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  1. Jan 2020
  2. www.sciencedirect.com www.sciencedirect.com
    The Structural Basis for Low Conductance in the Membrane Protein VDAC upon β-NADH Binding and Voltage Gating
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    sciencedirect.com/science/article/pii/S0969212619304332
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA
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      DOI: 10.7554/eLife.49787

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    ncbi.nlm.nih.gov/pmc/articles/PMC6887485/
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    Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes
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      DOI: 10.1016/j.chom.2019.12.005

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    sciencedirect.com/science/article/pii/S1931312819306341
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    Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
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      DOI: 10.1016/j.cell.2019.10.010

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    sciencedirect.com/science/article/pii/S0092867419311262
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    Capsid Structure of a Freshwater Cyanophage Siphoviridae Mic1
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      DOI: 10.1016/j.str.2019.07.003

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    cell.com/structure/abstract/S0969-2126(19)30235-7
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    Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan
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      DOI: 10.1016/j.immuni.2019.06.004

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    sciencedirect.com/science/article/pii/S1074761319302493
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    BPS Publications
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      DOI: 10.1111/bph.14798

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    bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14798
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    Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies
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    sciencedirect.com/science/article/pii/S1931312819302148
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    Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors
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      DOI: 10.1074/jbc.RA118.005649

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    jbc.org/content/293/46/17838.long
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    BPS Publications
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      DOI: 10.1111/bph.14821

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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14821
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    Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P2 Synthesis
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      DOI: 10.1016/j.molcel.2019.06.037

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    sciencedirect.com/science/article/pii/S1097276519304940
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    Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State
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      DOI: 10.1016/j.str.2019.10.013

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    sciencedirect.com/science/article/pii/S0969212619303545
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    Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins
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      DOI: 10.1016/j.chom.2019.05.004

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    Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies
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      DOI: 10.1016/j.cell.2019.05.025

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    cell.com/cell/fulltext/S0092-8674(19)30553-7
  16. elifesciences.org elifesciences.org
    Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit
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      DOI: 10.7554/eLife.46041

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    elifesciences.org/articles/46041
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    Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED
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    sciencedirect.com/science/article/pii/S0969212619302369
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A2α
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      DOI: 10.7554/eLife.44760

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    ncbi.nlm.nih.gov/pmc/articles/PMC6550875/
  19. www.sciencedirect.com www.sciencedirect.com
    Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope
    1
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      DOI: 10.1016/j.immuni.2019.04.014

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    sciencedirect.com/science/article/pii/S1074761319301943
  20. europepmc.org europepmc.org
    Untitled document
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      DOI: 10.7554/eLife.41848

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    europepmc.org/articles/PMC6300352/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.42636

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    ncbi.nlm.nih.gov/pmc/articles/PMC6395065/
  22. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S0969212618303848
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.45222

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    ncbi.nlm.nih.gov/pmc/articles/PMC6424560/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.45851

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    ncbi.nlm.nih.gov/pmc/articles/PMC6497441/
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      DOI: 10.1016/j.celrep.2018.12.065

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    sciencedirect.com/science/article/pii/S2211124718320102
  29. www.sciencedirect.com www.sciencedirect.com
    Aneuploidy in Oocytes Is Prevented by Sustained CDK1 Activity through Degron Masking in Cyclin B1
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      DOI: 10.1016/j.devcel.2019.01.008

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    sciencedirect.com/science/article/pii/S1534580719300085
  30. elifesciences.org elifesciences.org
    Structural and functional characterization of an otopetrin family proton channel
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      DOI: 10.7554/eLife.46710

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    elifesciences.org/articles/46710
  31. www.sciencedirect.com www.sciencedirect.com
    O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3
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      DOI: 10.1016/j.immuni.2019.01.007

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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.molcel.2018.11.006

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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.41741

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    ncbi.nlm.nih.gov/pmc/articles/PMC6336409/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.42426

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    ncbi.nlm.nih.gov/pmc/articles/PMC6361614/
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    sciencedirect.com/science/article/pii/S1097276518309481
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    tRNA Maturation Defects Lead to Inhibition of rRNA Processing via Synthesis of pppGpp
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      DOI: 10.1016/j.molcel.2019.03.030

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  37. europepmc.org europepmc.org
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      DOI: 10.7554/eLife.40548

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  38. Nov 2018
  39. www.sciencedirect.com www.sciencedirect.com
    Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD
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    sciencedirect.com/science/article/pii/S1097276518301035
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    Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors
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    sciencedirect.com/science/article/pii/S1097276518301412
  41. www.sciencedirect.com www.sciencedirect.com
    Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity
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    sciencedirect.com/science/article/pii/S2451945618300734
  42. www.sciencedirect.com www.sciencedirect.com
    Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma
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    sciencedirect.com/science/article/pii/S1534580718301072
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure of the human epithelial sodium channel by cryo-electron microscopy
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    ncbi.nlm.nih.gov/pmc/articles/PMC6197857/
  44. www.sciencedirect.com www.sciencedirect.com
    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
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    Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction
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    The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery
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    Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation
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    Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
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    Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain
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    Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site
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    Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module
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    Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109
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    Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding
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    Mechanotransduction by PCDH15 Relies on a Novel cis-Dimeric Architecture
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    Precise and Predictable CRISPR Chromosomal Rearrangements Reveal Principles of Cas9-Mediated Nucleotide Insertion
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    A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases
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    Homologous Lympho-Epithelial Kazal-type Inhibitor Domains Delay Blood Coagulation by Inhibiting Factor X and XI with Differential Specificity
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    Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin
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    Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment
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    Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus
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    Structure of the CLC-1 chloride channel from Homo sapiens
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    Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p
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    Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies
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    EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
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    Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance
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    An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3
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    Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin
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    Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase
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    A Rare Lysozyme Crystal Form Solved Using Highly Redundant Multiple Electron Diffraction Datasets from Micron-Sized Crystals
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    Analysis of Global and Site-Specific Radiation Damage in Cryo-EM
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    Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling
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    Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
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    Alternative splice variants of rhomboid proteins: Comparative analysis of database entries for select model organisms and validation of functional potential
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    GroEL Ring Separation and Exchange in the Chaperonin Reaction
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    Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH
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    HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage
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    Malaria parasite LIMP protein regulates sporozoite gliding motility and infectivity in mosquito and mammalian hosts.
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    A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants
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  132. Nov 2017
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    Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia
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    The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin
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    A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential
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    A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN
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    Genetic identification of a common collagen disease in Puerto Ricans via identity-by-descent mapping in a health system
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    Structural Basis for Apelin Control of the Human Apelin Receptor
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    Molecular Mechanism of AMPA Receptor Modulation by TARP/Stargazin
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    Autonomous Generation and Loading of DNA Guides by Bacterial Argonaute
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    Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes
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    Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins
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    Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability
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    Crystal Structure and Regulation of the Citrus Pol III Repressor MAF1 by Auxin and Phosphorylation
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    A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45
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    RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks
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    Structural and Functional Insights into Human Re-initiation Complexes
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    Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1/Neuroligin-2 Complex
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    Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors
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    Structure of the ACF7 EF-Hand-GAR Module and Delineation of Microtubule Binding Determinants
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    Preprotein Conformational Dynamics Drive Bivalent Translocase Docking and Secretion
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    Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide
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    Structural Basis of Egg Coat-Sperm Recognition at Fertilization
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    Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated
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    SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs
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    Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development
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    The Architecture of the Anbu Complex Reflects an Evolutionary Intermediate at the Origin of the Proteasome System
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    Structural Insight into Ubiquitin-Like Protein Recognition and Oligomeric States of JAMM/MPN+ Proteases
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    The Highly Dynamic Nature of ERdj5 Is Key to Efficient Elimination of Aberrant Protein Oligomers through ER-Associated Degradation
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    Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18
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    Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23
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    Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1
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    Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding
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    Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination
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      Pymol

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  166. elifesciences.org elifesciences.org
    Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations
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    Conformational Dynamics and Allostery in E2:E3 Interactions Drive Ubiquitination: gp78 and Ube2g2
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  168. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    Ion- and water-binding sites inside an occluded hourglass pore of a trimeric intracellular cation (TRIC) channel
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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0372-8
  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes
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    ncbi.nlm.nih.gov/pmc/articles/PMC5119991/
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    Human Adaptation of Ebola Virus during the West African Outbreak
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    ncbi.nlm.nih.gov/pmc/articles/PMC5101188/
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores
    1
    1. scibot 08 Nov 2017
      PyMol

      Curator: @chewbeccax

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    ncbi.nlm.nih.gov/pmc/articles/PMC5101189/
  172. www.sciencedirect.com www.sciencedirect.com
    Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket
    1
    1. scibot 08 Nov 2017
      Pymol

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S0092867416313800
  173. www.sciencedirect.com www.sciencedirect.com
    5′ End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding
    1
    1. scibot 08 Nov 2017
      PyMOL

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S0092867417301976
  174. www.sciencedirect.com www.sciencedirect.com
    Molecular Basis of Substrate Specific Acetylation by N-Terminal Acetyltransferase NatB
    1
    1. scibot 08 Nov 2017
      Pymol

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S0969212617300631
  175. elifesciences.org elifesciences.org
    Mechanism of ribosome rescue by ArfA and RF2
    1
    1. scibot 08 Nov 2017
      SCR_000305

      Curator: @kaitlinsung

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    elifesciences.org/content/6/e23687
  176. www.sciencedirect.com www.sciencedirect.com
    Mechanism of Substrate Translocation in an Alternating Access Transporter
    1
    1. scibot 08 Nov 2017
      PyMOL

      Curator: @kaitlinsung

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    sciencedirect.com/science/article/pii/S0092867417302891
  177. www.sciencedirect.com www.sciencedirect.com
    A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family
    1
    1. scibot 08 Nov 2017
      SCR_000305

      Curator: @kaitlinsung

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    sciencedirect.com/science/article/pii/S0092867417302507
  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Operon mRNAs are organized into ORF-centric structures that predict translation efficiency
    1
    1. scibot 08 Nov 2017
      PyMOL

      Curator: @gabimpine

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    ncbi.nlm.nih.gov/pmc/articles/PMC5318159/
  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal
    1
    1. scibot 08 Nov 2017
      SCR_000305

      Curator: @chewbeccax

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    ncbi.nlm.nih.gov/pmc/articles/PMC5357137/
  180. www.sciencedirect.com www.sciencedirect.com
    Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
    1
    1. scibot 08 Nov 2017
      PyMOL

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S1097276517300539
  181. www.sciencedirect.com www.sciencedirect.com
    Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores
    1
    1. scibot 08 Nov 2017
      PyMol

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S0092867416313861
  182. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity
    1
    1. scibot 08 Nov 2017
      PyMOL

      Curator: @kaitlinsung

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    sciencedirect.com/science/article/pii/S1097276517300904
  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases
    2
    1. scibot 08 Nov 2017
      SCR_000305

      Curator: @Zeljana_Babic

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      (PyMOL, RRID:SCR_000305)

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    2. scibot 08 Nov 2017
      SCR_000305

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    ncbi.nlm.nih.gov/pmc/articles/PMC5293489/
  184. www.sciencedirect.com www.sciencedirect.com
    Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity
    1
    1. scibot 08 Nov 2017
      PyMOL Molecular Graphics System

      Curator: @kaitlinsung

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    sciencedirect.com/science/article/pii/S0092867417301320
  185. www.sciencedirect.com www.sciencedirect.com
    Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1
    1
    1. scibot 08 Nov 2017
      PyMOL

      Curator: @kaitlinsung

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    sciencedirect.com/science/article/pii/S1097276517300412
  186. www.sciencedirect.com www.sciencedirect.com
    S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity
    1
    1. scibot 08 Nov 2017
      PYMOL

      Curator: @kaitlinsung

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    sciencedirect.com/science/article/pii/S1097276517300084
  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Origin of a folded repeat protein from an intrinsically disordered ancestor
    1
    1. scibot 08 Nov 2017
      SCR_000305

      Curator: @gabimpine

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    ncbi.nlm.nih.gov/pmc/articles/PMC5074805/
  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NusG inhibits RNA polymerase backtracking by stabilizing the minimal transcription bubble
    1
    1. scibot 08 Nov 2017
      SCR_000305

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    ncbi.nlm.nih.gov/pmc/articles/PMC5100998/
  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors
    1
    1. scibot 08 Nov 2017
      SCR_000305

      Curator: @gabimpine

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      (PyMOL, RRID:SCR_000305)

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    ncbi.nlm.nih.gov/pmc/articles/PMC5111884/
  190. www.sciencedirect.com www.sciencedirect.com
    Human Adaptation of Ebola Virus during the West African Outbreak
    1
    1. scibot 08 Nov 2017
      SCR_000305

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S0092867416313964