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Helminth proteins recapitulate key structural motifs of MIF to facilitate immunomodulation of host receptors

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1. scibot 27 Jun 2026
  
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  RRID:SCR_015748
  
  DOI: 10.1016/j.isci.2026.116513
  
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sciencedirect.com/science/article/pii/S2589004226018882
Apr 2026
aacrjournals.org aacrjournals.org

Combined inactivation of MEK and mTOR can lead to synergistic cell death in glioblastoma models and associates with NF1-deficiency and a mesenchymal subtype

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1. scibot 02 Apr 2026
  
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  RRID:SCR_015748
  
  DOI: 10.1158/1535-7163.MCT-23-0864
  
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aacrjournals.org/mct/article/24/12/1878/768319/Combined-Inactivation-of-MEK-and-mTOR-Can-Lead-to
Aug 2025
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Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction

1
1. scibot 15 Aug 2025
  
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  RRID:SCR_015748
  
  DOI: 10.1016/j.str.2025.07.016
  
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sciencedirect.com/science/article/pii/S0969212625002655
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer

1
1. scibot 04 Jul 2025
  
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  RRID:SCR_015748
  
  DOI: 10.1158/1535-7163.MCT-24-0699
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12214875/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

23ME-01473, an Fc Effector–Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell–Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation

1
1. scibot 27 Mar 2025
  
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  RRID:SCR_015748
  
  DOI: 10.1158/2767-9764.CRC-24-0478
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11927390/
Dec 2024
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Dual BACH1 regulation by complementary SCF-type E3 ligases

1
1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.cell.2024.11.006
  
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sciencedirect.com/science/article/pii/S0092867424013229
Mar 2024
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ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

2
1. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.cell.2024.02.013
  
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2. scibot 15 Mar 2024
  
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  RRID:SCR_015748
  
  DOI: 10.1016/j.cell.2024.02.013
  
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sciencedirect.com/science/article/pii/S009286742400179X
Nov 2022
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IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling

1
1. scibot 05 Nov 2022
  
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  RRID:SCR_015748
  
  DOI: 10.1016/j.celrep.2022.111489
  
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sciencedirect.com/science/article/pii/S2211124722013390
Mar 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Crystals of TELSAM–target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts

1
1. scibot 11 Mar 2022
  
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  RRID:SCR_015748
  
  DOI: 10.1098/rsob.210271
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8889177/
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Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel

1
1. scibot 04 Mar 2022
  
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  RRID:SCR_015748
  
  DOI: 10.1016/j.str.2022.02.005
  
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sciencedirect.com/science/article/pii/S0969212622000417
Jul 2021
www.nature.com www.nature.com

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

1
1. scibot 29 Jul 2021
  
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  DOI: 10.1038/s41589-019-0310-x
  
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  RRID:SCR_015748 RRIDCUR:Missing
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nature.com/articles/s41589-019-0310-x
Apr 2021
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Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form

1
1. scibot 14 Apr 2021
  
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  RRID:SCR_015748
  
  DOI: 10.1016/j.celrep.2021.108986
  
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sciencedirect.com/science/article/pii/S2211124721003004
Jan 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

1
1. scibot 08 Jan 2021
  
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  RRID:SCR_015748
  
  DOI: 10.7554/eLife.64922
  
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  Curator: @evieth
  
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  RRIDCUR:Validated RRID:SCR_015748
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ncbi.nlm.nih.gov/pmc/articles/PMC7781601/
Dec 2020
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Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment

1
1. scibot 23 Dec 2020
  
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  SCR_015748
  
  DOI: 10.1016/j.celrep.2020.108542
  
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  RRID:SCR_015748 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S221112472031531X
Sep 2020
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Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling

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1. scibot 09 Sep 2020
  
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  RRID:SCR_015748
  
  DOI: 10.1016/j.immuni.2020.02.004
  
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  Curator: @ethanbadger
  
  SciCrunch record: RRID:SCR_015748
  
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  RRIDCUR:Validated RRID:SCR_015748
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sciencedirect.com/science/article/pii/S1074761320300753
Nov 2018
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 05 Nov 2018
  
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  RRID:SCR_015748
  
  Curator: @evieth
  
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  (autoPROC, RRID:SCR_015748)
  
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  RRID:SCR_015748 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC6194298/
europepmc.org europepmc.org

A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants

1
1. scibot 05 Nov 2018
  
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  RRID:SCR_015748
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europepmc.org/articles/PMC5655547/