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Aug 2025
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The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition

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Evolutionarily diverse caveolins share a common structural framework built around amphipathic disks

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pmc.ncbi.nlm.nih.gov/articles/PMC12330381/
Jul 2025
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Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2

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  DOI: 10.1126/sciadv.adt2050
  
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Structural insights into heterohexameric assembly of epilepsy-related ligand–receptor complex LGI1–ADAM22

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Structural and functional insights into the evolution of SARS-CoV-2 KP.3.1.1 spike protein

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  DOI: 10.1016/j.celrep.2025.115941
  
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Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition

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  DOI: 10.1016/j.cell.2025.06.017
  
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Jun 2025
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Structural insights into the biotechnologically relevant reversible NADPH-oxidizing NiFe-hydrogenase from P. furiosus

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Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2

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Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation

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Structure, function and assembly of soybean primary cell wall cellulose synthases

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elifesciences.org/reviewed-preprints/96704v2
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AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone

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Structural basis of GluK2 kainate receptor activation by a partial agonist

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  DOI: 10.1038/s41594-025-01566-w
  
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nature.com/articles/s41594-025-01566-w
May 2025
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Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

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1. scibot 29 May 2025
  
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  DOI: 10.7554/eLife.105396
  
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elifesciences.org/articles/105396
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Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer

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1. scibot 17 May 2025
  
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Mar 2025
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Biochemical profiling and structural basis of ADAR1-mediated RNA editing

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Jan 2025
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Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C–MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies

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pmc.ncbi.nlm.nih.gov/articles/PMC11733532/
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Structural and functional analysis of the Nipah virus polymerase complex

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.cell.2024.12.021
  
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Structure of the Nipah virus polymerase complex

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  DOI: 10.1038/s44318-024-00321-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11730344/
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The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

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  DOI: 10.7554/eLife.96743
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695057/
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balıkçı-et-al-2024-structure-of-the-nipah-virus-polymerase-complex-html.html

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52.53.155.43/6dd1ebe61f74ea2219dbd41b0038f7255c729fc7/balıkçı-et-al-2024-structure-of-the-nipah-virus-polymerase-complex-html.html
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Structure of the Nipah virus polymerase complex

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Dec 2024
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can-24-2450-html.html

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52.53.155.43/eda542f05a259fcd2586bec9365306e8eda4954b/can-24-2450-html.html
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Structural insights into subunit-dependent functional regulation in epithelial sodium channels

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Dual BACH1 regulation by complementary SCF-type E3 ligases

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quinodoz-et-al-2024-de-novo-variants-in-lrrc8c-resulting-in-constitutive-channel-activation-cause-a-human-multisystem-html.html

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Nov 2024
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Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii

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  DOI: 10.1038/s44318-024-00274-3
  
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Cryo‐EM reveals transition states of the Acinetobacter baumannii F1 ‐ATPase rotary subunits γ and ε, unveiling novel compound targets

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pmc.ncbi.nlm.nih.gov/articles/PMC11580714/
Oct 2024
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Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED

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Sep 2024
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Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2

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  DOI: 10.1101/2024.09.17.613365
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11565912/
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Discovery and characterization of a pan-betacoronavirus S2-binding antibody

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Dynamic allostery drives autocrine and paracrine TGF-β signaling

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Aug 2024
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Structure of the human heparan-α-glucosaminide N-acetyltransferase (HGSNAT)

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  DOI: 10.7554/eLife.93510
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11357348/
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Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae

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  DOI: 10.1016/j.cell.2024.08.002
  
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Structural insights into the chloroplast protein import in land plants

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  DOI: 10.1016/j.cell.2024.08.003
  
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cell.com/cell/fulltext/S0092-8674(24)00894-8
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Mechanism of Ca2+ transport by ferroportin - ProQuest

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proquest.com/docview/2771288630
Jul 2024
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Structure of the Hir histone chaperone complex

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  DOI: 10.1016/j.molcel.2024.05.031
  
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An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II

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Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38

1
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Structural features of heteromeric channels composed of CALHM2 and CALHM4 paralogs

1
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A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2

1
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Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures

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POT1 recruits and regulates CST-Polα/primase at human telomeres

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Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

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Structural basis of ligand specificity and channel activation in an insect gustatory receptor

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Mar 2024
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Structural mechanisms for VMAT2 inhibition by tetrabenazine

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ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

2
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  DOI: 10.1016/j.cell.2024.02.013
  
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Structure of the plant plastid-encoded RNA polymerase

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Cryo-EM structures of the plant plastid-encoded RNA polymerase

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Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense

1
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Inhibition of Parkinson’s disease–related LRRK2 by type I and type II kinase inhibitors: Activity and structures

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  DOI: 10.1126/sciadv.adk6191
  
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Inhibition of Parkinson’s disease–related LRRK2 by type I and type II kinase inhibitors: Activity and structures

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Nov 2023
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Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase

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The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus

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Energy coupling and stoichiometry of Zn2+/H+ antiport by the prokaryotic cation diffusion facilitator YiiP

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Oct 2023
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Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly

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A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response

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Aug 2023
52.53.155.43 52.53.155.43

Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase

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Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels

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Jul 2023
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Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

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Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange

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Jun 2023
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A structural blueprint for interleukin-21 signal modulation

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Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment

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May 2023
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Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange

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  DOI: 10.1101/2023.03.06.531323
  
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Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

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Apr 2023
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Cryo-EM structure of the endothelin-1-ETB-Gi complex

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Structural and functional properties of a plant NRAMP-related aluminum transporter

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Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes

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  DOI: 10.1016/j.celrep.2023.112370
  
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Mar 2023
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Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses

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Structural basis of a transcription pre-initiation complex on a divergent promoter

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Mechanism of Ca2+ transport by ferroportin

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Nucleosome dyad determines the H1 C-terminus collapse on distinct DNA arms

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The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions

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Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules

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Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes

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Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

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A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM

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Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

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TITLE: Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

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Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC

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Conserved structural elements specialize ATAD1 as a membrane protein extraction machine

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RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex

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Analysis Of Memory B Cells Identifies Conserved Neutralizing Epitopes On The N-Terminal Domain Of Variant SARS-Cov-2 Spike Proteins

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Structural basis for catalyzed assembly of the Sonic hedgehog–Patched1 signaling complex

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Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats

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Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family

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Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes

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Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II

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Structural characterization of NrnC identifies unifying features of dinucleotidases

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Structural insights into the activation of human calcium-sensing receptor

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TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

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Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

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Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

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Regulation of human mTOR complexes by DEPTOR

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Negative charge in the RACK1 loop broadens the translational capacity of the human ribosome

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Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

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Cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

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High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor

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Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

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Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

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Bile salts alter the mouse norovirus capsid conformation; possible implications for cell attachment and immune evasion.

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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV

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Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis

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Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1

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Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

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Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

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Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

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Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

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Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

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A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

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Structure of bacterial phospholipid transporter MlaFEDB with substrate bound

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Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

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Structure of the human core transcription-export complex reveals a hub for multivalent interactions

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The structures of secretory and dimeric immunoglobulin A

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Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

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A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide

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cell.com/cell-reports/fulltext/S2211-1247(20)31417-0
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A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch

1
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Antibody escape by polyomavirus capsid mutation facilitates neurovirulence

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Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

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HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

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The architecture of EMC reveals a path for membrane protein insertion

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Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β

1
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Chemical and structural investigation of the paroxetine-human serotonin transporter complex

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Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1

1
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The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity

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Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

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Molecular principles of assembly, activation, and inhibition in epithelial sodium channel

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Structural basis of substrate recognition by a polypeptide processing and secretion transporter

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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

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Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

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Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

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Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

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Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies

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Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

1
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  DOI: 10.1016/j.chom.2019.04.011
  
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Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD

1
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  DOI: 10.1016/j.celrep.2019.08.052
  
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Structure of the human epithelial sodium channel by cryo-electron microscopy

1
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