216 Matching Annotations
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    Ms4a4a deficiency ameliorates plaque pathology in a mouse model of amyloid accumulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12371455/
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    Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice
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    sciencedirect.com/science/article/pii/S2211124725008800
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    Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S1074761325003334
  5. Aug 2025
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    CX3CR1 upregulation modulates microglial activation and preserves synapses in the hippocampus and frontal cortex of middle-aged mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12351399/
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    Ethanol Increases Diffuse Amyloid Plaque Load and Impairs Memory in the 5xFAD Mouse Model of Alzheimer's Disease
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    onlinelibrary.wiley.com/doi/10.1111/ejn.70218
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    Aggrecan protects against plaque accumulation and is essential for proper microglial responses to plaques
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    sciencedirect.com/science/article/pii/S2211124725008356
  9. Jul 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12306013/
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    G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation
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    cell.com/neuron/fulltext/S0896-6273(25)00478-7
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    Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S0092867425007378
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    Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer’s Disease Models
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    mdpi.com/1422-0067/26/14/6922
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Retained introns in phototransduction genes of 5xFAD mouse retina suggest vision impairment as an early diagnostic marker for Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12263821/
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    Global dissection of the impact of Alzheimer’s disease on brain architecture and behavior: High resolution MRH resolves robust regional effects
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    biorxiv.org/content/10.1101/2025.01.08.632011v1
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    TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice
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    cell.com/cell-stem-cell/fulltext/S1934-5909(25)00228-0
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    Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957132/
  19. Jun 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A longitudinal study of the 5xFAD mouse retina delineates Amyloid beta (Aβ)-mediated retinal pathology from age-related changes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12177965/
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    Extracellular matrix glycation epigenetically regulates brain aging and neurodegeneration in the in vitro aged neurovascular model
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    sciencedirect.com/science/article/pii/S0142961225004235
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    Potassium homeostasis during disease progression of Alzheimer's disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12148202/
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    Inflammasome signaling in astrocytes modulates hippocampal plasticity
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    sciencedirect.com/science/article/pii/S1074761325001700
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    Longitudinal progression of blood biomarkers reveals a key role of reactive astrocytosis in preclinical Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S2666634025001515
  25. May 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    N-N-Substituted Piperazine, Cmp2, Improves Cognitive and Motor Functions in 5xFAD Mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12111198/
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    GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration
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    Specific targeting of brain endothelial cells using enhancer AAV vectors
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    Mitochondrial Alterations in Alzheimer’s Disease: Insight from the 5xFAD Mouse Model
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    link.springer.com/article/10.1007/s12035-024-04632-4
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    Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S107476132500192X
  31. www.sciencedirect.com www.sciencedirect.com
    Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia
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  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Early involvement of D-serine in β-amyloid-dependent pathophysiology
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  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12064341/
  34. Apr 2025
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner
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  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dysregulated ac4C modification of mRNA in a mouse model of early-stage Alzheimer’s disease
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  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice
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  38. Mar 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sequential Proteomic Analysis Reveals the Key APOE4‐Induced Pathological and Molecular Features at the Presymptomatic Stage in Alzheimer's Disease Mice
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  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sex chromosomes and gonads modify microglial-mediated pathology in a mouse model of Alzheimer’s disease
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  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Adolescent binge alcohol exposure accelerates Alzheimer’s disease-associated basal forebrain neuropathology through proinflammatory HMGB1 signaling
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  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Retinal and thalamic alterations in the 5xFAD mouse model of Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875347/
  43. Feb 2025
  44. www.biorxiv.org www.biorxiv.org
    Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility
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    biorxiv.org/content/10.1101/2025.02.17.638718v1
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    Asymptomatic neonatal herpes simplex virus infection in mice leads to persistent CNS infection and long-term cognitive impairment
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  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
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    Microglial plasticity governed by state-specific enhancer landscapes
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    biorxiv.org/content/10.1101/2025.01.30.635595v1
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    A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion
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  49. Jan 2025
  50. www.sciencedirect.com www.sciencedirect.com
    A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion
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  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD4‐Derived Double‐Negative T Cells Ameliorate Alzheimer's Disease‐Like Phenotypes in the 5×FAD Mouse Model
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    pmc.ncbi.nlm.nih.gov/articles/PMC11754964/
  52. Dec 2024
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Photoacoustic and fluorescence dual-modality imaging of cerebral biomarkers in Alzheimer’s disease rodent model
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    pmc.ncbi.nlm.nih.gov/articles/PMC11665203/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Partial microglial depletion and repopulation exert subtle but differential effects on amyloid pathology at different disease stages
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    A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion
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    Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease
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  57. Nov 2024
  58. pubs.acs.org pubs.acs.org
    Delivering DNA Aptamers Across the Blood–Brain Barrier Reveals Heterogeneous Decreased ATP in Different Brain Regions of Alzheimer’s Disease Mouse Models
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    pubs.acs.org/doi/10.1021/acscentsci.4c00563
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nitroxyl Hybrids with Curcumin and Stilbene Scaffolds Display Potent Antioxidant Activity, Remodel the Amyloid Beta Oligomer, and Reverse Amyloid Beta-Induced Cytotoxicity
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  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial memory in Alzheimer's disease 5XFAD mice is enhanced by XPO1 inhibitor KPT-330
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    The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function
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    Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment
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  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oral Administration of Euonymus alatus Leaf Extract Ameliorates Alzheimer’s Disease Phenotypes in 5xFAD Transgenic Mice
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    Levetiracetam modulates brain metabolic networks and transcriptomic signatures in the 5XFAD mouse model of Alzheimer’s disease
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    Lateral mammillary body neurons in mouse brain are disproportionately vulnerable in Alzheimer’s disease
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    Deep learning-driven adaptive optics for single-molecule localization microscopy
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    SELENOK-dependent CD36 palmitoylation regulates microglial functions and Aβ phagocytosis
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    Midkine Attenuates Aβ Fibril Assembly and AmyloidPlaque Formation
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    A randomized, blinded study of photobiomodulation in a mouse model of Alzheimer’s disease showed no preventive effect
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  70. Sep 2024
  71. pubs.acs.org pubs.acs.org
    Delivering DNA Aptamers Across the Blood–Brain Barrier Reveals Heterogeneous Decreased ATP in Different Brain Regions of Alzheimer’s Disease Mouse Models
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    pubs.acs.org/doi/10.1021/acscentsci.4c00563
  72. Aug 2024
  73. www.pnas.org www.pnas.org
    Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain
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    pnas.org/doi/full/10.1073/pnas.2116241119
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    A novel humanized Tau-FAD mice represent a robust model for studying AD-related dysfunction
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    alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.080664
  75. www.nature.com www.nature.com
    Multisensory gamma stimulation promotes glymphatic clearance of amyloid
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    nature.com/articles/s41586-024-07132-6
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    Infiltrating Hematogenous Macrophages Aggregate Around β-Amyloid Plaques in an Age- and Sex-Dependent Manner in a Mouse Model of Alzheimer Disease
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  78. Jul 2024
  79. www.sciencedirect.com www.sciencedirect.com
    Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer’s progression
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    sciencedirect.com/science/article/pii/S2211124724008179
  80. Jun 2024
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP + B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11212436/
  82. May 2024
  83. www.sciencedirect.com www.sciencedirect.com
    An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination
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    sciencedirect.com/science/article/pii/S1074761324002589
  84. www.nature.com www.nature.com
    Specific exercise patterns generate an epigenetic molecular memory window that drives long-term memory formation and identifies ACVR1C as a bidirectional regulator of memory in mice
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    nature.com/articles/s41467-024-47996-w
  85. Apr 2024
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Peripheral HMGB1 is linked to O3 pathology of disease-associated astrocytes and amyloid
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    pmc.ncbi.nlm.nih.gov/articles/PMC11095433/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10989684/
  88. www.biorxiv.org www.biorxiv.org
    Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer’s disease in mice
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    biorxiv.org/content/10.1101/2024.01.27.573841v1
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    New rabies viral resources for multi-scale neural circuit mapping
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  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetic diversity promotes resilience in a mouse model of Alzheimer's disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11032575/
  91. Mar 2024
  92. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BIN1K358R suppresses glial response to plaques in mouse model of Alzheimer's disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11032570/
  93. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology
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    pmc.ncbi.nlm.nih.gov/articles/PMC7616318/
  94. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage
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    pmc.ncbi.nlm.nih.gov/articles/PMC11247689/
  95. www.sciencedirect.com www.sciencedirect.com
    The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s Disease
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    sciencedirect.com/science/article/pii/S2589004224005029
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aβ*56 is a stable oligomer that impairs memory function in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10905009/
  97. Feb 2024
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional connectivity favors aberrant visual network c-Fos expression accompanied by cortical synapse loss in amyloidosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC9881957/
  99. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer’s Disease Is Associated with Activation of HIF-1 Signaling Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11339108/
  100. www.sciencedirect.com www.sciencedirect.com
    Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury
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    sciencedirect.com/science/article/pii/S1074761324000323
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioural, metabolic and lipidomic characterisation of the 5xFADxTg30 mouse model of Alzheimer’s Disease.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10826307/
  102. Jan 2024
  103. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Over-expression of N-acetylaspartate synthase exacerbates pathological energetic deficit and accelerates cognitive decline in the 5xFAD mouse
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16044
  104. www.sciencedirect.com www.sciencedirect.com
    Current mouse models of Alzheimer’s disease for investigating therapeutic agents
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    sciencedirect.com/science/article/pii/B978032389833100015X
  105. www.biorxiv.org www.biorxiv.org
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  118. Nov 2023
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  129. Jun 2023
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  131. May 2023
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  135. Apr 2023
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  140. Mar 2023
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  151. Jan 2023
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  156. Nov 2022
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  158. Aug 2022
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  161. Apr 2022
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  169. Nov 2021
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  172. Oct 2021
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  174. Aug 2021
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  177. Jul 2021
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  185. Jun 2021
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  187. May 2021
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  189. Mar 2021
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  191. Jan 2021
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  193. Nov 2020
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