10.1038/s44318-025-00503-3
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AAV-mediated inhibition of endothelial IL-1β/IL-1R1 signaling alleviates the development of sepsis-associated encephalopathy

1
1. scibot 15 Jul 2025
  
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  stock number: 026175
  
  DOI: 10.1016/j.abb.2025.110535
  
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sciencedirect.com/science/article/pii/S0003986125002486
www.embopress.org www.embopress.org

FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons

1
1. scibot 15 Jul 2025
  
  in Public
  
  RRID:IMSR_JAX:026175
  
  DOI: 10.1038/s44318-025-00503-3
  
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embopress.org/doi/10.1038/s44318-025-00503-3
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina

1
1. scibot 26 Jun 2025
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1101/2025.03.22.644712
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12148056/
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Inhibitory input directs astrocyte morphogenesis through glial GABABR

1
1. scibot 26 Jun 2025
  
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  RRID:IMSR_JAX
  
  DOI: 10.1101/2023.03.14.532493
  
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  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:026175
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:026175
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biorxiv.org/content/10.1101/2023.03.14.532493v1
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The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

1
1. scibot 18 Jun 2025
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.cell.2025.05.029
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
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sciencedirect.com/science/article/pii/S0092867425006166
May 2025
www.biorxiv.org www.biorxiv.org

The superficial tufted and mitral cell output neurons of the mouse olfactory bulb have a dual role in insulin sensing

1
1. scibot 20 May 2025
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1101/2025.04.15.648999
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
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biorxiv.org/content/10.1101/2025.04.15.648999v1
Mar 2025
www.sciencedirect.com www.sciencedirect.com

A cellular and molecular basis of leptin resistance

1
1. scibot 06 Mar 2025
  
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  Jackson Laboratory Cat_026175
  
  DOI: 10.1016/j.cmet.2025.01.001
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:026175
  
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  RRID:IMSR_JAX:026175 RRIDCUR:Unresolved
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sciencedirect.com/science/article/pii/S1550413125000014
Feb 2025
www.sciencedirect.com www.sciencedirect.com

mTOR-mediated p62/SQSTM1 stabilization confers a robust survival mechanism for ovarian cancer

1
1. scibot 20 Feb 2025
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.canlet.2025.217565
  
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sciencedirect.com/science/article/pii/S0304383525001296
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

ErbB4 precludes the occurrence of PTSD-like fear responses by supporting the bimodal activity of the central amygdala

1
1. scibot 31 Dec 2024
  
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  026175
  
  DOI: 10.1038/s12276-024-01365-1
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
  Curator: @AleksanderDrozdz
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11671592/
Sep 2024
www.sciencedirect.com www.sciencedirect.com

TGF-β and RAS jointly unmask primed enhancers to drive metastasis

1
1. scibot 10 Sep 2024
  
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  Strain #: 026175
  
  DOI: 10.1016/j.cell.2024.08.014
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
  Curator: @vtello
  
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sciencedirect.com/science/article/pii/S009286742400905X
Aug 2024
www.nature.com www.nature.com

A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice

1
1. scibot 13 Aug 2024
  
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  Jackson strain number 026175
  
  DOI: 10.1038/s41593-024-01724-1
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
  Curator: @dhovakimyan1
  
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  RRID:IMSR_JAX:026175 DOI:10.1038/s41593-024-01724-1
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nature.com/articles/s41593-024-01724-1
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons

1
1. scibot 10 Jul 2024
  
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  RRID: IMSR_JAX: 026175
  
  DOI: 10.1016/j.isci.2024.110047
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
  Curator: @dhovakimyan1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11179071/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Localized translation and sarcomere maintenance requires ribosomal protein SA in mice

1
1. scibot 30 Jun 2024
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1172/JCI174527
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11213506/
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STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

1
1. scibot 21 Jun 2024
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.cell.2024.05.031
  
  Resource: (IMSR Cat# JAX_026175,RRID:IMSR_JAX:026175)
  
  Curator: @scibot
  
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Mar 2024
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Tonic TCR and IL-1β signaling mediate phenotypic alterations of naive CD4+ T cells

2
1. scibot 19 Mar 2024
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.celrep.2024.113954
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.celrep.2024.113954
  
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sciencedirect.com/science/article/pii/S2211124724002821
Feb 2024
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Gut-liver axis calibrates intestinal stem cell fitness

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  The Jackson LaboratoryCat# 026175
  
  DOI: 10.1016/j.cell.2024.01.001
  
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Jan 2024
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Growth Hormone Action in Somatostatin Neurons Regulates Anxiety and Fear Memory

1
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1523/JNEUROSCI.0254-23.2023
  
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jneurosci.org/content/43/40/6816
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Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity

1
1. scibot 09 Jan 2024
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.celrep.2023.113634
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10828548/
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Nucleus accumbens local circuit for cue-dependent aversive learning

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  026175
  
  DOI: 10.1016/j.celrep.2023.113488
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10795009/
Dec 2023
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Inhibitory input directs astrocyte morphogenesis through glial GABABR

1
1. scibot 23 Dec 2023
  
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  RRID:IMSR_JAX
  
  DOI: 10.1038/s41586-023-06010-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10733939/
Nov 2023
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Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1

1
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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.xcrm.2023.101282
  
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Sep 2023
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A sleep-active basalocortical pathway crucial for generation and maintenance of chronic pain

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ncbi.nlm.nih.gov/pmc/articles/PMC10010379/
Aug 2023
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Cell-type-specific plasticity shapes neocortical dynamics for motor learning

1
1. scibot 31 Aug 2023
  
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  JAX# 026175
  
  DOI: 10.1101/2023.08.09.552699
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10441538/
Jun 2023
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Fasting and prolonged food restriction differentially affect GH secretion independently of GH receptor signaling in AgRP neurons

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  DOI: 10.1111/jne.13254
  
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onlinelibrary.wiley.com/doi/10.1111/jne.13254
Apr 2023
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GIRK channel activity in prelimbic pyramidal neurons regulates the extinction of cocaine conditioned place preference in male mice

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  DOI: 10.1111/adb.13256
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10078116/
Feb 2023
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Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits

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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.neuron.2023.01.015
  
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Jan 2023
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The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer

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  DOI: 10.1016/j.celrep.2022.111878
  
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sciencedirect.com/science/article/pii/S2211124722017740
Dec 2022
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Specific and efficient gene knockout and overexpression in mouse interscapular brown adipocytes in vivo

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  DOI: 10.1016/j.xpro.2022.101895
  
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sciencedirect.com/science/article/pii/S2666166722007754
Nov 2022
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Genome-scale CRISPR screening in a single mouse liver

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  RRID:IMSR_JAX:026175
  
  DOI: 10.1016/j.xgen.2022.100217
  
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Sep 2022
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Global Chromatin Accessibility Profiling Analysis Reveals a Chronic Activation State in Aged Muscle Stem Cells

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Aug 2022
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The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis

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  The Jackson LaboratoryStock No. 026175
  
  DOI: 10.1016/j.cmet.2022.07.011
  
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academic.oup.com academic.oup.com

Ablation of growth hormone receptor in GABAergic neurons leads to increased pulsatile growth hormone secretion

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  RRID:IMSR_JAX:026175
  
  DOI: 10.1210/endocr/bqac103
  
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Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis

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Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateral hypothalamic orexin neurons

1
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  DOI: 10.1016/j.cub.2022.07.020
  
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sciencedirect.com/science/article/pii/S0960982222011216
Jul 2022
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Modulating the excitability of olfactory output neurons affects whole-body metabolism

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  DOI: 10.1523/JNEUROSCI.0190-22.2022
  
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jneurosci.org/content/42/30/5966
Jun 2022
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Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells

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  DOI: 10.1016/j.neuron.2022.06.003
  
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Oct 2021
academic.oup.com academic.oup.com

Leptin receptor expression in GABAergic cells is not sufficient to normalize metabolism and reproduction in mice

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  JAX:026175
  
  DOI: 10.1210/endocr/bqab168
  
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academic.oup.com/endo/article/162/11/bqab168/6353267
Aug 2021
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A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells

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1. scibot 25 Aug 2021
  
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  DOI: 10.1016/j.celrep.2021.109576
  
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sciencedirect.com/science/article/pii/S221112472101010X
Jul 2021
europepmc.org europepmc.org

In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.

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  DOI: 10.1038/s41467-019-08288-w
  
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europepmc.org/articles/PMC6344529/
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Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor

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  DOI: 10.1038/s41467-018-06347-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6155060/
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JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells

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1. scibot 27 Jul 2021
  
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  DOI: 10.1016/j.ccell.2018.10.008
  
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Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

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  DOI: 10.1016/j.cell.2021.06.028
  
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sciencedirect.com/science/article/pii/S0092867421007960
Jun 2021
cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org

LKB1/STK11 is a tumor suppressor in the progression of myeloproliferative neoplasms

1
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  DOI: 10.1158/2159-8290.CD-20-1353
  
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cancerdiscovery.aacrjournals.org/content/11/6/1398
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Acute gene inactivation in the adult mouse liver using the CRISPR-Cas9 technology

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1. scibot 23 Jun 2021
  
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  DOI: 10.1016/j.xpro.2021.100611
  
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sciencedirect.com/science/article/pii/S266616672100318X
Feb 2021
elifesciences.org elifesciences.org

Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice

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1. scibot 26 Feb 2021
  
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  RRID:IMSR_JAX:026175
  
  DOI: 10.7554/eLife.50712
  
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elifesciences.org/articles/50712
Sep 2020
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Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice

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  DOI: 10.7554/eLife.50712
  
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