396 Matching Annotations
  1. Aug 2025
  2. www.biorxiv.org www.biorxiv.org
    Cyclin-dependent kinase 9 inhibitors as oncogene signaling modulators in combination with targeted therapy for the treatment of colorectal cancer
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    biorxiv.org/content/10.1101/2025.08.13.669992v1
  3. www.sciencedirect.com www.sciencedirect.com
    AI-driven multimodal algorithm predicts immunotherapy and targeted therapy outcomes in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S2666379125003726
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12355176/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic Signatures of Poor Prognosis in Merkel Cell Carcinoma: A Single-Institution Prospective Study
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    pmc.ncbi.nlm.nih.gov/articles/PMC12336863/
  6. www.sciencedirect.com www.sciencedirect.com
    Bronze Age Yersinia pestis genome from sheep sheds light on hosts and evolution of a prehistoric plague lineage
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    sciencedirect.com/science/article/pii/S0092867425008517
  7. www.sciencedirect.com www.sciencedirect.com
    Whole-genome sequencing reveals three follicular lymphoma subtypes with distinct cell of origin and patient outcomes
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    sciencedirect.com/science/article/pii/S2666379125003519
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12319405/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC11790258/
  10. www.sciencedirect.com www.sciencedirect.com
    PARKIN protein-deficient iPSC line (FINi006-A) from an early-onset Parkinson’s disease female patient
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    sciencedirect.com/science/article/pii/S187350612500145X
  11. Jul 2025
  12. www.biorxiv.org www.biorxiv.org
    Bi-allelic mutations in KCTD11 cause a new form of autosomal recessive intermediate Charcot-Marie-Tooth disease
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    biorxiv.org/content/10.1101/2025.06.30.661538v1
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Complete loss of PAX4 causes transient neonatal diabetes in humans
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    pmc.ncbi.nlm.nih.gov/articles/PMC12275979/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study
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    pmc.ncbi.nlm.nih.gov/articles/PMC12260513/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in lethal prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11743868/
  16. 52.53.155.43 52.53.155.43
    Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html
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    52.53.155.43/baf73dc4816d69ae4de3fa32641dfd7bd010d8a5/Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clinical Significance of TP53-Mutant Clonal Hematopoiesis Across Diseases
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    pmc.ncbi.nlm.nih.gov/articles/PMC12209765/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-Throughput Drug Screening of Clear Cell Ovarian Cancer Organoids Reveals Vulnerability to Proteasome Inhibitors and Dinaciclib and Identifies AGR2 as a Therapeutic Target
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    pmc.ncbi.nlm.nih.gov/articles/PMC12188421/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identifying candidate genetic variants for egg number by analyzing over 1,000 fully sequenced layers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12203006/
  20. Jun 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cambridge Neoadjuvant Cancer of the Prostate (CANCAP03): A Window Study into the Effects of Olaparib ± Degarelix in Primary Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617790/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas
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    pmc.ncbi.nlm.nih.gov/articles/PMC12163602/
  23. 52.53.155.43 52.53.155.43
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    52.53.155.43/a7ee3b12d468dfb2dd9f5d25a6280eb2adf38466/PDF-html.html
  24. 52.53.155.43 52.53.155.43
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  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130809/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aged and BRCA-Mutated Stromal Cells Drive Epithelial Cell Transformation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130807/
  27. elifesciences.org elifesciences.org
    Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning
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    elifesciences.org/reviewed-preprints/101882v1
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromosome-level reference genome for the medically important Arabian horned viper (Cerastes gasperettii)
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    pmc.ncbi.nlm.nih.gov/articles/PMC12143202/
  29. May 2025
  30. www.sciencedirect.com www.sciencedirect.com
    Immunohistochemical and molecular evolutionary features of jejunoileal adenocarcinoma unveiled through comparative analysis with colorectal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1476558625000594
  31. www.sciencedirect.com www.sciencedirect.com
    Auditory neuropathy spectrum disorder and related auditory features in patients with hearing loss associated with the MT-TS1 m.7471dup variant
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    sciencedirect.com/science/article/pii/S1567724925000534
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clear-Cell Renal Cell Carcinoma Molecular Subtypes Differ by African and European Genetic Similarity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12044083/
  33. 52.53.155.43 52.53.155.43
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  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    M6Allele: a toolkit for detection of allele-specific RNA N6-methyladenosine modifications
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    pmc.ncbi.nlm.nih.gov/articles/PMC12087454/
  35. elifesciences.org elifesciences.org
    The potential of inversions to accumulate balanced sexual antagonism is supported by simulations and Drosophila experiments
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    elifesciences.org/articles/93338
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046327/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046333/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The genomic landscape of benign and malignant thyroid tumors from individuals carrying germline PTEN variants is distinct from sporadic thyroid cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC11534558/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans
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    pmc.ncbi.nlm.nih.gov/articles/PMC11998800/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Is Gauchian genotyping of GBA1 variants reliable?
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    pmc.ncbi.nlm.nih.gov/articles/PMC12064688/
  41. www.sciencedirect.com www.sciencedirect.com
    Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target
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    sciencedirect.com/science/article/pii/S1535610825001734
  42. Apr 2025
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12011380/
  44. 52.53.155.43 52.53.155.43
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  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clinical and Translational Results from PORTER, a Multicohort Phase I Platform Trial of Combination Immunotherapy in Metastatic Castration-Resistant Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11995007/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition
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    pmc.ncbi.nlm.nih.gov/articles/PMC11995001/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Impact of Li Fraumeni and Germline Retinoblastoma Mutations on Leiomyosarcoma Initiation, Outcomes and Genetic Testing Recommendations
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    pmc.ncbi.nlm.nih.gov/articles/PMC11479842/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Germline variants in patients from the Iranian hereditary colorectal cancer registry
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    pmc.ncbi.nlm.nih.gov/articles/PMC11995590/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Constructing a draft Indian cattle pangenome using short-read sequencing
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    pmc.ncbi.nlm.nih.gov/articles/PMC11994783/
  50. www.nature.com www.nature.com
    Transcriptome-wide association study of alternative polyadenylation identifies susceptibility genes in non-small cell lung cancer
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    nature.com/articles/s41388-025-03338-8
  51. www.sciencedirect.com www.sciencedirect.com
    Establishing a comprehensive panel of patient-derived xenograft models for high-grade endometrial carcinoma: molecular subtypes, genetic alterations, and therapeutic target profiling
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    sciencedirect.com/science/article/pii/S1476558625000375
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962403/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962405/
  54. Mar 2025
  55. 52.53.155.43 52.53.155.43
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    52.53.155.43/bd8b1eb80c0a90d93d052e69613b249b6f3108d9/PDF-html.html
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11907192/
  57. Feb 2025
  58. 52.53.155.43 52.53.155.43
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    Effect of MisMatch repair deficiency on metastasis occurrence in a syngeneic mouse model
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    sciencedirect.com/science/article/pii/S1476558625000247
  60. aacrjournals.org aacrjournals.org
    Multiomics Profiling Distinguishes Sebaceous Carcinoma from Benign Sebaceous Neoplasms and Provides Insight into the Genetic Evolution of Sebaceous Carcinogenesis
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    aacrjournals.org/clincancerres/article/30/21/4887/749133/Multiomics-Profiling-Distinguishes-Sebaceous
  61. www.sciencedirect.com www.sciencedirect.com
    Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy
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    sciencedirect.com/science/article/pii/S1934590925000025
  62. www.sciencedirect.com www.sciencedirect.com
    Whole genome sequencing powered ctDNA sequencing for breast cancer detection
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    sciencedirect.com/science/article/pii/S0923753425000535
  63. Jan 2025
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A chromosome-scale genome assembly of the pioneer plant Stylosanthes angustifolia: insights into genome evolution and drought adaptation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11758145/
  65. www.sciencedirect.com www.sciencedirect.com
    The potential of lazertinib and amivantamab combination therapy as a treatment strategy for uncommon EGFR-mutated NSCLC
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    sciencedirect.com/science/article/pii/S2666379125000023
  66. link.springer.com link.springer.com
    Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma
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    link.springer.com/article/10.1038/s41591-024-03216-y
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Telomere-to-telomere genome and resequencing of 254 individuals reveal evolution, genomic footprints in Asian icefish, Protosalanx chinensis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11707609/
  68. 52.53.155.43 52.53.155.43
    ccr-24-0427-html.html
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  69. 52.53.155.43 52.53.155.43
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  70. Dec 2024
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Comprehensive genomic characterization of hematologic malignancies at a pediatric tertiary care center
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    pmc.ncbi.nlm.nih.gov/articles/PMC11647012/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modeling Drug Responses and Evolutionary Dynamics using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple Negative Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617242/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The chromosome-level genome assembly of an endangered herb Bergenia scopulosa provides insights into local adaptation and genomic vulnerability under climate change
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    pmc.ncbi.nlm.nih.gov/articles/PMC11604060/
  74. 52.53.155.43 52.53.155.43
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  75. www.sciencedirect.com www.sciencedirect.com
    Genomic insights into Neolithic founding paternal lineages around the Qinghai-Xizang Plateau using integrated YanHuang resource
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    sciencedirect.com/science/article/pii/S258900422402683X
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines
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    pmc.ncbi.nlm.nih.gov/articles/PMC11621922/
  77. Nov 2024
  78. 52.53.155.43 52.53.155.43
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  79. 52.53.155.43 52.53.155.43
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  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Building a community-driven bioinformatics platform to facilitate Cannabis sativa multi-omics research
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    pmc.ncbi.nlm.nih.gov/articles/PMC11515022/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CannSeek? Yes we Can! An open-source single nucleotide polymorphism database and analysis portal for Cannabis sativa
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    pmc.ncbi.nlm.nih.gov/articles/PMC11480739/
  82. Oct 2024
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Clinical value of liquid biopsy in FGFR2 fusion-positive cholangiocarcinoma patients during targeted therapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443220/
  84. aacrjournals.org aacrjournals.org
    Clinical Outcome–Related Mutational Signatures Identified by Integrative Genomic Analysis in Nasopharyngeal Carcinoma
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    aacrjournals.org/clincancerres/article/26/24/6494/82920/Clinical-Outcome-Related-Mutational-Signatures
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Radiosensitizing Effect of PARP Inhibition on Chondrosarcoma and Chondrocyte Cells Is Dependent on Radiation LET
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    ncbi.nlm.nih.gov/pmc/articles/PMC11429578/
  86. Sep 2024
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The selected genes NR6A1, RSAD2-CMPK2, and COL3A1 contribute to body size variation in Meishan pigs through different patterns
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    ncbi.nlm.nih.gov/pmc/articles/PMC10548407/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel ERBB2 Variant Potentially Associated with Resistance against Anti-HER2 Monoclonal Antibody–Based Therapy in ERBB2-Amplified Metastatic Colorectal Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11393546/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Proteogenomics of Prostate Cancer Radioresistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11411600/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369621/
  91. Aug 2024
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant
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    ncbi.nlm.nih.gov/pmc/articles/PMC11406439/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transient Differentiation-State Plasticity Occurs During Acute Lymphoblastic Leukemia Initiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11325147/
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies
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    ncbi.nlm.nih.gov/pmc/articles/PMC11313601/
  95. www.biorxiv.org www.biorxiv.org
    A map of canine sequence variation relative to a Greenland wolf outgroup
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    biorxiv.org/content/10.1101/2024.06.03.597150v2
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deciphering cancer genomes with GenomeSpy: a grammar-based visualization toolkit
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  196. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Mitogenome evidence shows two radiation events and dispersals of matrilineal ancestry from northern coastal China to the Americas and Japan
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  198. Apr 2023
  199. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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    Genomic and transcriptomic characteristics of metastatic thyroid cancers with exceptional responses to radioactive iodine therapy.
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    Cell-Free Urine and Plasma DNA Mutational Analysis Predicts Neoadjuvant Chemotherapy Response and Outcome in Patients with Muscle-Invasive Bladder Cancer
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  203. Mar 2023
  204. academic.oup.com academic.oup.com
    Resequencing of a Pekin duck breeding population provides insights into the genomic response to short-term artificial selection
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  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Predicting Cancer Risk from Germline Whole-exome Sequencing Data Using a Novel Context-based Variant Aggregation Approach
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  206. www.sciencedirect.com www.sciencedirect.com
    Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson’s disease
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  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages
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  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  209. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A high-quality draft genome for Melaleuca alternifolia (tea tree): a new platform for evolutionary genomics of myrtaceous terpene-rich species
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  210. Feb 2023
  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive genomic profiling of upper tract urothelial carcinoma and urothelial carcinoma of the bladder identifies distinct molecular characterizations with potential implications for targeted therapy & immunotherapy
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  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  213. Jan 2023
  214. www.nature.com www.nature.com
    Germline rare deleterious variant load alters cancer risk, age of onset and tumor characteristics
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  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  217. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
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  218. Dec 2022
  219. www.sciencedirect.com www.sciencedirect.com
    Protocol to analyze population structure and migration history based on human genome variation data
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  220. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  221. Nov 2022
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    Reconstructing mutational lineages in breast cancer by multi-patient-targeted single-cell DNA sequencing
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  223. academic.oup.com academic.oup.com
    Selection signatures in goats reveal a novel deletion mutant underlying cashmere yield and diameter
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  224. Oct 2022
  225. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chromosome-level genome assembly for the Aldabra giant tortoise enables insights into the genetic health of a threatened population
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    Multiomic characterization and drug testing establish circulating tumor cells as an ex vivo tool for personalized medicine
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  228. Sep 2022
  229. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic Diversity and Selective Signature in Dabieshan Cattle Revealed by Whole-Genome Resequencing
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    Identification of candidate sex‐specific genomic regions in male and female Asian arowana genomes
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  231. www.sciencedirect.com www.sciencedirect.com
    Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer
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