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The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition

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sciencedirect.com/science/article/pii/S1097276525006161
Jul 2025
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Making plant tissue accessible for cryo-electron tomography

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elifesciences.org/reviewed-preprints/106455v1
Jun 2025
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Structural insights into the biotechnologically relevant reversible NADPH-oxidizing NiFe-hydrogenase from P. furiosus

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Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution

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elifesciences.org/reviewed-preprints/95557v2
May 2025
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Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

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elifesciences.org/articles/105396
Jan 2025
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Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C–MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies

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pmc.ncbi.nlm.nih.gov/articles/PMC11733532/
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Structural and functional analysis of the Nipah virus polymerase complex

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Dec 2024
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52.53.155.43/eda542f05a259fcd2586bec9365306e8eda4954b/can-24-2450-html.html
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Dual BACH1 regulation by complementary SCF-type E3 ligases

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1. scibot 10 Dec 2024
  
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sciencedirect.com/science/article/pii/S0092867424013229
Nov 2024
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Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii

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embopress.org/doi/10.1038/s44318-024-00274-3
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Inhibition of Parkinson’s Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures

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1. scibot 26 Nov 2024
  
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biorxiv.org/content/10.1101/2023.09.07.556689v1
Sep 2024
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Dynamic allostery drives autocrine and paracrine TGF-β signaling

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sciencedirect.com/science/article/pii/S0092867424009656
Aug 2024
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Structural insights into the chloroplast protein import in land plants

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  DOI: 10.1016/j.cell.2024.08.003
  
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cell.com/cell/fulltext/S0092-8674(24)00894-8
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Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae

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sciencedirect.com/science/article/pii/S0092867424008936
Jun 2024
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A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2

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1. scibot 21 Jun 2024
  
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sciencedirect.com/science/article/pii/S0021925824019707
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Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures

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cell.com/structure/fulltext/S0969-2126(24)00190-4
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POT1 recruits and regulates CST-Polα/primase at human telomeres

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cell.com/cell/fulltext/S0092-8674(24)00493-8
May 2024
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Autophagy preferentially degrades non-fibrillar polyQ aggregates

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Apr 2024
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Structural basis of ligand specificity and channel activation in an insect gustatory receptor

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cell.com/cell-reports/fulltext/S2211-1247(24)00363-2
Mar 2024
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Combinatorial selective ER-phagy remodels the ER during neurogenesis

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Structure of the plant plastid-encoded RNA polymerase

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Cryo-EM structures of the plant plastid-encoded RNA polymerase

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Feb 2024
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A metabolically controlled contact site between vacuoles and lipid droplets in yeast

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Nov 2023
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The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus

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cell.com/cell-reports/fulltext/S2211-1247(23)01378-5
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Membrane remodeling properties of the Parkinson’s disease protein LRRK2

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ncbi.nlm.nih.gov/pmc/articles/PMC10614619/
Oct 2023
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Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly

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A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response

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nature.com/articles/s41556-023-01248-z
Aug 2023
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Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ

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ncbi.nlm.nih.gov/pmc/articles/PMC10382156/
Jul 2023
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Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

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ncbi.nlm.nih.gov/pmc/articles/PMC10338036/
Mar 2023
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Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster

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ncbi.nlm.nih.gov/pmc/articles/PMC9977279/
Feb 2023
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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

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  DOI: 10.1038/s41467-023-36058-2
  
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nature.com/articles/s41467-023-36058-2
Jan 2023
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Nucleosome dyad determines the H1 C-terminus collapse on distinct DNA arms

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The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions

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sciencedirect.com/science/article/pii/S2211124722018010
Dec 2022
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Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules

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  DOI: 10.1038/s41594-022-00863-y
  
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Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes

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A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM

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Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

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TITLE: Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

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In situ architecture of the lipid transport protein VPS13C at ER–lysosome membrane contacts

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Conserved structural elements specialize ATAD1 as a membrane protein extraction machine

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Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB

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Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes

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Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

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Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells

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TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

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Regulation of human mTOR complexes by DEPTOR

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Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

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Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection

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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

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Structure and analysis of nanobody binding to the human ASIC1a ion channel

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Structures of translationally inactive mammalian ribosomes

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Structure of the Mechanosensitive Channel MscS Embedded in the Membrane Bilayer

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Structures of translationally inactive mammalian ribosomes

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Structural and functional characterization of an otopetrin family proton channel

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Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

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The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain

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Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP

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Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis

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Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex

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A pentameric protein ring with novel architecture is required for herpesviral packaging

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Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems

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Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

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Mimicry of Canonical Translation Elongation Underlies Alanine Tail Synthesis in RQC

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Structure of bacterial phospholipid transporter MlaFEDB with substrate bound

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Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

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A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide

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Structural basis of αE-catenin–F-actin catch bond behavior

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HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

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Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

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An ER translocon for multi-pass membrane protein biogenesis

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Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

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Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1

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Chemical and structural investigation of the paroxetine-human serotonin transporter complex

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Mechanical inhibition of isolated Vo from V/A-ATPase for proton conductance

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Structure and activation mechanism of the BBSome membrane protein trafficking complex

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Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

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Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β

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Molecular principles of assembly, activation, and inhibition in epithelial sodium channel

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Cryo-EM structure of VASH1-SVBP bound to microtubules

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The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity

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Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

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Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

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Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing

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Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR

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Regulation of Eag1 gating by its intracellular domains

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Regulatory switch at the cytoplasmic interface controls TRPV channel gating

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Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

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Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

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Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases

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Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins

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Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD

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Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies

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Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

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Structure of the human epithelial sodium channel by cryo-electron microscopy

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