64 Matching Annotations
  1. Aug 2025
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    Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
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    41594_2025_1631_MOESM4_ESM-html.html
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  4. Jul 2025
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    Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
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    science.org/doi/10.1126/sciadv.adt2050
  6. Jun 2025
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    Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
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    science.org/doi/10.1126/sciadv.adt2050
  8. Dec 2024
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    Dual BACH1 regulation by complementary SCF-type E3 ligases
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  10. Jan 2024
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    Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46
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    sciencedirect.com/science/article/pii/S0969212623004434
  12. Dec 2023
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    Electron counting with direct electron detectors in MicroED
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    sciencedirect.com/science/article/pii/S0969212623003969
  14. Jul 2023
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    Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
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  16. Jun 2023
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    Centromere/kinetochore is assembled through CENP-C oligomerization
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    sciencedirect.com/science/article/pii/S1097276523003799
  18. Mar 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9991059/
  20. Sep 2022
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    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
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    embopress.org/doi/10.15252/embr.202154136
  22. Aug 2022
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    Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope
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    ncbi.nlm.nih.gov/pmc/articles/PMC9279490/
  24. Mar 2022
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    Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8916777/
  26. Sep 2021
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    Structural basis and regulation of the reductive stress response
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    A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites
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    sciencedirect.com/science/article/pii/S0969212621002562
  29. Aug 2021
  30. pubs.acs.org pubs.acs.org
    Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies
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    pubs.acs.org/doi/10.1021/acs.biochem.7b01137
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    Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies
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    sciencedirect.com/science/article/pii/S0969212617301326
  34. Jul 2021
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    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
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    Structural Basis of CD160:HVEM Recognition
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    A Mutation Directs the Structural Switch of DNA Binding Proteins under Starvation to a Ferritin-like Protein Cage
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  38. Jan 2021
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization
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    ncbi.nlm.nih.gov/pmc/articles/PMC7834018/
  40. Dec 2020
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    Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment
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    sciencedirect.com/science/article/pii/S221112472031531X
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    A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide
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    cell.com/cell-reports/fulltext/S2211-1247(20)31417-0
  43. Nov 2020
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cannabidiol interactions with voltage-gated sodium channels
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    ncbi.nlm.nih.gov/pmc/articles/PMC7641581/
  45. Sep 2020
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl–/H+ transport cycle
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    Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
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    cell.com/molecular-cell/abstract/S1097-2765(18)30948-1
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    Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family
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    ncbi.nlm.nih.gov/pmc/articles/PMC7156268/
  49. Jan 2020
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    Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies
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    sciencedirect.com/science/article/pii/S1931312819305268
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    Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1
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    sciencedirect.com/science/article/pii/S2451945619302764
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility
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    An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death
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  57. Nov 2018
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6194298/
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    Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors
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    sciencedirect.com/science/article/pii/S1097276518301412
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    The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery
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    sciencedirect.com/science/article/pii/S0092867418311711
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    The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK
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    sciencedirect.com/science/article/pii/S1534580718306828
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p
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    ncbi.nlm.nih.gov/pmc/articles/PMC5940361/
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    elifesciences.org/articles/36422
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    Analysis of Global and Site-Specific Radiation Damage in Cryo-EM
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    sciencedirect.com/science/article/pii/S0969212618301254
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    The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix
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    sciencedirect.com/science/article/pii/S2451945618300837
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    Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
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  72. Nov 2017
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    Mapping the ER Interactome: The P Domains of Calnexin and Calreticulin as Plurivalent Adapters for Foldases and Chaperones
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    sciencedirect.com/science/article/pii/S0969212617302447
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A
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    ncbi.nlm.nih.gov/pmc/articles/PMC5045296/
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    Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated
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    sciencedirect.com/science/article/pii/S0092867417305858
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    A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases
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    ncbi.nlm.nih.gov/pmc/articles/PMC5468089/
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    Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1
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    Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes
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    ncbi.nlm.nih.gov/pmc/articles/PMC5119991/
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC5127641/
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    Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)
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    ncbi.nlm.nih.gov/pmc/articles/PMC3961105
  81. Nov 2016
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A
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