205 Matching Annotations
  1. Aug 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
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    sciencedirect.com/science/article/pii/S2211124725009453
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Diet-induced obesity promotes endothelial cell desensitization to VEGF-A and permanent islet vessel dysfunction in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12321391/
  4. Jul 2025
  5. www.sciencedirect.com www.sciencedirect.com
    Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals
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    sciencedirect.com/science/article/pii/S2211124725008368
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional and Mechanistic Explanation for the Unique Clinical Success of the Glucokinase Activator Dorzagliatin in the Treatment of Type 2 Diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12278794/
  7. www.sciencedirect.com www.sciencedirect.com
    The antigen presentation landscape of cytokine-stressed human pancreatic islets
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    sciencedirect.com/science/article/pii/S2211124725006989
  8. www.frontiersin.org www.frontiersin.org
    Frontiers | Gut-tropic α4β7+CD8+ T cells contribute to pancreatic β cell destruction in type 1 diabetes
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    frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1623428/full
  9. onlinelibrary.wiley.com onlinelibrary.wiley.com
    scRiskCell: A single-cell framework for quantifying islet risk cells and their adaptive dynamics in type 2 diabetes
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    onlinelibrary.wiley.com/doi/10.1002/imt2.70060
  10. www.biorxiv.org www.biorxiv.org
    Epigenetic adaptation of beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes
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    biorxiv.org/content/10.1101/2025.07.02.662814v1
  11. Jun 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative
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    pmc.ncbi.nlm.nih.gov/articles/PMC12185967/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12139852/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion
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    pmc.ncbi.nlm.nih.gov/articles/PMC12176968/
  15. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/ed006b4f5b91662bd0768819dd770495cdaa5e2c/PDF-html.html
  16. link.springer.com link.springer.com
    T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes
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    link.springer.com/article/10.1007/s00125-025-06458-8
  17. May 2025
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
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    pmc.ncbi.nlm.nih.gov/articles/PMC12086209/
  19. Apr 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11981631/
  21. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/abeaa6afb8a8bffa4edfa09216c49819d36bd556/PDF-html.html
  22. Mar 2025
  23. link.springer.com link.springer.com
    Regulating islet stress responses through CD47 activation
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    link.springer.com/article/10.1007/s00125-025-06409-3
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11938328/
  25. link.springer.com link.springer.com
    Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue
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    link.springer.com/article/10.1007/s00125-025-06401-x
  26. link.springer.com link.springer.com
    Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes
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    link.springer.com/article/10.1007/s00125-025-06384-9
  27. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/9f932175def02910028aeef91fa3dbdc5f9789b5/PDF-html.html
  28. www.sciencedirect.com www.sciencedirect.com
    Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay
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    sciencedirect.com/science/article/pii/S0092867425002065
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFN-α Induces Heterogenous ROS Production in Human β-Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870469/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870426/
  31. www.sciencedirect.com www.sciencedirect.com
    Islet single-cell transcriptomic profiling during obesity-induced beta cell expansion in female mice
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    sciencedirect.com/science/article/pii/S2589004225002913
  32. Feb 2025
  33. www.biorxiv.org www.biorxiv.org
    Linking molecular pathways and islet cell dysfunction in human type 1 diabetes
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    biorxiv.org/content/10.1101/2025.02.20.639325v1
  34. dx.doi.org dx.doi.org
    Cryopreservation of stem cell-derived beta-like cells enriches for insulin-producing cells with improved function
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    dx.doi.org/10.2337/db24-0346
  35. dx.doi.org dx.doi.org
    No evidence for persistent enteroviral B infection of pancreatic islets in type 1 diabetic and pre-diabetic patients from RNA-Seq data
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    dx.doi.org/10.2337/db24-0076
  36. dx.doi.org dx.doi.org
    Elevated cathepsin S serum levels in new-onset type 1 diabetes and autoantibody-positive siblings
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    dx.doi.org/10.2337/db23-0911
  37. dx.doi.org dx.doi.org
    RFX6 maintains gene expression and function of adult human islet α cells
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    dx.doi.org/10.2337/db23-0483
  38. dx.doi.org dx.doi.org
    Comprehensive characterization of islet remodeling in development and in diabetes using mass cytometry
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    dx.doi.org/10.1210/endocr/bqae094
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Recombinase-Mediated Cassette Exchange Platform for a Triple Independent Inducible Expression System for Human Pluripotent Stem Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11817695/
  40. Jan 2025
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TMEM55A-mediated PI5P signaling regulates α-cell actin depolymerization and glucagon secretion
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11702586/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BETA CELL DYSFUNCTION OCCURS INDEPENDENTLY OF INSULITIS IN TYPE 1 DIABETES PATHOGENESIS
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    pmc.ncbi.nlm.nih.gov/articles/PMC11703223/
  43. Dec 2024
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11649919/
  45. www.sciencedirect.com www.sciencedirect.com
    Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells
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    sciencedirect.com/science/article/pii/S2211124724013457
  46. www.biorxiv.org www.biorxiv.org
    Molecular Correlates of Glycine Receptor Activity in Human β Cells
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    biorxiv.org/content/10.1101/2024.12.02.626463v1
  47. Sep 2024
  48. link.springer.com link.springer.com
    Pancreatic δ Cells: An Overlooked Cell in Focus
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    link.springer.com/chapter/10.1007/978-3-031-62232-8_6
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11420665/
  50. Aug 2024
  51. www.cell.com www.cell.com
    α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
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    cell.com/cell-reports/pdfExtended/S2211-1247(18)30213-4
  52. Jul 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untangling the genetics of beta cell dysfunction and death in type 1 diabetes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11283044/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets
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    ncbi.nlm.nih.gov/pmc/articles/PMC11239501/
  55. 52.53.155.43 52.53.155.43
    functional-characterization-of-the-human-islet-mic-dcgd2ts6-html.html
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    52.53.155.43/6e9639fb0a98c5e5849fd2585b3aeae08ca334dc/functional-characterization-of-the-human-islet-mic-dcgd2ts6-html.html
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Network approach reveals preferential T-cell and macrophage association with α-linked β-cells in early stage of insulitis in NOD mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11228247/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of unique cell type responses in pancreatic islets to stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC11220140/
  58. www.biorxiv.org www.biorxiv.org
    HumanIslets: An integrated platform for human islet data access and analysis
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    biorxiv.org/content/10.1101/2024.06.19.599613v1
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RIPK3-mediated inflammation is a conserved β cell response to ER stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC11206196/
  60. Jun 2024
  61. www.biorxiv.org www.biorxiv.org
    Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
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    biorxiv.org/content/10.1101/2024.04.23.590798v1
  62. May 2024
  63. www.medrxiv.org www.medrxiv.org
    Elucidating the Epigenetic Landscape of Type 2 Diabetes: A Multi-Omics Analysis Revealing Novel CpG Sites and Their Association with Cardiometabolic Traits
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    medrxiv.org/content/10.1101/2024.05.20.24307650v1
  64. www.biorxiv.org www.biorxiv.org
    Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis
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    biorxiv.org/content/10.1101/2024.03.18.585508v1
  65. www.biorxiv.org www.biorxiv.org
    Network approach reveals preferential T-cell and macrophage association with α-linked β-cells in early stage of insulitis in NOD mice
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    biorxiv.org/content/10.1101/2024.05.06.592831v1
  66. www.nature.com www.nature.com
    AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics
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    nature.com/articles/s41467-024-47334-0
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NKX2-2 based nuclei sorting on frozen human archival pancreas enables the enrichment of islet endocrine populations for single-nucleus RNA sequencing
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    ncbi.nlm.nih.gov/pmc/articles/PMC11059690/
  68. Mar 2024
  69. dx.doi.org dx.doi.org
    DNA methylation-based assessment of cell composition in human pancreas and islets
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    dx.doi.org/10.2337/db23-0704
  70. www.mdpi.com www.mdpi.com
    Exploring Transcriptional Regulation of Beta Cell SASP by Brd4-Associated Proteins and Cell Cycle Control Protein p21
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    mdpi.com/2075-4655/8/1/10
  71. www.sciencedirect.com www.sciencedirect.com
    Three-dimensional imaging of the enteric nervous system in human pediatric colon reveals new features of Hirschsprung disease
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    sciencedirect.com/science/article/pii/S0016508524002877
  72. Dec 2023
  73. www.sciencedirect.com www.sciencedirect.com
    Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes
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    sciencedirect.com/science/article/pii/S1550413123004436
  74. link.springer.com link.springer.com
    Genetic risk converges on regulatory networks mediating early type 2 diabetes
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    link.springer.com/article/10.1038/s41586-023-06693-2
  75. Nov 2023
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The beta cell-immune cell interface in type 1 diabetes (T1D)
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    ncbi.nlm.nih.gov/pmc/articles/PMC10622886/
  77. Oct 2023
  78. link.springer.com link.springer.com
    Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data
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    link.springer.com/article/10.1186/s13059-023-03073-x
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An Integrated Map of Cell Type–Specific Gene Expression in Pancreatic Islets
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    ncbi.nlm.nih.gov/pmc/articles/PMC10588282/
  80. diabetesjournals.org diabetesjournals.org
    Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
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    diabetesjournals.org/diabetes/article/72/4/433/148248/Integrated-Physiology-of-the-Exocrine-and
  81. Sep 2023
  82. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202300941R
  83. Aug 2023
  84. 52.53.155.43 52.53.155.43
    Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress
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    52.53.155.43/3332fca9f9f5417145aee8b440787cc2ea4e4363/sciadv.abo3932-html.html
  85. joe.bioscientifica.com joe.bioscientifica.com
    The human α cell in health and disease
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    joe.bioscientifica.com/view/journals/joe/258/1/JOE-22-0298.xml
  86. www.sciencedirect.com www.sciencedirect.com
    Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes
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    sciencedirect.com/science/article/pii/S2211124723009245
  87. Jul 2023
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
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    ncbi.nlm.nih.gov/pmc/articles/PMC10328394/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inferring regulators of cell identity in the human adult pancreas
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    ncbi.nlm.nih.gov/pmc/articles/PMC10331937/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    When one becomes many - alternative splicing in beta cell function and failure
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    ncbi.nlm.nih.gov/pmc/articles/PMC6148369/
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiplexed in Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes
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    ncbi.nlm.nih.gov/pmc/articles/PMC6436557/
  92. Jun 2023
  93. www.sciencedirect.com www.sciencedirect.com
    Nutrient-dependent regulation of β-cell proinsulin content
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    sciencedirect.com/science/article/pii/S0021925823018641
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enrichment of stem cell-derived pancreatic beta-like cells and controlled graft size through pharmacological removal of proliferating cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10277834/
  95. www.biorxiv.org www.biorxiv.org
    Real Time In vivo Analysis of Pancreatic Beta-cell Autophagic Flux Reveals Impairment Before Onset of Autoimmune Diabetes
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    biorxiv.org/content/10.1101/2023.05.23.541935v1
  96. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Dissecting the Interrelationship between COVID-19 and Diabetes Mellitus
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    onlinelibrary.wiley.com/doi/10.1002/adbi.202300107
  97. May 2023
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits
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    ncbi.nlm.nih.gov/pmc/articles/PMC9366645/
  99. Apr 2023
  100. www.sciencedirect.com www.sciencedirect.com
    Generation of functional thymic organoids from human pluripotent stem cells.
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    sciencedirect.com/science/article/pii/S2213671123000607
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Peeling the onion: another layer in the regulation of insulin secretion
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    ncbi.nlm.nih.gov/pmc/articles/PMC10104890/
  102. Mar 2023
  103. www.nature.com www.nature.com
    Multivariate indicators of disease severity in COVID-19
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    nature.com/articles/s41598-023-31683-9
  104. www.biorxiv.org www.biorxiv.org
    Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes
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    biorxiv.org/content/10.1101/2023.03.02.530808v1
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex differences in islet stress responses support female β cell resilience
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    ncbi.nlm.nih.gov/pmc/articles/PMC9971554/
  106. www.biorxiv.org www.biorxiv.org
    An integrated map of cell type-specific gene expression in pancreatic islets
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    biorxiv.org/content/10.1101/2023.02.03.526994v1
  107. www.mdpi.com www.mdpi.com
    Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic β-Cell Loss upon Transplant
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    mdpi.com/2073-4409/12/5/698
  108. Feb 2023
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics
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    ncbi.nlm.nih.gov/pmc/articles/PMC9882100/
  110. journals.physiology.org journals.physiology.org
    ajpendo.00246.2022.pdf
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    journals.physiology.org/doi/pdfdirect/10.1152/ajpendo.00246.2022
  111. journals.physiology.org journals.physiology.org
    Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss
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    journals.physiology.org/doi/epdf/10.1152/ajpendo.00246.2022
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of functional human thymic cells from induced pluripotent stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8815270/
  113. Jan 2023
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  116. Dec 2022
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  120. Oct 2022
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  133. Jul 2022
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  144. Apr 2022
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  146. Mar 2022
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  149. Feb 2022
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  156. Dec 2021
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  159. Nov 2021
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  164. Sep 2021
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  167. Aug 2021
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  183. May 2021
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  192. Feb 2021
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  223. Jan 2020
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    Evaluating Vascularization of Heterotopic Islet Constructs for Type 1 Diabetes Using an In Vitro Platform
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  229. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell
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  230. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  233. www.jci.org www.jci.org
    Cross-reactive public TCR sequences undergo positive selection in the human thymic repertoire
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  234. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes
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  235. www.sciencedirect.com www.sciencedirect.com
    A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets
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  236. www.sciencedirect.com www.sciencedirect.com
    Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A
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  237. www.sciencedirect.com www.sciencedirect.com
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  238. www.sciencedirect.com www.sciencedirect.com
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  241. Nov 2018
  242. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  243. www.sciencedirect.com www.sciencedirect.com
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  244. www.cell.com www.cell.com
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  245. insight.jci.org insight.jci.org
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