123 Matching Annotations
  1. Last 7 days
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    Anti-tumor activity of trastuzumab deruxtecan in pediatric solid tumors with variable HER2 expression
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    aacrjournals.org/mct/article/25/1/156/771291/Antitumor-Activity-of-Trastuzumab-Deruxtecan-in
  3. Mar 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    JAK/STAT1-interferon-ISGylation networks in breast cancer resistance to inhibitors of FOXM1 and CDK4/6
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    pmc.ncbi.nlm.nih.gov/articles/PMC13009525/
  5. Jan 2026
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    PDCD5 promotes substrate release from the TRiC complex in cilia and flagella
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    sciencedirect.com/science/article/pii/S1097276525009864
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    Synergistic intragenic epigenetic deregulation by IDH2 and SRSF2 mutations causes mis-splicing of key transcriptional regulators
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    science.org/doi/10.1126/sciadv.adu8292
  8. Dec 2025
  9. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Microglial macrophage-derived ds-HMGB1 in DRG orchestrates neuropathic pain through immune-neural signaling
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    sciencedirect.com:5037/science/article/pii/S2211124725014433
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    CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen
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    nature.com/articles/s41523-025-00851-7
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Recruitment of FBXO22 for targeted degradation of NSD2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11581931/
  12. Nov 2025
  13. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004225024915-main-html.html
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  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12616242/
  15. Oct 2025
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    Balancing Activation and Repression: CoREST-p300 Antagonism Controls Retinoic Acid-Driven Differentiation in AML
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    biorxiv.org/content/10.1101/2025.10.13.682235v1
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    ACSS2-Mediated Metabolic-Epigenetic Crosstalk Drives Fulvestrant Resistance and Represents a Novel Therapeutic Target
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    biorxiv.org/content/10.1101/2025.09.23.678089v1
  18. Sep 2025
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    Molecular basis of DNA recognition by the HMG-box-C1 module of capicua
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    sciencedirect.com/science/article/pii/S0969212625003223
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    Targeting a pathogenic cryptic exon that drives HLRCC to induce exon skipping
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    pmc.ncbi.nlm.nih.gov/articles/PMC12396411/
  21. Aug 2025
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    YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition
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    sciencedirect.com/science/article/pii/S2211124725009593
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential control of growth and identity by HNF4α isoforms in pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12333154/
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    Imaging and targeting S1PR1 in HER2+ tumors
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  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Significance of FXa and its receptor PAR2 for the growth of colon cancer cells in vitro and in vivo
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    First-in-human Study of ABY-029, a Novel Fluorescent Peptide that Targets Epidermal Growth Factor Receptor, Applied to Soft-Tissue Sarcomas
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    pmc.ncbi.nlm.nih.gov/articles/PMC12312686/
  27. Jul 2025
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12306140/
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    A subset of evolutionarily conserved centriolar satellite core components is crucial for sperm flagellum biogenesis
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  30. Jun 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130801/
  32. May 2025
  33. www.sciencedirect.com www.sciencedirect.com
    Cytoplasmic DIS3 is an exosome-independent endoribonuclease with catalytic activity toward circular RNAs
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    sciencedirect.com/science/article/pii/S2211124725005406
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    hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation
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  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modulation of HER2 internalization enhances single-dose antibody-drug potency in HER2+ gastric cancer
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  37. Apr 2025
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid Leukemia
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    Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors
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  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Checkpoint Reversal Receptor Mediates Bipartite Activation and Enhances CAR T-cell Function
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  42. Mar 2025
  43. 52.53.155.43 52.53.155.43
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  45. Feb 2025
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival
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    Imlunestrant Is an Oral, Brain-Penetrant Selective Estrogen Receptor Degrader with Potent Antitumor Activity in ESR1 Wild-Type and Mutant Breast Cancer
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  48. aacrjournals.org aacrjournals.org
    A Genetically Encoded Magnetic Resonance Imaging Reporter Enables Sensitive Detection and Tracking of Spontaneous Metastases in Deep Tissues
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    aacrjournals.org/cancerres/article/83/5/673/716684/A-Genetically-Encoded-Magnetic-Resonance-Imaging
  49. Jan 2025
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    GLUT1 as a generic biomarker enables near-infrared fluorescence molecular imaging guided precise intraoperative tumor detection in breast cancer
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    link.springer.com/article/10.1007/s00259-025-07095-4
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    Anticancer effect of a single-chain variable fragment against pro-matrix metalloproteinase-7 in colon cancer
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  52. Dec 2024
  53. 52.53.155.43 52.53.155.43
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  54. Sep 2024
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    Intracellular Osteopontin Promotes the Release of TNFα by Mast Cells to Restrain Neuroendocrine Prostate Cancer
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  56. Aug 2024
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    Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis
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    Sortilin is dispensable for secondary injury processes following traumatic brain injury in mice
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  59. Jul 2024
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    Biogenesis of lysosome-related organelles complex-2 is an evolutionarily ancient proto-coatomer complex
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  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11252164/
  62. May 2024
  63. www.mdpi.com www.mdpi.com
    Valproic Acid Treatment after Traumatic Brain Injury in Mice Alleviates Neuronal Death and Inflammation in Association with Increased Plasma Lysophosphatidylcholines
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    mdpi.com/2073-4409/13/9/734
  64. Apr 2024
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Faa1 membrane binding drives positive feedback in autophagosome biogenesis via fatty acid activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993510/
  66. Mar 2024
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier
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    ncbi.nlm.nih.gov/pmc/articles/PMC10941402/
  68. Feb 2024
  69. link.springer.com link.springer.com
    Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Radix Paeoniae Rubra Against Glioma
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    link.springer.com/article/10.1007/s12010-024-04887-6
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    Association between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease
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  71. Dec 2023
  72. link.springer.com link.springer.com
    Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases
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    link.springer.com/article/10.1038/s41531-023-00604-y
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    CCDC146 is required for sperm flagellum biogenesis and male fertility in mice
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    link.springer.com/article/10.1007/s00018-023-05025-x
  74. Nov 2023
  75. www.biorxiv.org www.biorxiv.org
    Recruitment of FBXO22 for Targeted Degradation of NSD2
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    biorxiv.org/content/10.1101/2023.11.01.564830v1
  76. Aug 2023
  77. 52.53.155.43 52.53.155.43
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  78. May 2023
  79. www.sciencedirect.com www.sciencedirect.com
    The cilia and flagella associated protein CFAP52 orchestrated with CFAP45 is required for sperm motility in mice
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    sciencedirect.com/science/article/pii/S0021925823018860
  80. www.mdpi.com www.mdpi.com
    The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia
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  81. Mar 2023
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    Inhibition of monoamine oxidase-a increases respiration in isolated mouse cortical mitochondria
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    sciencedirect.com/science/article/pii/S0014488623000407
  83. Feb 2023
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy
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    ncbi.nlm.nih.gov/pmc/articles/PMC9917425/
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    Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9780084/
  87. Jan 2023
  88. www.mdpi.com www.mdpi.com
    Presenilin 1 Modulates Acetylcholinesterase Trafficking and Maturation
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  89. Aug 2022
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    Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice
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    Early posttraumatic CSF1R inhibition via PLX3397 leads to time- and sex-dependent effects on inflammation and neuronal maintenance after traumatic brain injury in mice
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    sciencedirect.com/science/article/pii/S0889159122003385
  92. Jun 2022
  93. journals.biologists.com journals.biologists.com
    Ccdc38 is required for sperm flagellum biogenesis and male fertility in mice
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    journals.biologists.com/dev/article/149/11/dev200516/275684/CCDC38-is-required-for-sperm-flagellum-biogenesis
  94. Apr 2022
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    Astrocytic GABA transporter controls sleep by modulating GABAergic signaling in Drosophila circadian neurons
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    An optimized protocol to analyze membrane protein degradation in yeast using quantitative western blot and flow cytometry
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    PA1 participates in the maintenance of blood–testis barrier integrity via cooperation with JUN in the Sertoli cells of mice
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    link.springer.com/article/10.1186/s13578-022-00773-y
  98. Mar 2022
  99. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sex hormones modulate pathogenic processes in experimental traumatic brain injury
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14678
  100. Feb 2022
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer.
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    ncbi.nlm.nih.gov/pmc/articles/PMC7854521/
  102. Dec 2021
  103. asbmr.onlinelibrary.wiley.com asbmr.onlinelibrary.wiley.com
    KIF26B silencing prevents osseous transdifferentiation of progenitor/stem cells and attenuates ectopic calcification in a murine model
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    asbmr.onlinelibrary.wiley.com/doi/10.1002/jbmr.4473
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    Sec3 exocyst component knockdown inhibits axonal formation and cortical neuronal migration during brain cortex development
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15554
  105. Nov 2021
  106. journals.biologists.com journals.biologists.com
    Tubular microdomains of Rab7-endosomes retrieve TrkA, a mechanism disrupted in Charcot-Marie-Tooth 2B
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    journals.biologists.com/jcs/article/134/20/jcs258559/272650/Tubular-microdomains-of-Rab7-positive-endosomes
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    Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load
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    ncbi.nlm.nih.gov/pmc/articles/PMC8547963/
  109. Oct 2021
  110. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Synaptotagmin-11 inhibits spontaneous neurotransmission through vti1a
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15523
  111. www.cell.com www.cell.com
    Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates
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    cell.com/current-biology/fulltext/S0960-9822(21)01250-1
  112. Sep 2021
  113. www.sciencedirect.com www.sciencedirect.com
    Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2
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    sciencedirect.com/science/article/pii/S1097276521006912
  114. Aug 2021
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    Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC5565368/
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  118. elifesciences.org elifesciences.org
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    elifesciences.org/articles/28199
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    Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye
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    biorxiv.org/content/10.1101/143347v1
  120. Jul 2021
  121. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Presence of melatonin‐catabolizing nonspecific enzymes myeloperoxidase and indoleamine 2,3‐dioxygenase in the ram reproductive tract
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    onlinelibrary.wiley.com/doi/10.1111/rda.13574
  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export
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