97 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12696101/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12695878/
  4. Dec 2025
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    99576supptables
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    pmc.ncbi.nlm.nih.gov/articles/instance/6538348/bin/jciinsight-4-99576-s040.pdf
  6. Nov 2025
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging
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    pmc.ncbi.nlm.nih.gov/articles/PMC12419459/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual-input regulation of β-cell proliferation by ATF6α and glucose via E2F1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12622758/
  9. link.springer.com link.springer.com
    Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells
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    link.springer.com/article/10.1007/s00125-025-06603-3
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proinflammatory Stress Activates Neutral Sphingomyelinase 2–Based Generation of a Ceramide-Enriched β-Cell EV Subpopulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12585158/
  11. Oct 2025
  12. www.biorxiv.org www.biorxiv.org
    Supervised machine learning identifies impaired mitochondrial quality control in β cells with development of type 2 diabetes
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    biorxiv.org/content/10.1101/2025.10.22.683335v1
  13. 54.241.53.176 54.241.53.176
    1-s2.0-S2212877825001759-main-html.html
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    Predictive prioritization of enhancers associated with pancreatic disease risk
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    sciencedirect.com/science/article/pii/S2666979X25002964
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12483614/
  16. Sep 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373512/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12276980/
  19. Aug 2025
  20. www.biorxiv.org www.biorxiv.org
    Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets
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    biorxiv.org/content/10.1101/2025.08.15.670586v1
  21. www.biorxiv.org www.biorxiv.org
    Glucagon and GLP-1 Accelerate Pseudo-Islet Assembly and Unmask Sex-Specific Islet Fragmentation Dynamics
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    biorxiv.org/content/10.1101/2025.08.10.669547v1
  22. Jul 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional and Mechanistic Explanation for the Unique Clinical Success of the Glucokinase Activator Dorzagliatin in the Treatment of Type 2 Diabetes
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12278794/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Osteocalcin induces phosphorylation of FOXO1 in human beta-cells and restores insulin expression under hyperglycemic conditions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12204463/
  25. Jun 2025
  26. 52.53.155.43 52.53.155.43
    PDF-html.html
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    VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells
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    sciencedirect.com/science/article/pii/S2211124725006059
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acute Inhibition of Adipose Triglyceride Lipase by NG497 Dysregulates Insulin and Glucagon Secretion From Human Islets
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    pmc.ncbi.nlm.nih.gov/articles/PMC12119457/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FOXM1 cooperates with ERα to regulate functional β-cell mass
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    pmc.ncbi.nlm.nih.gov/articles/PMC12145799/
  30. May 2025
  31. 52.53.155.43 52.53.155.43
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  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PAX4 gene delivery improves β-cell function in human islets of Type II diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11321267/
  33. Apr 2025
  34. 52.53.155.43 52.53.155.43
    1-s2.0-S2212877825000419-main-html.html
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  35. Mar 2025
  36. 52.53.155.43 52.53.155.43
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  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFN-α Induces Heterogenous ROS Production in Human β-Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870469/
  38. Feb 2025
  39. diabetesjournals.org diabetesjournals.org
    Leucine suppresses α-cell cAMP and glucagon secretion via a combination of cell-intrinsic and islet paracrine signaling
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    diabetesjournals.org/diabetes/article/73/9/1426/156849/Leucine-Suppresses-Cell-cAMP-and-Glucagon
  40. Jan 2025
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11748642/
  42. Dec 2024
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11649919/
  44. Oct 2024
  45. www.sciencedirect.com www.sciencedirect.com
    Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights
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    sciencedirect.com/science/article/pii/S155041312400370X
  46. Sep 2024
  47. www.biorxiv.org www.biorxiv.org
    Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes
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    biorxiv.org/content/10.1101/2024.09.18.613649v1
  48. www.nature.com www.nature.com
    Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence
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    nature.com/articles/s42255-024-01130-8
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulated and adaptive in vivo insulin secretion from islets only containing β-cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11422169/
  50. Aug 2024
  51. www.biorxiv.org www.biorxiv.org
    Limitations in mitochondrial programming restrain the differentiation and maturation of human stem cell-derived β cells
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    biorxiv.org/content/10.1101/2024.07.26.605318v1
  52. Local file Local file
    Co-opting regulation bypass repair as a gene correction strategy for monogenic diseases - PIIS1525001621002045.pdf
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  53. Jul 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose Transporters Are Key Components of the Human Glucostat
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    ncbi.nlm.nih.gov/pmc/articles/PMC11262048/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11247939/
  56. Jun 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas
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    ncbi.nlm.nih.gov/pmc/articles/PMC11176301/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intra-islet α-cell Gs signaling promotes glucagon release
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    ncbi.nlm.nih.gov/pmc/articles/PMC11180188/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immuno-scanning electron microscopy of islet primary cilia
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    ncbi.nlm.nih.gov/pmc/articles/PMC11166453/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The role of mu-opioid receptors in pancreatic islet alpha cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11118541/
  61. May 2024
  62. www.biorxiv.org www.biorxiv.org
    Proinflammatory stress activates neutral sphingomyelinase 2 based generation of a ceramide-enriched β cell EV subpopulation
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    biorxiv.org/content/10.1101/2024.04.17.589943v1
  63. dx.doi.org dx.doi.org
    Cell-surface ZnT8 antibody prevents and reverses autoimmune diabetes in mice
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    dx.doi.org/10.2337/db23-0568
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11030320/
  65. Mar 2024
  66. www.biorxiv.org www.biorxiv.org
    Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2
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    biorxiv.org/content/10.1101/2024.02.24.581864v1
  67. Feb 2024
  68. www.biorxiv.org www.biorxiv.org
    Comparative Multi-omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provides Insights into Type 2 Diabetes Genetics
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    biorxiv.org/content/10.1101/2024.02.17.580646v1
  69. www.biorxiv.org www.biorxiv.org
    Immuno-Scanning Electron Microscopy of Islet Primary Cilia
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    biorxiv.org/content/10.1101/2024.02.16.580695v1
  70. Oct 2023
  71. elifesciences.org elifesciences.org
    Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses
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    elifesciences.org/articles/85056
  72. Aug 2023
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leucine suppresses glucagon secretion from pancreatic islets by directly modulating α-cell cAMP
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    ncbi.nlm.nih.gov/pmc/articles/PMC10418066/
  74. Jul 2023
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
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    ncbi.nlm.nih.gov/pmc/articles/PMC10352338/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional Profile of Human Pancreatic Acinar Ductal Metaplasia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10328139/
  77. Jun 2023
  78. www.sciencedirect.com www.sciencedirect.com
    Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
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    sciencedirect.com/science/article/pii/S1550413123001845
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Utilization of commercial collagens for preparing well-differentiated human beta cells for confocal microscopy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10248405/
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Scanning electron microscopy of human islet cilia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10235940/
  81. www.nature.com www.nature.com
    The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets
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    nature.com/articles/s42255-023-00811-0
  82. www.biorxiv.org www.biorxiv.org
    Real Time In vivo Analysis of Pancreatic Beta-cell Autophagic Flux Reveals Impairment Before Onset of Autoimmune Diabetes
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    biorxiv.org/content/10.1101/2023.05.23.541935v1
  83. May 2023
  84. www.sciencedirect.com www.sciencedirect.com
    Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
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    sciencedirect.com/science/article/pii/S2211124723005405
  85. www.sciencedirect.com www.sciencedirect.com
    Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells
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    sciencedirect.com/science/article/pii/S2211124723005119
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Small molecule glucagon release inhibitors with activity in human islets
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    ncbi.nlm.nih.gov/pmc/articles/PMC10157210/
  87. Apr 2023
  88. www.sciencedirect.com www.sciencedirect.com
    A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice
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    sciencedirect.com/science/article/pii/S2211124723004059
  89. Mar 2023
  90. www.biorxiv.org www.biorxiv.org
    Scanning electron microscopy of human islet cilia
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    biorxiv.org/content/10.1101/2023.02.15.528685v1
  91. www.biorxiv.org www.biorxiv.org
    Loss of Secretory Pathway Ca2+ ATPase (SPCA1) Impairs Insulin Secretion and Reduces Autophagy in the Pancreatic Islet
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    biorxiv.org/content/10.1101/2021.08.30.458203v1
  92. link.springer.com link.springer.com
    Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells
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    link.springer.com/article/10.1007/s00125-023-05882-y
  93. Feb 2023
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide
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    ncbi.nlm.nih.gov/pmc/articles/PMC9939749/
  95. www.nature.com www.nature.com
    Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure
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    nature.com/articles/s41467-023-36315-4
  96. Jan 2023
  97. www.sciencedirect.com www.sciencedirect.com
    VGLL4 and MENIN function as TEAD1 corepressors to block pancreatic β cell proliferation
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    sciencedirect.com/science/article/pii/S2211124722018034
  98. Dec 2022
  99. www.nature.com www.nature.com
    A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk
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    nature.com/articles/s41588-022-01261-2
  100. link.springer.com link.springer.com
    Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped
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    link.springer.com/article/10.1007/s00125-022-05842-y
  101. Nov 2022
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    β Cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood
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    ncbi.nlm.nih.gov/pmc/articles/PMC9675460/
  103. Oct 2022
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha cell dysfunction in type 1 diabetes is independent of a senescence program
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    ncbi.nlm.nih.gov/pmc/articles/PMC9586489/
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Islet primary cilia motility controls insulin secretion
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    ncbi.nlm.nih.gov/pmc/articles/PMC9506710/
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fluorescence imaging of beta cell primary cilia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9540379/
  107. Jul 2022
  108. www.sciencedirect.com www.sciencedirect.com
    Effect of IL4 and IL10 on a human in vitro type 1 diabetes model
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    sciencedirect.com/science/article/pii/S1521661622001577
  109. academic.oup.com academic.oup.com
    Small molecule-mediated insulin hypersecretion induces transient ER stress response and loss of beta cell function
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    academic.oup.com/endo/article/163/7/bqac081/6596276
  110. Jun 2022
  111. dom-pubs.onlinelibrary.wiley.com dom-pubs.onlinelibrary.wiley.com
    Liraglutide increases islet Ca2+ oscillation frequency and insulin secretion by activating hyperpolarization-activated nucleotide-gated channels
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    dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14747
  112. www.sciencedirect.com www.sciencedirect.com
    DNA damage to β cells in culture recapitulates features of senescent β cells that accumulate in Type 1 Diabetes
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    sciencedirect.com/science/article/pii/S221287782200093X
  113. May 2022
  114. www.nature.com www.nature.com
    High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets
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    nature.com/articles/s41598-022-11668-w
  115. Apr 2022
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9043999/
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC8983383/
  118. Mar 2022
  119. www.nature.com www.nature.com
    Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes
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    nature.com/articles/s41467-022-28826-3
  120. Jan 2022
  121. www.jci.org www.jci.org
    BACH2 inhibition reverses β cell failure in type 2 diabetes models
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    jci.org/articles/view/153876
  122. Dec 2021
  123. diabetesjournals.org diabetesjournals.org
    ENTPD3 Marks Mature Stem Cell Derived Beta Cells Formed by Self-Aggregation in Vitro
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    diabetesjournals.org/diabetes/article/70/11/2554/123865/ENTPD3-Marks-Mature-Stem-Cell-Derived-Cells-Formed
  124. link.springer.com link.springer.com
    Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes
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    link.springer.com/article/10.1007/s00125-021-05619-9
  125. Nov 2021
  126. journals.plos.org journals.plos.org
    Chronic marijuana usage by human pancreas donors is associated with impaired islet function
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    journals.plos.org/plosone/article
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes
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    ncbi.nlm.nih.gov/pmc/articles/PMC7576569/
  128. Oct 2021
  129. www.pnas.org www.pnas.org
    Human islet T cells are highly reactive to preproinsulin in type 1 diabetes
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    pnas.org/content/118/41/e2107208118
  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combinatorial transcription factor profiles predict mature and functional human islet α and β cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8492318/
  131. academic.oup.com academic.oup.com
    Human Islet: Mini-organ with Mega-impact
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    academic.oup.com/edrv/article/42/5/605/6223906
  132. Sep 2021
  133. www.sciencedirect.com www.sciencedirect.com
    Co-opting regulation bypass repair as a gene correction strategy for monogenic diseases
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    sciencedirect.com/science/article/pii/S1525001621002045
  134. Aug 2021
  135. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1550413118306399
  136. Jun 2021
  137. www.nature.com www.nature.com
    Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans
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    nature.com/articles/s41598-021-90643-3
  138. Apr 2021
  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors
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    ncbi.nlm.nih.gov/pmc/articles/PMC8027116/
  140. Feb 2021
  141. www.sciencedirect.com www.sciencedirect.com
    Islet O-GlcNAcylation Is Required for Lipid Potentiation of Insulin Secretion through SERCA2
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    sciencedirect.com/science/article/pii/S2211124720305581
  142. Nov 2020
  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC7664344/