95 Matching Annotations
  1. Aug 2025
  2. www.biorxiv.org www.biorxiv.org
    Cyclin-dependent kinase 9 inhibitors as oncogene signaling modulators in combination with targeted therapy for the treatment of colorectal cancer
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    biorxiv.org/content/10.1101/2025.08.13.669992v1
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic Signatures of Poor Prognosis in Merkel Cell Carcinoma: A Single-Institution Prospective Study
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    pmc.ncbi.nlm.nih.gov/articles/PMC12336863/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12319405/
  5. Jul 2025
  6. www.biorxiv.org www.biorxiv.org
    Bi-allelic mutations in KCTD11 cause a new form of autosomal recessive intermediate Charcot-Marie-Tooth disease
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    biorxiv.org/content/10.1101/2025.06.30.661538v1
  7. www.medrxiv.org www.medrxiv.org
    Microhomology-Mediated End Joining as a Novel Mechanism Underlying Androgen Insensitivity Syndrome
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    medrxiv.org/content/10.1101/2025.06.24.25330003v1
  8. Jun 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SpatialSNV: A novel method for identifying and analyzing spatially resolved SNVs in tumor microenvironments
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    pmc.ncbi.nlm.nih.gov/articles/PMC12166308/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130809/
  11. May 2025
  12. www.sciencedirect.com www.sciencedirect.com
    Immunohistochemical and molecular evolutionary features of jejunoileal adenocarcinoma unveiled through comparative analysis with colorectal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1476558625000594
  13. dx.doi.org dx.doi.org
    Telomere-to-telomere genome of common bean (Phaseolus vulgaris L., YP4)
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    dx.doi.org/10.1093/gigascience/giaf001
  14. Apr 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12011380/
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    Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration
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    sciencedirect.com/science/article/pii/S2211124725003821
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition
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    pmc.ncbi.nlm.nih.gov/articles/PMC11995001/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Germline variants in patients from the Iranian hereditary colorectal cancer registry
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    pmc.ncbi.nlm.nih.gov/articles/PMC11995590/
  19. 52.53.155.43 52.53.155.43
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  20. Mar 2025
  21. 52.53.155.43 52.53.155.43
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  22. Feb 2025
  23. 52.53.155.43 52.53.155.43
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    mTOR-mediated p62/SQSTM1 stabilization confers a robust survival mechanism for ovarian cancer
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    sciencedirect.com/science/article/pii/S0304383525001296
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing inbreeding estimation and global conservation insights through chromosome-level assemblies of the Chinese and Malayan pangolin
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    pmc.ncbi.nlm.nih.gov/articles/PMC11825179/
  26. aacrjournals.org aacrjournals.org
    DNA methylation profiling identifies subgroups of lung adenocarcinoma with distinct immune cell composition, DNA methylation age, and clinical outcome
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    aacrjournals.org/clincancerres/article/28/17/3824/708062/DNA-Methylation-Profiling-Identifies-Subgroups-of
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    Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy
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    sciencedirect.com/science/article/pii/S1934590925000025
  28. Dec 2024
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inference of Genetic Diversity, Population Structure, and Selection Signatures in Xiangxi White Buffalo of China Through Whole-Genome Resequencing
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    pmc.ncbi.nlm.nih.gov/articles/PMC11594040/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modeling Drug Responses and Evolutionary Dynamics using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple Negative Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617242/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Construction and analysis of telomere-to-telomere genomes for 2 sweet oranges: Longhuihong and Newhall (Citrus sinensis)
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    pmc.ncbi.nlm.nih.gov/articles/PMC11590112/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Growth-dependent concentration gradient of the oscillating Min system in Escherichia coli
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    Development and validation of the utLIFE-PC algorithm for noninvasive detection of prostate cancer in urine: A prospective, observational study
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    sciencedirect.com/science/article/pii/S2666379124006414
  34. Nov 2024
  35. 52.53.155.43 52.53.155.43
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  36. Oct 2024
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Radiosensitizing Effect of PARP Inhibition on Chondrosarcoma and Chondrocyte Cells Is Dependent on Radiation LET
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    ncbi.nlm.nih.gov/pmc/articles/PMC11429578/
  38. Sep 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Whole-genome sequencing of the invasive golden apple snail Pomacea canaliculata from Asia reveals rapid expansion and adaptive evolution
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    ncbi.nlm.nih.gov/pmc/articles/PMC11417965/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Proteogenomics of Prostate Cancer Radioresistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11411600/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Telomere-to-telomere gap-free genome assembly of the endangered Yangtze finless porpoise and East Asian finless porpoise
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    ncbi.nlm.nih.gov/pmc/articles/PMC11403816/
  42. aacrjournals.org aacrjournals.org
    Shared cancer dataset analysis identifies and predicts the quantitative effects of pan-cancer somatic driver variants
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    aacrjournals.org/cancerres/article/83/1/74/711848/Shared-Cancer-Dataset-Analysis-Identifies-and
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369621/
  44. Aug 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deciphering cancer genomes with GenomeSpy: a grammar-based visualization toolkit
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  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A trade-off in evolution: the adaptive landscape of spiders without venom glands
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    ncbi.nlm.nih.gov/pmc/articles/PMC11299198/
  47. Jul 2024
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Further evidence from DNAH12 supports favorable fertility outcomes of infertile males with dynein axonemal heavy chain gene family variants
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    pmc.ncbi.nlm.nih.gov/articles/PMC11278020/
  49. May 2024
  50. aacrjournals.org aacrjournals.org
    Integrative molecular analyses of the MD Anderson prostate cancer patient-derived xenograft (MDA PCa PDX) series
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    aacrjournals.org/clincancerres/article/30/10/2272/745168/Integrative-Molecular-Analyses-of-the-MD-Anderson
  51. www.sciencedirect.com www.sciencedirect.com
    Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanoma
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    sciencedirect.com/science/article/pii/S1535610824001363
  52. Mar 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel type of monocytic leukemia stem cell revealed by the clinical use of venetoclax-based therapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527971/
  54. Jan 2024
  55. www.sciencedirect.com www.sciencedirect.com
    Genetic variants affecting NQO1 protein levels impact the efficacy of idebenone treatment in Leber hereditary optic neuropathy
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    sciencedirect.com/science/article/pii/S2666379123006122
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10786718/
  57. Dec 2023
  58. www.sciencedirect.com www.sciencedirect.com
    Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S1535610823004014
  59. link.springer.com link.springer.com
    Managing genomic diversity in conservation programs of Chinese domestic chickens
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    link.springer.com/article/10.1186/s12711-023-00866-3
  60. 52.53.155.43 52.53.155.43
    physiolgenomics.00070.2023-html.html
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  61. journals.physiology.org journals.physiology.org
    Single-cell reconstruction and mutation enrichment analysis identifies dysregulated cardiomyocyte and endothelial cells in congenital heart disease
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    journals.physiology.org/doi/10.1152/physiolgenomics.00070.2023
  62. Oct 2023
  63. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Immune checkpoint inhibitor-related molecular markers predict prognosis in extrahepatic cholangiocarcinoma
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    onlinelibrary.wiley.com/doi/10.1002/cam4.6441
  64. www.sciencedirect.com www.sciencedirect.com
    Individualized tumor-informed circulating tumor DNA analysis for postoperative monitoring of non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S1535610823002866
  65. Aug 2023
  66. 52.53.155.43 52.53.155.43
    Molecular and clonal evolution in vivo reveal a common pathway of distant relapse gliomas
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    Early clonal extinction in glioblastoma progression revealed by genetic barcoding
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    sciencedirect.com/science/article/pii/S1535610823002416
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Clinical features associated with outcomes and biomarker analysis of dabrafenib plus trametinib treatment in patients with BRAF-mutant melanoma brain metastases
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    ncbi.nlm.nih.gov/pmc/articles/PMC9898142/
  69. Jun 2023
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids
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    ncbi.nlm.nih.gov/pmc/articles/PMC10281085/
  71. Mar 2023
  72. www.sciencedirect.com www.sciencedirect.com
    Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson’s disease
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    sciencedirect.com/science/article/pii/S2589004223003553
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The first Antechinus reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies
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    ncbi.nlm.nih.gov/pmc/articles/PMC9631953/
  74. Feb 2023
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive genomic profiling of upper tract urothelial carcinoma and urothelial carcinoma of the bladder identifies distinct molecular characterizations with potential implications for targeted therapy & immunotherapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC9936149/
  76. Jan 2023
  77. www.nature.com www.nature.com
    Germline rare deleterious variant load alters cancer risk, age of onset and tumor characteristics
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    nature.com/articles/s41698-023-00354-3
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Phase II Trial of the Bruton Tyrosine-Kinase Inhibitor Zanubrutinib (BGB-3111) in Patients with Relapsed/Refractory Waldenström Macroglobulinemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9401548/
  79. Dec 2022
  80. www.sciencedirect.com www.sciencedirect.com
    Protocol to analyze population structure and migration history based on human genome variation data
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  82. Sep 2022
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic Diversity and Selective Signature in Dabieshan Cattle Revealed by Whole-Genome Resequencing
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    ncbi.nlm.nih.gov/pmc/articles/PMC9495734/
  84. Aug 2022
  85. 52.53.155.43 52.53.155.43
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  86. Jul 2022
  87. www.sciencedirect.com www.sciencedirect.com
    Spatiotemporal genomic analysis reveals distinct molecular features in recurrent stage I non-small cell lung cancers
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    sciencedirect.com/science/article/pii/S2211124722008415
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel RSPH4A Variants Associated With Primary Ciliary Dyskinesia–Related Infertility in Three Chinese Families
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    ncbi.nlm.nih.gov/pmc/articles/PMC9257073/
  89. May 2022
  90. aacrjournals.org aacrjournals.org
    Single cell characterization of the cellular landscape of acral melanoma identifies novel targets for immunotherapy
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    aacrjournals.org/clincancerres/article/28/10/2131/694823/Single-cell-Characterization-of-the-Cellular
  91. www.nature.com www.nature.com
    Mutational signature profiling classifies subtypes of clinically different mismatch-repair-deficient tumours with a differential immunogenic response potential
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    nature.com/articles/s41416-022-01754-1
  92. aacrjournals.org aacrjournals.org
    A Phenogenetic Axis that Modulates Clinical Manifestation and Predicts Treatment Outcome in Primary Myeloid NeoplasmsLandscape of Myeloid Neoplasms in a Chinese Cohort
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    aacrjournals.org/cancerrescommun/article/2/4/258/694752/A-Phenogenetic-Axis-that-Modulates-Clinical
  93. Apr 2022
  94. jeccr.biomedcentral.com jeccr.biomedcentral.com
    Growth factor independence underpins a paroxysmal, aggressive Wnt5aHigh/EphA2Low phenotype in glioblastoma stem cells, conducive to experimental combinatorial therapy
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    jeccr.biomedcentral.com/articles/10.1186/s13046-022-02333-1/tables/2
  95. www.sciencedirect.com www.sciencedirect.com
    Uncompensated mitochondrial oxidative stress underlies heart failure in an iPSC-derived model of congenital heart disease
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    sciencedirect.com/science/article/pii/S1934590922001011
  96. www.sciencedirect.com www.sciencedirect.com
    A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching
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    sciencedirect.com/science/article/pii/S2211124722003904
  97. Mar 2022
  98. academic.oup.com academic.oup.com
    Contribution of clinical and genetic approaches for diagnosing 209 index cases with 46,XY Differences of Sex Development
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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac064/6521524
  99. Feb 2022
  100. www.sciencedirect.com www.sciencedirect.com
    Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability
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    sciencedirect.com/science/article/pii/S2666379121003785
  101. Jan 2022
  102. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Novel variants underlying autosomal recessive neurodevelopmental disorders with intellectual disability in Iranian consanguineous families
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    onlinelibrary.wiley.com/doi/full/10.1002/jcla.24241
  103. Aug 2021
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5603764/
  105. academic.oup.com academic.oup.com
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    academic.oup.com/gigascience/article/6/9/gix067/4056272
  106. Jul 2021
  107. elifesciences.org elifesciences.org
    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy
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    elifesciences.org/articles/47327
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6007280/
  109. Jun 2021
  110. elifesciences.org elifesciences.org
    SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients
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    elifesciences.org/articles/67481
  111. Apr 2021
  112. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of DNA damage response variants with base editing screens
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    sciencedirect.com/science/article/pii/S0092867421000842
  113. Feb 2021
  114. www.sciencedirect.com www.sciencedirect.com
    Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S0092867420316135
  115. Jan 2021
  116. academic.oup.com academic.oup.com
    Genome diversity in Ukraine
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    academic.oup.com/gigascience/article/10/1/giaa159/6079618
  117. Oct 2020
  118. academic.oup.com academic.oup.com
    DNA Methylation Profiling and Genomic Analysis in 20 Children with Short Stature Who Were Born Small for Gestational Age
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    academic.oup.com/jcem/article/105/12/dgaa465/5873625
  119. Sep 2020
  120. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A novel composition of two heterozygous GFM1 mutations in a Chinese child with epilepsy and mental retardation
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    onlinelibrary.wiley.com/doi/10.1002/brb3.1791
  121. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Novel and de novo point and large microdeletion mutation in PRRT2‐related epilepsy
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    onlinelibrary.wiley.com/doi/10.1002/brb3.1597
  122. Jan 2020
  123. www.sciencedirect.com www.sciencedirect.com
    A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity
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