546 Matching Annotations
  1. Aug 2023
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
    1
    1. scibot 31 Aug 2023
      RRID:SCR_000305

      DOI: 10.21203/rs.3.rs-3182731/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10441460/
  3. www.sciencedirect.com www.sciencedirect.com
    Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis
    1
    1. scibot 27 Aug 2023
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      DOI: 10.1016/j.cell.2023.07.037

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    sciencedirect.com/science/article/pii/S0092867423008528
  4. 52.53.155.43 52.53.155.43
    Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase
    2
    1. scibot 18 Aug 2023
      RRID:SCR_000305

      DOI: 10.1016/j.celrep.2023.112972

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    2. scibot 16 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112972

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    52.53.155.43/0e339670ea77f60c3c58bff69139ee9d7a48f749/PIIS221112472300983X-html.html
  5. www.sciencedirect.com www.sciencedirect.com
    The design of functional proteins using tensorized energy calculations
    1
    1. scibot 16 Aug 2023
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      DOI: 10.1016/j.crmeth.2023.100560

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    sciencedirect.com/science/article/pii/S2667237523002047
  6. 52.53.155.43 52.53.155.43
    EMBO Reports - 2023 - Jiang-html.html
    1
    1. scibot 16 Aug 2023
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      DOI: 10.15252/embr.202356864

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    52.53.155.43/72eed5338814ac6922d23d3395f365b4e68799b2/EMBO Reports - 2023 - Jiang-html.html
  7. 52.53.155.43 52.53.155.43
    Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels
    2
    1. scibot 12 Aug 2023
      RRID:SCR_000305

      DOI: 10.1016/j.celrep.2023.112926

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    2. scibot 10 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112926

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    52.53.155.43/13d2314e1a08e5e99d70c8b4a30c497d5ddefb63/PIIS2211124723009373-html.html
  8. www.sciencedirect.com www.sciencedirect.com
    A tetracationic porphyrin with dual anti-prion activity
    1
    1. scibot 11 Aug 2023
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      DOI: 10.1016/j.isci.2023.107480

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    sciencedirect.com/science/article/pii/S2589004223015572
  9. Jul 2023
  10. www.sciencedirect.com www.sciencedirect.com
    Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
    1
    1. scibot 27 Jul 2023
      RRID:SCR_000305

      DOI: 10.1016/j.cell.2023.06.020

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    sciencedirect.com/science/article/pii/S0092867423006967
  11. www.sciencedirect.com www.sciencedirect.com
    Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity
    1
    1. scibot 21 Jul 2023
      RRID:SCR_000305

      DOI: 10.1016/j.celrep.2023.112827

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    sciencedirect.com/science/article/pii/S2211124723008380
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor
    1
    1. scibot 14 Jul 2023
      RRID:SCR_000305

      DOI: 10.7554/eLife.86029

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    ncbi.nlm.nih.gov/pmc/articles/PMC10338036/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic variants in MAD2L1BP (p31comet) cause female infertility characterized by oocyte maturation arrest
    1
    1. scibot 06 Jul 2023
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      DOI: 10.7554/eLife.85649

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    ncbi.nlm.nih.gov/pmc/articles/PMC10319434/
  14. www.sciencedirect.com www.sciencedirect.com
    Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER
    1
    1. scibot 05 Jul 2023
      RRID:SCR_000305

      DOI: 10.1016/j.celrep.2023.112700

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    sciencedirect.com/science/article/pii/S2211124723007118
  15. Jun 2023
  16. www.biorxiv.org www.biorxiv.org
    Cleaving DNA with DNA: cooperative tuning of structure and reactivity driven by copper ions
    1
    1. scibot 27 Jun 2023
      RRID:SCR_000305

      DOI: 10.1101/2023.06.06.543833

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    biorxiv.org/content/10.1101/2023.06.06.543833v2
  17. www.sciencedirect.com www.sciencedirect.com
    Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment
    1
    1. scibot 21 Jun 2023
      RRID:SCR_000305

      DOI: 10.1016/j.molcel.2023.05.036

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    sciencedirect.com/science/article/pii/S1097276523004203
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Belly roll, a GPI-anchored Ly6 protein, regulates Drosophila melanogaster escape behaviors by modulating the excitability of nociceptive peptidergic interneurons
    1
    1. scibot 17 Jun 2023
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      DOI: 10.7554/eLife.83856

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    ncbi.nlm.nih.gov/pmc/articles/PMC10264074/
  19. www.sciencedirect.com www.sciencedirect.com
    HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery
    1
    1. scibot 10 Jun 2023
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      DOI: 10.1016/j.immuni.2023.05.009

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    sciencedirect.com/science/article/pii/S1074761323002261
  20. www.sciencedirect.com www.sciencedirect.com
    Centromere/kinetochore is assembled through CENP-C oligomerization
    1
    1. scibot 09 Jun 2023
      RRID:SCR_000305

      DOI: 10.1016/j.molcel.2023.05.023

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    sciencedirect.com/science/article/pii/S1097276523003799
  21. dx.doi.org dx.doi.org
    3D-informed targeting of the Trop-2 signal-activation site drives selective cancer vulnerability
    1
    1. scibot 08 Jun 2023
      RRID:SCR_000305

      DOI: 10.1158/1535-7163.MCT-22-0352

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    dx.doi.org/10.1158/1535-7163.MCT-22-0352
  22. May 2023
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The genomic landscape of sensitivity to arsenic trioxide uncovered by genome-wide CRISPR-Cas9 screening
    1
    1. scibot 31 May 2023
      RRID:SCR_000305

      DOI: 10.3389/fonc.2023.1178686

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    ncbi.nlm.nih.gov/pmc/articles/PMC10214836/
  24. www.sciencedirect.com www.sciencedirect.com
    Unanticipated broad phylogeny of BEN DNA-binding domains revealed by structural homology searches
    1
    1. scibot 26 May 2023
      RRID:SCR_000305

      DOI: 10.1016/j.cub.2023.05.011

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    sciencedirect.com/science/article/pii/S096098222300605X
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast
    1
    1. scibot 25 May 2023
      RRID:SCR_000305

      DOI: 10.1098/rsob.220366

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    ncbi.nlm.nih.gov/pmc/articles/PMC10205182/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter
    1
    1. scibot 18 May 2023
      RRID:SCR_000305

      DOI: 10.7554/eLife.84006

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    ncbi.nlm.nih.gov/pmc/articles/PMC10185341/
  27. www.sciencedirect.com www.sciencedirect.com
    Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response
    1
    1. scibot 12 May 2023
      RRID:SCR_000305

      DOI: 10.1016/j.str.2023.04.010

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    sciencedirect.com/science/article/pii/S0969212623001338
  28. www.sciencedirect.com www.sciencedirect.com
    cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity
    1
    1. scibot 11 May 2023
      RRID:SCR_000305

      DOI: 10.1016/j.immuni.2023.04.005

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    sciencedirect.com/science/article/pii/S1074761323001735
  29. link.springer.com link.springer.com
    Bioinformatics and gene expression analysis of the legume F-box/WD40 proteins in NaCl and high temperature stress
    1
    1. scibot 09 May 2023
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      DOI: 10.1007/s10722-023-01592-x

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    link.springer.com/article/10.1007/s10722-023-01592-x
  30. www.mdpi.com www.mdpi.com
    An ABCC9 Missense Variant Is Associated with Sudden Cardiac Death and Dilated Cardiomyopathy in Juvenile Dogs
    1
    1. scibot 04 May 2023
      RRID:SCR_000305

      DOI: 10.3390/genes14050988

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    mdpi.com/2073-4425/14/5/988
  31. www.sciencedirect.com www.sciencedirect.com
    Examining asymmetric pairwise pre-reaction and transition states in enzymatic catalysis by molecular dynamics simulation and quantum mechanics/molecular mechanics calculation
    1
    1. scibot 04 May 2023
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      DOI: 10.1016/j.xpro.2023.102263

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    sciencedirect.com/science/article/pii/S2666166723002216
  32. www.sciencedirect.com www.sciencedirect.com
    BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses
    1
    1. scibot 03 May 2023
      RRID: SCR_000305

      DOI: 10.1016/j.cub.2023.04.021

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    sciencedirect.com/science/article/pii/S0960982223004694
  33. Apr 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Assessing structure and disorder prediction tools for de novo emerged proteins in the age of machine learning
    1
    1. scibot 29 Apr 2023
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      DOI: 10.12688/f1000research.130443.1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10126731/
  35. link.springer.com link.springer.com
    Entrectinib a Plausible Inhibitor for Osteopontin (SPP1) in Cervical Cancer—Integrated Bioinformatic Approach
    1
    1. scibot 25 Apr 2023
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      DOI: 10.1007/s12010-023-04541-7

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    link.springer.com/article/10.1007/s12010-023-04541-7
  36. www.sciencedirect.com www.sciencedirect.com
    Species-specific MARCO-alphavirus interactions dictate chikungunya virus viremia
    1
    1. scibot 22 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112418

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    sciencedirect.com/science/article/pii/S2211124723004291
  37. www.sciencedirect.com www.sciencedirect.com
    Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
    1
    1. scibot 06 Apr 2023
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      DOI: 10.1016/j.immuni.2023.03.009

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    sciencedirect.com/science/article/pii/S1074761323001292
  38. Mar 2023
  39. academic.oup.com academic.oup.com
    New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts
    1
    1. scibot 29 Mar 2023
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      DOI: 10.1093/nargab/lqad029

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    academic.oup.com/nargab/article/5/1/lqad029/7084609
  40. www.sciencedirect.com www.sciencedirect.com
    Structural features of the Notch ankyrin domain-Deltex WWE2 domain heterodimer determined by NMR spectroscopy and functional implications
    1
    1. scibot 28 Mar 2023
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      DOI: 10.1016/j.str.2023.03.003

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    sciencedirect.com/science/article/pii/S0969212623000795
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation
    1
    1. scibot 10 Mar 2023
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      DOI: 10.7554/eLife.86258

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    ncbi.nlm.nih.gov/pmc/articles/PMC9991059/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease
    1
    1. scibot 10 Mar 2023
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      DOI: 10.1016/j.immuni.2023.02.005

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    ncbi.nlm.nih.gov/pmc/articles/PMC9933850/
  43. www.nature.com www.nature.com
    Increased retinoic acid signaling decreases lung metastasis in salivary adenoid cystic carcinoma by inhibiting the noncanonical Notch1 pathway
    1
    1. scibot 08 Mar 2023
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      DOI: 10.1038/s12276-023-00957-7

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    nature.com/articles/s12276-023-00957-7
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster
    1
    1. scibot 05 Mar 2023
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      DOI: 10.7554/eLife.84424

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    ncbi.nlm.nih.gov/pmc/articles/PMC9977279/
  45. Feb 2023
  46. www.sciencedirect.com www.sciencedirect.com
    Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans
    1
    1. scibot 18 Feb 2023
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      DOI: 10.1016/j.immuni.2023.01.027

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    sciencedirect.com/science/article/pii/S1074761323000390
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DYF-5/MAK–dependent phosphorylation promotes ciliary tubulin unloading
    1
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    Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS
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    Cellular mechanism of action of forsythiaside for the treatment of diabetic kidney disease
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  52. Jan 2023
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    The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)
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    Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain
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    Canagliflozin promotes osteoblastic MC3T3-E1 differentiation via AMPK/RUNX2 and improves bone microarchitecture in type 2 diabetic mice
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  57. Dec 2022
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    Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding
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    Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes
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    Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes
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    Mitoguardin-2–mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation
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  66. Oct 2022
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    Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation
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  68. Sep 2022
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    Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor
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  71. Aug 2022
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    Protocol to identify host-viral protein interactions between coagulation-related proteins and their genetic variants with SARS-CoV-2 proteins
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    Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC
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    Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye
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  77. Jul 2022
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  79. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  80. Jun 2022
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    Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes
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  82. journals.plos.org journals.plos.org
    Inhibition of histone H3-H4 chaperone pathways rescues C. elegans sterility by H2B loss
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    Rational exploration of fold atlas for human solute carrier proteins
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    The time-zero HSQC method improves the linear free energy relationship of a polypeptide chain through the accurate measurement of residue-specific equilibrium constants
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    Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex
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    Mussel-inspired monomer – A new selective protease inhibitor against dentine collagen degradation
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    A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations
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    Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion
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  89. May 2022
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    Aβ-induced synaptic impairments require CaMKII activity that is stimulated by indirect signaling events
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    The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels
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    Broad and ultra-potent cross-clade neutralization of HIV-1 by a vaccine-induced CD4 binding site bovine antibody
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  93. Apr 2022
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    Whole genome sequencing identifies a deletion mutation in the unknown-functional KCNG2 from familial sick sinus syndrome
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  95. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax
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    RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex
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    Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis
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  100. Mar 2022
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    Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
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    Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphosite-dependent Presentation of Dual Phosphorylated Peptides by MHC Class I Molecules
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  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis
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  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis of nanobodies neutralizing SARS-CoV-2 variants
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  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crystals of TELSAM–target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts
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    Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB
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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and ion-release mechanism of PIB-4-type ATPases
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    Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance
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    Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel
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    Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
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    Structural basis for catalyzed assembly of the Sonic hedgehog–Patched1 signaling complex
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  114. Feb 2022
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae
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    The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria
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    Naegleria’s mitotic spindles are built from unique tubulins and highlight core spindle features
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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats
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  119. Jan 2022
  120. link.springer.com link.springer.com
    Florigen and its homologs of FT/CETS/PEBP/RKIP/YbhB family may be the enzymes of small molecule metabolism: review of the evidence
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    Structural basis of bacteriophage lambda capsid maturation
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  122. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Novel variants underlying autosomal recessive neurodevelopmental disorders with intellectual disability in Iranian consanguineous families
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  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1
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    Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion
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  125. Dec 2021
  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors
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  128. Nov 2021
  129. www.sciencedirect.com www.sciencedirect.com
    Paratope states in solution improve structure prediction and docking
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Orchestrated actin nucleation by the Candida albicans polarisome complex enables filamentous growth
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    Structure and assembly pattern of a freshwater short-tailed cyanophage Pam1
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  132. Oct 2021
  133. www.sciencedirect.com www.sciencedirect.com
    Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells
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    Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel
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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2
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  136. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A novel receptor for platelet-activating factor and lysophosphatidylcholine in Trypanosoma cruzi
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  137. onlinelibrary.wiley.com onlinelibrary.wiley.com
    TPRG1-AS1 induces RBM24 expression and inhibits liver cancer progression by sponging miR-4691-5p and miR-3659
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      DOI: 10.1111/liv.15026

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  138. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Andrographolide prevents bone loss via targeting ERRalpha-regulated metabolic adaption of osteoclastogenesis
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  139. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Expression and distribution of synaptotagmin family members in the zebrafish retina
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  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural characterization of NrnC identifies unifying features of dinucleotidases
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  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Arg-293 of Cryptochrome1 is responsible for the allosteric regulation of CLOCK-CRY1 binding in circadian rhythm
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  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase
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