11 Matching Annotations
  1. Jan 2026
  2. www.biorxiv.org www.biorxiv.org
    System-wide profiling reveals metabolic alterations in a G2019S LRRK2 knockin mouse model of Parkinson’s disease: systemic depletion of pyrimidine nucleosides
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    biorxiv.org/content/10.64898/2025.12.31.697225v1
  3. Nov 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The G2019S LRRK2 mutation exacerbates α-synuclein and tau neuropathology through divergent pathways in Parkinson’s disease models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12605561/
  5. Sep 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12397289/
  7. 52.53.155.43 52.53.155.43
    2025.08.28.672006v1.full-html.html
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    52.53.155.43/1c78deaa12ef1065bee04217bb87fcbf90d61c87/2025.08.28.672006v1.full-html.html
  8. May 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12068872/
  10. Apr 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Soluble Immune Factor Profiles in Blood and CSF Associated with LRRK2 Mutations and Parkinson’s Disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11974741/
  12. Mar 2025
  13. elifesciences.org elifesciences.org
    Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease
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    elifesciences.org/reviewed-preprints/101035
  14. Aug 2023
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10400961/
  16. Jun 2023
  17. link.springer.com link.springer.com
    Mutant LRRK2 exacerbates immune response and neurodegeneration in a chronic model of experimental colitis
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    link.springer.com/article/10.1007/s00401-023-02595-9
  18. Nov 2022
  19. www.nature.com www.nature.com
    R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations
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    nature.com/articles/s42003-022-04136-8
  20. Aug 2022
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC9531054/