662 Matching Annotations
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    Expression of endogenous retroviral elements is associated with extracellular matrix remodeling in prostate cancer
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    link.springer.com/article/10.1186/s13100-025-00382-9
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IGFBP3-SphK1/S1P Signaling Axis Drives Enzalutamide Resistance in Advanced Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12795166/
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    ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2666379125006135
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    Tachykinin signaling defines distinct populations of glia in the enteric nervous system
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    sciencedirect.com/science/article/pii/S0896627325009274
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    Multi-omics identifies oxidative stress, prothrombotic pathways, and lactoperoxidase variants as key factors in COVID-19 severity
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    sciencedirect.com/science/article/pii/S2352396425005614
  7. Dec 2025
  8. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    TIM-3 inhibition enhances breast tumor progression and metastasis: A paradoxical immune checkpoint response
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    sciencedirect.com:5037/science/article/pii/S0021925825029485
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    Extracellular matrix-myCAF signatures correlate with resistance to neoadjuvant aPD-L1 immune checkpoint inhibition with durvalumab + metformin in HPV+ HNSCC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12703361/
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    2025.12.04.692414.full-html.html
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    Positive feedback between histone H4K16 lactylation and glycolysis promotes MAFLD progression
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    link.springer.com/article/10.1007/s12072-025-10978-1
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    Olaparib and radiotherapy induce type I interferon and CD8+ T cell-dependent sensitization to immunotherapy in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12137021/
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    FRA1 drives melanoma metastasis through an actionable transcriptional network
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    pmc.ncbi.nlm.nih.gov/articles/PMC12669035/
  14. Nov 2025
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    Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors
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    MYC and p53 Alterations Cooperate through VEGF Signaling to Repress Cytotoxic T Cell and Immunotherapy Responses in Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12471896/
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    PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12477665/
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    Inhibiting cholesterol synthesis halts rhabdomyosarcoma growth via ER stress and cell cycle arrest
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    embopress.org/doi/10.1038/s44321-025-00336-x
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    MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer
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    sciencedirect.com/science/article/pii/S2211124725013762
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12616242/
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    CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
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    science.org/doi/10.1126/sciadv.adu0726
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    Oncostatin M induces epigenetic reprogramming in renal cell carcinoma-associated endothelial cells
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    nature.com/articles/s42003-025-08907-x
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intracellular Interleukin-1α in Peritumoral Monocytes Induces IL8 Production and Inhibits Mitophagy to Promote Stemness and Metastasis of Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12580797/
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    Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var
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    pmc.ncbi.nlm.nih.gov/articles/PMC12583703/
  25. Oct 2025
  26. www.sciencedirect.com www.sciencedirect.com
    Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS)
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    sciencedirect.com/science/article/pii/S1476558625001241
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    Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
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    sciencedirect.com/science/article/pii/S1934590925003674
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    Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction
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  29. www.biorxiv.org www.biorxiv.org
    Metabolic Alterations driven by PFKFB3 upregulation confer Resistance to Trastuzumab in HER2-Positive Breast Cancer
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    biorxiv.org/content/10.1101/2025.10.09.681343v1
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    CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma
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    biorxiv.org/content/10.1101/2025.10.14.681840v1
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    Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors
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    nature.com/articles/s41467-025-64255-8
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic and Immune Landscape of Pancreatic Ductal Adenocarcinoma Associated with Germline Pathogenic Variants in ATM
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    Cancer-associated fibroblasts expressing FSTL3 promote vasculogenic mimicry formation and drive colon cancer malignancy
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    Single Cell Analyses Reveal a Functionally Heterogeneous Exhausted CD8+ T Cell Subpopulation that is Correlated with Response to Checkpoint Therapy in Melanoma
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    Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility
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    ACSS2-Mediated Metabolic-Epigenetic Crosstalk Drives Fulvestrant Resistance and Represents a Novel Therapeutic Target
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    biorxiv.org/content/10.1101/2025.09.23.678089v1
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    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    Non-cell-autonomous tumor promotion in DICER1 cancer predisposition
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  39. Sep 2025
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    Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4
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    Seclidemstat (SP-2577) Induces Transcriptomic Reprogramming and Cytotoxicity in Multiple Fusion–Positive Sarcomas
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    Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development
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    Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling
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    Human papillomavirus integration induces oncogenic host gene fusions in oropharyngeal cancers
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    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    PPAR-δ Orchestrates a Pro-metastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer
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  47. Aug 2025
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    Retinoic acid disrupts an NPM1c/ROS/SENP3/ARF oncogenic axis in acute myeloid leukemia
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    Altered Protein Lipidation in Cancer: A Hidden Link to Sensory Neuronal Dysfunction
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    Transient gene melting governs the timing of oligodendrocyte maturation
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    Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy
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    Interplay of YEATS2 and GCDH regulates histone crotonylation and drives EMT in head and neck cancer
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    Evaluation of ferroptosis as a biomarker to predict treatment outcomes of cancer immunotherapy
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    Functional Role of Small Extrachromosomal Circular DNA in Colorectal Cancer
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    Whole-genome sequencing reveals three follicular lymphoma subtypes with distinct cell of origin and patient outcomes
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    Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
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    CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
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  60. Jul 2025
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    Palmitate‐Induced Primary Rat Senescent Astrocytes Exhibit Higher Inflammatory Activity and a Distinct Transcriptomic Profile Compared to Reactive Astrocytes
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    Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites
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    Dual Regulation of FZD1/7 by IGF2BP3 Enhances Stem-like Properties and Carboplatin Resistance in Triple-Negative Breast Cancer
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    PALB2 mutations increase oncogenic properties of breast epithelial cells by enhancing JAM3 and PARVB expression
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    An immune responsive tumor microenvironment imprints into PBMCs and predicts outcome in advanced pancreatic cancer: lessons from the PREDICT trial
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    Combined Inhibition of XPO1 and DNA Methylation Exerts Synergistic Effects in DLBCL
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    Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma
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    The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
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    High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA
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    Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis in Mice
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    ahajournals.org/doi/10.1161/ATVBAHA.123.319674
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    High-Throughput Drug Screening of Clear Cell Ovarian Cancer Organoids Reveals Vulnerability to Proteasome Inhibitors and Dinaciclib and Identifies AGR2 as a Therapeutic Target
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    Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer
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  75. Jun 2025
  76. rupress.org rupress.org
    Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation
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    POLQ mediated end-joining promotes DNA damage tolerance in neuroblastoma
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    The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
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    DDAH1 Promotes Cisplatin Chemoresistance in Patients with Locally Advanced Nasopharyngeal Carcinoma via the EGFR-JAK2-STAT3 Pathway
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    Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
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    RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis
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    Phase 2 trial of regorafenib in recurrent or metastatic adenoid cystic carcinoma
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    Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer
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  86. May 2025
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    The Influence of the Germline HSD3B1 Adrenal-Permissive Allele (c.1100 C) on the Somatic Alteration Landscape, the Transcriptome, and Immune Cell Infiltration in Prostate Cancer
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    Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple Myeloma
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    Hippo signaling is essential for the maintenance of zona glomerulosa cell fate in the murine adrenal cortex
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    IL-6-mediated tumorigenicity and antioxidant state in squamous cell carcinoma cells are driven by CD109 via stabilization of IL-6 receptor-alpha and activation of STAT3/NRF2 pathway
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  180. Sep 2024
  181. www.biorxiv.org www.biorxiv.org
    A Comprehensive Proteogenomic and Spatial Analysis of Innate and Acquired Resistance of Metastatic Melanoma to Immune Checkpoint Blockade Therapies
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    biorxiv.org/content/10.1101/2024.09.12.612675v1
  182. www.sciencedirect.com www.sciencedirect.com
    CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway
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  183. www.sciencedirect.com www.sciencedirect.com
    Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity
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  184. www.sciencedirect.com www.sciencedirect.com
    Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques
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    sciencedirect.com/science/article/pii/S1097276519300061
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IL36G-producing neutrophil-like monocytes promote cachexia in cancer
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  186. www.sciencedirect.com www.sciencedirect.com
    Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming
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  187. www.sciencedirect.com www.sciencedirect.com
    MAML3-fusions modulate vascular and immune tumour microenvironment and confer high metastatic risk in pheochromocytoma and paraganglioma
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  188. Aug 2024
  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures
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  190. www.sciencedirect.com www.sciencedirect.com
    Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis
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    Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cadmium activation of wild-type and constitutively active estrogen receptor alpha
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  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Contribution and Clinical Implication of Cancer-Associated Fibroblasts in Glioblastoma
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  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transient Differentiation-State Plasticity Occurs During Acute Lymphoblastic Leukemia Initiation
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  195. www.sciencedirect.com www.sciencedirect.com
    Epithelial organoid supports resident memory CD8 T cell differentiation
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  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p53R172H and p53R245W Hotspot Mutations Drive Distinct Transcriptomes in Mouse Mammary Tumors Through a Convergent Transcriptional Mediator
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    ncbi.nlm.nih.gov/pmc/articles/PMC11310746/
  197. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor Vessel Normalization via PFKFB3 Inhibition Alleviates Hypoxia and Increases Tumor Necrosis in Rectal Cancer upon Radiotherapy
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    BCL6 confers resistance to HDAC inhibitors in DLBCL
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  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma
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  200. Jul 2024
  201. www.sciencedirect.com www.sciencedirect.com
    Pandemic-associated pernio harbors footprints of an abortive SARS-CoV-2 infection
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    IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma
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    Identification of immunosenescence of unconventional T cells in hepatocellular carcinoma
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  204. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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  205. 52.53.155.43 52.53.155.43
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    RNF185 control of COL3A1 expression limits prostate cancer migration and metastatic potential
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  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of ADAM29 does not affect viability and fertility in mice but improves wound healing
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  208. Jun 2024
  209. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The clock gene BHLHE40 and atypical CCNG2 control androgen-induced cellular senescence as a novel tumor suppressive pathway in prostate cancer
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  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Short-chain fatty acid valerate reduces voluntary alcohol intake in male mice
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  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma
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  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Surgical tumour resection deregulates Hallmarks of Cancer in resected tissue and the surrounding microenvironment
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  213. aacrjournals.org aacrjournals.org
    Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
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    aacrjournals.org/cancerres/article/84/11/1834/745520/Obesogenic-High-Fat-Diet-and-MYC-Cooperate-to
  214. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Memory/Active T-Cell Activation Is Associated with Immunotherapeutic Response in Fumarate Hydratase–Deficient Renal Cell Carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11145163/
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    NR4A1 transcriptionally regulates the differentiation of stem-like CD8+ T cells in the tumor microenvironment
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