154 Matching Annotations
  1. Last 7 days
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    Dynamic allostery drives autocrine and paracrine TGF-β signaling
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    1. scibot 17 Sep 2024
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    sciencedirect.com/science/article/pii/S0092867424009656
  3. Aug 2024
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    Structural insights into the chloroplast protein import in land plants
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    sciencedirect.com/science/article/pii/S0092867424008948
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    Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae
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    Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance
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    sciencedirect.com/science/article/pii/S0092867424008420
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    Architecture of native kinetochores revealed by structural studies utilizing a thermophilic yeast
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    sciencedirect.com/science/article/pii/S0960982224009394
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    Mechanism of Ca2+ transport by ferroportin - ProQuest
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      DOI: 10.7554/eLife.82947

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    proquest.com/docview/2771288630
  9. Jul 2024
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    Structure of the Hir histone chaperone complex
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    Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11212993/
  12. Jun 2024
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    POT1 recruits and regulates CST-Polα/primase at human telomeres
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    sciencedirect.com/science/article/pii/S0092867424004938
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    Cryo-electron tomography reveals the packaging pattern of RuBisCOs in Synechococcus β-carboxysome
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    sciencedirect.com/science/article/pii/S0969212624001849
  15. Apr 2024
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    Structural basis of ligand specificity and channel activation in an insect gustatory receptor
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    ncbi.nlm.nih.gov/pmc/articles/PMC11100771/
  17. Mar 2024
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    Structural mechanisms for VMAT2 inhibition by tetrabenazine
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      DOI: 10.7554/eLife.91973

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    ncbi.nlm.nih.gov/pmc/articles/PMC10959523/
  19. Nov 2023
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    Architecture of the bacteriophage lambda tail
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    1. scibot 03 Nov 2023
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  21. Oct 2023
  22. www.nature.com www.nature.com
    A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response
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      DOI: 10.1038/s41556-023-01248-z

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  23. Aug 2023
  24. 52.53.155.43 52.53.155.43
    Recognition determinants of improved HIV-1 neutralization by a heavy chain matured pediatric antibody
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    52.53.155.43/4e2892b16e328023e4cde9b31b0daa48de916ef6/PIIS2589004223016565-html.html
  25. 52.53.155.43 52.53.155.43
    EMBO Reports - 2023 - Jiang-html.html
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      DOI: 10.15252/embr.202356864

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  26. 52.53.155.43 52.53.155.43
    Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels
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    Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ
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      DOI: 10.7554/eLife.87672

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    ncbi.nlm.nih.gov/pmc/articles/PMC10382156/
  28. Jul 2023
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    Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor
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      DOI: 10.7554/eLife.86029

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    ncbi.nlm.nih.gov/pmc/articles/PMC10338036/
  30. Jun 2023
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    Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment
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    sciencedirect.com/science/article/pii/S1097276523004203
  32. May 2023
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    Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response
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    sciencedirect.com/science/article/pii/S0969212623001338
  34. Apr 2023
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    Cryo-EM structure of the endothelin-1-ETB-Gi complex
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      DOI: 10.7554/eLife.85821

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    ncbi.nlm.nih.gov/pmc/articles/PMC10129325/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural and functional properties of a plant NRAMP-related aluminum transporter
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      DOI: 10.7554/eLife.85641

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    ncbi.nlm.nih.gov/pmc/articles/PMC10115441/
  37. Mar 2023
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines
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    ncbi.nlm.nih.gov/pmc/articles/PMC9986124/
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    Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster
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      DOI: 10.7554/eLife.84424

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    ncbi.nlm.nih.gov/pmc/articles/PMC9977279/
  40. Feb 2023
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    Structural basis of a transcription pre-initiation complex on a divergent promoter
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    sciencedirect.com/science/article/pii/S109727652300031X
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    Mechanism of Ca2+ transport by ferroportin
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      DOI: 10.7554/eLife.82947

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    ncbi.nlm.nih.gov/pmc/articles/PMC9883014/
  43. Jan 2023
  44. www.sciencedirect.com www.sciencedirect.com
    Nucleosome dyad determines the H1 C-terminus collapse on distinct DNA arms
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    sciencedirect.com/science/article/pii/S0969212622004919
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    The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions
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    sciencedirect.com/science/article/pii/S2211124722018010
  46. Dec 2022
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    Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules
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      DOI: 10.1038/s41594-022-00863-y

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    nature.com/articles/s41594-022-00863-y
  48. Oct 2022
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    A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM
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      DOI: 10.1016/j.xpro.2022.101732

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    sciencedirect.com/science/article/pii/S2666166722006128
  50. Sep 2022
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    Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice
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    sciencedirect.com/science/article/pii/S1074761322004976
  52. Aug 2022
  53. www.sciencedirect.com www.sciencedirect.com
    TITLE: Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways
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      DOI: 10.1016/j.isci.2022.104914

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    sciencedirect.com/science/article/pii/S2589004222011865
  54. Jul 2022
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Conserved structural elements specialize ATAD1 as a membrane protein extraction machine
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      DOI: 10.7554/eLife.73941

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    ncbi.nlm.nih.gov/pmc/articles/PMC9273213/
  56. Jun 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Rational exploration of fold atlas for human solute carrier proteins
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    sciencedirect.com/science/article/pii/S0969212622001897
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    Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex
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      DOI: 10.1016/j.cell.2022.04.016

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    sciencedirect.com/science/article/pii/S0092867422004639
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    Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine
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      DOI: 10.1016/j.molcel.2022.05.016

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    sciencedirect.com/science/article/pii/S109727652200483X
  60. Apr 2022
  61. www.sciencedirect.com www.sciencedirect.com
    RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex
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      DOI: 10.1016/j.celrep.2022.110732

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    sciencedirect.com/science/article/pii/S2211124722004934
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    Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy
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      DOI: 10.7554/eLife.76494

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    elifesciences.org/articles/76494
  63. Mar 2022
  64. www.sciencedirect.com www.sciencedirect.com
    Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses
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      DOI: 10.1016/j.cell.2022.02.023

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    Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel
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  69. Feb 2022
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    Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats
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  72. Jan 2022
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    Structural basis of bacteriophage lambda capsid maturation
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    Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II
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  75. Dec 2021
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    Conserved and divergent features of neuronal CaMKII holoenzyme structure, function, and high-order assembly
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  77. Nov 2021
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    Structure and assembly pattern of a freshwater short-tailed cyanophage Pam1
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  79. Oct 2021
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    Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells
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    Structural characterization of NrnC identifies unifying features of dinucleotidases
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  83. Sep 2021
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    Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome
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    Regulation of human mTOR complexes by DEPTOR
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    Negative charge in the RACK1 loop broadens the translational capacity of the human ribosome
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    Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
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    High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor
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  90. Aug 2021
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    Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection
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    Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy
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    Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation
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    Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling
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    Structure and analysis of nanobody binding to the human ASIC1a ion channel
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    Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core
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    Structures of translationally inactive mammalian ribosomes
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  99. Jul 2021
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    High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms
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    Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands
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    Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii
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    Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM
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    Self-capping of nucleoprotein filaments protects Newcastle Disease Virus genome
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    Structure of the Mechanosensitive Channel MscS Embedded in the Membrane Bilayer
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    Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor
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    Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition
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    Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody
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    Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis
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    Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched
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  112. May 2021
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    CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation
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    Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP
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    Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis
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    Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization
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  117. Apr 2021
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    Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex
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    Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor
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  120. Mar 2021
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    Structure and immune recognition of the porcine epidemic diarrhea virus spike protein
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    A pentameric protein ring with novel architecture is required for herpesviral packaging
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    Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems
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  124. Feb 2021
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    Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy
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    Mimicry of Canonical Translation Elongation Underlies Alanine Tail Synthesis in RQC
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  127. Jan 2021
  128. elifesciences.org elifesciences.org
    Atomic structures of respiratory complex III 2, complex IV, and supercomplex III 2-IV from vascular plants
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    Structure of bacterial phospholipid transporter MlaFEDB with substrate bound
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  130. Dec 2020
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    Structure of the human core transcription-export complex reveals a hub for multivalent interactions
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    The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism
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    Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
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    The structures of secretory and dimeric immunoglobulin A
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    A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide
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    Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters
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  137. Nov 2020
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    Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates
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    Structural basis of αE-catenin–F-actin catch bond behavior
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  140. Oct 2020
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    Molecular mechanism for direct actin force-sensing by α-catenin
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    A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antibody escape by polyomavirus capsid mutation facilitates neurovirulence
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  144. Sep 2020
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    An ER translocon for multi-pass membrane protein biogenesis
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    EDF1 coordinates cellular responses to ribosome collisions
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    Structural basis of substrate recognition by a polypeptide processing and secretion transporter
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    Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding
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    Mechanical inhibition of isolated Vo from V/A-ATPase for proton conductance
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    Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5
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    Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β
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    Chemical and structural investigation of the paroxetine-human serotonin transporter complex
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    Atomic structure of a mitochondrial complex I intermediate from vascular plants
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    Structure and activation mechanism of the BBSome membrane protein trafficking complex
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    Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction
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    Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175
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    Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2
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    Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism
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    Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
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    Cryo-EM structure of VASH1-SVBP bound to microtubules
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    Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1
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    Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization
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    Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction
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  165. Jan 2020
  166. elifesciences.org elifesciences.org
    Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR
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    Regulation of Eag1 gating by its intracellular domains
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  168. www.cell.com www.cell.com
    Capsid Structure of a Freshwater Cyanophage Siphoviridae Mic1
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    1. scibot 13 Jan 2020
      RRID:SCR_016274

      DOI: 10.1016/j.str.2019.07.003

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    2. scibot 13 Jan 2020
      RRID:SCR_016274

      DOI: 10.1016/j.str.2019.07.003

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    cell.com/structure/abstract/S0969-2126(19)30235-7
  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulatory switch at the cytoplasmic interface controls TRPV channel gating
    1
    1. scibot 13 Jan 2020
      RRID:SCR_016274

      DOI: 10.7554/eLife.47746

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    ncbi.nlm.nih.gov/pmc/articles/PMC6538378/
  170. www.sciencedirect.com www.sciencedirect.com
    Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies
    1
    1. scibot 13 Jan 2020
      SCR_016274

      DOI: 10.1016/j.chom.2019.04.011

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    sciencedirect.com/science/article/pii/S1931312819302148
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases
    1
    1. scibot 13 Jan 2020
      RRID:SCR_016274

      DOI: 10.7554/eLife.44071

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    ncbi.nlm.nih.gov/pmc/articles/PMC6602582/
  172. www.sciencedirect.com www.sciencedirect.com
    Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins
    1
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      SCR_016274

      DOI: 10.1016/j.chom.2019.05.004

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    sciencedirect.com/science/article/pii/S1931312819302495
  173. www.sciencedirect.com www.sciencedirect.com
    Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability
    1
    1. scibot 13 Jan 2020
      RRID:SCR_016274

      DOI: 10.1016/j.immuni.2019.10.008

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    sciencedirect.com/science/article/pii/S1074761319304522
  174. www.sciencedirect.com www.sciencedirect.com
    Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State
    1
    1. scibot 13 Jan 2020
      RRID:SCR_016274

      DOI: 10.1016/j.str.2019.10.013

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    sciencedirect.com/science/article/pii/S0969212619303545
  175. elifesciences.org elifesciences.org
    Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit
    1
    1. scibot 13 Jan 2020
      RRID:SCR_016274

      DOI: 10.7554/eLife.46041

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    elifesciences.org/articles/46041
  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes
    1
    1. scibot 13 Jan 2020
      RRID:SCR_016274

      DOI: 10.7554/eLife.45779

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    ncbi.nlm.nih.gov/pmc/articles/PMC6544438/
  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:SCR_016274

      DOI: 10.7554/eLife.43584

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    ncbi.nlm.nih.gov/pmc/articles/PMC6375701/
  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:SCR_016274

      DOI: 10.7554/eLife.44248

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    ncbi.nlm.nih.gov/pmc/articles/PMC6519985/
  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms
    1
    1. scibot 13 Jan 2020
      RRID:SCR_016274

      DOI: 10.7554/eLife.43075

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    ncbi.nlm.nih.gov/pmc/articles/PMC6365055/
  180. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:SCR_016274

      DOI: 10.1016/j.molcel.2018.10.014

      Resource: RELION (RRID:SCR_016274)

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276518308463
  181. www.sciencedirect.com www.sciencedirect.com
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    1. scibot 12 Jan 2020
      RRID:SCR_016274

      DOI: 10.1016/j.chom.2019.03.002

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    sciencedirect.com/science/article/pii/S1931312819301143
  182. Nov 2018
  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure of the human epithelial sodium channel by cryo-electron microscopy
    1
    1. scibot 05 Nov 2018
      RRID:SCR_016274

      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC6197857/
  184. www.sciencedirect.com www.sciencedirect.com
    Human SEIPIN Binds Anionic Phospholipids
    1
    1. scibot 05 Nov 2018
      RELION

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1534580718307391
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 05 Nov 2018
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    ncbi.nlm.nih.gov/pmc/articles/PMC6168287/
  186. www.sciencedirect.com www.sciencedirect.com
    Human β-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability
    1
    1. scibot 05 Nov 2018
      Relion

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1534580718306841
  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
    1
    1. scibot 05 Nov 2018
      RRID:SCR_016274

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    ncbi.nlm.nih.gov/pmc/articles/PMC6133545/
  188. www.sciencedirect.com www.sciencedirect.com
    TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
    1
    1. scibot 05 Nov 2018
      Relion

      Curator: @Jmenke

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      (RELION, RRID:SCR_016274)

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    sciencedirect.com/science/article/pii/S0896627318306317
  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 05 Nov 2018
      RRID:SCR_016274

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    ncbi.nlm.nih.gov/pmc/articles/PMC6086659/
  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 05 Nov 2018
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    ncbi.nlm.nih.gov/pmc/articles/PMC6092121/
  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 05 Nov 2018
      RRID:SCR_016274

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    ncbi.nlm.nih.gov/pmc/articles/PMC6086657/
  192. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 05 Nov 2018
      RRID:SCR_016274

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    sciencedirect.com/science/article/pii/S0969212618302429
  193. elifesciences.org elifesciences.org
    Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION
    1
    1. scibot 05 Nov 2018
      RRID:SCR_016274

      Curator: @evieth

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    elifesciences.org/articles/36861
  194. elifesciences.org elifesciences.org
    Multivalency regulates activity in an intrinsically disordered transcription factor
    1
    1. scibot 05 Nov 2018
      RELION

      Curator: @evieth

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    elifesciences.org/articles/36258