91 Matching Annotations
  1. Aug 2025
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    Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
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    sciencedirect.com/science/article/pii/S0969212625002655
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    41594_2025_1631_MOESM4_ESM-html.html
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  4. Mar 2025
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    23ME-01473, an Fc Effector–Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell–Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation
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  6. Jan 2025
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide
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    pmc.ncbi.nlm.nih.gov/articles/PMC11706664/
  8. Dec 2024
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    Dual BACH1 regulation by complementary SCF-type E3 ligases
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  10. Aug 2024
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    Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes
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  12. Jul 2024
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    Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38
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  14. May 2024
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    A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation
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  16. Apr 2024
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    Staphylococcus aureus skin colonization is mediated by SasG lectin variation
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  18. Feb 2024
  19. elifesciences.org elifesciences.org
    Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition
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    elifesciences.org/articles/39611
  20. Jan 2024
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    Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46
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  22. Jul 2023
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    Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
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    Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity
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  25. Mar 2023
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    Immunodominant surface epitopes power immune evasion in the African trypanosome
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  27. Nov 2022
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    IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling
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  29. Aug 2022
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    Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC
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    Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope
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  32. Apr 2022
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    Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis
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  34. Mar 2022
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    Phosphosite-dependent Presentation of Dual Phosphorylated Peptides by MHC Class I Molecules
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    Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis
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    Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB
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  38. Jan 2022
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1
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  40. Nov 2021
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    Structure and assembly pattern of a freshwater short-tailed cyanophage Pam1
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  42. Oct 2021
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    Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2
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  44. Sep 2021
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    Structural basis and regulation of the reductive stress response
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    Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
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  47. Aug 2021
  48. pubs.acs.org pubs.acs.org
    Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies
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  51. Jul 2021
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    Structural Basis of CD160:HVEM Recognition
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    Analysis of Global and Site-Specific Radiation Damage in Cryo-EM
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    A Mutation Directs the Structural Switch of DNA Binding Proteins under Starvation to a Ferritin-like Protein Cage
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    Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins
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    A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family
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  61. Jun 2021
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    Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1
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    B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV
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  64. Apr 2021
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    Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form
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  66. Mar 2021
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    Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
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  68. Feb 2021
  69. www.cell.com www.cell.com
    Calmodulin binds to Drosophila TRP with an unexpected mode
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    cell.com/structure/abstract/S0969-2126(20)30463-9
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    Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC7289601/
  71. Jan 2021
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    Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization
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    A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations
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  74. Dec 2020
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    Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment
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  76. Nov 2020
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    Cannabidiol interactions with voltage-gated sodium channels
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  78. Sep 2020
  79. www.cell.com www.cell.com
    Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
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    cell.com/molecular-cell/abstract/S1097-2765(18)30948-1
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    Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas
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    Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family
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    Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling
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    Crystal structure of the catalytic C‐lobe of the HECT‐type ubiquitin ligase E6AP
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    onlinelibrary.wiley.com/doi/10.1002/pro.3832
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    Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies
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  85. Jan 2020
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    Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins
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    Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint
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    Structure-based inhibitors of amyloid beta core suggest a common interface with tau
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    An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death
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  95. Apr 2019
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)
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    ncbi.nlm.nih.gov/pmc/articles/PMC3961105
  97. Nov 2018
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    Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells
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    Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p
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    EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
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    Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens
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    The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix
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    Structural basis of host recognition and biofilm formation by Salmonella Saf pili.
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  112. Nov 2017
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    Mapping the ER Interactome: The P Domains of Calnexin and Calreticulin as Plurivalent Adapters for Foldases and Chaperones
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    Structure and Cooperativity of the Cytosolic Domain of the CorA Mg2+ Channel from Escherichia coli
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    Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases
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    Structural Insight into Ubiquitin-Like Protein Recognition and Oligomeric States of JAMM/MPN+ Proteases
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    Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination
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    Covalent Protein Labeling at Glutamic Acids
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    Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense
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    A conformational switch regulates the ubiquitin ligase HUWE1
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    Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
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