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Jan 2026
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Molecular mechanism of MDA5 nucleation and filament formation by LGP2

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.molcel.2025.12.019
  
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sciencedirect.com/science/article/pii/S1097276525010172
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Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.11.041
  
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sciencedirect.com/science/article/pii/S0092867425013765
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Development of a colorimetric biosensor based on G-quadruplex aptamer and gold nanoparticles for rapid and sensitive detection of HPV18

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1. scibot 05 Jan 2026
  
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  DOI: 10.1016/j.microc.2026.116811
  
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sciencedirect.com/science/article/pii/S0026265X26000111
Dec 2025
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The role of kinase domain dimerization in EGFR activation

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1. scibot 20 Dec 2025
  
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  DOI: 10.1016/j.str.2025.11.017
  
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sciencedirect.com:5037/science/article/pii/S0969212625004770
Nov 2025
rupress.org rupress.org

Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation

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1. scibot 18 Nov 2025
  
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  DOI: 10.1083/jcb.202409067
  
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rupress.org/jcb/article/225/1/e202409067/278468/Actin-arginylation-alters-myosin-engagement-and-F
Sep 2025
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Molecular basis of DNA recognition by the HMG-box-C1 module of capicua

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1. scibot 18 Sep 2025
  
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  DOI: 10.1016/j.str.2025.08.018
  
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sciencedirect.com/science/article/pii/S0969212625003223
Jul 2025
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Structural and functional insights into the evolution of SARS-CoV-2 KP.3.1.1 spike protein

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115941
  
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sciencedirect.com/science/article/pii/S2211124725007120
Jun 2025
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Structural insights into the biotechnologically relevant reversible NADPH-oxidizing NiFe-hydrogenase from P. furiosus

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1. scibot 26 Jun 2025
  
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sciencedirect.com/science/article/pii/S0969212625002151
May 2025
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Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

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1. scibot 29 May 2025
  
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  DOI: 10.7554/eLife.105396
  
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elifesciences.org/articles/105396
Mar 2025
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23ME-01473, an Fc Effector–Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell–Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation

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1. scibot 27 Mar 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0478
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11927390/
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SI/II Pocket of Ras: An Opportunity for a Once “Undruggable” Target

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1. scibot 07 Mar 2025
  
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  DOI: 10.1021/acsomega.4c10493
  
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pubs.acs.org/doi/full/10.1021/acsomega.4c10493
Feb 2025
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Structure of the F-tractin–F-actin complex

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1. scibot 12 Feb 2025
  
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  DOI: 10.1083/jcb.202409192
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11809415/
Jan 2025
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Structural and functional analysis of the Nipah virus polymerase complex

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.cell.2024.12.021
  
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Structure of the Nipah virus polymerase complex

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1. scibot 16 Jan 2025
  
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  DOI: 10.1038/s44318-024-00321-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11730344/
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Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide

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1. scibot 09 Jan 2025
  
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  DOI: 10.1098/rsob.240310
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11706664/
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balıkçı-et-al-2024-structure-of-the-nipah-virus-polymerase-complex-html.html

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1. scibot 04 Jan 2025
  
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52.53.155.43/6dd1ebe61f74ea2219dbd41b0038f7255c729fc7/balıkçı-et-al-2024-structure-of-the-nipah-virus-polymerase-complex-html.html
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Structure of the Nipah virus polymerase complex

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1. scibot 04 Jan 2025
  
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  DOI: 10.1038/s44318-024-00321-z
  
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embopress.org/doi/10.1038/s44318-024-00321-z
Dec 2024
onlinelibrary.wiley.com onlinelibrary.wiley.com

Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies

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1. scibot 13 Dec 2024
  
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  DOI: 10.1111/jnc.16274
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16274
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Structural insights into subunit-dependent functional regulation in epithelial sodium channels

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.str.2024.11.013
  
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Nov 2024
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Cryo‐EM reveals transition states of the Acinetobacter baumannii F1 ‐ATPase rotary subunits γ and ε, unveiling novel compound targets

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1. scibot 26 Nov 2024
  
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  DOI: 10.1096/fj.202401629R
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11580714/
May 2024
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A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation

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1. scibot 31 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114259
  
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sciencedirect.com/science/article/pii/S2211124724005874
Apr 2024
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Staphylococcus aureus skin colonization is mediated by SasG lectin variation

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1. scibot 04 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114022
  
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sciencedirect.com/science/article/pii/S2211124724003504
Mar 2024
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Structural mechanisms for VMAT2 inhibition by tetrabenazine

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1. scibot 27 Mar 2024
  
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  DOI: 10.7554/eLife.91973
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10959523/
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ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

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1. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.cell.2024.02.013
  
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sciencedirect.com/science/article/pii/S009286742400179X
Jan 2024
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Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46

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1. scibot 11 Jan 2024
  
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  DOI: 10.1016/j.str.2023.12.001
  
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sciencedirect.com/science/article/pii/S0969212623004434
Dec 2023
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The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent

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1. scibot 20 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113516
  
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sciencedirect.com/science/article/pii/S2211124723015280
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Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense

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1. scibot 16 Dec 2023
  
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  DOI: 10.1016/j.molcel.2023.11.007
  
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sciencedirect.com/science/article/pii/S1097276523009498
Nov 2023
www.cell.com www.cell.com

The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113366
  
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cell.com/cell-reports/fulltext/S2211-1247(23)01378-5
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Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa

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  DOI: 10.1016/j.cell.2023.10.002
  
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sciencedirect.com/science/article/pii/S009286742301084X
Oct 2023
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KANK1 shapes focal adhesions by orchestrating protein binding, mechanical force sensing, and phase separation

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1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.113321
  
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sciencedirect.com/science/article/pii/S2211124723013335
Aug 2023
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Recognition determinants of improved HIV-1 neutralization by a heavy chain matured pediatric antibody

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  DOI: 10.1016/j.isci.2023.107579
  
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52.53.155.43/4e2892b16e328023e4cde9b31b0daa48de916ef6/PIIS2589004223016565-html.html
Jul 2023
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Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity

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  DOI: 10.1016/j.celrep.2023.112827
  
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sciencedirect.com/science/article/pii/S2211124723008380
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Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

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1. scibot 14 Jul 2023
  
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  DOI: 10.7554/eLife.86029
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10338036/
May 2023
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Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

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  DOI: 10.1016/j.str.2023.04.010
  
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sciencedirect.com/science/article/pii/S0969212623001338
Mar 2023
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Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster

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1. scibot 05 Mar 2023
  
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  DOI: 10.7554/eLife.84424
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9977279/
Nov 2022
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Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

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1. scibot 16 Nov 2022
  
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TITLE: Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

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Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex

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RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex

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Analysis Of Memory B Cells Identifies Conserved Neutralizing Epitopes On The N-Terminal Domain Of Variant SARS-Cov-2 Spike Proteins

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Crystals of TELSAM–target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts

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Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel

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Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes

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Structure and assembly pattern of a freshwater short-tailed cyanophage Pam1

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Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells

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Structural insights into the activation of human calcium-sensing receptor

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Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation

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Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

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Regulation of human mTOR complexes by DEPTOR

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McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

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Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies

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Untitled document

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A Rare Lysozyme Crystal Form Solved Using Highly Redundant Multiple Electron Diffraction Datasets from Micron-Sized Crystals

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Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies

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Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases

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Structure and analysis of nanobody binding to the human ASIC1a ion channel

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Structures of translationally inactive mammalian ribosomes

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Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

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Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex

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Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway

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Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events

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Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

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Structures of translationally inactive mammalian ribosomes

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Structural and functional characterization of an otopetrin family proton channel

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Homer Tetramer Promotes Actin Bundling Activity of Drebrin

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A Mutation Directs the Structural Switch of DNA Binding Proteins under Starvation to a Ferritin-like Protein Cage

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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV

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Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP

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Comprehensive analysis of genomic alterations, clinical outcomes, putative functions and potential therapeutic value of MMP11 in human breast cancer

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Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex

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A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

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Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody

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Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

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A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

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The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism

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A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide

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Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

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Structural basis of αE-catenin–F-actin catch bond behavior

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Cannabidiol interactions with voltage-gated sodium channels

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Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation

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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

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Structure of RNA polymerase bound to ribosomal 30S subunit

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Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

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A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling

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Mechanisms of nucleotide selection by telomerase

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Molecular principles of assembly, activation, and inhibition in epithelial sodium channel

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Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody

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Mechanical inhibition of isolated Vo from V/A-ATPase for proton conductance

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Chemical and structural investigation of the paroxetine-human serotonin transporter complex

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Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

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The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity

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Structure and activation mechanism of the BBSome membrane protein trafficking complex

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Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation

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Structural basis of substrate recognition by a polypeptide processing and secretion transporter

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Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies

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Identification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer Formation

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Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes

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Regulatory switch at the cytoplasmic interface controls TRPV channel gating

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Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

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BPS Publications

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Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

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Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

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Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors

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Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events

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Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility

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An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death

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Structure of the human epithelial sodium channel by cryo-electron microscopy

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Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody

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Human β-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability

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A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication

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Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus

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Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p

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Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase

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Discrimination against RNA Backbones by a ssDNA Binding Protein

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Structure-based membrane dome mechanism for Piezo mechanosensitivity

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Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC

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Robo1 Forms a Compact Dimer-of-Dimers Assembly

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GroEL Ring Separation and Exchange in the Chaperonin Reaction

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The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets.

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HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage

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A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants

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europepmc.org/articles/PMC5655547/
Nov 2017
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ncbi.nlm.nih.gov/pmc/articles/PMC5655137/
www.sciencedirect.com www.sciencedirect.com

The Mammalian Proteasome Activator PA28 Forms an Asymmetric α4β3 Complex

1
1. scibot 08 Nov 2017
  
  in Public
  
  MolProbity
  
  Curator: @Jmenke
  
  Resource used:
  
  (MolProbity, RRID:SCR_014226)
  
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sciencedirect.com/science/article/pii/S0969212617302472
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Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes

1
1. scibot 08 Nov 2017
  
  in Public
  
  MolProbity
  
  Curator: @Jmenke
  
  Resource used:
  
  (MolProbity, RRID:SCR_014226)
  
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  RRID:SCR_014226 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S0092867416314672
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Crystal Structure and Regulation of the Citrus Pol III Repressor MAF1 by Auxin and Phosphorylation

1
1. scibot 08 Nov 2017
  
  in Public
  
  MOLPROBITY
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S0969212617302198
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Structural Basis of Egg Coat-Sperm Recognition at Fertilization

1
1. scibot 08 Nov 2017
  
  in Public
  
  MolProbity
  
  Curator: @chewbeccax
  
  Resource used:
  
  (MolProbity, RRID:SCR_014226)
  
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sciencedirect.com/science/article/pii/S0092867417305949
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Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated

1
1. scibot 08 Nov 2017
  
  in Public
  
  Molprobity
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S0092867417305858
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Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly

1
1. scibot 08 Nov 2017
  
  in Public
  
  MOLPROBITY
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S0969212617301545
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The Highly Dynamic Nature of ERdj5 Is Key to Efficient Elimination of Aberrant Protein Oligomers through ER-Associated Degradation

1
1. scibot 08 Nov 2017
  
  in Public
  
  MolProbity
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S0969212617301028
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Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1

1
1. scibot 08 Nov 2017
  
  in Public
  
  Molprobity
  
  Curator: @Zeljana_Babic
  
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sciencedirect.com/science/article/pii/S0969212617301314
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

1
1. scibot 08 Nov 2017
  
  in Public
  
  SCR_014226
  
  Curator: @kaitlinsung
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5413351/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes

1
1. scibot 08 Nov 2017
  
  in Public
  
  MolProbity
  
  Curator: @chewbeccax
  
  Resource used:
  
  (MolProbity, RRID:SCR_014226)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5119991/
elifesciences.org elifesciences.org

Mechanism of ribosome rescue by ArfA and RF2

1
1. scibot 08 Nov 2017
  
  in Public
  
  SCR_014226
  
  Curator: @kaitlinsung
  
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elifesciences.org/content/6/e23687
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Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity

1
1. scibot 08 Nov 2017
  
  in Public
  
  Molprobity
  
  Curator: @kaitlinsung
  
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sciencedirect.com/science/article/pii/S0092867417301320
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NusG inhibits RNA polymerase backtracking by stabilizing the minimal transcription bubble

1
1. scibot 08 Nov 2017
  
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  SCR_014226
  
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  (MolProbity, RRID:SCR_014226)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5100998/
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NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

1
1. scibot 08 Nov 2017
  
  in Public
  
  SCR_014226
  
  Curator: @gabimpine
  
  Resource used:
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5111884/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)

1
1. scibot 08 Nov 2017
  
  in Public
  
  MolProbity
  
  Curator: @jcabotaj
  
  Curator note:
  
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ncbi.nlm.nih.gov/pmc/articles/PMC3961105

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