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    Intraperitoneal activation of myeloid cells clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer
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  3. Jun 2024
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    A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11178360/
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    Uncovering strain- and age-dependent innate immune responses to SARS-CoV-2 infection in air-liquid-interface cultured nasal epithelia
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    Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule
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    sciencedirect.com/science/article/pii/S1550413124001773
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    SIMS: A deep-learning label transfer tool for single-cell RNA sequencing analysis
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    sciencedirect.com/science/article/pii/S2666979X24001654
  8. May 2024
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    An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination
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    sciencedirect.com/science/article/pii/S1074761324002589
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    Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
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    Mapping the tumor stress network reveals dynamic shifts in the stromal oxidative stress response
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    sciencedirect.com/science/article/pii/S2211124724005643
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    Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity
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    sciencedirect.com/science/article/pii/S2211124724005783
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    PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma
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    Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanoma
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    Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells
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    Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
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    A phosphate transporter in VIPergic neurons of the suprachiasmatic nucleus gates locomotor activity during the light/dark transition in mice
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    Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers
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    Genome sequence analyses identify novel risk loci for multiple system atrophy
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    Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease
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    Psilocybin Promotes Cell-Type-Specific Changes in the Orbitofrontal Cortex Revealed by Single-Nucleus RNA-seq
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    Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3′ UTR of FAIM2
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    cell.com/cell-genomics/fulltext/S2666-979X(24)00122-8
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    Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome
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  24. Apr 2024
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    Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses
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    Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
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    Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization
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  28. aacrjournals.org aacrjournals.org
    Single-cell transcriptomics reveals pre-existing COVID-19 vulnerability factors in lung cancer patients
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    aacrjournals.org/mcr/article/22/3/240/734706/Single-Cell-Transcriptomics-Reveals-Pre-existing
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    Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators
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    Generation of human cerebral organoids with a structured outer subventricular zone
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    Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells
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    Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti–PD-1 Therapy
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      DOI: 10.1158/2326-6066.CIR-23-0486

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    Telomere dysfunction alters intestinal stem cell dynamics to promote cancer
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  34. Mar 2024
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    Topographical and cell type-specific connectivity of rostral and caudal forelimb corticospinal neuron populations
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    Spatial patterning controls neuron numbers in the Drosophila visual system
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deciphering the spatiotemporal transcriptional and chromatin accessibility of human retinal organoid development at the single-cell level
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    Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content
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      DOI: 10.1111/ejn.16307

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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias
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    Transgenic tools targeting the basal ganglia reveal both evolutionary conservation and specialization of neural circuits in zebrafish
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    sciencedirect.com/science/article/pii/S2211124724002444
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    The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling
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  42. Feb 2024
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    Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer’s disease profile and possible mechanisms of disease protection
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes
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  45. www.embopress.org www.embopress.org
    Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer’s and related dementias
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    A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancer
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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comparative transcriptomic analysis of bovine mesenchymal stromal cells reveals tissue-source and species-specific differences
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    Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice
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    Microglia maintain structural integrity during fetal brain morphogenesis
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    PD-1 blockade induces reactivation of non-productive T cell responses characterized by NF-kB signaling in patients with pancreatic cancer
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  51. Jan 2024
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    Dietary folate and cofactors accelerate age-dependent p16 epimutation to promote intestinal tumorigenesis
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    Establishing a 3D culture system for early organogenesis of monkey embryos ex vivo and single-cell transcriptome analysis of cultured embryos
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    PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiation and Function
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    Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation
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    A clinical trial of therapeutic vaccination in lymphoma with serial tumor sampling and single cell analysis
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  57. www.nature.com www.nature.com
    A new genomic framework to categorize pediatric acute myeloid leukemia
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    Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins
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    Intercellular crosstalk shapes purinergic metabolism and signaling in cancer cells
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    β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer
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    Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development
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  62. Dec 2023
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    Molecular organization of neuronal cell types and neuromodulatory systems in the zebrafish telencephalon
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    HAMSAB diet ameliorates dysfunctional signaling in pancreatic islets in autoimmune diabetes
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    Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection.
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    mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection
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    AA2P-mediated DNA demethylation synergizes with stem cell agonists to promote expansion of hematopoietic stem cells
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    Multipotent progenitors instruct ontogeny of the superior colliculus
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    Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma
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  70. www.nature.com www.nature.com
    Profiling human brain vascular cells using single-cell transcriptomics and organoids
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deciphering the distinct transcriptomic and gene regulatory map in adult macaque basal ganglia cells
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      DOI: 10.1093/gigascience/giad095

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  72. www.science.org www.science.org
    A single-cell multi-omic atlas spanning the adult rhesus macaque brain
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      DOI: 10.1126/sciadv.adh1914

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  73. 52.53.155.43 52.53.155.43
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  74. 52.53.155.43 52.53.155.43
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  75. Nov 2023
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals
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      DOI: 10.7554/eLife.91406

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    Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve
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    Hypoxia-sensitive cells trigger NK cell activation via the KLF4-ASH1L-ICAM-1 axis, contributing to impairment in the rat epididymis
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer-prone Phenotypes and Gene Expression Heterogeneity at Single-cell Resolution in Cigarette-smoking Lungs
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  80. www.biorxiv.org www.biorxiv.org
    Age-induced midbrain-striatum assembloids model early phenotypes of Parkinson’s disease
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    Integrative multi-omic profiling of adult mouse brain endothelial cells and potential implications in Alzheimer’s disease
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    Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
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    Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids
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  84. Oct 2023
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    Alpha-1 adrenergic signaling drives cardiac regeneration via extracellular matrix remodeling transcriptional program in zebrafish macrophages
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell transcriptomics illuminates regulatory steps driving anterior-posterior patterning of Drosophila embryonic mesoderm
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    Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development
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    Unedited allogeneic iNKT cells show extended persistence in MHC-mismatched canine recipients
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A single-cell multi-omic atlas spanning the adult rhesus macaque brain
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    BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer’s disease and related dementias
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    Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19
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    A prognostic matrix code defines functional glioblastoma phenotypes and niches
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    Single-cell transcriptome profiling reveals immune and stromal cell heterogeneity in primary Sjögren’s syndrome
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  96. Sep 2023
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    Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology
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    Highly multiplexed spatial analysis identifies tissue-resident memory T cells as drivers of ulcerative and immune checkpoint inhibitor induced colitis
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    Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths
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    Spatially Distinct Otic Mesenchyme Cells show Molecular and Functional Heterogeneity Patterns Before Hearing Onset
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    Enrichment of carcinogen-driven “mitochondria-primed” human skin stem cells and their identification using single-cell analyses
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    Metabolic signature and proteasome activity controls synovial migration of CDC42hi CD14+ cells in rheumatoid arthritis
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    Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice
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  106. www.biorxiv.org www.biorxiv.org
    Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3’ UTR of FAIM2
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    Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease
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    Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia
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    Single-cell analysis of the developing human ovary defines distinct insights into ovarian somatic and germline progenitors
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    Homeostatic PD-1 signaling restrains EOMES-dependent oligoclonal expansion of liver-resident CD8 T cells
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    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    Distinct mechanisms of mismatch repair deficiency delineate two modes of response to PD-1 immunotherapy in endometrial carcinoma
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    Integrative single-cell and bulk transcriptomes analyses identify intrinsic HNSCC subtypes with distinct prognoses and therapeutic vulnerabilities
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    Early clonal extinction in glioblastoma progression revealed by genetic barcoding
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    Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus
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  116. Jul 2023
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    Temporal transcriptome features identify early skeletal commitment during human epiphysis development at single-cell resolution
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    FOXC2 promotes vasculogenic mimicry and resistance to anti-angiogenic therapy
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    sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons
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    Cross-organ single-cell transcriptome profiling reveals macrophage and dendritic cell heterogeneity in zebrafish
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    Title: TET1 Facilitates Specification of Early Human Lineages including Germ Cells
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    A single-cell atlas of the sexually dimorphic Drosophila foreleg and its sensory organs during development
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    Single-cell transcriptome atlas of Drosophila gastrula 2.0
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    Obesity during preclinical Alzheimer's disease development exacerbates brain metabolic decline
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  125. Jun 2023
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    Transcriptomic landscape of early hair follicle and epidermal development
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    Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination
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    The maturation and aging trajectory of Marchantia polymorpha at single-cell resolution
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    Metabolic signature and proteasome activity controls synovial migration of CDC42hiCD14+ cells in rheumatoid arthritis
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    Organized B cell sites in cartilaginous fishes reveal the evolutionary foundation of germinal centers
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  132. www.biorxiv.org www.biorxiv.org
    A prognostic matrix code defines functional glioblastoma phenotypes and niches
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    hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data
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  134. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    iBRIDGE: A Data Integration Method to Identify Inflamed Tumors from Single-Cell RNAseq Data and Differentiate Cell Type–Specific Markers of Immune-Cell Infiltration
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    Aldehyde Dehydrogenase, a Marker of Normal and Malignant Stem Cells, Typifies Mesenchymal Progenitors in Perivascular Niches
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    Integrated spatial transcriptome and metabolism study reveals metabolic heterogeneity in human injured brain
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  137. May 2023
  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Developmental dynamics of chromatin accessibility during post-implantation development of monkey embryos
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    Efficient self-organization of blastoids solely from mouse ESCs is facilitated by transient reactivation of 2C gene network
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    Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle
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    Integrative transcriptomics and cell systems analyses reveal protective pathways controlled by Igfbp-3 in anthracycline-induced cardiotoxicity
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    Modeling human ectopic pregnancies with trophoblast and vascular organoids
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    Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation
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    Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases
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    An in vivo neuroimmune organoid model to study human microglia phenotypes
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    Metaphocytes are IL-22BP-producing cells regulated by ETS transcription factor Spic and essential for zebrafish barrier immunity
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    Analysis of candidate genes for cleft lip ± cleft palate using murine single-cell expression data
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    Immune mechanisms shape the clonal landscape during early progression of prostate cancer
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    Age-dependent immune and lymphatic responses after spinal cord injury
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    Bovine blastocyst-like structures derived from stem cell cultures
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  152. Apr 2023
  153. www.biorxiv.org www.biorxiv.org
    Brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke
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  154. Mar 2023
  155. www.sciencedirect.com www.sciencedirect.com
    A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans
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  156. europepmc.org europepmc.org
    Epigenetic dosage identifies two major and functionally distinct β cell subtypes
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    Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass
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  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multimodal mapping of cell types and projections in the central nucleus of the amygdala
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    Endothelial and Leptin Receptor+ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow
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    Single-cell transcriptomic profiling redefines the origin and specification of early adrenogonadal progenitors
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  161. Feb 2023
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    Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson’s disease
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    Runx1 controls auditory sensory neuron diversity in mice
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  165. www.cell.com www.cell.com
    The developmental basis of fingerprint pattern formation and variation
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  166. aacrjournals.org aacrjournals.org
    Single-cell analysis in lung adenocarcinoma implicates RNA editing in cancer innate immunity and patient prognosis
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes
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    Single-cell RNA-seq analysis reveals dual sensing of HIV-1 in blood Axl+ dendritic cells
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver
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  170. Jan 2023
  171. aacrjournals.org aacrjournals.org
    Spatial transcriptomic analysis of a diverse patient cohort reveals a conserved architecture in triple-negative breast cancer
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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma in Female Smokers and Never Smokers
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  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
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  174. Dec 2022
  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies
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  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell RNA sequencing uncovers dynamic roadmap and cell-cell communication during buffalo spermatogenesis
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    Nail-associated mesenchymal cells contribute to and are essential for dorsal digit tip regeneration
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deciphering Transcriptional Networks during Human Cardiac Development
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    Dental niche cells directly contribute to tooth reconstitution and morphogenesis
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    BAF complex maintains glioma stem cells in pediatric H3K27M-glioma
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  182. Nov 2022
  183. www.nature.com www.nature.com
    Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
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    Systematic single-cell pathway analysis to characterize early T cell activation
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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular and anatomical characterization of parabrachial neurons and their axonal projections
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    Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled NEUROG2 overexpression
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    CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation
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    Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia
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  190. Oct 2022
  191. alzres.biomedcentral.com alzres.biomedcentral.com
    Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ
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    SYK coordinates neuroprotective microglial responses in neurodegenerative disease
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    Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation
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    Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms
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  195. Sep 2022
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    Single-Cell RNA Sequencing Reveals Molecular Features of Heterogeneity in the Murine Retinal Pigment Epithelium
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    Landscape and age dynamics of immune cells in the Egyptian rousette bat
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    Sublethal cytochrome c release generates drug-tolerant persister cells
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  201. Aug 2022
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    Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors
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    Immunodeficiency syndromes differentially impact the functional spectrum of SARS-CoV-2-specific T cells elicited by mRNA vaccination
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    Detection of m6A in single cultured cells using scDART-seq
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    Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila
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    Identification of a drug-response gene in multiple myeloma through longitudinal single-cell transcriptome sequencing
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  208. Jul 2022
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    Group 3 innate lymphocytes make a distinct contribution to Type 17 immunity in bladder defence
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    Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice
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    Digital Cell Atlas of Mouse Uterus: From Regenerative Stage to Maturational Stage
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  214. May 2022
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    F1000Research Article: Integration of single-cell RNA-Seq and CyTOF data characterises heterogeneity of rare cell subpopulations.
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  217. Apr 2022
  218. www.sciencedirect.com www.sciencedirect.com
    Single-cell atlas of the aging mouse colon
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    KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis
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    Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease
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  221. Mar 2022
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    Single nucleus multi-omics identifies human cortical cell regulatory genome diversity
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