701 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC7618455/
  3. arxiv.org arxiv.org
    2510.17064v3.pdf
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    arxiv.org/pdf/2510.17064
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Serotonin modulates lineage plasticity in neuroendocrine prostate cancer via epigenetic reprogramming
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    pmc.ncbi.nlm.nih.gov/articles/PMC13040212/
  5. 54.241.53.176 54.241.53.176
    Integrating interferon gamma receptor pathways, antigenicity, and immune contexture as predictors of immunotherapeutic strategies for mucosal melanomas
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    54.241.53.176/3e63435d4731406bfcdb4ffda4d231800522dc1e/inline-supplementary-material-1-html.html
  6. Apr 2026
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting senescence-like tumor-associated macrophages sensitizes chemotherapy in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13009420/
  8. Mar 2026
  9. www.nature.com www.nature.com
    Loss of ABCA3 disrupts lipid balance and leads to AMPK-dependent suppression of SREBP1 in glioblastoma stem cells
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    nature.com/articles/s41388-026-03736-6
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Baseline tumor features and systemic immune dynamics underlying efficacy in MSS metastatic colorectal cancer treated with regorafenib, ipilimumab, and nivolumab
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    pmc.ncbi.nlm.nih.gov/articles/PMC13015846/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ROME, an Ancient Gene with a Novel Function in Vertebrates, Is a Key Modulator of Embryonal Development and Cancer Metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012068/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LSD1 Performs Demethylase-Independent and Context-Specific Roles in Ewing Sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012034/
  13. 54.241.53.176 54.241.53.176
    1-s2.0-S1525001626002078-main-html.html
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    54.241.53.176/1bbab35eaaabafd7256ed6ca4414216ab2c9bdd6/1-s2.0-S1525001626002078-main-html.html
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12995289/
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    Cancer cell-derived sialylated IgG interacting with Siglec-7/9/10 is a potential immunotherapeutic target in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000777
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dysregulated lipid metabolism and hypomyelination in postnatal peroxisome-deficient Pex2 knockout Zellweger mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12971716/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Multi-Step Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12974268/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Up-regulation of an epithelial miRNA is associated with immune evasion in progressive bronchial premalignant lesions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12969512/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic enrichment and functional impact of TP53 and CYLD alterations in recurrent and metastatic HPV-associated head and neck cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12959380/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    OGDHL promotes prostate cancer progression and regulates neuroendocrine marker expression and nucleotide abundance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12949684/
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    Reconstruction of T cell infiltration in an osteosarcoma PDX-organoid interactive biobank for personalized immunotherapy
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    sciencedirect.com/science/article/pii/S2666379126000613
  22. Feb 2026
  23. www.sciencedirect.com www.sciencedirect.com
    MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species
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    sciencedirect.com/science/article/pii/S1074761326000336
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrative Clinical and Molecular Evaluation of Renal Cell Carcinoma with Merlin Protein Deficiency and Biallelic Loss of NF2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12924687/
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    Genetic loss of CHD1 regulates distinct histone post-translational modifications in the development of castration-resistant prostate cancer
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    sciencedirect.com/science/article/pii/S1476558626000187
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    Heterogeneity and plasticity of the naive CD4+ T cell compartment
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    sciencedirect.com/science/article/pii/S2211124726000586
  27. 54.241.53.176 54.241.53.176
    2026.02.12.705483.full-html.html
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    54.241.53.176/e417c792f55970f31d0a8038bf2e5c0f6db5e57a/2026.02.12.705483.full-html.html
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BICC1 interacts with PKD1 and PKD2 to drive cystogenesis in ADPKD
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    pmc.ncbi.nlm.nih.gov/articles/PMC12900513/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defective DNA Damage Response is a Targetable Therapeutic Vulnerability in ESR1 Mutant Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12898867/
  30. www.sciencedirect.com www.sciencedirect.com
    NF-κB and STAT3 signaling uniquely stratify survival in female glioblastoma patients
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    sciencedirect.com/science/article/pii/S2589004226001367
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The molecular and functional landscape of resistance to FOLFIRI chemotherapy in metastatic colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12877753/
  32. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Bidirectional Communication Between Astrocytes and Neurons via Extracellular Vesicles: A Multi-Omics Approach
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    onlinelibrary.wiley.com/doi/10.1111/jnc.70373
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aberrant Hippo-YAP/TEAD Signaling Drives Malignant Transcriptional Reprogramming in External Auditory Canal Squamous Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12862246/
  34. Jan 2026
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lazertinib with stereotactic body radiotherapy in oligometastatic EGFR-mutant non-small-cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12874586/
  36. www.sciencedirect.com www.sciencedirect.com
    A Jagged1-regulated hybrid-EMT state identifies pancreatic cancer stem cells
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    sciencedirect.com/science/article/pii/S221112472501681X
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Circ72309 modulates gemcitabine metabolism and gemcitabine sensitivity in pancreatic cancer: Serum Circ72309 levels as a potential predictor of treatment response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12823056/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A prognostic signature for lung adenocarcinoma in patients who have never smoked
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    pmc.ncbi.nlm.nih.gov/articles/PMC12822368/
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    Multistep molecular trajectory of monocytic myeloid-derived suppressor cell induction by diffuse large B-cell lymphoma cells
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    sciencedirect.com/science/article/pii/S0006291X26000501
  40. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A-Dependent hnRNPA2B1/COX-2 Axis
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202519490
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FNDC4 Drives Metastasis and Immune Evasion in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12809120/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Using an Unbiased Coexpression Network to Reveal Cross‐Talking Pathways of Phosphoinositide‐3‐Kinase Regulatory Subunit 1 in Skin Aging and Rejuvenation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12811739/
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    Multi-Omics Profiling Reveals Distinct Immunosuppression and Metabolic Dysregulation in Aggressive Subtypes of Thyroid Cancer
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    sciencedirect.com/science/article/pii/S1535947626000083
  44. www.nature.com www.nature.com
    RAS/MEK/PI3K pathway inhibition augments response to CD40 agonism by targeting CD11b+ Bregs thereby overcoming melanoma PD1-resistance
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    nature.com/articles/s41467-025-67315-1
  45. link.springer.com link.springer.com
    Expression of endogenous retroviral elements is associated with extracellular matrix remodeling in prostate cancer
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    link.springer.com/article/10.1186/s13100-025-00382-9
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IGFBP3-SphK1/S1P Signaling Axis Drives Enzalutamide Resistance in Advanced Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12795166/
  47. www.sciencedirect.com www.sciencedirect.com
    ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2666379125006135
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tachykinin signaling defines distinct populations of glia in the enteric nervous system
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    pmc.ncbi.nlm.nih.gov/articles/PMC12832054/
  49. www.sciencedirect.com www.sciencedirect.com
    Multi-omics identifies oxidative stress, prothrombotic pathways, and lactoperoxidase variants as key factors in COVID-19 severity
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    sciencedirect.com/science/article/pii/S2352396425005614
  50. Dec 2025
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TIM-3 inhibition enhances breast tumor progression and metastasis: A paradoxical immune checkpoint response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12856319/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Extracellular matrix-myCAF signatures correlate with resistance to neoadjuvant aPD-L1 immune checkpoint inhibition with durvalumab + metformin in HPV+ HNSCC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12703361/
  53. 54.241.53.176 54.241.53.176
    2025.12.04.692414.full-html.html
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    54.241.53.176/4dc137cabeb3d8739cc92ea208202d3aee2e5903/2025.12.04.692414.full-html.html
  54. link.springer.com link.springer.com
    Positive feedback between histone H4K16 lactylation and glycolysis promotes MAFLD progression
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    link.springer.com/article/10.1007/s12072-025-10978-1
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Olaparib and radiotherapy induce type I interferon and CD8+ T cell-dependent sensitization to immunotherapy in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12137021/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FRA1 drives melanoma metastasis through an actionable transcriptional network
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    pmc.ncbi.nlm.nih.gov/articles/PMC12669035/
  57. Nov 2025
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12638015/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MYC and p53 Alterations Cooperate through VEGF Signaling to Repress Cytotoxic T Cell and Immunotherapy Responses in Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12471896/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12477665/
  61. www.embopress.org www.embopress.org
    Inhibiting cholesterol synthesis halts rhabdomyosarcoma growth via ER stress and cell cycle arrest
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    embopress.org/doi/10.1038/s44321-025-00336-x
  62. www.sciencedirect.com www.sciencedirect.com
    MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer
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    sciencedirect.com/science/article/pii/S2211124725013762
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12616242/
  64. www.science.org www.science.org
    CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
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    science.org/doi/10.1126/sciadv.adu0726
  65. www.nature.com www.nature.com
    Oncostatin M induces epigenetic reprogramming in renal cell carcinoma-associated endothelial cells
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    nature.com/articles/s42003-025-08907-x
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intracellular Interleukin-1α in Peritumoral Monocytes Induces IL8 Production and Inhibits Mitophagy to Promote Stemness and Metastasis of Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12580797/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var
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    pmc.ncbi.nlm.nih.gov/articles/PMC12583703/
  68. Oct 2025
  69. www.sciencedirect.com www.sciencedirect.com
    Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS)
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    sciencedirect.com/science/article/pii/S1476558625001241
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    Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
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    sciencedirect.com/science/article/pii/S1934590925003674
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12541299/
  72. www.biorxiv.org www.biorxiv.org
    Metabolic Alterations driven by PFKFB3 upregulation confer Resistance to Trastuzumab in HER2-Positive Breast Cancer
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    biorxiv.org/content/10.1101/2025.10.09.681343v1
  73. www.biorxiv.org www.biorxiv.org
    CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma
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    biorxiv.org/content/10.1101/2025.10.14.681840v1
  74. www.nature.com www.nature.com
    Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors
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    nature.com/articles/s41467-025-64255-8
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic and Immune Landscape of Pancreatic Ductal Adenocarcinoma Associated with Germline Pathogenic Variants in ATM
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    pmc.ncbi.nlm.nih.gov/articles/PMC12500237/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cancer-associated fibroblasts expressing FSTL3 promote vasculogenic mimicry formation and drive colon cancer malignancy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12501291/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single Cell Analyses Reveal a Functionally Heterogeneous Exhausted CD8+ T Cell Subpopulation that is Correlated with Response to Checkpoint Therapy in Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12356630/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility
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    pmc.ncbi.nlm.nih.gov/articles/PMC12490860/
  79. www.biorxiv.org www.biorxiv.org
    ACSS2-Mediated Metabolic-Epigenetic Crosstalk Drives Fulvestrant Resistance and Represents a Novel Therapeutic Target
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    biorxiv.org/content/10.1101/2025.09.23.678089v1
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  81. www.sciencedirect.com www.sciencedirect.com
    Non-cell-autonomous tumor promotion in DICER1 cancer predisposition
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    sciencedirect.com/science/article/pii/S1534580725005398
  82. Sep 2025
  83. www.sciencedirect.com www.sciencedirect.com
    Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4
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    sciencedirect.com/science/article/pii/S1074761325004145
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Seclidemstat (SP-2577) Induces Transcriptomic Reprogramming and Cytotoxicity in Multiple Fusion–Positive Sarcomas
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    pmc.ncbi.nlm.nih.gov/articles/PMC12421227/
  85. www.sciencedirect.com www.sciencedirect.com
    Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development
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    sciencedirect.com/science/article/pii/S2666979X25002423
  86. www.sciencedirect.com www.sciencedirect.com
    Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling
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    sciencedirect.com/science/article/pii/S009286742500978X
  87. aacrjournals.org aacrjournals.org
    Human papillomavirus integration induces oncogenic host gene fusions in oropharyngeal cancers
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    aacrjournals.org/cancerdiscovery/article/15/9/1927/764362/Human-Papillomavirus-Integration-Induces-Oncogenic
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875962/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PPAR-δ Orchestrates a Pro-metastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12402788/
  90. Aug 2025
  91. www.nature.com www.nature.com
    Retinoic acid disrupts an NPM1c/ROS/SENP3/ARF oncogenic axis in acute myeloid leukemia
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    nature.com/articles/s41375-025-02731-2
  92. www.sciencedirect.com www.sciencedirect.com
    Altered Protein Lipidation in Cancer: A Hidden Link to Sensory Neuronal Dysfunction
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    sciencedirect.com/science/article/pii/S1476927125003172
  93. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225016992-main-html.html
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