651 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12638015/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MYC and p53 Alterations Cooperate through VEGF Signaling to Repress Cytotoxic T Cell and Immunotherapy Responses in Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12471896/
  4. Nov 2025
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12477665/
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    Inhibiting cholesterol synthesis halts rhabdomyosarcoma growth via ER stress and cell cycle arrest
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    embopress.org/doi/10.1038/s44321-025-00336-x
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    MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer
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    sciencedirect.com/science/article/pii/S2211124725013762
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12616242/
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    CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
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    science.org/doi/10.1126/sciadv.adu0726
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    Oncostatin M induces epigenetic reprogramming in renal cell carcinoma-associated endothelial cells
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    nature.com/articles/s42003-025-08907-x
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intracellular Interleukin-1α in Peritumoral Monocytes Induces IL8 Production and Inhibits Mitophagy to Promote Stemness and Metastasis of Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12580797/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var
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    pmc.ncbi.nlm.nih.gov/articles/PMC12583703/
  13. Oct 2025
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    Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS)
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    sciencedirect.com/science/article/pii/S1476558625001241
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    Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
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    sciencedirect.com/science/article/pii/S1934590925003674
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12541299/
  17. www.biorxiv.org www.biorxiv.org
    Metabolic Alterations driven by PFKFB3 upregulation confer Resistance to Trastuzumab in HER2-Positive Breast Cancer
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    biorxiv.org/content/10.1101/2025.10.09.681343v1
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    CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma
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    biorxiv.org/content/10.1101/2025.10.14.681840v1
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    Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors
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    nature.com/articles/s41467-025-64255-8
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic and Immune Landscape of Pancreatic Ductal Adenocarcinoma Associated with Germline Pathogenic Variants in ATM
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    pmc.ncbi.nlm.nih.gov/articles/PMC12500237/
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    Cancer-associated fibroblasts expressing FSTL3 promote vasculogenic mimicry formation and drive colon cancer malignancy
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  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single Cell Analyses Reveal a Functionally Heterogeneous Exhausted CD8+ T Cell Subpopulation that is Correlated with Response to Checkpoint Therapy in Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12356630/
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    Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility
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    pmc.ncbi.nlm.nih.gov/articles/PMC12490860/
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    ACSS2-Mediated Metabolic-Epigenetic Crosstalk Drives Fulvestrant Resistance and Represents a Novel Therapeutic Target
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    biorxiv.org/content/10.1101/2025.09.23.678089v1
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    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
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    Non-cell-autonomous tumor promotion in DICER1 cancer predisposition
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  27. Sep 2025
  28. www.sciencedirect.com www.sciencedirect.com
    Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4
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    sciencedirect.com/science/article/pii/S1074761325004145
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    Seclidemstat (SP-2577) Induces Transcriptomic Reprogramming and Cytotoxicity in Multiple Fusion–Positive Sarcomas
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    Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development
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    Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling
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    Human papillomavirus integration induces oncogenic host gene fusions in oropharyngeal cancers
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    PKN2 is a dependency of the mesenchymal-like cancer cell state
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  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PPAR-δ Orchestrates a Pro-metastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12402788/
  35. Aug 2025
  36. www.nature.com www.nature.com
    Retinoic acid disrupts an NPM1c/ROS/SENP3/ARF oncogenic axis in acute myeloid leukemia
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    Altered Protein Lipidation in Cancer: A Hidden Link to Sensory Neuronal Dysfunction
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    Transient gene melting governs the timing of oligodendrocyte maturation
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    Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12363560/
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    Interplay of YEATS2 and GCDH regulates histone crotonylation and drives EMT in head and neck cancer
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    FRA1 drives melanoma metastasis through an actionable transcriptional network
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    Evaluation of ferroptosis as a biomarker to predict treatment outcomes of cancer immunotherapy
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    Functional Role of Small Extrachromosomal Circular DNA in Colorectal Cancer
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    Whole-genome sequencing reveals three follicular lymphoma subtypes with distinct cell of origin and patient outcomes
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    Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
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    CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
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  48. Jul 2025
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Palmitate‐Induced Primary Rat Senescent Astrocytes Exhibit Higher Inflammatory Activity and a Distinct Transcriptomic Profile Compared to Reactive Astrocytes
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    Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites
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    Dual Regulation of FZD1/7 by IGF2BP3 Enhances Stem-like Properties and Carboplatin Resistance in Triple-Negative Breast Cancer
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    PALB2 mutations increase oncogenic properties of breast epithelial cells by enhancing JAM3 and PARVB expression
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    An immune responsive tumor microenvironment imprints into PBMCs and predicts outcome in advanced pancreatic cancer: lessons from the PREDICT trial
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    Combined Inhibition of XPO1 and DNA Methylation Exerts Synergistic Effects in DLBCL
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    Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma
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    The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
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    High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA
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    Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis in Mice
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    ahajournals.org/doi/10.1161/ATVBAHA.123.319674
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    High-Throughput Drug Screening of Clear Cell Ovarian Cancer Organoids Reveals Vulnerability to Proteasome Inhibitors and Dinaciclib and Identifies AGR2 as a Therapeutic Target
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    Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer
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  63. Jun 2025
  64. rupress.org rupress.org
    Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation
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    POLQ mediated end-joining promotes DNA damage tolerance in neuroblastoma
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    The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
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    DDAH1 Promotes Cisplatin Chemoresistance in Patients with Locally Advanced Nasopharyngeal Carcinoma via the EGFR-JAK2-STAT3 Pathway
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    Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
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    RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis
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    Phase 2 trial of regorafenib in recurrent or metastatic adenoid cystic carcinoma
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    Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer
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  74. May 2025
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    The Influence of the Germline HSD3B1 Adrenal-Permissive Allele (c.1100 C) on the Somatic Alteration Landscape, the Transcriptome, and Immune Cell Infiltration in Prostate Cancer
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  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple Myeloma
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  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hippo signaling is essential for the maintenance of zona glomerulosa cell fate in the murine adrenal cortex
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  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IL-6-mediated tumorigenicity and antioxidant state in squamous cell carcinoma cells are driven by CD109 via stabilization of IL-6 receptor-alpha and activation of STAT3/NRF2 pathway
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  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Emerin Dysregulation Drives the Very-Small-Nuclear Phenotype and Lineage Plasticity That Associate with a Clinically Aggressive Subtype of Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079098/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Treatment Efficacy and Molecular Dynamics of Neoadjuvant Durvalumab and Olaparib in Resectable Urothelial Bladder Cancer: The NEODURVARIB Trial
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    MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors
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    DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation
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    Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids
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  85. Apr 2025
  86. elifesciences.org elifesciences.org
    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
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    elifesciences.org/reviewed-preprints/106492
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    PDZK1 inhibits MRP2-mediated oxaliplatin chemosensitivity in hepatocellular carcinoma
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  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis
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    Protocol for deep-learning-driven cell type label transfer in single-cell RNA sequencing data
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    A common ground: an in silico assessment of the sources of intrinsic ex vivo resistance to venetoclax in acute myeloid leukemia
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    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
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  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  188. Jul 2024
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  196. Jun 2024
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    Surgical tumour resection deregulates Hallmarks of Cancer in resected tissue and the surrounding microenvironment
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    Memory/Active T-Cell Activation Is Associated with Immunotherapeutic Response in Fumarate Hydratase–Deficient Renal Cell Carcinoma
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  204. May 2024
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    A cocktail of rapamycin, acarbose, and phenylbutyrate prevents age-related cognitive decline in mice by targeting multiple aging pathways
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    ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF
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    Targeting ferroptosis-elicited inflammation suppresses hepatocellular carcinoma metastasis and enhances sorafenib efficacy
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    T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells
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    The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects
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    Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy
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    A phosphate transporter in VIPergic neurons of the suprachiasmatic nucleus gates locomotor activity during the light/dark transition in mice
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