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Jun 2026
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Faf1 accelerates p97-mediated protein unfolding by promoting ubiquitin engagement

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The molecular architecture of tunneling nanotubes

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May 2026
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Implantable vascularized endocrine constructs for clinically scalable insulin delivery

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Apr 2026
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The phage nucleus synergizes with an anti-defense protein to resist bacterial immunity

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Mar 2026
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A correlative workflow for synaptic imaging by cryo-electron tomography

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sciencedirect.com/science/article/pii/S0969212626000596
Jan 2026
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Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly

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sciencedirect.com/science/article/pii/S0092867425013765
Dec 2025
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The role of kinase domain dimerization in EGFR activation

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sciencedirect.com:5037/science/article/pii/S0969212625004770
Nov 2025
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Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

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elifesciences.org/articles/100799
Oct 2025
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The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility

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Molecular mechanisms governing the formation of distinct Upf1-containing complexes in yeast

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sciencedirect.com/science/article/pii/S2211124725011866
Sep 2025
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Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

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elifesciences.org/reviewed-preprints/100799
Aug 2025
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41594_2025_1631_MOESM4_ESM-html.html

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52.53.155.43/2894f1585e3ca7aaaea575ab75ca401271c73618/41594_2025_1631_MOESM4_ESM-html.html
Jul 2025
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Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology

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1. scibot 22 Jul 2025
  
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science.org/doi/10.1126/sciadv.adu6354
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Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology

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Structural insights into heterohexameric assembly of epilepsy-related ligand–receptor complex LGI1–ADAM22

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  DOI: 10.7554/eLife.105918
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12226019/
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Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition

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  DOI: 10.1016/j.cell.2025.06.017
  
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A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses

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  DOI: 10.1016/j.neuron.2025.05.030
  
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sciencedirect.com/science/article/pii/S0896627325004301
Jun 2025
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Structural insights into the biotechnologically relevant reversible NADPH-oxidizing NiFe-hydrogenase from P. furiosus

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1. scibot 26 Jun 2025
  
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Jan 2025
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Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C–MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies

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1. scibot 25 Jan 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2450
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11733532/
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Structural and functional analysis of the Nipah virus polymerase complex

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.cell.2024.12.021
  
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Passage of the HIV capsid cracks the nuclear pore

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sciencedirect.com/science/article/pii/S0092867424014211
Dec 2024
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can-24-2450-html.html

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52.53.155.43/eda542f05a259fcd2586bec9365306e8eda4954b/can-24-2450-html.html
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Structural insights into subunit-dependent functional regulation in epithelial sodium channels

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ay-et-al-2024-in-vivo-hiv-1-nuclear-condensates-safeguard-against-cgas-and-license-reverse-transcription-html.html

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1. scibot 06 Dec 2024
  
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  DOI: 10.1038/s44318-024-00316-w
  
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52.53.155.43/98d4e7e92a777001c6d187b7ec7d0b4005ca7287/ay-et-al-2024-in-vivo-hiv-1-nuclear-condensates-safeguard-against-cgas-and-license-reverse-transcription-html.html
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In vivo HIV-1 nuclear condensates safeguard against cGAS and license reverse transcription

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embopress.org/doi/10.1038/s44318-024-00316-w
Sep 2024
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Discovery and characterization of a pan-betacoronavirus S2-binding antibody

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Dynamic allostery drives autocrine and paracrine TGF-β signaling

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  DOI: 10.1016/j.cell.2024.08.036
  
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sciencedirect.com/science/article/pii/S0092867424009656
Jul 2024
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Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

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1. scibot 14 Jul 2024
  
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  DOI: 10.1101/2024.06.18.599606
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11212993/
Jun 2024
www.cell.com www.cell.com

POT1 recruits and regulates CST-Polα/primase at human telomeres

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  DOI: 10.1016/j.cell.2024.05.002
  
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cell.com/cell/fulltext/S0092-8674(24)00493-8
May 2024
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Autophagy preferentially degrades non-fibrillar polyQ aggregates

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  DOI: 10.1016/j.molcel.2024.04.018
  
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sciencedirect.com/science/article/pii/S1097276524003836
Apr 2024
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Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission

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  DOI: 10.1016/j.devcel.2024.04.008
  
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sciencedirect.com/science/article/pii/S1534580724002338
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Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

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  DOI: 10.1038/s41594-024-01268-9
  
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nature.com/articles/s41594-024-01268-9
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Structural basis of ligand specificity and channel activation in an insect gustatory receptor

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  DOI: 10.1016/j.celrep.2024.114035
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00363-2
Mar 2024
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Structural mechanisms for VMAT2 inhibition by tetrabenazine

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1. scibot 27 Mar 2024
  
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  DOI: 10.7554/eLife.91973
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10959523/
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ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

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  DOI: 10.1016/j.cell.2024.02.013
  
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  DOI: 10.1016/j.cell.2024.02.013
  
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sciencedirect.com/science/article/pii/S009286742400179X
Feb 2024
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A metabolically controlled contact site between vacuoles and lipid droplets in yeast

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1. scibot 21 Feb 2024
  
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  DOI: 10.1016/j.devcel.2024.01.016
  
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The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus

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Membrane remodeling properties of the Parkinson’s disease protein LRRK2

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Oct 2023
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Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly

1
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Aug 2023
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Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels

2
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Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ

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ncbi.nlm.nih.gov/pmc/articles/PMC10382156/
Jul 2023
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Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

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Jun 2023
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A structural blueprint for interleukin-21 signal modulation

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Apr 2023
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Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes

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Feb 2023
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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

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Jan 2023
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Nucleosome dyad determines the H1 C-terminus collapse on distinct DNA arms

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The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions

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Dec 2022
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Anti-CD73 antibody activates human B cells, enhances humoral responses and induces redistribution of B cells in patients with cancer

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Nov 2022
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Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

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Oct 2022
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Condensation of the fusion focus by the intrinsically disordered region of the formin Fus1 is essential for cell-cell fusion

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In situ structural analysis reveals membrane shape transitions during autophagosome formation

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A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM

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Sep 2022
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Ultrastructural analysis of wild-type and RIM1α knockout active zones in a large cortical synapse

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Jun 2022
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Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex

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Apr 2022
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RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex

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Analysis Of Memory B Cells Identifies Conserved Neutralizing Epitopes On The N-Terminal Domain Of Variant SARS-Cov-2 Spike Proteins

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ncbi.nlm.nih.gov/pmc/articles/PMC8986478/
Mar 2022
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Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB

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Jan 2022
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Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

1
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ncbi.nlm.nih.gov/pmc/articles/PMC8776254/
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Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

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ncbi.nlm.nih.gov/pmc/articles/PMC8673750/
Oct 2021
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Cnm1 mediates nucleus–mitochondria contact site formation in response to phospholipid levels

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rupress.org/jcb/article/220/11/e202104100/212719/Cnm1-mediates-nucleus-mitochondria-contact-site
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Ultrastructure of ipsilateral and contralateral tectopulvinar projections in the mouse

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TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

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ncbi.nlm.nih.gov/pmc/articles/PMC8480983/
Sep 2021
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Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

1
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ncbi.nlm.nih.gov/pmc/articles/PMC8423902/
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Regulation of human mTOR complexes by DEPTOR

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Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

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Cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

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  DOI: 10.1016/j.celrep.2021.109628
  
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Aug 2021
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The 3D architecture and molecular foundations of de novo centriole assembly via bicentrioles

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Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

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  DOI: 10.1016/j.celrep.2021.109604
  
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Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy

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ncbi.nlm.nih.gov/pmc/articles/PMC8360650/
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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

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  DOI: 10.7554/eLife.68710
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8357420/
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In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission

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A contractile injection system stimulates tubeworm metamorphosis by translocating a proteinaceous effector

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1. scibot 30 Jul 2021
  
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The molecular architecture of engulfment during Bacillus subtilis sporulation

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1. scibot 29 Jul 2021
  
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  SerialEM
  
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Self-capping of nucleoprotein filaments protects Newcastle Disease Virus genome

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1. scibot 29 Jul 2021
  
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Jun 2021
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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV

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sciencedirect.com/science/article/pii/S0092867421005353
May 2021
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The structure and spontaneous curvature of clathrin lattices at the plasma membrane

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cell.com/developmental-cell/fulltext/S1534-5807(21)00243-4
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In situ architecture of neuronal α-Synuclein inclusions

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ncbi.nlm.nih.gov/pmc/articles/PMC8046968/
Apr 2021
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Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex

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Mar 2021
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Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

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ncbi.nlm.nih.gov/pmc/articles/PMC7962591/
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A pentameric protein ring with novel architecture is required for herpesviral packaging

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Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems

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  DOI: 10.1016/j.molcel.2020.12.033
  
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Feb 2021
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Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

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ncbi.nlm.nih.gov/pmc/articles/PMC7434445/
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Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

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Cone-shaped HIV-1 capsids are transported through intact nuclear pores

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  DOI: 10.1016/j.cell.2021.01.025
  
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Jan 2021
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Atomic structures of respiratory complex III 2, complex IV, and supercomplex III 2-IV from vascular plants

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  DOI: 10.7554/eLife.62047
  
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Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

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ncbi.nlm.nih.gov/pmc/articles/PMC7785296/
Dec 2020
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Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

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1. scibot 12 Dec 2020
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7723414/
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Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

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  DOI: 10.1016/j.chom.2020.11.007
  
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sciencedirect.com/science/article/pii/S1931312820306247
Oct 2020
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A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch

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ncbi.nlm.nih.gov/pmc/articles/PMC7577740/
Sep 2020
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Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices

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  DOI: 10.1016/j.neuron.2020.09.004
  
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Chemical and structural investigation of the paroxetine-human serotonin transporter complex

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ncbi.nlm.nih.gov/pmc/articles/PMC7470834/
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Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

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Structure and activation mechanism of the BBSome membrane protein trafficking complex

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elifesciences.org/articles/53322
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Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1

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Atomic structure of a mitochondrial complex I intermediate from vascular plants

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ncbi.nlm.nih.gov/pmc/articles/PMC7447434/
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Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β

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  DOI: 10.1016/j.cell.2019.12.030
  
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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

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ncbi.nlm.nih.gov/pmc/articles/PMC7311918/
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Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

1
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ncbi.nlm.nih.gov/pmc/articles/PMC7434445/
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Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

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ncbi.nlm.nih.gov/pmc/articles/PMC7141809/
Jan 2020
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Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity

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  DOI: 10.1016/j.devcel.2019.10.018
  
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Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing

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  DOI: 10.1016/j.str.2019.09.011
  
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sciencedirect.com/science/article/pii/S096921261930317X

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