311 Matching Annotations
  1. Last 7 days
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    LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
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    sciencedirect.com/science/article/pii/S2666979X25002356
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    Transient gene melting governs the timing of oligodendrocyte maturation
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    sciencedirect.com/science/article/pii/S009286742500861X
  4. Aug 2025
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Androgen receptor–mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12315708/
  6. Jul 2025
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    β-catenin functions as a molecular adapter for disordered cBAF interactions
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    sciencedirect.com/science/article/pii/S1097276525005763
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    Multiomics uncovers the epigenomic and transcriptomic response to viral and bacterial stimulation in turbot
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    pmc.ncbi.nlm.nih.gov/articles/PMC12263217/
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    TAF1 is required for fetal but not adult hematopoiesis in mice
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    sciencedirect.com/science/article/pii/S1534580725004058
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    The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells
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    sciencedirect.com/science/article/pii/S1074761325002481
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    Modulation of glucocorticoid receptor function under iron overload
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    Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1074761325002742
  13. Jun 2025
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    IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming
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    elifesciences.org/articles/100406
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    C-terminal binding protein 2 interacts with JUNB to control macrophage inflammation
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    Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration
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    cell.com/developmental-cell/abstract/S1534-5807(25)00260-6
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    The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits
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  19. May 2025
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    Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3′ end processing factors
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    MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors
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    Repeat-element RNAs integrate a neuronal growth circuit
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  23. Apr 2025
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interspecific hybridization in Brassica species leads to changes in agronomic traits through the regulation of gene expression by chromatin accessibility and DNA methylation
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    Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration
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    Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell
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  27. Mar 2025
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    Orchestration of pluripotent stem cell genome reactivation during mitotic exit
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    m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice
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    A telomere-to-telomere phased genome of an octoploid strawberry reveals a receptor kinase conferring anthracnose resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11899574/
  31. Feb 2025
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia
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  33. aacrjournals.org aacrjournals.org
    Systematic characterization of p53-regulated long non-coding RNAs across human cancers reveals remarkable heterogeneity among different tumor types
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    Epigenome reprogramming through H3K27 and H3K4 trimethylation as a resistance mechanism to DNA methylation inhibition in BRAFV600E-mutated colorectal cancer
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    Lost in translation? Evidence for a muted proteomic response to thermal stress in a stenothermal Antarctic fish and possible evolutionary mechanisms
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  36. Jan 2025
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Natural killer cell–mediated cytotoxicity shapes the clonal evolution of B cell leukaemia
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    FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma
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    A single-nuclei transcriptome census of the Arabidopsis maturing root identifies that MYB67 controls phellem cell maturation
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  40. Dec 2024
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    BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia
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    A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model
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    Integrated proteomic and transcriptomic landscape of human placenta in small for gestational age infants
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    Single chromatin fiber profiling and nucleosome position mapping in the human brain
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  45. Nov 2024
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Core circadian transcription factor Bmal1 mediates β cell response and recovery from pro-inflammatory injury
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    Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction
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  49. Oct 2024
  50. www.biorxiv.org www.biorxiv.org
    MITF Targets in Gastrointestinal Stromal Tumors: Implications in Autophagy and Extracellular Vesicle Secretion
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    biorxiv.org/content/10.1101/2024.09.10.612253v1
  51. Sep 2024
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    CoBATCH for High-Throughput Single-Cell Epigenomic Profiling
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    Paneth cell TNF signaling induces gut bacterial translocation and sepsis
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    Streamlined regulation of chloroplast development in the liverwort Marchantia polymorpha
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    GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant
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  56. Aug 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability
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    EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells
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  59. Jul 2024
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    Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling
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    The primitive endoderm supports lineage plasticity to enable regulative development
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    Evolutionary and biomedical implications of sex differences in the primate brain transcriptome
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    Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
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    ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma
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    The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors
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  66. Jun 2024
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The clock gene BHLHE40 and atypical CCNG2 control androgen-induced cellular senescence as a novel tumor suppressive pathway in prostate cancer
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    Cell-type-specific effects of age and sex on human cortical neurons
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  69. May 2024
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer
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    Bile acid metabolism mediates cholesterol homeostasis and promotes tumorigenesis in clear cell renal cell carcinoma
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    T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells
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    Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
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    Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging
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    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
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    Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
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  78. Apr 2024
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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  81. Mar 2024
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    From degraded to deciphered: ATAC-seq’s application potential in forensic diagnosis
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    link.springer.com/article/10.1007/s00414-024-03206-2
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    DNA methylation-environment interactions in the human genome
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    The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling
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  85. Feb 2024
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis
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  87. www.biorxiv.org www.biorxiv.org
    A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancer
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    biorxiv.org/content/10.1101/2023.12.10.570854v1
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    A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
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    Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer
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    Genome-wide p63-target gene analyses reveal TAp63/NRF2-dependent oxidative stress responses
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  91. Jan 2024
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma
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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiation and Function
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    ncbi.nlm.nih.gov/pmc/articles/PMC10769259/
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    β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10330305/
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    Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10794847/
  96. Dec 2023
  97. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis
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    Pluripotency state transition of embryonic stem cells requires the turnover of histone chaperone FACT on chromatin
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    Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma
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  100. Nov 2023
  101. www.nature.com www.nature.com
    Selective inhibition of CDK9 in triple negative breast cancer
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    nature.com/articles/s41388-023-02892-3
  102. www.science.org www.science.org
    LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
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    science.org/doi/10.1126/sciadv.adh9543
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    LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
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    ncbi.nlm.nih.gov/pmc/articles/PMC10619931/
  104. Oct 2023
  105. www.sciencedirect.com www.sciencedirect.com
    Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells
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  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    nf-core/clipseq - a robust Nextflow pipeline for comprehensive CLIP data analysis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10565428/
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCN driven oncogenesis involves cooperation with WDR5 to activate canonical MYC targets and G9a to repress differentiation genes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10541123/
  108. www.nature.com www.nature.com
    TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression
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    nature.com/articles/s41467-023-41927-x
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification
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  110. Sep 2023
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  223. Jun 2021
  224. www.cell.com www.cell.com
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    H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve.
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    PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR
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  228. May 2021
  229. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets
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    Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
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    An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors
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    Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells
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    Chromatin Accessibility Dynamics and a Hierarchical Transcriptional Regulatory Network Structure for Plant Somatic Embryogenesis
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  236. Apr 2021
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    5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer’s disease
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    Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia
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    Analysis of Brugada syndrome loci reveals that fine-mapping clustered GWAS hits enhances the annotation of disease-relevant variants
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  240. Mar 2021
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    KDM6B-dependent chromatin remodeling underpins effective virus-specific CD8+ T cell differentiation
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  246. Feb 2021
  247. www.biorxiv.org www.biorxiv.org
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    The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages
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