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Molecular mechanisms governing the formation of distinct Upf1-containing complexes in yeast

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1. scibot 11 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116415
  
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sciencedirect.com/science/article/pii/S2211124725011866
Oct 2025
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Lipids modulate the open probability of RyR1 under cryo-EM conditions

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1. scibot 01 Oct 2025
  
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  DOI: 10.1016/j.str.2025.09.003
  
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sciencedirect.com/science/article/pii/S0969212625003466
Sep 2025
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Requirements for establishment and epigenetic stability of mammalian heterochromatin

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1. scibot 19 Sep 2025
  
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  DOI: 10.1016/j.molcel.2025.08.025
  
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sciencedirect.com/science/article/pii/S1097276525007105
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Structural evolution of nitrogenase over 3 billion years

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1. scibot 16 Sep 2025
  
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  DOI: 10.7554/eLife.105613
  
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elifesciences.org/articles/105613
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Structural basis of adenosine 2A receptor-balanced signaling activation relies on allosterically mediated structural dynamics

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1. scibot 09 Sep 2025
  
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  DOI: 10.1016/j.chembiol.2025.08.005
  
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sciencedirect.com/science/article/pii/S2451945625002582
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Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

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1. scibot 04 Sep 2025
  
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  DOI: 10.7554/eLife.100799.2
  
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elifesciences.org/reviewed-preprints/100799
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Allosteric regulation of the Golgi-localized PPM1H phosphatase by Rab GTPases modulates LRRK2 substrate dephosphorylation in Parkinson’s disease

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1. scibot 04 Sep 2025
  
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  DOI: 10.1016/j.jbc.2025.110679
  
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sciencedirect.com/science/article/pii/S0021925825025311
Aug 2025
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Functional and clinical insights into nuclear receptor variants for advancing precision diagnostics in male infertility

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1. scibot 29 Aug 2025
  
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  DOI: 10.1016/j.ebiom.2025.105899
  
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sciencedirect.com/science/article/pii/S2352396425003433
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The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.015
  
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sciencedirect.com/science/article/pii/S1097276525006161
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Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.str.2025.07.016
  
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sciencedirect.com/science/article/pii/S0969212625002655
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Evolutionarily diverse caveolins share a common structural framework built around amphipathic disks

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1. scibot 12 Aug 2025
  
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  DOI: 10.1083/jcb.202411175
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12330381/
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Reconstructed cell-type-specific rhythms in human brain link Alzheimer’s pathology, circadian stress, and ribosomal disruption

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1. scibot 07 Aug 2025
  
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  DOI: 10.1016/j.neuron.2025.07.010
  
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sciencedirect.com/science/article/pii/S0896627325005173
Jul 2025
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MyD88 polymerization and association to cellular membranes in a yeast heterologous model

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1. scibot 30 Jul 2025
  
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  DOI: 10.1007/s00018-025-05827-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12297185/
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41556_2025_1712_MOESM4_ESM-html.html

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1. scibot 29 Jul 2025
  
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  DOI: 10.17504
  
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52.53.155.43/e8133be4a6a5cba631389479a5d84b0633fcb0c3/41556_2025_1712_MOESM4_ESM-html.html
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Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2

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1. scibot 25 Jul 2025
  
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  DOI: 10.1126/sciadv.adt2050
  
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science.org/doi/10.1126/sciadv.adt2050
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LAG3-MHCII interaction induces a tight cell-cell interface at the immunological synapse

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1. scibot 11 Jul 2025
  
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  DOI: 10.1093/jimmun/vkaf120
  
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academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf120/8175755
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Structural serology of polyclonal antibody responses to mRNA-1273 and NVX-CoV2373 COVID-19 vaccines

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1. scibot 09 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115986
  
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sciencedirect.com/science/article/pii/S2211124725007570
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Structural insights into heterohexameric assembly of epilepsy-related ligand–receptor complex LGI1–ADAM22

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1. scibot 08 Jul 2025
  
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  DOI: 10.7554/eLife.105918
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12226019/
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Structural and functional insights into the evolution of SARS-CoV-2 KP.3.1.1 spike protein

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115941
  
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Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.017
  
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sciencedirect.com/science/article/pii/S009286742500683X
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Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

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1. scibot 04 Jul 2025
  
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  DOI: 10.7554/eLife.105396.2
  
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elifesciences.org/reviewed-preprints/105396v2
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Site-resolved assessment of targeted protein degradation

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1. scibot 03 Jul 2025
  
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  DOI: 10.1016/j.chembiol.2025.06.002
  
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sciencedirect.com/science/article/pii/S2451945625001977
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Genetic characteristics of novel extreme alkaline-inducible promoter located in five prime upstream region of peptidyl-prolyl cis/trans isomerase from Vibrio anguillarum

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1. scibot 03 Jul 2025
  
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  DOI: 10.1038/s41598-025-98559-y
  
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link.springer.com/article/10.1038/s41598-025-98559-y
Jun 2025
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Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115921
  
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Structural insights into the biotechnologically relevant reversible NADPH-oxidizing NiFe-hydrogenase from P. furiosus

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.str.2025.05.017
  
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sciencedirect.com/science/article/pii/S0969212625002151
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Repeated duplications and losses shaped SMC complex evolution from archaeal ancestors to modern eukaryotes

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115855
  
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sciencedirect.com/science/article/pii/S2211124725006266
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Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2

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1. scibot 11 Jun 2025
  
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  RRID:SCR_015872
  
  DOI: 10.1126/sciadv.adt2050
  
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science.org/doi/10.1126/sciadv.adt2050
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Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.immuni.2025.05.011
  
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sciencedirect.com/science/article/pii/S1074761325002328
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Structure, function and assembly of soybean primary cell wall cellulose synthases

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1. scibot 11 Jun 2025
  
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  ChimeraX
  
  DOI: 10.7554/eLife.96704.2
  
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elifesciences.org/reviewed-preprints/96704v2
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Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution

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1. scibot 11 Jun 2025
  
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  USCF ChimeraX
  
  DOI: 10.7554/eLife.95557.2
  
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elifesciences.org/reviewed-preprints/95557v2
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AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone

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1. scibot 11 Jun 2025
  
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  DOI: 10.7554/eLife.103159.2
  
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elifesciences.org/reviewed-preprints/103159v2
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Structural basis of GluK2 kainate receptor activation by a partial agonist

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1. scibot 11 Jun 2025
  
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  DOI: 10.1038/s41594-025-01566-w
  
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nature.com/articles/s41594-025-01566-w
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Rifampin mediated decapsulation and enhanced bacterial clearance: a new mechanism of rifamycins

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1. scibot 05 Jun 2025
  
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  RRID:SCR_01587
  
  DOI: 10.1016/j.ebiom.2025.105787
  
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sciencedirect.com/science/article/pii/S2352396425002312
May 2025
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Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.cell.2025.04.039
  
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sciencedirect.com/science/article/pii/S0092867425005094
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Comparison of Shared Class I HLA-Bound Noncanonical Neoepitopes between Normal and Neoplastic Tissues of Pancreatic Adenocarcinoma

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1. scibot 20 May 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-2251
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12079097/
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Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer

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1. scibot 17 May 2025
  
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  RRID:SCR_015872
  
  DOI: 10.1016/j.immuni.2025.04.010
  
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sciencedirect.com/science/article/pii/S1074761325001736
Apr 2025
www.biorxiv.org www.biorxiv.org

Segmented filamentous bacteria undergo a structural transition at their adhesive tip during unicellular to filament development

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1. scibot 13 Apr 2025
  
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  DOI: 10.1101/2025.04.09.647586
  
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Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors

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Cryo-EM structure of the R388 plasmid conjugative pilus reveals a helical polymer characterized by an unusual pilin/phospholipid binary complex

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The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function

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Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding

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Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae

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Doublet microtubule inner junction protein FAP20 recruits tubulin to the microtubule lattice

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Discovery, structure, and function of filamentous 3-methylcrotonyl-CoA carboxylase

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Cryo-EM structure of human hexameric MCM2-7 complex

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Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining

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PDF-html.html

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Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase

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Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C–MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies

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Structural and functional analysis of the Nipah virus polymerase complex

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Passage of the HIV capsid cracks the nuclear pore

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Skin disease-associated GJB4 variants differentially influence connexin stability, cell viability and channel function

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Structure of the Nipah virus polymerase complex

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pdf-html.html

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Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy

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The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

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balıkçı-et-al-2024-structure-of-the-nipah-virus-polymerase-complex-html.html

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PDF-html.html

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Control of 3′ splice site selection by the yeast splicing factor Fyv6

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can-24-2450-html.html

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Tubulin sequence divergence is associated with the use of distinct microtubule regulators

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Structural insights into subunit-dependent functional regulation in epithelial sodium channels

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quinodoz-et-al-2024-de-novo-variants-in-lrrc8c-resulting-in-constitutive-channel-activation-cause-a-human-multisystem-html.html

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ay-et-al-2024-in-vivo-hiv-1-nuclear-condensates-safeguard-against-cgas-and-license-reverse-transcription-html.html

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In vivo HIV-1 nuclear condensates safeguard against cGAS and license reverse transcription

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Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii

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Inhibition of Parkinson’s Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures

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Functional implications of the exon 9 splice insert in GluK1 kainate receptors

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Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED

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Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2

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Discovery and characterization of a pan-betacoronavirus S2-binding antibody

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Dynamic allostery drives autocrine and paracrine TGF-β signaling

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  DOI: 10.1016/j.cell.2024.08.036
  
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Structure of the human heparan-α-glucosaminide N-acetyltransferase (HGSNAT)

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  DOI: 10.7554/eLife.93510
  
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Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae

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Structural insights into the chloroplast protein import in land plants

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  DOI: 10.1016/j.cell.2024.08.003
  
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Generation of densely labeled oligonucleotides for the detection of small genomic elements

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  DOI: 10.1016/j.crmeth.2024.100840
  
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VAP-mediated membrane-tethering mechanisms implicate ER-PM contact function in pH homeostasis

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  DOI: 10.1016/j.celrep.2024.114592
  
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A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance

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  DOI: 10.1016/j.cell.2024.07.006
  
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Mechanism of Ca2+ transport by ferroportin - ProQuest

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  DOI: 10.7554/eLife.82947
  
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Unraveling Structural Disparities in Human and Mycobacterium Tuberculosis Type-I Fatty Acid Synthase

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  DOI: 10.1101/2024.07.17.603935
  
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The antagonistic role of an E3 ligase pair in regulating plant NLR-mediated autoimmunity and fungal pathogen resistance

1
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ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma

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Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38

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Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

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A force-sensitive mutation reveals a non-canonical role for dynein in anaphase progression

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  DOI: 10.1083/jcb.202310022
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11215527/
Jun 2024
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Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi

1
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  DOI: 10.1038/s41467-024-49590-6
  
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A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2

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  DOI: 10.1016/j.jbc.2024.107469
  
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Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures

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cell.com/structure/fulltext/S0969-2126(24)00190-4
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POT1 recruits and regulates CST-Polα/primase at human telomeres

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  DOI: 10.1016/j.cell.2024.05.002
  
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Cryo-electron tomography reveals the packaging pattern of RuBisCOs in Synechococcus β-carboxysome

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Mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems

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Generation of densely labeled oligonucleotides for the detection of small genomic elements

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  DOI: 10.1101/2024.03.15.583980
  
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Mechanism of phage sensing and abortion by toxin-antitoxin-chaperone systems

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  DOI: 10.1101/2024.02.24.581848
  
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52.53.155.43/4aa6535dd34f5fc46fb2bd54c194c220c5ed4165/2024.02.24.581848v1.full-html.html
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Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi

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  RRID: SCR_01587
  
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biorxiv.org/content/10.1101/2023.12.28.573590v1
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Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses

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Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

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  DOI: 10.1038/s41594-024-01268-9
  
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Structural basis of ligand specificity and channel activation in an insect gustatory receptor

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  DOI: 10.1016/j.celrep.2024.114035
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00363-2
Mar 2024
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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH

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sciencedirect.com/science/article/pii/S1097276524001722
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ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

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  DOI: 10.1016/j.cell.2024.02.013
  
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Combinatorial selective ER-phagy remodels the ER during neurogenesis

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  DOI: 10.1038/s41556-024-01356-4
  
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Structure of the plant plastid-encoded RNA polymerase

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  DOI: 10.1016/j.cell.2024.01.036
  
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  DOI: 10.1016/j.cell.2024.01.036
  
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Cryo-EM structures of the plant plastid-encoded RNA polymerase

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  DOI: 10.1016/j.cell.2024.01.026
  
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sciencedirect.com/science/article/pii/S0092867424000631
Feb 2024
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LeishIF4E2 is a cap-binding protein that plays a role in Leishmania cell cycle progression

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  DOI: 10.1096/fj.202301665R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202301665R
Jan 2024
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Protocol to reveal the binding partner of secreted housekeeping enzymes in Listeria monocytogenes via in silico prediction to in vivo validation

1
1. scibot 26 Jan 2024
  
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  UCSF Chimera 1.15 or ChimeraX 1.2.5RBVI, UCSFVersion 1.15/1.2.5; https://www.cgl.ucsf.edu/chimera/download.html, https://www.cgl.ucsf.edu/chimerax/download.html
  
  DOI: 10.1016/j.xpro.2024.102839
  
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Dual phosphorylation of DGK5-mediated PA burst regulates ROS in plant immunity

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  DOI: 10.1016/j.cell.2023.12.030
  
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Recruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B

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  DOI: 10.1016/j.molcel.2023.12.011
  
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sciencedirect.com/science/article/pii/S1097276523010304
Dec 2023
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Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense

1
1. scibot 16 Dec 2023
  
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  DOI: 10.1016/j.molcel.2023.11.007
  
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Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

1
1. scibot 15 Dec 2023
  
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Nov 2023
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Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

1
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The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus

1
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cell.com/cell-reports/fulltext/S2211-1247(23)01378-5
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Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa

1
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Sep 2023
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Mechanism and evolutionary origins of alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10

1
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Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle

1
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  DOI: 10.1016/j.cell.2023.08.017
  
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Aug 2023
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An unconventional TOG domain is required for CLASP localization

1
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  DOI: 10.1016/j.cub.2023.07.009
  
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52.53.155.43 52.53.155.43

Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase

2
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  DOI: 10.1016/j.celrep.2023.112972
  
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Recognition determinants of improved HIV-1 neutralization by a heavy chain matured pediatric antibody

1
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52.53.155.43/4e2892b16e328023e4cde9b31b0daa48de916ef6/PIIS2589004223016565-html.html
link.springer.com link.springer.com

Acetylation of p53 in the Cerebral Cortex after Photothrombotic Stroke

1
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  DOI: 10.1007/s12975-023-01183-z
  
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EMBO Reports - 2023 - Jiang-html.html

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  DOI: 10.15252/embr.202356864
  
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52.53.155.43/72eed5338814ac6922d23d3395f365b4e68799b2/EMBO Reports - 2023 - Jiang-html.html
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Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels

2
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  DOI: 10.1016/j.celrep.2023.112926
  
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52.53.155.43/13d2314e1a08e5e99d70c8b4a30c497d5ddefb63/PIIS2211124723009373-html.html
Jul 2023
www.sciencedirect.com www.sciencedirect.com

Mechanism of orphan subunit recognition during assembly quality control

1
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  DOI: 10.1016/j.cell.2023.06.016
  
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Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

1
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  DOI: 10.7554/eLife.86029
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10338036/
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Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange

1
1. scibot 12 Jul 2023
  
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  DOI: 10.7554/eLife.87178
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10328499/
Jun 2023
www.embopress.org www.embopress.org

PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems

1
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  DOI: 10.15252/embr.202256399
  
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A structural blueprint for interleukin-21 signal modulation

1
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  DOI: 10.1016/j.celrep.2023.112657
  
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Post-injury hydraulic fracturing drives fissure formation in the zebrafish basal epidermal cell layer

1
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  DOI: 10.1016/j.cub.2023.05.021
  
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sciencedirect.com/science/article/pii/S0960982223006164
May 2023
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Unanticipated broad phylogeny of BEN DNA-binding domains revealed by structural homology searches

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  DOI: 10.1016/j.cub.2023.05.011
  
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52.53.155.43 52.53.155.43

Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange

1
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  RRID:S CR_01 5872
  
  DOI: 10.1101/2023.03.06.531323
  
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52.53.155.43/6d6e42f4ace892f9f8318210e37bdd24819e1a2c/2023.03.06.531323v2.full-html.html
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Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

1
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  DOI: 10.1016/j.str.2023.04.010
  
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ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines

1
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  DOI: 10.1016/j.cell.2023.04.024
  
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Apr 2023
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Assessing structure and disorder prediction tools for de novo emerged proteins in the age of machine learning

1
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  DOI: 10.12688/f1000research.130443.1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10126731/
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Structural and functional properties of a plant NRAMP-related aluminum transporter

1
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  DOI: 10.7554/eLife.85641
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10115441/
Mar 2023
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Immunodominant surface epitopes power immune evasion in the African trypanosome

1
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  DOI: 10.1016/j.celrep.2023.112262
  
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Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster

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ncbi.nlm.nih.gov/pmc/articles/PMC9977279/
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Nitrogenase resurrection and the evolution of a singular enzymatic mechanism

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  DOI: 10.7554/eLife.85003
  
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elifesciences.org/articles/85003
Feb 2023
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Mechanism of Ca2+ transport by ferroportin

1
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ncbi.nlm.nih.gov/pmc/articles/PMC9883014/
Jan 2023
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Nucleosome dyad determines the H1 C-terminus collapse on distinct DNA arms

1
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  DOI: 10.1016/j.str.2022.12.005
  
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Dec 2022
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Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding

1
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  DOI: 10.1016/j.str.2022.11.008
  
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Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules

1
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  DOI: 10.1038/s41594-022-00863-y
  
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nature.com/articles/s41594-022-00863-y
Nov 2022
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Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes

1
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  DOI: 10.1016/j.cell.2022.10.030
  
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cell.com/cell/fulltext/S0092-8674(22)01376-9
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Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

1
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  DOI: 10.1016/j.immuni.2022.10.019
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9606073/
Oct 2022
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A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

1
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  DOI: 10.7554/eLife.79771
  
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In situ structural analysis reveals membrane shape transitions during autophagosome formation

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  DOI: 10.1073/pnas.2209823119
  
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Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

1
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Aug 2022
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Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC

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SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns

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  DOI: 10.1016/j.chom.2022.07.002
  
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In situ architecture of the lipid transport protein VPS13C at ER–lysosome membrane contacts

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The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex

1
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Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex

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  DOI: 10.1016/j.cell.2022.04.016
  
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Apr 2022
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RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex

1
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  DOI: 10.1016/j.celrep.2022.110732
  
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Mar 2022
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Facile discovery of surrogate cytokine agonists

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  DOI: 10.1016/j.cell.2022.02.025
  
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Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB

1
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Structure and ion-release mechanism of PIB-4-type ATPases

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Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance

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  DOI: 10.1016/j.molcel.2022.01.028
  
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Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel

1
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Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae

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Naegleria’s mitotic spindles are built from unique tubulins and highlight core spindle features

2
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  DOI: 10.1016/j.cub.2022.01.034
  
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Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats

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  DOI: 10.7554/eLife.72908
  
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Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family

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  DOI: 10.7554/eLife.74589
  
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Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes

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  DOI: 10.7554/eLife.72629
  
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Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

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  DOI: 10.7554/eLife.74512
  
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Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

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  DOI: 10.1186/s12915-021-01220-z
  
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Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

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  DOI: 10.1016/j.celrep.2021.110210
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8673750/
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Structural characterization of NrnC identifies unifying features of dinucleotidases

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TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

1
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ncbi.nlm.nih.gov/pmc/articles/PMC8480983/
Sep 2021
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Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

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  DOI: 10.7554/eLife.71420
  
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Regulation of human mTOR complexes by DEPTOR

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ncbi.nlm.nih.gov/pmc/articles/PMC8439649/
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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

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Clathrin packets move in slow axonal transport and deliver functional payloads to synapses

1
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  DOI: 10.1016/j.neuron.2021.08.016
  
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Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes

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  DOI: 10.1016/j.str.2021.08.002
  
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High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor

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  DOI: 10.1016/j.str.2021.08.001
  
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Aug 2021
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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

1
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Structure and analysis of nanobody binding to the human ASIC1a ion channel

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  DOI: 10.7554/eLife.67115
  
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Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

1
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Jun 2021
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RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis

1
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  DOI: 10.1016/j.molcel.2021.06.005
  
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May 2021
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Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP

1
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  DOI: 10.1016/j.molcel.2020.11.002
  
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Apr 2021
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Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex

1
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  DOI: 10.1016/j.str.2021.04.003
  
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The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design

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  DOI: 10.1016/j.immuni.2021.03.008
  
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sciencedirect.com/science/article/pii/S1074761321001205
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Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

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1. scibot 06 Apr 2021
  
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  DOI: 10.7554/eLife.66097
  
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elifesciences.org/articles/66097
Feb 2021
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A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

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1. scibot 25 Feb 2021
  
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  DOI: 10.7554/eLife.52158
  
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elifesciences.org/articles/52158
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Mimicry of Canonical Translation Elongation Underlies Alanine Tail Synthesis in RQC

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1. scibot 01 Feb 2021
  
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  DOI: 10.1016/j.molcel.2020.11.001
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30779-6
Jan 2021
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Atomic structures of respiratory complex III 2, complex IV, and supercomplex III 2-IV from vascular plants

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1. scibot 23 Jan 2021
  
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  DOI: 10.7554/eLife.62047
  
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elifesciences.org/articles/62047
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Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

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1. scibot 08 Jan 2021
  
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  DOI: 10.7554/eLife.62611
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7785296/
Dec 2020
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Structure of the human core transcription-export complex reveals a hub for multivalent interactions

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  DOI: 10.7554/eLife.61503
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7744094/
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The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism

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1. scibot 13 Dec 2020
  
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  DOI: 10.1016/j.celrep.2020.108476
  
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sciencedirect.com/science/article/pii/S2211124720314650
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The structures of secretory and dimeric immunoglobulin A

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  DOI: 10.7554/eLife.56098
  
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elifesciences.org/articles/56098
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Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11

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  DOI: 10.7554/eLife.59018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7704109/
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A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide

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1. scibot 07 Dec 2020
  
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  DOI: 10.1016/j.celrep.2020.108428
  
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cell.com/cell-reports/fulltext/S2211-1247(20)31417-0
Nov 2020
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Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

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  DOI: 10.7554/eLife.61496
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7652416/
Oct 2020
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Molecular mechanism for direct actin force-sensing by α-catenin

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ncbi.nlm.nih.gov/pmc/articles/PMC7588232/
Sep 2020
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HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

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1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107583
  
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Structural basis of substrate recognition by a polypeptide processing and secretion transporter

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  DOI: 10.7554/eLife.51492
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6959990/
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Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

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  DOI: 10.7554/eLife.56185
  
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elifesciences.org/articles/56185
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Molecular principles of assembly, activation, and inhibition in epithelial sodium channel

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  DOI: 10.7554/eLife.59038
  
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elifesciences.org/articles/59038
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The architecture of EMC reveals a path for membrane protein insertion

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  DOI: 10.7554/eLife.57887
  
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elifesciences.org/articles/57887
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Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

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  DOI: 10.7554/eLife.52774
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7112951/

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