504 Matching Annotations
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  2. 52.53.155.43 52.53.155.43
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  3. Aug 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutational analysis of early, low-grade bowel polyps defines a subgroup with concurrent, high-risk oncogenic drivers independent of polyp size
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    pmc.ncbi.nlm.nih.gov/articles/PMC12361885/
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    Image-based drug screening combined with molecular profiling identifies signatures and drivers of therapy resistance in pediatric AML
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    sciencedirect.com/science/article/pii/S2666379125003775
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    AI-driven multimodal algorithm predicts immunotherapy and targeted therapy outcomes in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S2666379125003726
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    AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12355176/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Weak evidence for heritable changes in response to selection by aphids in Arabidopsis accessions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12342813/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic Signatures of Poor Prognosis in Merkel Cell Carcinoma: A Single-Institution Prospective Study
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    pmc.ncbi.nlm.nih.gov/articles/PMC12336863/
  10. www.science.org www.science.org
    Histone acetylation readers Bdf1 and Yaf9 direct SWR1 remodeler to +1 nucleosome
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    science.org/doi/10.1126/sciadv.adt2002
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    Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation
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    sciencedirect.com/science/article/pii/S109727652500615X
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    Bronze Age Yersinia pestis genome from sheep sheds light on hosts and evolution of a prehistoric plague lineage
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    sciencedirect.com/science/article/pii/S0092867425008517
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    Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328722/
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    Histone acetylation readers Bdf1 and Yaf9 direct SWR1 remodeler to +1 nucleosome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12327448/
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    Functional Role of Small Extrachromosomal Circular DNA in Colorectal Cancer
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    biorxiv.org/content/10.1101/2025.08.01.668183v1
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    Whole-genome sequencing reveals three follicular lymphoma subtypes with distinct cell of origin and patient outcomes
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    cell.com/iscience/abstract/S2589-0042(25)01529-9
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm
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    pmc.ncbi.nlm.nih.gov/articles/PMC12314525/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12314522/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC11790258/
  21. Jul 2025
  22. www.nature.com www.nature.com
    Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoids
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    nature.com/articles/s41467-025-61442-5
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    Clinical Significance of TERT Promoter Mutations in Neuroblastoma
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    ascopubs.org/doi/10.1200/PO-25-00074
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study
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    Shared genomic features of HIV+ diffuse large B-cell lymphoma in two African cohorts
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    nature.com/articles/s41598-025-10529-6
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Exposing the DNA methylation-responsive compartment of the leukaemic genome in T-ALL cell lines support its potential as a novel therapeutic target in T-ALL
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    pmc.ncbi.nlm.nih.gov/articles/PMC12224799/
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    Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recovery
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    link.springer.com/article/10.1038/s44161-025-00672-8
  28. 52.53.155.43 52.53.155.43
    Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html
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  29. www.sciencedirect.com www.sciencedirect.com
    The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells
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    sciencedirect.com/science/article/pii/S1074761325002481
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q
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  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-Throughput Drug Screening of Clear Cell Ovarian Cancer Organoids Reveals Vulnerability to Proteasome Inhibitors and Dinaciclib and Identifies AGR2 as a Therapeutic Target
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    Identifying candidate genetic variants for egg number by analyzing over 1,000 fully sequenced layers
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    Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer
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  34. Jun 2025
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    C-terminal binding protein 2 interacts with JUNB to control macrophage inflammation
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    TBX3 advances the developmental chromatin landscape toward the hepatic fate
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    Satb1 directs the differentiation of TH17 cells through suppression of IL-2 expression
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  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas
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  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SpatialSNV: A novel method for identifying and analyzing spatially resolved SNVs in tumor microenvironments
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  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aged and BRCA-Mutated Stromal Cells Drive Epithelial Cell Transformation
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  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy
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    Chromosome-level reference genome for the medically important Arabian horned viper (Cerastes gasperettii)
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    The role of holobiont composition and environmental history in thermotolerance of Tropical Eastern Pacific corals
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    cell.com/current-biology/abstract/S0960-9822(25)00651-7
  47. May 2025
  48. www.sciencedirect.com www.sciencedirect.com
    The human proteome with direct physical access to DNA
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    Seasonally migratory songbirds have different historic population size characteristics than resident relatives
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    The potential of inversions to accumulate balanced sexual antagonism is supported by simulations and Drosophila experiments
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    elifesciences.org/articles/93338
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    Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression
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    A tumour necrosis factor-α responsive cryptic promoter drives overexpression of the human endogenous retrovirus ERVK-7
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    CHAS infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders
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  55. Apr 2025
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid Leukemia
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  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clinical and Translational Results from PORTER, a Multicohort Phase I Platform Trial of Combination Immunotherapy in Metastatic Castration-Resistant Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11995007/
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    Ultrasensitive Detection and Monitoring of Circulating Tumor DNA Using Structural Variants in Early-Stage Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11994999/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition
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  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957141/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Constructing a draft Indian cattle pangenome using short-read sequencing
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    Establishing a comprehensive panel of patient-derived xenograft models for high-grade endometrial carcinoma: molecular subtypes, genetic alterations, and therapeutic target profiling
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  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
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    Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution
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  66. Mar 2025
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Effects of environmental salinity on global and endocrine‐specific transcriptomic profiles in the caudal neurosecretory system of salmonid fishes
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  69. www.cell.com www.cell.com
    Glucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation
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    cell.com/cell-stem-cell/fulltext/S1934-5909(25)00088-8
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    Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer
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  72. Feb 2025
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  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11836641/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic evidence for hybridization and introgression between blue peafowl and endangered green peafowl and molecular foundation of leucistic plumage of blue peafowl
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    Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants
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    Microevolution of Cryptococcus neoformans in high CO2 converges on mutations isolated from patients with relapsed cryptococcosis
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    mTOR-mediated p62/SQSTM1 stabilization confers a robust survival mechanism for ovarian cancer
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    sciencedirect.com/science/article/pii/S0304383525001296
  79. aacrjournals.org aacrjournals.org
    Multiomics Profiling Distinguishes Sebaceous Carcinoma from Benign Sebaceous Neoplasms and Provides Insight into the Genetic Evolution of Sebaceous Carcinogenesis
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    Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy
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    Whole genome sequencing powered ctDNA sequencing for breast cancer detection
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    sciencedirect.com/science/article/pii/S0923753425000535
  82. Jan 2025
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for transcriptomic and epigenomic analyses of tip-like endothelial cells using scRNA-seq and ChIP-seq
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    pmc.ncbi.nlm.nih.gov/articles/PMC11772138/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Natural killer cell–mediated cytotoxicity shapes the clonal evolution of B cell leukaemia
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  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Utilizing Patient-Derived Xenografts to Model Precision Oncology for Biliary Tract Cancer
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  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11733536/
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    KDM6B-dependent epigenetic programming of uterine fibroblasts in early pregnancy regulates parturition timing in mice
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  88. link.springer.com link.springer.com
    Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma
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    link.springer.com/article/10.1038/s41591-024-03216-y
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Efficacy of CBP/p300 Dual Inhibitors against De-repression of KREMEN2 in cBAF-Deficient Cancers
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    Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs
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  91. Dec 2024
  92. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia
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  93. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Whole-genome re-sequencing of the Baikal seal and other phocid seals for a glimpse into their genetic diversity, demographic history, and phylogeny
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  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer
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  192. www.sciencedirect.com www.sciencedirect.com
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  193. www.biorxiv.org www.biorxiv.org
    ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
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  194. Oct 2023
  195. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular and functional characterization of the Drosophila melanogaster conserved smORFome
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    Loss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism
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    Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells
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  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers
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  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neoantigen targetability in progressive advanced melanoma
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  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas
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  201. 52.53.155.43 52.53.155.43
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  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification
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    Allele-specific regulatory effects on the pig transcriptome
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  204. Sep 2023
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    Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a mutation in adenylyl cyclase with trade-offs for pathogenicity
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    Integration of eQTL and machine learning to dissect causal genes with pleiotropic effects in genetic regulation networks of seed cotton yield
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  207. Aug 2023
  208. www.biorxiv.org www.biorxiv.org
    Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3’ UTR of FAIM2
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  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct mechanisms of mismatch repair deficiency delineate two modes of response to PD-1 immunotherapy in endometrial carcinoma
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  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone variants shape chromatin states in Arabidopsis
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    Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome
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    Clinical features associated with outcomes and biomarker analysis of dabrafenib plus trametinib treatment in patients with BRAF-mutant melanoma brain metastases
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  214. Jul 2023
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    The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina
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    A new haplotype-resolved turkey genome to enable turkey genetics and genomics research
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    Title: TET1 Facilitates Specification of Early Human Lineages including Germ Cells
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