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The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.015
  
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sciencedirect.com/science/article/pii/S1097276525006161
Aug 2025
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In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment

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1. scibot 13 Aug 2025
  
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  DOI: 10.1073/pnas.2511890122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12337332/
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Evolutionarily diverse caveolins share a common structural framework built around amphipathic disks

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1. scibot 12 Aug 2025
  
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  DOI: 10.1083/jcb.202411175
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12330381/
Jul 2025
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Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2

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1. scibot 25 Jul 2025
  
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  DOI: 10.1126/sciadv.adt2050
  
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science.org/doi/10.1126/sciadv.adt2050
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Structural insights into heterohexameric assembly of epilepsy-related ligand–receptor complex LGI1–ADAM22

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  DOI: 10.7554/eLife.105918
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12226019/
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Structural and functional insights into the evolution of SARS-CoV-2 KP.3.1.1 spike protein

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115941
  
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Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition

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  DOI: 10.1016/j.cell.2025.06.017
  
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Jun 2025
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Structural insights into the biotechnologically relevant reversible NADPH-oxidizing NiFe-hydrogenase from P. furiosus

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.str.2025.05.017
  
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sciencedirect.com/science/article/pii/S0969212625002151
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Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2

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1. scibot 11 Jun 2025
  
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  DOI: 10.1126/sciadv.adt2050
  
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science.org/doi/10.1126/sciadv.adt2050
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Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation

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1. scibot 11 Jun 2025
  
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sciencedirect.com/science/article/pii/S1074761325002328
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Structural basis of GluK2 kainate receptor activation by a partial agonist

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1. scibot 11 Jun 2025
  
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  DOI: 10.1038/s41594-025-01566-w
  
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nature.com/articles/s41594-025-01566-w
May 2025
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Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

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1. scibot 29 May 2025
  
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  DOI: 10.7554/eLife.105396
  
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elifesciences.org/articles/105396
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Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.010
  
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sciencedirect.com/science/article/pii/S1074761325001736
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PNUTS:PP1 recruitment to Tox4 regulates chromosomal dispersal in Drosophila germline development

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115693
  
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sciencedirect.com/science/article/pii/S2211124725004644
Apr 2025
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Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment

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1. scibot 03 Apr 2025
  
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  https://www.phenix-online.org/
  
  DOI: 10.1016/j.str.2020.03.013
  
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sciencedirect.com/science/article/pii/S0969212620300952
Mar 2025
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Biochemical profiling and structural basis of ADAR1-mediated RNA editing

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.02.017
  
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sciencedirect.com/science/article/pii/S1097276525001480
Feb 2025
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Structure of the F-tractin–F-actin complex

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1. scibot 12 Feb 2025
  
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  DOI: 10.1083/jcb.202409192
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11809415/
Jan 2025
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Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C–MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies

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1. scibot 25 Jan 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2450
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11733532/
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Structural and functional analysis of the Nipah virus polymerase complex

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.cell.2024.12.021
  
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Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide

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1. scibot 09 Jan 2025
  
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  DOI: 10.1098/rsob.240310
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11706664/
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Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders

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1. scibot 09 Jan 2025
  
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  DOI: 10.1016/j.chembiol.2024.12.006
  
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sciencedirect.com/science/article/pii/S2451945624005166
Dec 2024
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Control of 3′ splice site selection by the yeast splicing factor Fyv6

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  DOI: 10.7554/eLife.100449
  
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elifesciences.org/articles/100449
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can-24-2450-html.html

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  DOI: 10.1158/0008-5472.can-24-2450
  
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52.53.155.43/eda542f05a259fcd2586bec9365306e8eda4954b/can-24-2450-html.html
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Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies

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1. scibot 13 Dec 2024
  
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  DOI: 10.1111/jnc.16274
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16274
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Structural insights into subunit-dependent functional regulation in epithelial sodium channels

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  DOI: 10.1016/j.str.2024.11.013
  
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Dual BACH1 regulation by complementary SCF-type E3 ligases

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.cell.2024.11.006
  
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quinodoz-et-al-2024-de-novo-variants-in-lrrc8c-resulting-in-constitutive-channel-activation-cause-a-human-multisystem-html.html

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  DOI: 10.1038/s44318-024-00322-y
  
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52.53.155.43/3ab1f2ac64d4a9d1e1b8c8801c1d180b19e6523a/quinodoz-et-al-2024-de-novo-variants-in-lrrc8c-resulting-in-constitutive-channel-activation-cause-a-human-multisystem-html.html
Nov 2024
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Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii

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  DOI: 10.1038/s44318-024-00274-3
  
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embopress.org/doi/10.1038/s44318-024-00274-3
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Inhibition of Parkinson’s Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures

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1. scibot 26 Nov 2024
  
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  DOI: 10.1101/2023.09.07.556689
  
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biorxiv.org/content/10.1101/2023.09.07.556689v1
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Structural basis of signaling complex inhibition by IL-6 domain-swapped dimers

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1. scibot 24 Nov 2024
  
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  Phenix
  
  DOI: 10.1016/j.str.2024.10.028
  
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sciencedirect.com/science/article/pii/S0969212624004635
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Functional implications of the exon 9 splice insert in GluK1 kainate receptors

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  DOI: 10.7554/eLife.89755
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11540303/
Oct 2024
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Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED

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  DOI: 10.1016/j.molcel.2024.09.002
  
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sciencedirect.com/science/article/pii/S1097276524007354
Sep 2024
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Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2

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1. scibot 28 Sep 2024
  
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  RRID:SCR_014224
  
  DOI: 10.1101/2024.09.17.613365
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11565912/
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Discovery and characterization of a pan-betacoronavirus S2-binding antibody

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1. scibot 27 Sep 2024
  
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  DOI: 10.1016/j.str.2024.08.022
  
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sciencedirect.com/science/article/pii/S0969212624003691
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Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

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  DOI: 10.1016/j.chom.2019.04.011
  
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sciencedirect.com/science/article/pii/S1931312819302148
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Dynamic allostery drives autocrine and paracrine TGF-β signaling

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Structure of the human heparan-α-glucosaminide N-acetyltransferase (HGSNAT)

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Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae

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Structural insights into the chloroplast protein import in land plants

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Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance

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Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination

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Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes

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Mechanism of Ca2+ transport by ferroportin - ProQuest

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Structure of the Hir histone chaperone complex

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An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II

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Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38

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A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2

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Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures

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POT1 recruits and regulates CST-Polα/primase at human telomeres

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Cryo-electron tomography reveals the packaging pattern of RuBisCOs in Synechococcus β-carboxysome

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A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation

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Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses

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Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

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Staphylococcus aureus skin colonization is mediated by SasG lectin variation

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Structural basis of ligand specificity and channel activation in an insect gustatory receptor

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Structural mechanisms for VMAT2 inhibition by tetrabenazine

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Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance

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ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

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Structure of the plant plastid-encoded RNA polymerase

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Cryo-EM structures of the plant plastid-encoded RNA polymerase

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Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition

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The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent

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Titin domains with reduced core hydrophobicity cause dilated cardiomyopathy

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Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense

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Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase

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Architecture of the bacteriophage lambda tail

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Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa

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Energy coupling and stoichiometry of Zn2+/H+ antiport by the prokaryotic cation diffusion facilitator YiiP

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Oct 2023
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KANK1 shapes focal adhesions by orchestrating protein binding, mechanical force sensing, and phase separation

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A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response

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Sep 2023
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RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations

1
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  DOI: 10.1158/2159-8290.CD-23-0475
  
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Aug 2023
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Recognition determinants of improved HIV-1 neutralization by a heavy chain matured pediatric antibody

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Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels

2
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Jul 2023
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Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity

1
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Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

1
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cd-23-0475-html.html

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Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange

1
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Jun 2023
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A structural blueprint for interleukin-21 signal modulation

1
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Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment

1
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New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

1
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May 2023
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High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter

1
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Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

1
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Apr 2023
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Cryo-EM structure of the endothelin-1-ETB-Gi complex

1
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Structural and functional properties of a plant NRAMP-related aluminum transporter

1
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Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

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Mar 2023
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Immunodominant surface epitopes power immune evasion in the African trypanosome

1
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Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster

1
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Feb 2023
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Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation

1
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Structural basis of a transcription pre-initiation complex on a divergent promoter

1
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Mechanism of Ca2+ transport by ferroportin

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Jan 2023
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Nucleosome dyad determines the H1 C-terminus collapse on distinct DNA arms

1
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Dec 2022
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Structure of human phagocyte NADPH oxidase in the resting state

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Nov 2022
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Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes

1
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Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

1
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IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling

1
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Oct 2022
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BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass

1
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Sep 2022
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Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

1
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Aug 2022
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Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC

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Jul 2022
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Conserved structural elements specialize ATAD1 as a membrane protein extraction machine

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Jun 2022
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Rational exploration of fold atlas for human solute carrier proteins

1
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Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex

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May 2022
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Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

1
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Apr 2022
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Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax

1
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RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex

1
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Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis

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Analysis Of Memory B Cells Identifies Conserved Neutralizing Epitopes On The N-Terminal Domain Of Variant SARS-Cov-2 Spike Proteins

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Facile discovery of surrogate cytokine agonists

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Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses

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Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis

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Structural basis of nanobodies neutralizing SARS-CoV-2 variants

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Crystals of TELSAM–target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts

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Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB

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Structure and ion-release mechanism of PIB-4-type ATPases

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Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance

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Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel

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Structural basis for catalyzed assembly of the Sonic hedgehog–Patched1 signaling complex

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Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

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Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats

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Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family

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Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes

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Structural basis of bacteriophage lambda capsid maturation

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Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II

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Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1

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Rational engineering enables co-crystallization and structural determination of the HIV-1 matrix-tRNA complex

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Structure and assembly pattern of a freshwater short-tailed cyanophage Pam1

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Pan-ebolavirus protective therapy by two multifunctional human antibodies

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Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells

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Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2

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Structural characterization of NrnC identifies unifying features of dinucleotidases

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Structural insights into the activation of human calcium-sensing receptor

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TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

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Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

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Structural basis and regulation of the reductive stress response

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Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation

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Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

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Regulation of human mTOR complexes by DEPTOR

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Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

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High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor

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Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection

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McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

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HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization

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A Rare Lysozyme Crystal Form Solved Using Highly Redundant Multiple Electron Diffraction Datasets from Micron-Sized Crystals

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Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies

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Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

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Structure and analysis of nanobody binding to the human ASIC1a ion channel

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Structures of translationally inactive mammalian ribosomes

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Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

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Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex

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High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms

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Regulation of the endosomal SNX27-retromer by OTULIN

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Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii

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Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway

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Structure of the Mechanosensitive Channel MscS Embedded in the Membrane Bilayer

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Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

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Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues

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Structures of translationally inactive mammalian ribosomes

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Structural and functional characterization of an otopetrin family proton channel

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Homer Tetramer Promotes Actin Bundling Activity of Drebrin

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Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor

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Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition

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sciencedirect.com/science/article/pii/S096921261830368X
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Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins

1
1. scibot 27 Jul 2021
  
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  Phenix
  
  DOI: 10.1016/j.neuron.2018.10.046
  
  Resource: Phenix (RRID:SCR_014224)
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S0896627318309541
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Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis

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1. scibot 27 Jul 2021
  
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  PHENIX
  
  DOI: 10.1016/j.molcel.2018.10.012
  
  Resource: Phenix (RRID:SCR_014224)
  
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sciencedirect.com/science/article/pii/S109727651830844X
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Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

1
1. scibot 27 Jul 2021
  
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  Phenix
  
  DOI: 10.1016/j.cell.2018.10.026
  
  Resource: Phenix (RRID:SCR_014224)
  
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sciencedirect.com/science/article/pii/S0092867418313795
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A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates

1
1. scibot 27 Jul 2021
  
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  Phenix
  
  DOI: 10.1016/j.celrep.2018.10.031
  
  Resource: Phenix (RRID:SCR_014224)
  
  Curator: @evieth
  
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sciencedirect.com/science/article/pii/S2211124718316073
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Untitled document

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1. scibot 27 Jul 2021
  
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  RRID:SCR_014224
  
  DOI: 10.1016/j.celrep.2018.11.058
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6342559/
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Untitled document

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1. scibot 27 Jul 2021
  
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  RRID:SCR_0142224
  
  DOI: 10.1016/j.str.2018.06.006
  
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sciencedirect.com/science/article/pii/S0969212618302120
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Structural Basis of Mitochondrial Transcription Initiation

1
1. scibot 27 Jul 2021
  
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  RRID:SCR_0214224
  
  DOI: 10.1016/j.cell.2017.10.036
  
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  Curator: @evieth
  
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sciencedirect.com/science/article/pii/S009286741731262X
Jun 2021
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Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1

1
1. scibot 30 Jun 2021
  
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  RRID:SCR_014224
  
  DOI: 10.1016/j.str.2021.06.005
  
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sciencedirect.com/science/article/pii/S0969212621002094
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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV

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1. scibot 14 Jun 2021
  
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  RRID:SCR_014224
  
  DOI: 10.1016/j.cell.2021.04.032
  
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sciencedirect.com/science/article/pii/S0092867421005353
May 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation

1
1. scibot 12 May 2021
  
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  RRID:SCR_014224
  
  DOI: 10.7554/eLife.65168
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8099430/
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The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain

1
1. scibot 09 May 2021
  
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  RRID:SCR_014224
  
  DOI: 10.1016/j.str.2020.06.008
  
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sciencedirect.com/science/article/pii/S0969212620302112
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Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP

1
1. scibot 08 May 2021
  
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  RRID:SCR_014224
  
  DOI: 10.1016/j.molcel.2020.11.002
  
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Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis

1
1. scibot 07 May 2021
  
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  RRID:SCR_014224
  
  DOI: 10.1016/j.molcel.2020.08.010
  
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sciencedirect.com/science/article/pii/S1097276520305530
Apr 2021
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Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1

1
1. scibot 29 Apr 2021
  
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  RRID:SCR_014224
  
  DOI: 10.1016/j.chom.2021.02.018
  
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sciencedirect.com/science/article/pii/S1931312821000974

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