218 Matching Annotations
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    Increased serum Neurofilament light chain levels in Parkinson’s Disease patients carrying the p.A53T SNCA mutation: Data from the PPMI study
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    medrxiv.org/content/10.1101/2025.08.28.25334674v1
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    Serum Neurofilament light chain predicts autonomic symptoms in early Parkinson’s disease
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    tandfonline.com/doi/abs/10.1080/17582024.2025.2554531
  4. movementdisorders.onlinelibrary.wiley.com movementdisorders.onlinelibrary.wiley.com
    Compound Heterozygous Structural Variants in Cases with Unsolved PRKN-Associated Parkinson's Disease
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    movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.70027
  5. Aug 2025
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    Wearable tracking of walking and non-walking as progression markers in early Parkinson’s disease
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    medrxiv.org/content/10.1101/2025.08.19.25333986v1
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    Towards Harmonizing Quantification of Dopamine Neuron Imaging Biomarkers in Parkinson’s Disease: The Centamine Scale
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    medrxiv.org/content/10.1101/2025.08.19.25333801v1
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    Long-read sequencing identifies FGF14 repeat expansions in Parkinson’s disease
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    medrxiv.org/content/10.1101/2025.08.14.25333596v1
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    Relationship Between VMAT2-PET and DAT-SPECT Caudate Binding and Parkinson’s Disease Cognitive Decline
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    sciencedirect.com/science/article/pii/S1353802025007497
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    Investigating the Association Between Choroid Plexus Volume and the Pathogenesis of Parkinson's Disease
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    sciencedirect.com/science/article/pii/S135380202500728X
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Baseline α-synuclein seeding activity and disease progression in sporadic and genetic Parkinson's disease in the PPMI cohort
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    pmc.ncbi.nlm.nih.gov/articles/PMC12354789/
  12. movementdisorders.onlinelibrary.wiley.com movementdisorders.onlinelibrary.wiley.com
    Glymphatic Dysfunction in Non-Manifesting Carriers of LRRK2 and GBA Pathogenic Variants
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    movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.30306
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    Fall Frequency, Risk Factors, and Outcomes in Parkinson’s Disease: A Cross-Sectional Analysis
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    medrxiv.org/content/10.1101/2025.08.05.25332959v1
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    Non-motor symptom subtypes in early Parkinson's disease
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    sciencedirect.com/science/article/pii/S1353802025007230
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LRRK2 kinase activity regulates Parkinson’s disease-relevant lipids at the lysosome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12330094/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Two-step detection of Lewy body pathology via smell-function testing and CSF α-synuclein seed amplification
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    pmc.ncbi.nlm.nih.gov/articles/PMC12325632/
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    Optimizing Parkinson’s Disease progression scales using computational methods
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    medrxiv.org/content/10.1101/2025.07.31.25332494v1
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    The Need for Developing Consensus-Based Guidelines in Assessing Parkinson’s Disease Laterality
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    medrxiv.org/content/10.1101/2025.07.24.25332091v1
  19. Jul 2025
  20. www.mdpi.com www.mdpi.com
    Predicting Cognitive Decline in Parkinson’s Disease Using Artificial Neural Networks: An Explainable AI Approach
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    mdpi.com/2076-3425/15/8/782
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SAGEFusionNet: An Auxiliary Supervised Graph Neural Network for Brain Age Prediction as a Neurodegenerative Biomarker
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    pmc.ncbi.nlm.nih.gov/articles/PMC12293683/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multi-cohort machine learning identifies predictors of cognitive impairment in Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12297691/
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    Modeling the Heterogeneity and Trajectories of Cognitive Dysfunction in Parkinson’s Disease Using Partially Ordered Set Models
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    medrxiv.org/content/10.1101/2025.07.21.25331873v1
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    Trajectories of Pontine Volume in Patients with Multiple System Atrophy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12273624/
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    Neuroplastic Effects of Dance Training in Parkinson’s Disease: Functional and Structural Modulation in Speech-Related Brain Regions
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    medrxiv.org/content/10.1101/2025.07.03.25330757v1
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    Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12244338/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ensemblex: an accuracy-weighted ensemble genetic demultiplexing framework for population-scale scRNAseq sample pooling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12224856/
  28. Jun 2025
  29. academic.oup.com academic.oup.com
    Neuroimaging-based data-driven subtypes of spatiotemporal atrophy due to Parkinson’s disease
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    academic.oup.com/braincomms/article/7/2/fcaf146/8114734
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dopa Responsiveness in Parkinson's Disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11452786/
  31. www.nature.com www.nature.com
    Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI
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    nature.com/articles/s41597-025-05028-2
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    Development and Validation of PARCOMS Composite Scales for Assessing Disease Progression and Treatment Effects in Parkinson’s Disease
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    link.springer.com/article/10.1007/s40120-025-00771-5
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clinical progression and genetic pathways in body-first and brain-first Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12181842/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evaluating language model embeddings for Parkinson’s disease cohort harmonization using a novel manually curated variable mapping schema
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    pmc.ncbi.nlm.nih.gov/articles/PMC12181335/
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    Wrist accelerometry and machine learning sensitively capture disease progression in prodromal Parkinson’s disease
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    nature.com/articles/s41531-025-01034-8
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    Diagnostic and prognostic value of α-synuclein seed amplification assay kinetic measures in Parkinson's disease: a longitudinal cohort study
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    thelancet.com/journals/laneur/article/PIIS1474-4422(25)00157-7/abstract
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    Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson’s disease motor severity
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    nature.com/articles/s41531-025-01010-2
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CSF Biomarker-Based Cognitive Trajectories in Parkinson's Disease-Subjective Cognitive Decline
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    pmc.ncbi.nlm.nih.gov/articles/PMC12343326/
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    Epigenome‐wide association study, meta‐analysis, and multiscore profiling of whole blood in Parkinson's disease
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    onlinelibrary.wiley.com/doi/10.1002/acn3.52292
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Subregional analysis of the amygdala, thalamus, and hypothalamus at the pre-decline stage in Parkinson’s disease with later cognitive impairment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12098468/
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    An individualized tractography pipeline for the nucleus basalis of Meynert lateral tract
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    pmc.ncbi.nlm.nih.gov/articles/PMC12148219/
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    Optimizing wrist-worn wearable compliance with insights from two Parkinson’s disease cohort studies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12144100/
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    Wearables-derived risk score for unintrusive detection of α-synuclein aggregation or dopaminergic deficit
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    sciencedirect.com/science/article/pii/S2352396425002269
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Longitudinal prevalence of neurogenic orthostatic hypotension in the idiopathic Parkinson Progression Marker Initiative (PPMI) cohort
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    pmc.ncbi.nlm.nih.gov/articles/PMC11128342/
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    The Parkinson's Disease Cognitive Composite: Lessons Forgotten from Preclinical Alzheimer's Cognitive Composites
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    movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.30246
  46. May 2025
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12106619/
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    Motor asymmetry in Parkinson’s disease: Diagnostic thresholds based on clinical scores and DaTSCAN imaging
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    sciencedirect.com/science/article/pii/S2590112525000544
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Examining the Relationship Between Physical Function and Anxiety/Depression in Parkinson's
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    pmc.ncbi.nlm.nih.gov/articles/PMC12105650/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments
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    pmc.ncbi.nlm.nih.gov/articles/PMC12092246/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Early BMI Change, Cognitive Decline, and CSF AD Biomarkers Alterations in Parkinson's Disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12093342/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Relationships between neuropsychiatric symptoms, subtypes of astrocyte activities, and brain pathologies in Alzheimer's disease and Parkinson's disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12089078/
  53. www.neurology.org www.neurology.org
    Predicting CSF α-Synuclein Seed Amplification Assay Status From Demographics and Clinical Data | Neurology Open Access
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    neurology.org/doi/10.1212/WN9.0000000000000008
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Independent validation of the PrecivityAD2™ blood test to identify presence or absence of brain amyloid pathology in individuals with cognitive impairment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12036378/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Predicting dementia in people with Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12075756/
  56. www.nature.com www.nature.com
    Modulatory effect of levodopa on the basal ganglia-cerebellum connectivity in Parkinson’s disease
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    nature.com/articles/s41531-025-00954-9
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Item Response Modeling and Artificial Neural Network for Differentiation of Parkinson's Patients and Subjects Without Evidence of Dopaminergic Deficit
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    pmc.ncbi.nlm.nih.gov/articles/PMC12072227/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Plasma Glucosylceramide Levels Are Regulated by ATP10D and Are Not Involved in Parkinson's Disease Pathogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12010051/
  59. Apr 2025
  60. www.neurology.org www.neurology.org
    α-Synuclein Seed Amplification Assay Amplification Parameters and the Risk of Progression in Prodromal Parkinson Disease | Neurology
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    neurology.org/doi/10.1212/WNL.0000000000210279
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    Hyposmia in Parkinson’s disease; exploring selective odour loss
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    pmc.ncbi.nlm.nih.gov/articles/PMC11971265/
  62. journals.plos.org journals.plos.org
    An integrative network approach for longitudinal stratification in Parkinson’s disease
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    journals.plos.org/ploscompbiol/article
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson’s Disease Psychosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962800/
  64. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Domain‐Specific Prediction of Clinical Progression in Parkinson's Disease Using the Mosaic Approach
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    onlinelibrary.wiley.com/doi/10.1002/brb3.70289
  65. www.medrxiv.org www.medrxiv.org
    Amplification parameters of the alpha-synuclein seed amplification assay on CSF predict the clinical subtype of Parkinson’s Disease at 10-year follow-up
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    medrxiv.org/content/10.1101/2025.03.27.25324778v1
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Carriers of LRRK2 pathogenic variants show a milder, anatomically distinct brain signature of Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11952604/
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    Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease
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    onlinelibrary.wiley.com/doi/10.1002/ana.27223
  68. Mar 2025
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LRRK2-associated parkinsonism with and without in vivo evidence of alpha-synuclein aggregates: longitudinal clinical and biomarker characterization
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    pmc.ncbi.nlm.nih.gov/articles/PMC11925012/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    History of Traumatic Brain Injury Does Not Influence Rate of Progression of Clinical or Pathological Outcomes in Two Early Parkinson's Disease Cohorts
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    pmc.ncbi.nlm.nih.gov/articles/PMC11926254/
  71. www.medrxiv.org www.medrxiv.org
    Using polygenic and transcriptional risk scores to investigate psychiatric and cognitive symptoms in Parkinson’s disease
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    medrxiv.org/content/10.1101/2025.03.20.25324166v1
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    Longitudinal Assessment of DNA Repair Signature Trajectory in Prodromal versus Established Parkinson’s Disease
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    medrxiv.org/content/10.1101/2025.03.19.25324249v1
  73. www.sciencedirect.com www.sciencedirect.com
    Free Water Imaging Reveals Asynchronous Dopaminergic Degeneration in Substantia Nigra and Ventral Tegmental Area in Prodromal and Early Parkinson's Disease
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    sciencedirect.com/science/article/pii/S0361923025001212
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AskBeacon—performing genomic data exchange and analytics with natural language
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    pmc.ncbi.nlm.nih.gov/articles/PMC11889448/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11861111/
  76. www.medrxiv.org www.medrxiv.org
    Nasal septum deviation correlates with asymmetry in Parkinson’s disease
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    medrxiv.org/content/10.1101/2025.02.27.25322941v1
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    A monoclonal antibody-based immunoassay reinforces DOPA decarboxylase in cerebrospinal fluid as a diagnostic and prognostic biomarker for Parkinson’s disease
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    medrxiv.org/content/10.1101/2025.02.26.25322938v1
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Male sex accelerates cognitive decline in GBA1 Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11880540/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson’s disease: A DNA co-methylation network analysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11873129/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RGS10 attenuates systemic immune dysregulation induced by chronic inflammatory stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC11852585/
  81. Feb 2025
  82. www.medrxiv.org www.medrxiv.org
    Progression GWAS followed by functional characterization implicates E3 ubiquitin ligase TRIM2 as a potential genetic modifier of Parkinson’s disease progression
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    medrxiv.org/content/10.1101/2025.02.21.25322301v1
  83. www.medrxiv.org www.medrxiv.org
    Contralateral spread of unilateral tremor in Parkinson’s Disease
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    medrxiv.org/content/10.1101/2025.02.20.25322608v1
  84. www.sciencedirect.com www.sciencedirect.com
    Can we detect cognitive “super-agers” in Parkinson’s disease? Cognitive, neuropsychiatric and motor outcomes in the first 10 years of Parkinson’s disease.
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    sciencedirect.com/science/article/pii/S1353802025000860
  85. www.nature.com www.nature.com
    Patient-centered brain transcriptomic and multimodal imaging determinants of clinical progression, physical activity, and treatment needs in Parkinson’s disease
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    nature.com/articles/s41531-025-00878-4
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Motor and nonmotor features of p.A53T alpha-synuclein PD vs idiopathic PD: longitudinal data from the PPMI study
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    pmc.ncbi.nlm.nih.gov/articles/PMC11814018/
  87. 52.53.155.43 52.53.155.43
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  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptomics profiling of Parkinson’s disease progression subtypes reveals distinctive patterns of gene expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11791511/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment
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    pmc.ncbi.nlm.nih.gov/articles/PMC11779843/
  90. www.nature.com www.nature.com
    Relative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson’s disease
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    nature.com/articles/s41531-024-00818-8
  91. www.medrxiv.org www.medrxiv.org
    Decline in striatal binding ratio associated with accelerated decline in performance on Symbol Digit Modality but not MoCA in Parkinson’s disease psychosis
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    medrxiv.org/content/10.1101/2024.08.01.24311353v1
  92. Jan 2025
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  94. bpspsychub.onlinelibrary.wiley.com bpspsychub.onlinelibrary.wiley.com
    Dopamine genetic risk scores and psychiatric symptoms: Interacting risk factors for impulse control behaviours in de novo Parkinson's disease
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  118. Oct 2024
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  129. Aug 2024
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  141. Jul 2024
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  157. Jun 2024
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  162. May 2024
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  170. Apr 2024
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  179. Mar 2024
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  183. Feb 2024
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  190. Jan 2024
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  200. Nov 2023
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  213. Sep 2023
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