315 Matching Annotations
  1. Last 7 days
  2. www.biorxiv.org www.biorxiv.org
    Unraveling Genome- and Immunome-wide Genetic Diversity in Jaguars (Panthera onca): Implications for Targeted Conservation
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    1. scibot 17 May 2024
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      DOI: 10.1101/2024.05.06.592690

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    biorxiv.org/content/10.1101/2024.05.06.592690v1
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    SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson’s disease in human dopaminergic neurons and a mouse model
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    1. scibot 16 May 2024
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      DOI: 10.1016/j.xcrm.2024.101570

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    sciencedirect.com/science/article/pii/S2666379124002623
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    Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor
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    1. scibot 14 May 2024
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      DOI: 10.1016/j.cell.2024.04.023

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    2. scibot 14 May 2024
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      DOI: 10.1016/j.cell.2024.04.023

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    sciencedirect.com/science/article/pii/S0092867424004483
  5. www.sciencedirect.com www.sciencedirect.com
    Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
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    1. scibot 14 May 2024
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      DOI: 10.1016/j.stem.2024.04.015

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    sciencedirect.com/science/article/pii/S1934590924001425
  6. May 2024
  7. 52.53.155.43 52.53.155.43
    Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems
    1
    1. scibot 10 May 2024
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      DOI: 10.1101/2024.02.19.579948

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    52.53.155.43/cd1f9c7be80d56e211920ba04afd056c82fa391f/2024.02.19.579948.full-html.html
  8. www.cell.com www.cell.com
    ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models
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    1. scibot 10 May 2024
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      DOI: 10.1016/j.isci.2024.109800

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    cell.com/iscience/abstract/S2589-0042(24)01022-8
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Swd2/Cps35 determines H3K4 tri-methylation via interactions with Set1 and Rad6
    1
    1. scibot 09 May 2024
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      DOI: 10.1186/s12915-024-01903-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11069235/
  10. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
    1
    1. scibot 03 May 2024
      RRID:SCR_016368

      DOI: 10.7554/eLife.90683

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    elifesciences.org/articles/90683
  11. www.sciencedirect.com www.sciencedirect.com
    Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
    1
    1. scibot 03 May 2024
      RRID:SCR_016368

      DOI: 10.1016/j.ccell.2024.04.007

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    sciencedirect.com/science/article/pii/S1535610824001314
  12. www.cell.com www.cell.com
    Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3′ UTR of FAIM2
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    1. scibot 02 May 2024
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      DOI: 10.1016/j.xgen.2024.100556

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    cell.com/cell-genomics/fulltext/S2666-979X(24)00122-8
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    MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons
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    1. scibot 02 May 2024
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      DOI: 10.1016/j.neuron.2024.04.007

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    sciencedirect.com/science/article/pii/S0896627324002459
  14. Apr 2024
  15. www.sciencedirect.com www.sciencedirect.com
    Detection of ac4C in human mRNA is preserved upon data reassessment
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    1. scibot 20 Apr 2024
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      DOI: 10.1016/j.molcel.2024.03.018

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    sciencedirect.com/science/article/pii/S1097276524002284
  16. www.sciencedirect.com www.sciencedirect.com
    Dual-role transcription factors stabilize intermediate expression levels
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    1. scibot 18 Apr 2024
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      DOI: 10.1016/j.cell.2024.03.023

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    sciencedirect.com/science/article/pii/S0092867424003143
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGFβ signaling
    1
    1. scibot 13 Apr 2024
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      DOI: 10.1007/s00018-024-05183-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11006627/
  18. link.springer.com link.springer.com
    EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells
    1
    1. scibot 10 Apr 2024
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      DOI: 10.1007/s00018-024-05209-z

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    A senescence restriction point acting on chromatin integrates oncogenic signals
    1
    1. scibot 04 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114044

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    sciencedirect.com/science/article/pii/S2211124724003723
  20. www.sciencedirect.com www.sciencedirect.com
    Telomere dysfunction alters intestinal stem cell dynamics to promote cancer
    1
    1. scibot 04 Apr 2024
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      DOI: 10.1016/j.devcel.2024.03.020

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    sciencedirect.com/science/article/pii/S1534580724001886
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of several common APOBEC-type mutations in bladder tumors suggests links to viral infection
    1
    1. scibot 03 Apr 2024
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      DOI: 10.1158/1940-6207.CAPR-23-0112

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    ncbi.nlm.nih.gov/pmc/articles/PMC10592262/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling
    1
    1. scibot 03 Apr 2024
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      DOI: 10.1126/sciadv.adk4423

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    ncbi.nlm.nih.gov/pmc/articles/PMC10971413/
  23. Mar 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immune dysfunction mediated by the competitive endogenous RNA network in fetal side placental tissue of polycystic ovary syndrome
    1
    1. scibot 23 Mar 2024
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      DOI: 10.1371/journal.pone.0300461

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    ncbi.nlm.nih.gov/pmc/articles/PMC10956758/
  25. www.sciencedirect.com www.sciencedirect.com
    Peripheral neuronal activation shapes the microbiome and alters gut physiology
    1
    1. scibot 22 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113953

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    sciencedirect.com/science/article/pii/S221112472400281X
  26. link.springer.com link.springer.com
    From degraded to deciphered: ATAC-seq’s application potential in forensic diagnosis
    1
    1. scibot 19 Mar 2024
      RRID:SCR_016368

      DOI: 10.1007/s00414-024-03206-2

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    link.springer.com/article/10.1007/s00414-024-03206-2
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress-Induced Inflammation
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    1. scibot 17 Mar 2024
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      DOI: 10.1158/0008-5472.CAN-23-1237

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    ncbi.nlm.nih.gov/pmc/articles/PMC10940857/
  28. www.sciencedirect.com www.sciencedirect.com
    CD8+ T cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by shifts in clonal dominance
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      DOI: 10.1016/j.celrep.2024.113887

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      DOI: 10.1016/j.celrep.2024.113887

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    sciencedirect.com/science/article/pii/S2211124724002158
  29. www.sciencedirect.com www.sciencedirect.com
    The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling
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    1. scibot 05 Mar 2024
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      DOI: 10.1016/j.immuni.2024.02.004

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    sciencedirect.com/science/article/pii/S1074761324000803
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Treatment response in first-line metastatic pancreatic ductal adenocarcinoma is stratified by a composite index of tumor proliferation and CD8 T cell infiltration
    1
    1. scibot 03 Mar 2024
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      DOI: 10.1158/1078-0432.CCR-23-0535

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    ncbi.nlm.nih.gov/pmc/articles/PMC10530235/
  31. Feb 2024
  32. 52.53.155.43 52.53.155.43
    Transcriptional response of the heart to vagus nerve stimulation
    2
    1. scibot 22 Feb 2024
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      DOI: 10.1152/physiolgenomics.00095.2023

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      DOI: 10.1152/physiolgenomics.00095.2023

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    52.53.155.43/1d74c7a9de06d0c8fd1f9db4b510dc74e1613524/kellett-et-al-2024-transcriptional-response-of-the-heart-to-vagus-nerve-stimulation-html.html
  33. www.cell.com www.cell.com
    Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis
    1
    1. scibot 21 Feb 2024
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      DOI: 10.1016/j.neuron.2024.01.028

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    cell.com/neuron/fulltext/S0896-6273(24)00054-0
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    SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway
    1
    1. scibot 16 Feb 2024
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      DOI: 10.1016/j.devcel.2024.01.024

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    sciencedirect.com/science/article/pii/S1534580724000443
  35. www.biorxiv.org www.biorxiv.org
    A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancer
    1
    1. scibot 09 Feb 2024
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      DOI: 10.1101/2023.12.10.570854

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    biorxiv.org/content/10.1101/2023.12.10.570854v1
  36. link.springer.com link.springer.com
    The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer
    1
    1. scibot 07 Feb 2024
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      DOI: 10.1186/s13059-023-03161-y

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    link.springer.com/article/10.1186/s13059-023-03161-y
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
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      DOI: 10.1158/2159-8290.CD-22-1401

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524254/
  38. www.sciencedirect.com www.sciencedirect.com
    Microglia maintain structural integrity during fetal brain morphogenesis
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      DOI: 10.1016/j.cell.2024.01.012

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    sciencedirect.com/science/article/pii/S0092867424000448
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PHF6 suppresses self-renewal of leukemic stem cells in AML
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      DOI: 10.1101/2024.01.06.573649

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802281/
  40. www.sciencedirect.com www.sciencedirect.com
    Development of sexual dimorphism of skeletal muscles through the adrenal cortex, caused by androgen-induced global gene suppression
    2
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      DOI: 10.1016/j.celrep.2024.113715

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      DOI: 10.1016/j.celrep.2024.113715

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    sciencedirect.com/science/article/pii/S2211124724000433
  41. Jan 2024
  42. www.sciencedirect.com www.sciencedirect.com
    5-Hydroxymethylcytosine signals in serum are a predictor of chemoresistance in high-grade serous ovarian cancer
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    1. scibot 25 Jan 2024
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      DOI: 10.1016/j.ygyno.2024.01.001

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    sciencedirect.com/science/article/pii/S0090825824000015
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiation and Function
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    1. scibot 20 Jan 2024
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      DOI: 10.1101/2023.12.20.570481

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    ncbi.nlm.nih.gov/pmc/articles/PMC10769259/
  44. www.sciencedirect.com www.sciencedirect.com
    Inherited blood cancer predisposition through altered transcription elongation
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    1. scibot 19 Jan 2024
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      DOI: 10.1016/j.cell.2023.12.016

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    sciencedirect.com/science/article/pii/S009286742301348X
  45. dx.doi.org dx.doi.org
    Early microbial intervention reshapes phenotypes of newborn Bos taurus through metabolic regulations
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    1. scibot 18 Jan 2024
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      DOI: 10.1093/gigascience/giad118

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    Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation
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    Pluripotency state transition of embryonic stem cells requires the turnover of histone chaperone FACT on chromatin
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    Glucose stress causes mRNA retention in nuclear Nab2 condensates
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    Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma
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    Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis
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    A single-cell multi-omic atlas spanning the adult rhesus macaque brain
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    Genetic swamping of the critically endangered Scottish wildcat was recent and accelerated by disease
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    Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis
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    A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fate
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  57. Nov 2023
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    Genomic and transcriptomic characterization of delta SARS-CoV-2 infection in free-ranging white-tailed deer (Odocoileus virginianus)
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    Selective inhibition of CDK9 in triple negative breast cancer
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    Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51
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    LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
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    Broodstock nutritional programming differentially affects the hepatic transcriptome and genome-wide DNA methylome of farmed gilthead sea bream (Sparus aurata) depending on genetic background
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    Zinc Finger MYND-Type Containing 8 (ZMYND8) is epigenetically regulated in mutant Isocitrate Dehydrogenase 1 (IDH1) glioma to promote radioresistance
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    Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure
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    ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
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    Molecular and functional characterization of the Drosophila melanogaster conserved smORFome
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    Loss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism
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    Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells
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    A single-cell multi-omic atlas spanning the adult rhesus macaque brain
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    Chromatin accessibility landscape of human triple-negative breast cancer cell lines reveals variation by patient donor ancestry
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    TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression
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    Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification
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    Chromosome-level reference genome of tetraploid Isoetes sinensis provides insights into evolution and adaption of lycophytes
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    Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
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  82. Aug 2023
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    Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3’ UTR of FAIM2
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    Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression
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    SnakeMAGs: a simple, efficient, flexible and scalable workflow to reconstruct prokaryotic genomes from metagenomes
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
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    Deficiency of the Polycomb protein RYBP and TET methylcytosine oxidases promotes extensive CpG island hypermethylation and malignant transformation
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    Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission
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    Histone variants shape chromatin states in Arabidopsis
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  90. Jul 2023
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmacological HDAC inhibition impairs pancreatic β-cell function through an epigenome-wide reprogramming
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    Bacterial clade-specific analysis identifies distinct epithelial responses in inflammatory bowel disease
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    A clinical metagenomic study of biopsies from Mexican endophthalmitis patients reveals the presence of complex bacterial communities and a diversity of resistance genes
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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    DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres
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    Modelling host-Trypanosoma brucei gambiense interactions in vitro using human induced pluripotent stem cell-derived cortical brain organoids
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    Comparative analysis of microRNA expression profiles in shoot and root tissues of contrasting rice cultivars (Oryza sativa L.) with different salt stress tolerance
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    Developmental dynamics of chromatin accessibility during post-implantation development of monkey embryos
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    Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases
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    KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition
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    L1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
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  114. Apr 2023
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    A hyper-quiescent chromatin state formed during aging is reversed by regeneration
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    Maternal and food microbial sources shape the infant microbiome of a rural Ethiopian population
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    Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis
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    Novel enhancers conferring compensatory transcriptional regulation of Nkx2-5 in heart development
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    INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II
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    Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload
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    Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting
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    Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
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    SnakeMAGs: a simple, efficient, flexible and scalable workflow to reconstruct prokaryotic genomes from metagenomes
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    Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye
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  132. Feb 2023
  133. www.sciencedirect.com www.sciencedirect.com
    Human hematopoietic stem cell vulnerability to ferroptosis
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    The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma
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    DDR2 coordinates EMT and metabolic reprogramming as a shared effector of FOXQ1 and SNAI1
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  136. Jan 2023
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    Enrichment of oral-derived bacteria in inflamed colorectal tumors and distinct associations of Fusobacterium in the mesenchymal subtype
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    Genomic view of the diversity and functional role of archaea and bacteria in the skeleton of the reef-building corals Porites lutea and Isopora palifera
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors
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  140. www.biorxiv.org www.biorxiv.org
    A chromosome-scale assembly for tetraploid sour cherry (Prunus cerasus L.) ‘Montmorency’ identifies three distinct ancestral Prunus genomes
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  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Resistance to white spot syndrome virus in the European shore crab is associated with suppressed virion trafficking and heightened immune responses
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis
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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry
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  145. Dec 2022
  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting metabolic adaptations in the breast cancer–liver metastatic niche using dietary approaches to improve endocrine therapy efficacy
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  147. aacrjournals.org aacrjournals.org
    BAF complex maintains glioma stem cells in pediatric H3K27M-glioma
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  148. Nov 2022
  149. www.sciencedirect.com www.sciencedirect.com
    Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation
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  150. aacrjournals.org aacrjournals.org
    Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma
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    Essential role of MESP1-RING1A complex in cardiac differentiation
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  152. aacrjournals.org aacrjournals.org
    DDR2 Coordinates EMT and Metabolic Reprogramming as a Shared Effector of FOXQ1 and SNAI1
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  153. academic.oup.com academic.oup.com
    High-quality genome assembles from key Hawaiian coral species
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  154. www.sciencedirect.com www.sciencedirect.com
    Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
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  155. Oct 2022
  156. aacrjournals.org aacrjournals.org
    CircIPO7 Promotes Nasopharyngeal Carcinoma Metastasis and Cisplatin Chemoresistance by Facilitating YBX1 Nuclear Localization
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  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification
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  158. www.sciencedirect.com www.sciencedirect.com
    A cis-regulatory lexicon of DNA motif combinations mediating cell-type-specific gene regulation
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  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dicer1 deficient mice exhibit premature ageing and metabolic perturbations in adipocytes
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  160. Sep 2022
  161. aacrjournals.org aacrjournals.org
    PU.1-dependent enhancer inhibition separates Tet2-deficient hematopoiesis from malignant transformation
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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In Vivo Genome-Wide CRISPR Activation Screening Identifies Functionally Important Long Noncoding RNAs in Hepatocellular Carcinoma
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  163. www.sciencedirect.com www.sciencedirect.com
    Genomic analysis reveals cryptic diversity in aphelids and sheds light on the emergence of Fungi
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    Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer
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    Loss of key endosymbiont genes may facilitate early host control of the chromatophore in Paulinella
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  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAG2 promotes the myelination transcriptional program in oligodendrocytes
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    The human mitochondrial genome contains a second light strand promoter
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    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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  169. Aug 2022
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    Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors
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  171. 52.53.155.43 52.53.155.43
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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Losartan blocks osteosarcoma-elicited monocyte recruitment, and combined with the kinase inhibitor toceranib, exerts significant clinical benefit in canine metastatic osteosarcoma
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    LncRNA and mRNA expression profiles in brown adipose tissue of obesity-prone and obesity-resistant mice
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    TOP1 CAD-seq: A protocol to map catalytically engaged topoisomerase 1 in human cells
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  175. Jul 2022
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    EGFR signaling activates intestinal stem cells by promoting mitochondrial biogenesis and β-oxidation
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  177. academic.oup.com academic.oup.com
    A chromosome-level genome assembly and intestinal transcriptome of Trypoxylus dichotomus (Coleoptera: Scarabaeidae) to understand its lignocellulose digestion ability
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  178. www.cell.com www.cell.com
    Bacterial growth in multicellular aggregates leads to the emergence of complex life cycles
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  179. Jun 2022
  180. aacrjournals.org aacrjournals.org
    Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors
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  181. aacrjournals.org aacrjournals.org
    Porcupine inhibition disrupts mitochondrial function and homeostasis in WNT ligand-addicted pancreatic cancer
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  182. elifesciences.org elifesciences.org
    Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3
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      DOI: 10.7554/eLife.66909

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  183. www.sciencedirect.com www.sciencedirect.com
    Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine
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    JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation
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    Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs
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    Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion
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  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Whole Transcriptome Analysis in Peripheral Blood Suggests That Energy Metabolism and Inflammation Are Involved in Major Depressive Disorder
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  188. May 2022
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    A chromosome-level reference genome of Ensete glaucum gives insight into diversity and chromosomal and repetitive sequence evolution in the Musaceae
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  190. Apr 2022
  191. www.sciencedirect.com www.sciencedirect.com
    RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex
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    An adult-stage transcriptional program for survival of serotonergic connectivity
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    HNF4A modulates glucocorticoid action in the liver
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  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chromosome-level genome of the globe skimmer dragonfly (Pantala flavescens)
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    A high-quality assembled genome and its comparative analysis decode the adaptive molecular mechanism of the number one Chinese cotton variety CRI-12
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  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Presence of H3K4me3 on Paternally Expressed Genes of the Paternal Genome From Sperm to Implantation
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  197. Mar 2022
  198. elifesciences.org elifesciences.org
    Novel insights from a multiomics dissection of the Hayflick limit
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  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit
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  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A test of the pioneer factor hypothesis using ectopic liver gene activation
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  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma
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    Identification of new ETV6 modulators through a high throughput functional screening
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  204. Feb 2022
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    Simultaneous cellular and molecular phenotyping of embryonic mutants using single-cell regulatory trajectories
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    Uncovering the mesendoderm gene regulatory network through multi-omic data integration
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    Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs
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  208. Jan 2022
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    Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration
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    Multimodal regulatory elements within a hormone-specific super enhancer control a heterogeneous transcriptional response
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    Construction of Strand-seq libraries in open nanoliter arrays
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    Heat shock factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells
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    MAP3K7 loss drives enhanced androgen signaling and independently confers risk of recurrence in prostate cancer with joint loss of CHD1
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  214. Dec 2021
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    Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells
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  216. www.cell.com www.cell.com
    MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”
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    Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis
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  218. Nov 2021
  219. mcr.aacrjournals.org mcr.aacrjournals.org
    SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation
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  220. www.nature.com www.nature.com
    CHD5 inhibits metastasis of neuroblastoma
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    Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1
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    Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis
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    Sequence features of retrotransposons allow for epigenetic variability
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    Kr-h1 maintains distinct caste-specific neurotranscriptomes in response to socially regulated hormones
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  225. Oct 2021
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    Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells
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    Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses
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