296 Matching Annotations
  1. Last 7 days
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    Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization
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    1. scibot 20 Apr 2024
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    sciencedirect.com/science/article/pii/S1535610824001193
  3. Apr 2024
  4. aacrjournals.org aacrjournals.org
    Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis
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    1. scibot 19 Apr 2024
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      DOI: 10.1158/0008-5472.CAN-23-1542

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    aacrjournals.org/cancerres/article/84/4/527/734130/Mesothelin-Secretion-by-Pancreatic-Cancer-Cells-Co
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    Proteomic analysis of the serum in dogs with pulmonary hypertension secondary to myxomatous mitral valve disease: the preliminary study
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    1. scibot 11 Apr 2024
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      DOI: 10.3389/fvets.2024.1327453

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    ncbi.nlm.nih.gov/pmc/articles/PMC11002142/
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    Dynamic localization of the chromosomal passenger complex in trypanosomes is controlled by the orphan kinesins KIN-A and KIN-B
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    1. scibot 04 Apr 2024
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      DOI: 10.7554/eLife.93522

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    ncbi.nlm.nih.gov/pmc/articles/PMC10987093/
  7. Mar 2024
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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    sciencedirect.com/science/article/pii/S1097276524001722
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    Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment
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      DOI: 10.1016/j.cmet.2024.02.009

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      DOI: 10.1016/j.cmet.2024.02.009

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    sciencedirect.com/science/article/pii/S155041312400055X
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    Structure of the plant plastid-encoded RNA polymerase
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      DOI: 10.1016/j.cell.2024.01.036

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    sciencedirect.com/science/article/pii/S009286742400103X
  11. Feb 2024
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    Origin of eukaryotic-like Vps23 shapes an ancient functional interplay between ESCRT and ubiquitin system in Asgard archaea
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    sciencedirect.com/science/article/pii/S2211124724001098
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    Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B
    1
    1. scibot 10 Feb 2024
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      DOI: 10.1126/sciadv.adj1205

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    ncbi.nlm.nih.gov/pmc/articles/PMC10848721/
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    A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
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      DOI: 10.1038/s41467-024-45067-8

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    nature.com/articles/s41467-024-45067-8
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    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
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    1. scibot 06 Feb 2024
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      DOI: 10.1158/2159-8290.CD-22-1401

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524254/
  16. Jan 2024
  17. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Comparative Analysis of Various Spider Silks in Regard to Nerve Regeneration: Material Properties and Schwann Cell Response
    1
    1. scibot 24 Jan 2024
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      DOI: 10.1002/adhm.202302968

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    Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome
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    1. scibot 23 Jan 2024
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      DOI: 10.1016/j.neuron.2023.12.014

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    Temporal landscape of mitochondrial proteostasis governed by the UPRmt
    1
    1. scibot 12 Jan 2024
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      DOI: 10.1126/sciadv.adh8228

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    Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B
    1
    1. scibot 12 Jan 2024
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      DOI: 10.1126/sciadv.adj1205

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    Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
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      DOI: 10.1016/j.ccell.2023.12.019

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    sciencedirect.com/science/article/pii/S1535610823004476
  22. Dec 2023
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    RAF-like protein kinases mediate a deeply conserved, rapid auxin response
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      DOI: 10.1016/j.cell.2023.11.021

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    sciencedirect.com/science/article/pii/S0092867423012758
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    Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer
    1
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      DOI: 10.1371/journal.pgen.1011043

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    ncbi.nlm.nih.gov/pmc/articles/PMC10715669/
  25. pubs.acs.org pubs.acs.org
    Shotgun Proteomic-Based Approach with a Q-Exactive Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometer for Protein Adductomics on a 3D Human Brain Tumor Neurospheroid Culture Model: The Identification of Adduct Formation in Calmodulin-Dependent Protein Kinase-2 and Annexin-A1 Induced by Pesticide Mixture
    1
    1. scibot 07 Dec 2023
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      DOI: 10.1021/acs.jproteome.3c00484

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    pubs.acs.org/doi/full/10.1021/acs.jproteome.3c00484
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    A proteomic insight reveals the role of food-associated Lactiplantibacillus plantarum C9O4 in reverting intestinal inflammation
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      DOI: 10.1016/j.isci.2023.108481

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    sciencedirect.com/science/article/pii/S2589004223025580
  27. Nov 2023
  28. www.sciencedirect.com www.sciencedirect.com
    RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.molcel.2023.10.012

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    sciencedirect.com/science/article/pii/S1097276523008493
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Variability analysis of LC-MS experimental factors and their impact on machine learning
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    1. scibot 26 Nov 2023
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      DOI: 10.1093/gigascience/giad096

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  30. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Establishing an early indicator for data sharing and reuse
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      DOI: 10.1002/leap.1586

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    onlinelibrary.wiley.com/doi/10.1002/leap.1586
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Differential Proteome Profiling Analysis under Pesticide Stress by the Use of a Nano-UHPLC-MS/MS Untargeted Proteomic-Based Approach on a 3D-Developed Neurospheroid Model: Identification of Protein Interactions, Prognostic Biomarkers, and Potential Therapeutic Targets in Human IDH Mutant High-Grade Gliomas
    1
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      DOI: 10.1021/acs.jproteome.3c00395

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    ncbi.nlm.nih.gov/pmc/articles/PMC10629271/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma
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      DOI: 10.7554/eLife.85654

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      DOI: 10.7554/eLife.85654

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    ncbi.nlm.nih.gov/pmc/articles/PMC10629828/
  33. Sep 2023
  34. www.science.org www.science.org
    Temporal landscape of mitochondrial proteostasis governed by the UPRmt
    1
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      DOI: 10.1126/sciadv.adh8228

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    science.org/doi/10.1126/sciadv.adh8228
  35. www.sciencedirect.com www.sciencedirect.com
    Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly
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      DOI: 10.1016/j.cub.2023.08.063

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    sciencedirect.com/science/article/pii/S0960982223011430
  36. Aug 2023
  37. www.sciencedirect.com www.sciencedirect.com
    MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy
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      DOI: 10.1016/j.celrep.2023.113045

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    sciencedirect.com/science/article/pii/S2211124723010562
  38. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease
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      DOI: 10.1111/jnc.15924

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15924
  39. Jul 2023
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    Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition
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      DOI: 10.1016/j.neuron.2023.06.019

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    sciencedirect.com/science/article/pii/S0896627323004786
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    Mechanism of orphan subunit recognition during assembly quality control
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      DOI: 10.1016/j.cell.2023.06.016

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    sciencedirect.com/science/article/pii/S0092867423006943
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA
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      DOI: 10.12688/wellcomeopenres.17893.1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10354459/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses
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      DOI: 10.1158/2643-3230.BCD-22-0029

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    ncbi.nlm.nih.gov/pmc/articles/PMC9816815/
  44. www.biorxiv.org www.biorxiv.org
    Parkinson’s VP535[D620N] mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B
    1
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      DOI: 10.1101/2023.06.07.544051

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    biorxiv.org/content/10.1101/2023.06.07.544051v1
  45. Jun 2023
  46. www.sciencedirect.com www.sciencedirect.com
    ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation
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      DOI: 10.1016/j.chembiol.2023.05.010

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    sciencedirect.com/science/article/pii/S2451945623001538
  47. aacrjournals.org aacrjournals.org
    ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
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    1. scibot 03 Jun 2023
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      DOI: 10.1158/0008-5472.CAN-22-1826

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    aacrjournals.org/cancerres/article/83/7/1128/718992/ROS-Induction-Targets-Persister-Cancer-Cells-with
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    The Rab5 effector FERRY links early endosomes with mRNA localization
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      DOI: 10.1016/j.molcel.2023.05.012

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    sciencedirect.com/science/article/pii/S1097276523003611
  49. May 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Proteomics of immune cells from liver tumors reveals immunotherapy targets
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      DOI: 10.1016/j.xgen.2023.100331

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    BAP1 loss is associated with higher ASS1 expression in epithelioid mesothelioma: implications for therapeutic stratification.
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  53. Apr 2023
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    Vascular cells improve functionality of human cardiac organoids
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    Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface
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    Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair
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    N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Potential Targets for Neuroprotection
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    Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
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    Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets
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    Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin
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    Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory biomarkers of vitreoretinal eye diseases
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    Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2
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    The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
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    RNA-DNA hybrids prevent resection at dysfunctional telomeres
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  69. Jan 2023
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    A mitochondrion-free eukaryote contains proteins capable of import into an exogenous mitochondrion-related organelle
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    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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    EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal
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    Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non–Hodgkin Lymphoma
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    Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
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    Neuronal and astrocytic contributions to Huntington’s disease dissected with zinc finger protein transcriptional repressors
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    Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma
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    SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
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  78. Dec 2022
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    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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    Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning
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    Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2
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  86. Sep 2022
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    Convergent cerebrospinal fluid proteomes and metabolic ontologies in humans and animal models of Rett syndrome
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  91. Aug 2022
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    Substrate spectrum of PPM1D in the cellular response to DNA double-strand breaks
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  94. Jul 2022
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    Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth
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    Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition
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  98. Jun 2022
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    Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML
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    MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
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    Proteomic-Based Machine Learning Analysis Reveals PYGB as a Novel Immunohistochemical Biomarker to Distinguish Inverted Urothelial Papilloma From Low-Grade Papillary Urothelial Carcinoma With Inverted Growth
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    Dual roles for ATP in the regulation of phase separated protein aggregates in Xenopus oocyte nucleoli
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    In Vivo Identification of Protein Kinase Substrates by Kinase‐Oriented Substrate Screening (KIOSS)
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  152. www.nature.com www.nature.com
    Regulation of the endosomal SNX27-retromer by OTULIN
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    RIPLET and not TRIM25 is required for endogenous RIG‐I‐dependent anti‐viral responses
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  154. wellcomeopenresearch.org wellcomeopenresearch.org
    Proteomic analysis of a filaggrin-deficient skin organoid model shows evidence of increased transcriptional-translational activity, keratinocyte-immune crosstalk and disordered axon guidance
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  155. elifesciences.org elifesciences.org
    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy
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  156. www.embopress.org www.embopress.org
    The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban
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    SALM1 controls synapse development by promoting F‐actin/PIP2‐dependent Neurexin clustering
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    Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3
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    USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification
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    In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation
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  161. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Hyaluronan synthesis supports glutamate transporter activity
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  162. jcs.biologists.org jcs.biologists.org
    Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling
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  163. www.sciencedirect.com www.sciencedirect.com
    Optimization of mass spectrometric parameters improve the identification performance of capillary zone electrophoresis for single-shot bottom-up proteomics analysis
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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of microcompartmentation on flux distribution and metabolic pools in Chlamydomonas reinhardtii chloroplasts
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    Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
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  166. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Hydrogen sulfide regulates muscle RING finger‐1 protein S‐sulfhydration at Cys44 to prevent cardiac structural damage in diabetic cardiomyopathy
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    Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo
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    The Neuroprotective Role of the GM1 Oligosaccharide, II<Superscript>3</Superscript>Neu5Ac-Gg<Subscript>4</Subscript>, in Neuroblastoma Cells
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    Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance
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    Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics
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    UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors
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    Spatially Distinct Pools of TORC1 Balance Protein Homeostasis
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    Chemical Cross-Linking Enables Drafting ClpXP Proximity Maps and Taking Snapshots of In Situ Interaction Networks
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    Genome-wide Rules of Nucleosome Phasing in Drosophila
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  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis
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    Symbiotic nitrogen fixation in the reproductive structures of a basidiomycete fungus
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    Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
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    Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis
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  180. Jun 2021
  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Differences and commonalities in plasma membrane recruitment of the two morphogenetically distinct retroviruses HIV-1 and MMTV
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  182. elifesciences.org elifesciences.org
    Quantitative mapping of human hair greying and reversal in relation to life stress
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    Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin
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  184. www.cell.com www.cell.com
    TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis
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  185. May 2021
  186. www.mdpi.com www.mdpi.com
    Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence
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    Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity
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  188. mcr.aacrjournals.org mcr.aacrjournals.org
    Crosstalk between YAP and RAR-RXR drives expression of stemness genes to promote 5-FU resistance and self-renewal in colorectal cancer cells
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  189. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Diagnostic Biomarkers from Proteomic Characterization of Cerebrospinal Fluid in Patients with Brain Malignancies
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    ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
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    Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP
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  192. Apr 2021
  193. www.sciencedirect.com www.sciencedirect.com
    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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    Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin
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    Erosion of human X chromosome inactivation causes major remodeling of the iPSC proteome
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    Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190
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    Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome
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    Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila
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    Insight into the human pathodegradome of the V8 protease from Staphylococcus aureus
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    BET Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection
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  204. Mar 2021
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    Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling
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    Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
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    SUMO is a pervasive regulator of meiosis
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    Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine
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    Proteogenomics of glioblastoma associates molecular patterns with survival
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    Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function
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    Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia
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  212. Feb 2021
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    Identification of host proteins differentially associated with HIV-1 RNA splice variants
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  214. www.cell.com www.cell.com
    Fatal Perinatal Mitochondrial Cardiac Failure Caused by Recurrent De Novo Duplications in the ATAD3 Locus
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    Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation
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    Factor H Is Bound by Outer Membrane-Displayed Carbohydrate Metabolism Enzymes of Extraintestinal Pathogenic Escherichia coli and Contributes to Opsonophagocytosis Resistance in Bacteria
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    The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers
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  219. Jan 2021
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    Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage
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    Impact of WIN site inhibitor on the WDR5 interactome
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  222. Dec 2020
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    B-Cell-Specific Myd88 L252P Expression Causes a Premalignant Gammopathy Resembling IgM MGUS
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    The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion
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    RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells
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    Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact
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  227. Nov 2020
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    Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum
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    Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast
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  230. Oct 2020
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    An optimized quantitative proteomics method establishes the cell type‐resolved mouse brain secretome
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    Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B
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    Re-establishment of the epigenetic state and rescue of kinome deregulation in Ts65Dn mice upon treatment with green tea extract and environmental enrichment
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    Fatal Perinatal Mitochondrial Cardiac Failure Caused by Recurrent De Novo Duplications in the ATAD3 Locus
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    Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
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  236. Sep 2020
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    Identification of genes required for glucan exopolysaccharide production in Lactobacillus johnsonii suggests a novel mechanism of biosynthesis
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    Comparative proteomics analysis of Tibetan hull-less barley under osmotic stress via data-independent acquisition mass spectrometry
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