181 Matching Annotations
  1. Aug 2025
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    Transient gene melting governs the timing of oligodendrocyte maturation
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    sciencedirect.com/science/article/pii/S009286742500861X
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential Efficacy of Bevacizumab and Erlotinib in Preclinical Models of Renal Medullary Carcinoma and Fumarate Hydratase–Deficient Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12323885/
  4. Jul 2025
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Expression and function of β-site amyloid precursor protein cleaving enzyme 2 in vascular endothelium | American Journal of Physiology-Heart and Circulatory Physiology | American Physiological Society
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    pmc.ncbi.nlm.nih.gov/articles/PMC12286421/
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    Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
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    science.org/doi/10.1126/sciadv.adt2050
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    Macrophage fatty acid metabolism under chronic hypoxia shapes γδ T cell recruitment via CCL22.
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    sciencedirect.com/science/article/pii/S2589004225012866
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    Site-resolved assessment of targeted protein degradation
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    sciencedirect.com/science/article/pii/S2451945625001977
  9. Jun 2025
  10. 52.53.155.43 52.53.155.43
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    Overexpression of high affinity Type I adenosine receptors promotes the growth of uterine leiomyomas
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    52.53.155.43/98b549de2dada4d95e18fb3c1cbf3f9e072cd46c/PDF-html.html
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130801/
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    Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
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    science.org/doi/10.1126/sciadv.adt2050
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer’s Disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12140498/
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    Zmym2 Alters Expression of Key Craniofacial Genes
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    onlinelibrary.wiley.com/doi/10.1002/dvg.70018
  16. May 2025
  17. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225009654-main-html.html
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  18. Apr 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12011380/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular elucidation of brain lipofuscin in aging and Neuronal Ceroid Lipofuscinosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957193/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Checkpoint Reversal Receptor Mediates Bipartite Activation and Enhances CAR T-cell Function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11955954/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP
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    pmc.ncbi.nlm.nih.gov/articles/PMC11951697/
  23. Mar 2025
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    Antagonistic roles for MITF and TFE3 in melanoma plasticity
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    sciencedirect.com/science/article/pii/S2211124725002451
  25. 52.53.155.43 52.53.155.43
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  26. Feb 2025
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850729/
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    Pre-clinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms (MPN) transformed to AML
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    sciencedirect.com/science/article/pii/S0006497124110634
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    RBM43 controls PGC1α translation and a PGC1α-STING signaling axis
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    sciencedirect.com/science/article/pii/S1550413125000130
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Imlunestrant Is an Oral, Brain-Penetrant Selective Estrogen Receptor Degrader with Potent Antitumor Activity in ESR1 Wild-Type and Mutant Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11831106/
  31. Jan 2025
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pre-Clinical Rationale for Amcenestrant Combinations in HER2+/ER+ Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11765389/
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    Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders
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    sciencedirect.com/science/article/pii/S2451945624005166
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11703504/
  35. Dec 2024
  36. 52.53.155.43 52.53.155.43
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    Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain
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    sciencedirect.com/science/article/pii/S2211124724013676
  39. Nov 2024
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    Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency
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    DELE1 maintains muscle proteostasis to promote growth and survival in mitochondrial myopathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11574132/
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    Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy
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    link.springer.com/article/10.1007/s00401-024-02817-8
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    The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer
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  44. Oct 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of a [89Zr]Zr-labeled human antibody using a novel phage-displayed human scFv library
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    ncbi.nlm.nih.gov/pmc/articles/PMC10984770/
  46. Sep 2024
  47. www.science.org www.science.org
    Signal flow in the NMDA receptor–dependent phosphoproteome regulates postsynaptic plasticity for aversive learning
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    science.org/doi/10.1126/scisignal.ado9852
  48. Aug 2024
  49. www.sciencedirect.com www.sciencedirect.com
    Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis
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    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    cell.com/cell/fulltext/S0092-8674(20)30163-X
  51. Jul 2024
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    Biogenesis of lysosome-related organelles complex-2 is an evolutionarily ancient proto-coatomer complex
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    sciencedirect.com/science/article/pii/S0960982224008996
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    Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes
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    sciencedirect.com/science/article/pii/S0896627324004914
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction
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    ncbi.nlm.nih.gov/pmc/articles/PMC7945993/
  55. Jun 2024
  56. www.sciencedirect.com www.sciencedirect.com
    CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons
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    sciencedirect.com/science/article/pii/S2211124724006582
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    Neurodegeneration and glial morphological changes are both prevented by TRPM2 inhibition during the progression of a Parkinson's disease mouse model
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    sciencedirect.com/science/article/pii/S0014488624001067
  58. Apr 2024
  59. www.sciencedirect.com www.sciencedirect.com
    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    sciencedirect.com/science/article/pii/S2211124724004777
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Faa1 membrane binding drives positive feedback in autophagosome biogenesis via fatty acid activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993510/
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    Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery
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  62. Mar 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10959120/
  64. www.sciencedirect.com www.sciencedirect.com
    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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    Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1
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  66. Feb 2024
  67. www.biorxiv.org www.biorxiv.org
    NMDAR Phosphoproteome Controls Synaptic Growth and Learning
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    biorxiv.org/content/10.1101/2023.12.15.571360v1
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    O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology
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    link.springer.com/article/10.1038/s41589-024-01551-2
  69. www.biorxiv.org www.biorxiv.org
    Sulfatase 2 Inhibition Sensitizes Triple-Negative Breast Cancer Cells to Chemotherapy Through Augmentation of Extracellular ATP
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    biorxiv.org/content/10.1101/2023.09.15.557965v1
  70. Jan 2024
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10794847/
  72. Dec 2023
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10715669/
  74. journals.sagepub.com journals.sagepub.com
    Urokinase-type plasminogen activator promotes N-cadherin-mediated synaptic recovery in the ischemic brain - Ariel Diaz, Paola Merino, Patrick McCann, Manuel A Yepes, Laura G Quiceno, Enrique Torre, Amelia Tomkins, Xiaodong Zhang, Chadwick M Hales, Frank C Tong, Manuel Yepes, 2021
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    journals.sagepub.com/doi/full/10.1177/0271678X211002297
  75. Nov 2023
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10680432/
  77. www.sciencedirect.com www.sciencedirect.com
    Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
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    sciencedirect.com/science/article/pii/S2211124723014729
  78. www.sciencedirect.com www.sciencedirect.com
    Impact of Mutations Defining SARS-CoV-2 Omicron Subvariants BA.2.12.1 and BA.4/5 on Spike Function and Neutralization
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    sciencedirect.com/science/article/pii/S2589004223023763
  79. Oct 2023
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Zmym4 is required for early cranial gene expression and craniofacial cartilage formation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10579616/
  81. Sep 2023
  82. www.sciencedirect.com www.sciencedirect.com
    Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling
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  83. Jul 2023
  84. 52.53.155.43 52.53.155.43
    Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
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  85. Jun 2023
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10241187/
  87. May 2023
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    MFN2-dependent recruitment of ATAT1 coordinates mitochondria motility with α-tubulin acetylation and is disrupted in CMT2A
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    52.53.155.43/1cd99c82025dc1153ce972501103b9ca6bf46148/2023.03.15.532838v1.full-html.html
  89. www.sciencedirect.com www.sciencedirect.com
    Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
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    sciencedirect.com/science/article/pii/S221112472300459X
  90. Apr 2023
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    Salmonella invasion of a cell is self-limiting due to effector-driven activation of N-WASP
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    sciencedirect.com/science/article/pii/S2589004223007204
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prolonged maternal exposure to glucocorticoids alters selenoprotein expression in the developing brain
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    ncbi.nlm.nih.gov/pmc/articles/PMC10080067/
  93. Mar 2023
  94. www.biorxiv.org www.biorxiv.org
    Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo
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    biorxiv.org/content/10.1101/2023.03.24.534149v1
  95. Feb 2023
  96. www.sciencedirect.com www.sciencedirect.com
    PIMT regulates Hepatic Gluconeogenesis in Mice
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    sciencedirect.com/science/article/pii/S2589004223001979
  97. www.mdpi.com www.mdpi.com
    Selenium Protects Mouse Hypothalamic Cells from Glucocorticoid-Induced Endoplasmic Reticulum Stress Vulnerability and Insulin Signaling Impairment
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    mdpi.com/2076-3921/12/2/526
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy
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    ncbi.nlm.nih.gov/pmc/articles/PMC9917425/
  99. Jan 2023
  100. www.mdpi.com www.mdpi.com
    Presenilin 1 Modulates Acetylcholinesterase Trafficking and Maturation
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    mdpi.com/1422-0067/24/2/1437
  101. Dec 2022
  102. www.nature.com www.nature.com
    Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules
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    nature.com/articles/s41594-022-00863-y
  103. www.sciencedirect.com www.sciencedirect.com
    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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  104. Nov 2022
  105. www.sciencedirect.com www.sciencedirect.com
    Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2
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    sciencedirect.com/science/article/pii/S2211124722015443
  106. Sep 2022
  107. www.sciencedirect.com www.sciencedirect.com
    Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior
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  108. Aug 2022
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
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    ncbi.nlm.nih.gov/pmc/articles/PMC9368268/
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Determinants of Spike Infectivity, Processing and Neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2
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    ncbi.nlm.nih.gov/pmc/articles/PMC9289044/
  111. chemistry-europe.onlinelibrary.wiley.com chemistry-europe.onlinelibrary.wiley.com
    Applications and Limitations of Oxime-Linked “Split PROTACs”
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    chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200275
  112. Jul 2022
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative Cardiovascular Physiology and Pathophysiology: Male and female high-fat diet-fed Dahl SS rats are largely protected from vascular dysfunctions: PVAT contributions reveal sex differences
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    ncbi.nlm.nih.gov/pmc/articles/PMC8321809/
  114. Jun 2022
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number
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    ncbi.nlm.nih.gov/pmc/articles/PMC9236612/
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deletion of the Sodium-Dependent Glutamate Transporter GLT-1 in Maturing Oligodendrocytes Attenuates Myelination of Callosal Axons During a Postnatal Phase of Central Nervous System Development
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    ncbi.nlm.nih.gov/pmc/articles/PMC9203689/
  117. www.nature.com www.nature.com
    Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning
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    nature.com/articles/s41380-022-01643-2
  118. May 2022
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