303 Matching Annotations
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    Protocol for affinity purification-mass spectrometry interactome profiling in larvae of Drosophila melanogaster
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    Autophagy preferentially degrades non-fibrillar polyQ aggregates
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  4. May 2024
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    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
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    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
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  8. Apr 2024
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    Systematic analysis of proteome turnover in an organoid model of pancreatic cancer by dSILO
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    Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization
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    Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis
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    Proteomic analysis of the serum in dogs with pulmonary hypertension secondary to myxomatous mitral valve disease: the preliminary study
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    Dynamic localization of the chromosomal passenger complex in trypanosomes is controlled by the orphan kinesins KIN-A and KIN-B
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  14. Mar 2024
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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    Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment
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    Structure of the plant plastid-encoded RNA polymerase
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  18. Feb 2024
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    Origin of eukaryotic-like Vps23 shapes an ancient functional interplay between ESCRT and ubiquitin system in Asgard archaea
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    Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B
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    A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
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    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
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  23. Jan 2024
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    Comparative Analysis of Various Spider Silks in Regard to Nerve Regeneration: Material Properties and Schwann Cell Response
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    Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome
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    Temporal landscape of mitochondrial proteostasis governed by the UPRmt
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    Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B
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    Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
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  29. Dec 2023
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    RAF-like protein kinases mediate a deeply conserved, rapid auxin response
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    Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer
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    Shotgun Proteomic-Based Approach with a Q-Exactive Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometer for Protein Adductomics on a 3D Human Brain Tumor Neurospheroid Culture Model: The Identification of Adduct Formation in Calmodulin-Dependent Protein Kinase-2 and Annexin-A1 Induced by Pesticide Mixture
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    A proteomic insight reveals the role of food-associated Lactiplantibacillus plantarum C9O4 in reverting intestinal inflammation
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  34. Nov 2023
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    RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
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    Variability analysis of LC-MS experimental factors and their impact on machine learning
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      DOI: 10.1093/gigascience/giad096

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    Establishing an early indicator for data sharing and reuse
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    Differential Proteome Profiling Analysis under Pesticide Stress by the Use of a Nano-UHPLC-MS/MS Untargeted Proteomic-Based Approach on a 3D-Developed Neurospheroid Model: Identification of Protein Interactions, Prognostic Biomarkers, and Potential Therapeutic Targets in Human IDH Mutant High-Grade Gliomas
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      DOI: 10.1021/acs.jproteome.3c00395

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    ncbi.nlm.nih.gov/pmc/articles/PMC10629271/
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    Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma
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      DOI: 10.7554/eLife.85654

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      DOI: 10.7554/eLife.85654

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    ncbi.nlm.nih.gov/pmc/articles/PMC10629828/
  40. Sep 2023
  41. www.science.org www.science.org
    Temporal landscape of mitochondrial proteostasis governed by the UPRmt
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      DOI: 10.1126/sciadv.adh8228

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    Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly
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      DOI: 10.1016/j.cub.2023.08.063

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    sciencedirect.com/science/article/pii/S0960982223011430
  43. Aug 2023
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    MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy
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      DOI: 10.1016/j.celrep.2023.113045

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    sciencedirect.com/science/article/pii/S2211124723010562
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    Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease
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      DOI: 10.1111/jnc.15924

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15924
  46. Jul 2023
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    Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition
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      DOI: 10.1016/j.neuron.2023.06.019

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    sciencedirect.com/science/article/pii/S0896627323004786
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    Mechanism of orphan subunit recognition during assembly quality control
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      DOI: 10.1016/j.cell.2023.06.016

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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA
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      DOI: 10.12688/wellcomeopenres.17893.1

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    Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses
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    Parkinson’s VP535[D620N] mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B
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    ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation
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    ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
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    The Rab5 effector FERRY links early endosomes with mRNA localization
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    Proteomics of immune cells from liver tumors reveals immunotherapy targets
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    BAP1 loss is associated with higher ASS1 expression in epithelioid mesothelioma: implications for therapeutic stratification.
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  60. Apr 2023
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    Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface
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    Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair
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    TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment
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    N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Potential Targets for Neuroprotection
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    Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
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  67. Mar 2023
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    Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets
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    Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin
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    Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory biomarkers of vitreoretinal eye diseases
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    Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2
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  73. Feb 2023
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    The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
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    RNA-DNA hybrids prevent resection at dysfunctional telomeres
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  76. Jan 2023
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    A mitochondrion-free eukaryote contains proteins capable of import into an exogenous mitochondrion-related organelle
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    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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    EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal
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    Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non–Hodgkin Lymphoma
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    Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
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    Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma
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    SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
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    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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  93. Sep 2022
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    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    Convergent cerebrospinal fluid proteomes and metabolic ontologies in humans and animal models of Rett syndrome
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  98. Aug 2022
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    Comparative phosphoproteomic profiling in the prefrontal cortex of prenatally stressed male offspring rats
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    Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth
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  105. Jun 2022
  106. aacrjournals.org aacrjournals.org
    Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML
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    Regionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment
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  118. Mar 2022
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  123. Feb 2022
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    Dual roles for ATP in the regulation of phase separated protein aggregates in Xenopus oocyte nucleoli
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  125. Dec 2021
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    Extracellular Vesicles Induce an Aggressive Phenotype in Luminal Breast Cancer Cells Via PKM2 Phosphorylation
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  130. Nov 2021
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    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
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    A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer
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    Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription
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  137. Sep 2021
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  139. Aug 2021
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    Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes
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    Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling
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    Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior
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    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
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    Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE
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    Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence
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    Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity
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  195. mcr.aacrjournals.org mcr.aacrjournals.org
    Crosstalk between YAP and RAR-RXR drives expression of stemness genes to promote 5-FU resistance and self-renewal in colorectal cancer cells
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      DOI: 10.1158/1541-7786.MCR-20-0462

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  196. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Diagnostic Biomarkers from Proteomic Characterization of Cerebrospinal Fluid in Patients with Brain Malignancies
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    ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
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    Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP
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  199. Apr 2021
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    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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    Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin
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    Erosion of human X chromosome inactivation causes major remodeling of the iPSC proteome
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    Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190
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    Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome
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  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila
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    Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics
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    Integrated Omics of Metastatic Colorectal Cancer
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    A membrane arm of mitochondrial complex I sufficient to promote respirasome formation
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    Insight into the human pathodegradome of the V8 protease from Staphylococcus aureus
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    BET Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection
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  211. Mar 2021
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    Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling
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    Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
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    SUMO is a pervasive regulator of meiosis
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    Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine
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    Proteogenomics of glioblastoma associates molecular patterns with survival
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    Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function
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    Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia
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  219. Feb 2021
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    Identification of host proteins differentially associated with HIV-1 RNA splice variants
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  221. www.cell.com www.cell.com
    Fatal Perinatal Mitochondrial Cardiac Failure Caused by Recurrent De Novo Duplications in the ATAD3 Locus
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    Population-scale proteome variation in human induced pluripotent stem cells
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  223. www.cell.com www.cell.com
    Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation
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    cell.com/cell-reports/abstract/S2211-1247(20)30020-6
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    Factor H Is Bound by Outer Membrane-Displayed Carbohydrate Metabolism Enzymes of Extraintestinal Pathogenic Escherichia coli and Contributes to Opsonophagocytosis Resistance in Bacteria
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    The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers
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  226. Jan 2021
  227. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage
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    Impact of WIN site inhibitor on the WDR5 interactome
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  229. Dec 2020
  230. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    B-Cell-Specific Myd88 L252P Expression Causes a Premalignant Gammopathy Resembling IgM MGUS
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    The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion
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    RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells
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    Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact
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  234. Nov 2020
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    Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum
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  236. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast
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