132 Matching Annotations
  1. Last 7 days
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    Internalized SNCA/α-synuclein fibrils become truncated and resist degradation in neurons while glial cells rapidly degrade SNCA fibrils
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    tandfonline.com/doi/abs/10.1080/15548627.2025.2579147
  3. Sep 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Evaluation of PTK7-Targeted Radionuclide Therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12402794/
  5. Aug 2025
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    Ceramide transfer protein regulates G-protein coupled phospholipase signalling in Drosophila photoreceptors
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    biorxiv.org/content/10.1101/2025.08.05.668821v1
  7. May 2025
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    Ca2+ binding to Esyt modulates membrane contact site density in Drosophila photoreceptors
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    rupress.org/jcb/article/224/5/e202407190/277301/Ca2-binding-to-Esyt-modulates-membrane-contact
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    eIF5A controls mitoprotein import by relieving ribosome stalling at TIM50 translocase mRNA
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    pmc.ncbi.nlm.nih.gov/articles/PMC11551009/
  10. Apr 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Altered Mitochondrial Bioenergetics and Calcium Kinetics in Young‐Onset PLA2G6 Parkinson's Disease iPSCs
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    pmc.ncbi.nlm.nih.gov/articles/PMC11973445/
  12. Feb 2025
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11821485/
  14. Dec 2024
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    Activity-dependent COX-2 proteolysis modulates aerobic respiration and proliferation in a prostaglandin-independent manner
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    sciencedirect.com/science/article/pii/S2589004224026282
  16. Nov 2024
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HERC3 facilitates ERAD of select membrane proteins by recognizing membrane-spanning domains
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    pmc.ncbi.nlm.nih.gov/articles/PMC11082371/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular basis of neurodegeneration in a mouse model of Polr3-related disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11537486/
  19. Sep 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pretargeted Radioimmunotherapy with the Novel Anti-oxMIF/HSG Bispecific Antibody ON105 Results in Significant Tumor Regression in Murine Models of Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11372362/
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    A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2451945624003234
  22. Aug 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC11325149/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11321020/
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    Small GTPase ActIvitY ANalyzing (SAIYAN) system: A method to detect GTPase activation in living cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11303508/
  26. Jul 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor invasiveness is regulated by the concerted function of APC, formins and Arp2/3 complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC11053316/
  28. Jun 2024
  29. 52.53.155.43 52.53.155.43
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  30. www.cell.com www.cell.com
    POT1 recruits and regulates CST-Polα/primase at human telomeres
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    cell.com/cell/fulltext/S0092-8674(24)00493-8
  31. May 2024
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
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    ncbi.nlm.nih.gov/pmc/articles/PMC11094420/
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    Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size
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  34. Feb 2024
  35. 52.53.155.43 52.53.155.43
    HERC3 E3 ligase provides an ERAD branch eliminating select membrane proteins
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  36. elifesciences.org elifesciences.org
    Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition
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    elifesciences.org/articles/39611
  37. Dec 2023
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10715669/
  39. Aug 2023
  40. link.springer.com link.springer.com
    Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse
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    link.springer.com/article/10.1186/s40478-023-01633-7
  41. Jul 2023
  42. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Obesity during preclinical Alzheimer's disease development exacerbates brain metabolic decline
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15900
  43. Mar 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC9988257/
  45. Jan 2023
  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Brain-derived neurotrophic factor (BDNF) induces antagonistic action to Nogo signaling by the upregulation of lateral olfactory tract usher substance (LOTUS) expression
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15732
  47. Dec 2022
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Critical roles for ‘housekeeping’ nucleases in type III CRISPR-Cas immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC9762709/
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    LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB
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    link.springer.com/article/10.1186/s10020-022-00581-7
  50. Nov 2022
  51. www.researchsquare.com www.researchsquare.com
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    researchsquare.com/article/rs-7072571/'https://www.researchsquare.com/article/rs-7072571/v1
  52. rupress.org rupress.org
    Mitoguardin-2–mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation
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  53. Oct 2022
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Uncovering the mechanisms of transcription elongation by eukaryotic RNA polymerases I, II, and III
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    ncbi.nlm.nih.gov/pmc/articles/PMC9593817/
  55. alzres.biomedcentral.com alzres.biomedcentral.com
    Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ
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    alzres.biomedcentral.com/articles/10.1186/s13195-022-01096-3
  56. Jun 2022
  57. www.sciencedirect.com www.sciencedirect.com
    JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation
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    sciencedirect.com/science/article/pii/S2211124722006647
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    A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression
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  59. May 2022
  60. elifesciences.org elifesciences.org
    Enhanced C/EBPβ function promotes hypertrophic versus hyperplastic fat tissue growth and prevents steatosis in response to high-fat diet feeding
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    elifesciences.org/articles/62625
  61. Apr 2022
  62. www.sciencedirect.com www.sciencedirect.com
    A unique mode of nucleic acid immunity performed by a multifunctional bacterial enzyme
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    sciencedirect.com/science/article/pii/S1931312822001305
  63. Mar 2022
  64. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Cardiomyocyte substructure reverts to an immature phenotype during heart failure
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP277273
  65. www.eneuro.org www.eneuro.org
    The anti-diabetic drug metformin regulates voltage-gated sodium channel NaV1.7 via the ubiquitin-ligase NEDD4-2
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    eneuro.org/content/9/2/ENEURO.0409-21.2022
  66. Jan 2022
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors
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    ncbi.nlm.nih.gov/pmc/articles/PMC8719881/
  68. Oct 2021
  69. www.sciencedirect.com www.sciencedirect.com
    Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses
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    sciencedirect.com/science/article/pii/S1097276521008327
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SUMOylation contributes to proteostasis of the chloroplast protein import receptor TOC159 during early development
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    ncbi.nlm.nih.gov/pmc/articles/PMC8497054/
  71. Aug 2021
  72. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/10.1002/jcp.26330/full
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC5809144/
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    Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
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    sciencedirect.com/science/article/pii/S1097276521005827
  76. Jul 2021
  77. www.mdpi.com www.mdpi.com
    Recruitment of DNA Repair MRN Complex by Intrinsically Disordered Protein Domain Fused to Cas9 Improves Efficiency of CRISPR-Mediated Genome Editing
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    mdpi.com/2218-273X/9/10/584/htm
  78. www.embopress.org www.embopress.org
    Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes
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    embopress.org/doi/full/10.15252/embr.201947728
  79. advances.sciencemag.org advances.sciencemag.org
    RNA binding activates RIG-I by releasing an autorepressed signaling domain
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    advances.sciencemag.org/content/5/10/eaax3641.full
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    Mechanisms underlying TNFα‐induced enhancement of force generation in airway smooth muscle
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    physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.14220
  81. academic.oup.com academic.oup.com
    Regulation of BTB dynamics in spermatogenesis – insights from the adjudin toxicant model
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    academic.oup.com/toxsci/advance-article/doi/10.1093/toxsci/kfz180/5545528
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    Natural changes in light interact with circadian regulation at promoters to control gene expression in cyanobacteria
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    Novel smoothened antagonists as anti‐neoplastic agents for the treatment of osteosarcoma
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    Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling
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    Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells
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    The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells
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    Protein Kinase C Lambda Mediates Acid-Sensing Ion Channel 1a-Dependent Cortical Synaptic Plasticity and Pain Hypersensitivity
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    Amino acid restriction increases β‐cell death under challenging conditions
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    Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms
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    ncbi.nlm.nih.gov/pmc/articles/PMC6257811/
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    Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter
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    elifesciences.org/articles/27283
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    Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria
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    sciencedirect.com/science/article/pii/S1097276517304409
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    COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis
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    The Exon Junction Complex Undergoes a Compositional Switch that Alters mRNP Structure and Nonsense-Mediated mRNA Decay Activity
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    sciencedirect.com/science/article/pii/S2211124718318096
  96. europepmc.org europepmc.org
    A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants
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    europepmc.org/articles/PMC5655547/
  97. May 2021
  98. www.sciencedirect.com www.sciencedirect.com
    Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway
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    sciencedirect.com/science/article/pii/S0960982221006229
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    Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8102063/
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    Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon
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    sciencedirect.com/science/article/pii/S0896627320304906
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    Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis
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  103. Feb 2021
  104. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Nogo receptor antagonist LOTUS exerts suppression on axonal growth‐inhibiting receptor PIR‐B
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15013
  105. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Homogentisic acid affects human osteoblastic functionality by oxidative stress and alteration of the Wnt/β‐catenin signaling pathway
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    onlinelibrary.wiley.com/doi/10.1002/jcp.29575
  106. Jan 2021
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ecd promotes U5 snRNP maturation and Prp8 stability
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    ncbi.nlm.nih.gov/pmc/articles/PMC7897482/
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC7868890/
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders
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    ncbi.nlm.nih.gov/pmc/articles/PMC7787664/
  110. Dec 2020
  111. www.sciencedirect.com www.sciencedirect.com
    The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism
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    sciencedirect.com/science/article/pii/S2211124720314650
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    CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes
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    sciencedirect.com/science/article/pii/S1043661820316418
  113. Oct 2020
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    TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity
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    sciencedirect.com/science/article/pii/S2211124720313152
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments
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    ncbi.nlm.nih.gov/pmc/articles/PMC7541089/
  116. Sep 2020
  117. journals.plos.org journals.plos.org
    Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins
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    journals.plos.org/plosone/article
  118. elifesciences.org elifesciences.org
    Mechanisms of nucleotide selection by telomerase
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    elifesciences.org/articles/55438
  119. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14853
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression
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