Hypothesis

21 Matching Annotations

Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lipopolysaccharide-induced cytokine signaling activates a temporal innate defense program and represses pancreatic β-cell identity

1
1. scibot 02 Dec 2025
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.1016/j.jbc.2025.110811
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12663513/
Aug 2025
www.cell.com www.cell.com

HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes

1
1. scibot 13 Aug 2025
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.1016/j.cmet.2025.07.007
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

cell.com/cell-metabolism/fulltext/S1550-4131(25)00334-1
Jul 2025
dx.doi.org dx.doi.org

Dynamic Ca2+-Dependent Transcription Links Metabolic Stress to Impaired β-Cell Identity

1
1. scibot 12 Jul 2025
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.2337/db24-1141
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

dx.doi.org/10.2337/db24-1141
Jun 2025
52.53.155.43 52.53.155.43

Deletion of Ascl1 in pancreatic β-cells improves insulin secretion, promotes parasympathetic innervation, and attenuates dedifferentiation during metabolic stress

1
1. scibot 24 Jun 2025
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.1016/j.molmet.2023.101811
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

52.53.155.43/b1a8b4466726dfc851796ffaf4a6ed2d264a732e/Online_Supplemental_Materials_5-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types

1
1. scibot 11 Jun 2025
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.1152/ajpregu.00259.2023
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11381023/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity

1
1. scibot 15 Feb 2025
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.3389/fimmu.2025.1504583
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11814175/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dual role of neuroplastin in pancreatic β cells: Regulating insulin secretion and promoting islet inflammation

1
1. scibot 23 Aug 2024
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.1073/pnas.2411234121
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11331099/
Jan 2024
www.sciencedirect.com www.sciencedirect.com

TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet

1
1. scibot 18 Jan 2024
  
  in Public
  
  Strain #026801
  
  DOI: 10.1016/j.celrep.2024.113673
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124724000019
link.springer.com link.springer.com

NRF2 is required for neonatal mouse beta cell growth by maintaining redox balance and promoting mitochondrial biogenesis and function

1
1. scibot 18 Jan 2024
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.1007/s00125-023-06071-7
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

link.springer.com/article/10.1007/s00125-023-06071-7
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

1
1. scibot 08 Sep 2023
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.7554/eLife.90006
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10482429/
Aug 2023
link.springer.com link.springer.com

SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells

1
1. scibot 16 Aug 2023
  
  in Public
  
  MGI:5614359
  
  DOI: 10.1007/s00125-023-05979-4
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @anisehay
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRIDCUR:Unresolved RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRIDCUR:Unresolved

RRID:IMSR_JAX:026801

Annotators

scibot

URL

link.springer.com/article/10.1007/s00125-023-05979-4
Jun 2023
www.sciencedirect.com www.sciencedirect.com

Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

1
1. scibot 09 Jun 2023
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.1016/j.celrep.2023.112615
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124723006265
May 2023
www.sciencedirect.com www.sciencedirect.com

Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells

1
1. scibot 12 May 2023
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.1016/j.celrep.2023.112500
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124723005119
Jan 2023
www.sciencedirect.com www.sciencedirect.com

Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma

1
1. scibot 26 Jan 2023
  
  in Public
  
  Stock No:026801
  
  DOI: 10.1016/j.devcel.2022.12.012
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @MufeiL
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1534580722008942
Jun 2022
www.sciencedirect.com www.sciencedirect.com

IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells

1
1. scibot 08 Jun 2022
  
  in Public
  
  Jackson LaboratoryCat# 026801
  
  DOI: 10.1016/j.devcel.2022.05.013
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1534580722003707
Feb 2022
www.sciencedirect.com www.sciencedirect.com

A distinct hypothalamus-to-β cell circuit modulates insulin secretion

1
1. scibot 02 Feb 2022
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.1016/j.cmet.2021.12.020
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413121006574
Jul 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells

1
1. scibot 23 Jul 2021
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.7554/eLife.61308
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8289414/
Feb 2021
www.nature.com www.nature.com

PDX1 LOW MAFA LOW β-cells contribute to islet function and insulin release

2
1. scibot 02 Feb 2021
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.1038/s41467-020-20632-z
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801 RRIDCUR:Validated
2. scibot 02 Feb 2021
  
  in Public
  
  RRID:IMSR_JAX:026801
  
  DOI: 10.1038/s41467-020-20632-z
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801 RRIDCUR:Validated
Visit annotations in context

Tags

RRIDCUR:Validated

RRID:IMSR_JAX:026801

Annotators

scibot

URL

nature.com/articles/s41467-020-20632-z
Sep 2020
www.nature.com www.nature.com

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

1
1. scibot 03 Sep 2020
  
  in Public
  
  JAX stock no. 026801
  
  DOI: 10.1038/s41467-020-14309-w
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  Curator comments: IMSR Cat# JAX:026801, B6(Cg)-Ins1tm1.1(cre)Thor/J Mus musculus
  
  What is this?
  
  RRID:IMSR_JAX:026801 RRIDCUR:Missing
Visit annotations in context

Tags

RRIDCUR:Missing

RRID:IMSR_JAX:026801

Annotators

scibot

URL

nature.com/articles/s41467-020-14309-w
Aug 2020
www.jci.org www.jci.org

Sel1L-Hrd1 ER-associated degradation maintains β-cell identity via TGFβ signaling

1
1. scibot 19 Aug 2020
  
  in Public
  
  JAX 026801
  
  DOI: 10.1172/JCI134874
  
  Resource: (IMSR Cat# JAX_026801,RRID:IMSR_JAX:026801)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:026801
  
  Curator comments: B6(Cg)-Ins1tm1.1(cre)Thor/J Mus musculus IMSR Cat# JAX:026801
  
  What is this?
  
  RRID:IMSR_JAX:026801
Visit annotations in context

Tags

RRID:IMSR_JAX:026801

Annotators

scibot

URL

jci.org/articles/view/134874