106 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13057016/
  3. Mar 2026
  4. www.sciencedirect.com www.sciencedirect.com
    Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes
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    sciencedirect.com/science/article/pii/S2211124726002226
  5. www.biorxiv.org www.biorxiv.org
    Synthetic Immunological Niche Reveals Early Immune Dysregulation and Stratifies Therapeutic Response in Type 1 Diabetes
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    biorxiv.org/content/10.64898/2026.03.06.710219v1
  6. www.nature.com www.nature.com
    Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes
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    nature.com/articles/s41591-026-04213-z
  7. Feb 2026
  8. www.nature.com www.nature.com
    Zinc accumulation-induced integrated stress response triggers β-cell identity loss
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    nature.com/articles/s41422-026-01222-y
  9. Jan 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A web tool for easy and versatile analysis of human endocrine pancreas single‐cell RNAseq data
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    pmc.ncbi.nlm.nih.gov/articles/PMC12803539/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Elucidating the Epigenetic Landscape of Type 2 Diabetes Mellitus: A Multi-Omics Analysis Revealing Novel CpG Sites and Their Association with Cardiometabolic Traits
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    pmc.ncbi.nlm.nih.gov/articles/PMC12813400/
  12. Dec 2025
  13. www.biorxiv.org www.biorxiv.org
    Regulatory element modules as universal features for single-cell chromatin analysis
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    biorxiv.org/content/10.64898/2025.12.10.692786v1
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    Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets
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    nature.com/articles/s41467-025-66459-4
  15. Nov 2025
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12646676/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Recessive TMEM167A variants cause neonatal diabetes, microcephaly, and epilepsy syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12618065/
  18. www.science.org www.science.org
    An islet-resident macrophage antioxidant program preserves β cell physiology
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    science.org/doi/10.1126/sciimmunol.adz5181
  19. link.springer.com link.springer.com
    Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells
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    link.springer.com/article/10.1007/s00125-025-06603-3
  20. Oct 2025
  21. www.biorxiv.org www.biorxiv.org
    Supervised machine learning identifies impaired mitochondrial quality control in β cells with development of type 2 diabetes
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    biorxiv.org/content/10.1101/2025.10.22.683335v1
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12500894/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene
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    pmc.ncbi.nlm.nih.gov/articles/PMC12504421/
  24. Sep 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12422192/
  26. www.science.org www.science.org
    Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression
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    science.org/doi/10.1126/sciadv.ady0080
  27. Aug 2025
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Diet-induced obesity promotes endothelial cell desensitization to VEGF-A and permanent islet vessel dysfunction in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12321391/
  29. Jul 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional and Mechanistic Explanation for the Unique Clinical Success of the Glucokinase Activator Dorzagliatin in the Treatment of Type 2 Diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12278794/
  31. www.sciencedirect.com www.sciencedirect.com
    The antigen presentation landscape of cytokine-stressed human pancreatic islets
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    sciencedirect.com/science/article/pii/S2211124725006989
  32. www.frontiersin.org www.frontiersin.org
    Frontiers | Gut-tropic α4β7+CD8+ T cells contribute to pancreatic β cell destruction in type 1 diabetes
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    frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1623428/full
  33. www.biorxiv.org www.biorxiv.org
    Epigenetic adaptation of beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes
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    biorxiv.org/content/10.1101/2025.07.02.662814v1
  34. diabetesjournals.org diabetesjournals.org
    Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
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    diabetesjournals.org/diabetes/article/72/4/433/148248/Integrated-Physiology-of-the-Exocrine-and
  35. Jun 2025
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12139852/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry
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    pmc.ncbi.nlm.nih.gov/articles/PMC8609965/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion
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    pmc.ncbi.nlm.nih.gov/articles/PMC12176968/
  39. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/ed006b4f5b91662bd0768819dd770495cdaa5e2c/PDF-html.html
  40. link.springer.com link.springer.com
    T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes
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    link.springer.com/article/10.1007/s00125-025-06458-8
  41. May 2025
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
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    pmc.ncbi.nlm.nih.gov/articles/PMC12086209/
  43. Apr 2025
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11981631/
  45. 52.53.155.43 52.53.155.43
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  46. Mar 2025
  47. link.springer.com link.springer.com
    Regulating islet stress responses through CD47 activation
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    link.springer.com/article/10.1007/s00125-025-06409-3
  48. 52.53.155.43 52.53.155.43
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  49. www.sciencedirect.com www.sciencedirect.com
    Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay
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    sciencedirect.com/science/article/pii/S0092867425002065
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFN-α Induces Heterogenous ROS Production in Human β-Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870469/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870426/
  52. Feb 2025
  53. www.biorxiv.org www.biorxiv.org
    Linking molecular pathways and islet cell dysfunction in human type 1 diabetes
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    biorxiv.org/content/10.1101/2025.02.20.639325v1
  54. dx.doi.org dx.doi.org
    No evidence for persistent enteroviral B infection of pancreatic islets in type 1 diabetic and pre-diabetic patients from RNA-Seq data
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    dx.doi.org/10.2337/db24-0076
  55. dx.doi.org dx.doi.org
    Elevated cathepsin S serum levels in new-onset type 1 diabetes and autoantibody-positive siblings
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    dx.doi.org/10.2337/db23-0911
  56. dx.doi.org dx.doi.org
    RFX6 maintains gene expression and function of adult human islet α cells
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    dx.doi.org/10.2337/db23-0483
  57. dx.doi.org dx.doi.org
    Comprehensive characterization of islet remodeling in development and in diabetes using mass cytometry
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    dx.doi.org/10.1210/endocr/bqae094
  58. Jan 2025
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TMEM55A-mediated PI5P signaling regulates α-cell actin depolymerization and glucagon secretion
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    pmc.ncbi.nlm.nih.gov/articles/PMC11702586/
  60. Dec 2024
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11649919/
  62. www.biorxiv.org www.biorxiv.org
    Molecular Correlates of Glycine Receptor Activity in Human β Cells
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    biorxiv.org/content/10.1101/2024.12.02.626463v1
  63. Sep 2024
  64. link.springer.com link.springer.com
    Pancreatic δ Cells: An Overlooked Cell in Focus
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    link.springer.com/chapter/10.1007/978-3-031-62232-8_6
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11420665/
  66. Jul 2024
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of unique cell type responses in pancreatic islets to stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC11220140/
  68. www.biorxiv.org www.biorxiv.org
    HumanIslets: An integrated platform for human islet data access and analysis
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    biorxiv.org/content/10.1101/2024.06.19.599613v1
  69. Jun 2024
  70. www.biorxiv.org www.biorxiv.org
    Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
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    biorxiv.org/content/10.1101/2024.04.23.590798v1
  71. May 2024
  72. www.medrxiv.org www.medrxiv.org
    Elucidating the Epigenetic Landscape of Type 2 Diabetes: A Multi-Omics Analysis Revealing Novel CpG Sites and Their Association with Cardiometabolic Traits
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    medrxiv.org/content/10.1101/2024.05.20.24307650v1
  73. www.biorxiv.org www.biorxiv.org
    Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis
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    biorxiv.org/content/10.1101/2024.03.18.585508v1
  74. www.nature.com www.nature.com
    AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics
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    nature.com/articles/s41467-024-47334-0
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NKX2-2 based nuclei sorting on frozen human archival pancreas enables the enrichment of islet endocrine populations for single-nucleus RNA sequencing
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    ncbi.nlm.nih.gov/pmc/articles/PMC11059690/
  76. Apr 2024
  77. www.sciencedirect.com www.sciencedirect.com
    Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets
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    sciencedirect.com/science/article/pii/S2666379124002040
  78. Mar 2024
  79. dx.doi.org dx.doi.org
    DNA methylation-based assessment of cell composition in human pancreas and islets
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    dx.doi.org/10.2337/db23-0704
  80. www.mdpi.com www.mdpi.com
    Exploring Transcriptional Regulation of Beta Cell SASP by Brd4-Associated Proteins and Cell Cycle Control Protein p21
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    mdpi.com/2075-4655/8/1/10
  81. Dec 2023
  82. www.sciencedirect.com www.sciencedirect.com
    Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes
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    sciencedirect.com/science/article/pii/S1550413123004436
  83. www.nature.com www.nature.com
    Genetic risk converges on regulatory networks mediating early type 2 diabetes
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    nature.com/articles/s41586-023-06693-2
  84. Oct 2023
  85. link.springer.com link.springer.com
    Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data
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    link.springer.com/article/10.1186/s13059-023-03073-x
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An Integrated Map of Cell Type–Specific Gene Expression in Pancreatic Islets
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    ncbi.nlm.nih.gov/pmc/articles/PMC10588282/
  87. Aug 2023
  88. 52.53.155.43 52.53.155.43
    Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress
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    52.53.155.43/3332fca9f9f5417145aee8b440787cc2ea4e4363/sciadv.abo3932-html.html
  89. joe.bioscientifica.com joe.bioscientifica.com
    The human α cell in health and disease
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    joe.bioscientifica.com/view/journals/joe/258/1/JOE-22-0298.xml
  90. www.sciencedirect.com www.sciencedirect.com
    Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes
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    sciencedirect.com/science/article/pii/S2211124723009245
  91. Jul 2023
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
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    ncbi.nlm.nih.gov/pmc/articles/PMC10328394/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inferring regulators of cell identity in the human adult pancreas
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    ncbi.nlm.nih.gov/pmc/articles/PMC10331937/
  94. May 2023
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits
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    ncbi.nlm.nih.gov/pmc/articles/PMC9366645/
  96. Apr 2023
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Peeling the onion: another layer in the regulation of insulin secretion
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    ncbi.nlm.nih.gov/pmc/articles/PMC10104890/
  98. Mar 2023
  99. www.nature.com www.nature.com
    Multivariate indicators of disease severity in COVID-19
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    nature.com/articles/s41598-023-31683-9
  100. www.biorxiv.org www.biorxiv.org
    Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes
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    biorxiv.org/content/10.1101/2023.03.02.530808v1
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex differences in islet stress responses support female β cell resilience
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    ncbi.nlm.nih.gov/pmc/articles/PMC9971554/
  102. www.biorxiv.org www.biorxiv.org
    An integrated map of cell type-specific gene expression in pancreatic islets
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    biorxiv.org/content/10.1101/2023.02.03.526994v1
  103. Feb 2023
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics
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    ncbi.nlm.nih.gov/pmc/articles/PMC9882100/
  105. journals.physiology.org journals.physiology.org
    ajpendo.00246.2022.pdf
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    journals.physiology.org/doi/pdfdirect/10.1152/ajpendo.00246.2022
  106. journals.physiology.org journals.physiology.org
    Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss
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    journals.physiology.org/doi/epdf/10.1152/ajpendo.00246.2022
  107. Jan 2023
  108. diabetesjournals.org diabetesjournals.org
    A Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for in vivo β-Cell Imaging and Islet-Specific Therapies
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    diabetesjournals.org/diabetes/article/72/2/184/147931/Cell-Surface-Autoantibody-Targets-Zinc-Transporter
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ARID1A loss in pancreas leads to islet developmental defect and metabolic disturbance
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    ncbi.nlm.nih.gov/pmc/articles/PMC9840936/
  110. Dec 2022
  111. diabetesjournals.org diabetesjournals.org
    Dynamic Ins2 Gene Activity Defines β-cell Maturity States
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    diabetesjournals.org/diabetes/article/71/12/2612/147687/Dynamic-Ins2-Gene-Activity-Defines-Cell-Maturity
  112. Oct 2022
  113. 52.53.155.43 52.53.155.43
    Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress
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    52.53.155.43/3332fca9f9f5417145aee8b440787cc2ea4e4363/sciadv.abo3932-html.html
  114. academic.oup.com academic.oup.com
    Sex differences in the molecular programs of pancreatic cells contribute to the differential risks of type 2 diabetes
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    academic.oup.com/endo/article/163/11/bqac156/6708266
  115. www.science.org www.science.org
    Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress
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    science.org/doi/10.1126/sciadv.abo3932
  116. www.sciencedirect.com www.sciencedirect.com
    Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program
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    sciencedirect.com/science/article/pii/S155041312200403X
  117. Sep 2022
  118. www.sciencedirect.com www.sciencedirect.com
    Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways
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    sciencedirect.com/science/article/pii/S2589004222013281
  119. Aug 2022
  120. www.nature.com www.nature.com
    Every islet matters: improving the impact of human islet research
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    nature.com/articles/s42255-022-00607-8
  121. www.nature.com www.nature.com
    Adaptation to chronic ER stress enforces pancreatic β-cell plasticity
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    nature.com/articles/s41467-022-32425-7
  122. Jul 2022
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gene Expression Signatures Reveal Common Virus Infection Pathways in Target Tissues of Type 1 Diabetes, Hashimoto’s Thyroiditis, and Celiac Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC9251511/
  124. Jun 2022
  125. www.nature.com www.nature.com
    Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes
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    nature.com/articles/s42255-022-00531-x
  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody–positive individuals
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    ncbi.nlm.nih.gov/pmc/articles/PMC9151702/
  127. May 2022
  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pancreatic islet reserve in type 1 diabetes
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    ncbi.nlm.nih.gov/pmc/articles/PMC9059955/
  129. Apr 2022
  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stripenn detects architectural stripes from chromatin conformation data using computer vision
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    ncbi.nlm.nih.gov/pmc/articles/PMC8948182/
  131. Feb 2022
  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Islet Lymphocytes Maintain a Stable Regulatory Phenotype Under Homeostatic Conditions and Metabolic Stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC8821107/
  133. www.sciencedirect.com www.sciencedirect.com
    Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state
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    sciencedirect.com/science/article/pii/S1550413121006859
  134. Nov 2021
  135. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry
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    pmc.ncbi.nlm.nih.gov/articles/PMC8609965/
  136. Oct 2021
  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combinatorial transcription factor profiles predict mature and functional human islet α and β cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8492318/
  138. academic.oup.com academic.oup.com
    Human Islet: Mini-organ with Mega-impact
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    academic.oup.com/edrv/article/42/5/605/6223906
  139. Jun 2021
  140. www.nature.com www.nature.com
    Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans
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    nature.com/articles/s41598-021-90643-3
  141. Feb 2021
  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD8 T cells compensate for impaired humoral immunity in COVID-19 patients with hematologic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC7872363/
  143. Nov 2020
  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC7664344/
  145. Oct 2020
  146. www.nature.com www.nature.com
    Aberrant methylation underlies insulin gene expression in human insulinoma
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    nature.com/articles/s41467-020-18839-1
  147. Sep 2020
  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D
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    ncbi.nlm.nih.gov/pmc/articles/PMC7471622/
  149. www.nature.com www.nature.com
    Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
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    nature.com/articles/s41588-020-0637-y
  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange
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    ncbi.nlm.nih.gov/pmc/articles/PMC7170893/
  151. www.science.org www.science.org
    Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
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  152. Jan 2020
  153. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)
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    diabetes.diabetesjournals.org/content/68/7/1394