Hypothesis

76 Matching Annotations

Oct 2025
www.biorxiv.org www.biorxiv.org

Epithelial-Mesenchymal Transition is Associated with Altered Immune Composition and Cytotoxic Function in Triple-Negative Breast Cancer

1
1. scibot 28 Oct 2025
  
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  RRID:SCR_015963
  
  DOI: 10.1101/2025.10.22.683714
  
  Resource: Zeiss LSM 800 with Airyscan Microscope (RRID:SCR_015963)
  
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biorxiv.org/content/10.1101/2025.10.22.683714v1
Jun 2025
dx.doi.org dx.doi.org

Combined PTEN knockdown and local insulin in chronic experimental diabetic neuropathy

1
1. scibot 26 Jun 2025
  
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  DOI: 10.2337/db22-0743
  
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dx.doi.org/10.2337/db22-0743
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A Novel Phosphorylated Tau Conformer Implicated in the Tauopathy Pathogenesis of Human Neurons

1
1. scibot 21 May 2025
  
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  SCR_015963
  
  DOI: 10.3390/biom15040585
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12025006/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Loss of fatty acid-binding protein 7 promotes B16F10 melanoma metastasis

1
1. scibot 02 Apr 2025
  
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  DOI: 10.1038/s41598-024-80874-5
  
  Resource: Zeiss LSM 800 with Airyscan Microscope (RRID:SCR_015963)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11947267/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival

1
1. scibot 27 Feb 2025
  
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  DOI: 10.1038/s44319-024-00361-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11850729/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The pro-apoptotic function of the C. elegans BCL-2 homolog CED-9 requires interaction with the APAF-1 homolog CED-4

2
1. scibot 15 Feb 2025
  
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  DOI: 10.1126/sciadv.adn0325
  
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2. scibot 15 Feb 2025
  
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  RRID:SCR_015963
  
  DOI: 10.1126/sciadv.adn0325
  
  Resource: Zeiss LSM 800 with Airyscan Microscope (RRID:SCR_015963)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11817491/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

DCAF13-mediated K63-linked ubiquitination of RNA polymerase I promotes uncontrolled proliferation in Breast Cancer

7
1. scibot 07 Feb 2025
  
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  RRID:SCR_015963
  
  DOI: 10.1038/s41467-025-55851-9
  
  Resource: Zeiss LSM 800 with Airyscan Microscope (RRID:SCR_015963)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_015963
  
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2. scibot 06 Feb 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
3. scibot 05 Feb 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
4. scibot 04 Feb 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
5. scibot 03 Feb 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
6. scibot 02 Feb 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
7. scibot 01 Feb 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11718263/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

DCAF13-mediated K63-linked ubiquitination of RNA polymerase I promotes uncontrolled proliferation in Breast Cancer

17
1. scibot 31 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
2. scibot 30 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
3. scibot 29 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
4. scibot 28 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
5. scibot 27 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
6. scibot 26 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
7. scibot 25 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
8. scibot 24 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
9. scibot 23 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
10. scibot 22 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
11. scibot 21 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
12. scibot 20 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
13. scibot 19 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
14. scibot 18 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
15. scibot 17 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
16. scibot 16 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_015963
17. scibot 15 Jan 2025
  
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  RRID:SCR_015963
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11718263/
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Skin disease-associated GJB4 variants differentially influence connexin stability, cell viability and channel function

1
1. scibot 17 Jan 2025
  
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  RRID:SCR_015963
  
  DOI: 10.1113/JP286367
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP286367
www.sciencedirect.com www.sciencedirect.com

Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation

1
1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115155
  
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sciencedirect.com/science/article/pii/S2211124724015067
Dec 2024
rupress.org rupress.org

KPNA3 regulates histone locus body formation by modulating condensation and nuclear import of NPAT

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1. scibot 05 Dec 2024
  
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  DOI: 10.1083/jcb.202401036
  
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rupress.org/jcb/article/224/1/e202401036/277130/KPNA3-regulates-histone-locus-body-formation-by
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Prevention of prostate cancer metastasis by a CRISPR-delivering nanoplatform for interleukin-30 genome editing

1
1. scibot 21 Nov 2024
  
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  DOI: 10.1016/j.ymthe.2024.09.011
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11573607/
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling

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1. scibot 26 Jul 2024
  
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  DOI: 10.1016/j.celrep.2023.112117
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9989824/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Insulin and Leptin/Upd2 Exert Opposing Influences on Synapse Number in Fat-Sensing Neurons

1
1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.cmet.2020.08.017
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7642105/
52.53.155.43 52.53.155.43

Kv2 channels do not function as canonical delayed rectifiers in spinal motoneurons

1
1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110444
  
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52.53.155.43/57b93724ed58bb99655ecac3374a37ea7bdc3d90/1-s2.0-S2589004224016699-main-html.html
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Chronic Treatment with Serotonin Selective Reuptake Inhibitors Does Not Affect Regrowth of Serotonin Axons Following Amphetamine Injury in the Mouse Forebrain

1
1. scibot 18 Feb 2024
  
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  DOI: 10.1523/ENEURO.0444-22.2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10867722/
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Anti-TLR4 biological response to titanium nitride-coated dental implants: anti-inflammatory response and extracellular matrix synthesis

2
1. scibot 21 Dec 2023
  
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  RRID:SCR_015963
  
  DOI: 10.3389/fbioe.2023.1266799
  
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2. scibot 21 Dec 2023
  
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  RRID:SCR_015963
  
  DOI: 10.3389/fbioe.2023.1266799
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10728300/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Interleukin-30 subverts prostate cancer-endothelium crosstalk by fostering angiogenesis and activating immunoregulatory and oncogenic signaling pathways

1
1. scibot 15 Dec 2023
  
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  RRID:SCR_015963
  
  DOI: 10.1186/s13046-023-02902-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10714661/
Aug 2023
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Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease

1
1. scibot 23 Aug 2023
  
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  RRID:SCR_015963
  
  DOI: 10.1016/j.cmet.2023.07.014
  
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sciencedirect.com/science/article/pii/S1550413123002735
Jul 2023
www.jneurosci.org www.jneurosci.org

A visual pathway into central complex for high frequency motion-defined bars in Drosophila

1
1. scibot 06 Jul 2023
  
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  RRID:SCR_015963
  
  DOI: 10.1523/JNEUROSCI.0128-23.2023
  
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jneurosci.org/content/43/26/4821
Mar 2023
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LncRNA INPP5F ameliorates stress-induced hypertension via the miR-335/Cttn axis in rostral ventrolateral medulla

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  DOI: 10.1111/cns.14142
  
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onlinelibrary.wiley.com/doi/10.1111/cns.14142
Feb 2023
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Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling

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  DOI: 10.1016/j.celrep.2023.112117
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9989824/
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PINK1-mediated mitophagy promotes oxidative phosphorylation and redox homeostasis to induce drug-tolerant persister cancer cells

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  DOI: 10.1158/0008-5472.CAN-22-2370
  
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  DOI: 10.1158/0008-5472.CAN-22-2370
  
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aacrjournals.org/cancerres/article/83/3/398/716188/PINK1-Mediated-Mitophagy-Promotes-Oxidative
Nov 2022
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Reelin regulates the migration of late-born hippocampal CA1 neurons via cofilin phosphorylation

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Long-Term Changes in Axon Calibers after Injury: Observations on the Mouse Corticospinal Tract

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  DOI: 10.3390/ijms23137391
  
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Group 3 innate lymphocytes make a distinct contribution to Type 17 immunity in bladder defence

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  DOI: 10.1016/j.isci.2022.104660
  
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sciencedirect.com/science/article/pii/S2589004222009324
Jun 2022
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Dual antibody strategy for high-resolution imaging of murine Purkinje cells and their dendrites across multiple layers

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  DOI: 10.1016/j.xpro.2022.101427
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9189630/
Apr 2022
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Rapid fluorescent vital imaging of olfactory epithelium

2
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  DOI: 10.1016/j.isci.2022.104222
  
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  DOI: 10.1016/j.isci.2022.104222
  
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Feb 2022
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The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in Caenorhabditis elegans

2
1. scibot 11 Feb 2022
  
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  RRID:SCR_015963
  
  DOI: 10.7554/eLife.74557
  
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  DOI: 10.7554/eLife.74557
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8816384/
Nov 2021
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Heterogeneity in form and function of the rat extensor digitorum longus motor unit

1
1. scibot 13 Nov 2021
  
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  DOI: 10.1111/joa.13590
  
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onlinelibrary.wiley.com/doi/10.1111/joa.13590
Aug 2021
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Untitled document

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  DOI: 10.1111/jnc.14629
  
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Untitled document

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  DOI: 10.7554/eLife.38771
  
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europepmc.org/articles/PMC6037479/
May 2021
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C-bouton components on rat extensor digitorum longus motoneurons are resistant to chronic functional overload

1
1. scibot 20 May 2021
  
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  DOI: 10.1111/joa.13439
  
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onlinelibrary.wiley.com/doi/10.1111/joa.13439
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Loss of Ambra1 promotes melanoma growth and invasion

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1. scibot 12 May 2021
  
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  RRID:SCR_015963
  
  DOI: 10.1038/s41467-021-22772-2
  
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nature.com/articles/s41467-021-22772-2
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G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD

1
1. scibot 08 May 2021
  
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  DOI: 10.1016/j.neuron.2020.06.027
  
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sciencedirect.com/science/article/pii/S0896627320304815
Apr 2021
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Insulin and Leptin/Upd2 Exert Opposing Influences on Synapse Number in Fat-Sensing Neurons

1
1. scibot 29 Apr 2021
  
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  RRID:SCR_015963
  
  DOI: 10.1016/j.cmet.2020.08.017
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7642105/
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Pathogenic GRM7 mutations associated with neurodevelopmental disorders impair axon outgrowth and presynaptic terminal development

1
1. scibot 08 Apr 2021
  
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  RRID:SCR_015963
  
  DOI: 10.1523/JNEUROSCI.2108-20.2021
  
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jneurosci.org/content/41/11/2344
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Neddylation is required for presynaptic clustering of mGlu7 and maturation of presynaptic terminals

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1. scibot 01 Apr 2021
  
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  DOI: 10.1038/s12276-021-00585-z
  
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nature.com/articles/s12276-021-00585-z
Mar 2021
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α‐Synuclein Abnormalities Trigger Focal Tau Pathology, Spreading to Various Brain Areas in Parkinson’s Disease

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1. scibot 04 Mar 2021
  
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  DOI: 10.1111/jnc.15257
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15257
Nov 2020
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Celecoxib-Dependent Neuroprotection in a Rat Model of Transient Middle Cerebral Artery Occlusion (tMCAO) Involves Modifications in Unfolded Protein Response (UPR) and Proteasome

1
1. scibot 13 Nov 2020
  
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  DOI: 10.1007/s12035-020-02202-y
  
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link.springer.com/article/10.1007/s12035-020-02202-y
Sep 2020
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N‐linked glycosylation of the mGlu7 receptor regulates the forward trafficking and transsynaptic interaction with Elfn1

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  DOI: 10.1096/fj.202001544R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001544R
Jan 2020
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Epileptogenesis-Associated Alterations of Heat Shock Protein 70 in a Rat Post-Status Epilepticus Model

1
1. scibot 13 Jan 2020
  
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  RRID:SCR_015963
  
  DOI: 10.1016/j.neuroscience.2019.06.031
  
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Post‐ischemic salubrinal administration reduces necroptosis in a rat model of global cerebral ischemia

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1111/jnc.14789
  
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onlinelibrary.wiley.com/doi/abs/10.1111/jnc.14789
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Profiling the expression of endoplasmic reticulum stress associated heat shock proteins in animal epilepsy models

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.neuroscience.2019.12.015
  
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sciencedirect.com/science/article/pii/S0306452219308632
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Untitled document

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  DOI: 10.1016/j.celrep.2018.12.025
  
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sciencedirect.com/science/article/pii/S2211124718319557
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Allatostatin-C/AstC-R2 Is a Novel Pathway to Modulate the Circadian Activity Pattern in Drosophila

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cub.2018.11.005
  
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sciencedirect.com/science/article/pii/S0960982218314714
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Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium

1
1. scibot 12 Jan 2020
  
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  RRID:SCR_015963
  
  DOI: 10.1016/j.devcel.2019.04.034
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6658618/
Nov 2018
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Untitled document

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1550413118306296
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Untitled document

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ncbi.nlm.nih.gov/pmc/articles/PMC6037479/

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