47 Matching Annotations
  1. Aug 2025
  2. www.pnas.org www.pnas.org
    Generation of actionable, cancer-specific neoantigens from KRAS(G12C) with adagrasib
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    pnas.org/doi/abs/10.1073/pnas.2509012122
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structure and function of the human apoptotic scramblase Xkr4
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    pmc.ncbi.nlm.nih.gov/articles/PMC12334663/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12318133/
  5. Jul 2025
  6. elifesciences.org elifesciences.org
    Conduction pathway for potassium through the E. coli pump KdpFABC
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    elifesciences.org/reviewed-preprints/107397
  7. Jun 2025
  8. 52.53.155.43 52.53.155.43
    science.adp2742-html.html
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    52.53.155.43/defb0e26d194d6fcb6fbd31330ba0c9e7b261ec2/science.adp2742-html.html
  9. www.science.org www.science.org
    BRAF oncogenic mutants evade autoinhibition through a common mechanism
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    science.org/doi/10.1126/science.adp2742
  10. Apr 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel
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    pmc.ncbi.nlm.nih.gov/articles/PMC12002230/
  12. Feb 2025
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel
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    pmc.ncbi.nlm.nih.gov/articles/PMC11840039/
  14. www.science.org www.science.org
    Human naïve B cells recognize prepandemic influenza virus hemagglutinins
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    science.org/doi/10.1126/sciimmunol.ado9572
  15. Jan 2025
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A fiducial-assisted strategy compatible with resolving small MFS transporter structures in multiple conformations using cryo-EM
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695964/
  17. Dec 2024
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32
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    pmc.ncbi.nlm.nih.gov/articles/PMC11621456/
  19. www.nature.com www.nature.com
    Substrate translocation and inhibition in human dicarboxylate transporter NaDC3
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    nature.com/articles/s41594-024-01433-0
  20. www.biorxiv.org www.biorxiv.org
    Identification of a proteolysis regulator for an essential enzyme in Mycobacterium tuberculosis
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    biorxiv.org/content/10.1101/2024.03.29.587195v1
  21. www.pnas.org www.pnas.org
    Identification of a depupylation regulator for an essential enzyme in <i>Mycobacterium tuberculosis</i>
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    pnas.org/doi/abs/10.1073/pnas.2407239121
  22. www.nature.com www.nature.com
    Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain
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    nature.com/articles/s41589-024-01751-w
  23. www.sciencedirect.com www.sciencedirect.com
    Role of Ring6 in the Function of the E. coli MCE Protein LetB
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    sciencedirect.com/science/article/pii/S0022283622000274
  24. www.jlr.org www.jlr.org
    Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency
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    jlr.org/article/S0022-2275(22)00107-9/fulltext
  25. Sep 2024
  26. www.cell.com www.cell.com
    Structural Insights into the Diversity and DNA Cleavage Mechanism of Fanzor
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    cell.com/cell/fulltext/S0092-8674(24)00844-4
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK
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    ncbi.nlm.nih.gov/pmc/articles/PMC11413322/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11364545/
  29. Aug 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and function of the human apoptotic scramblase Xkr4
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    ncbi.nlm.nih.gov/pmc/articles/PMC11326236/
  31. www.nature.com www.nature.com
    Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants
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    nature.com/articles/s41586-024-07743-z
  32. Jul 2024
  33. www.biorxiv.org www.biorxiv.org
    Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration
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    biorxiv.org/content/10.1101/2024.07.18.604174v1
  34. www.biorxiv.org www.biorxiv.org
    Dissecting human monoclonal antibody responses from mRNA- and protein-based XBB.1.5 COVID-19 monovalent vaccines
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    biorxiv.org/content/10.1101/2024.07.15.602781v1
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De novo design of proteins housing excitonically coupled chlorophyll special pairs
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    ncbi.nlm.nih.gov/pmc/articles/PMC11213709/
  36. Jun 2024
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proton-coupled transport mechanism of the efflux pump NorA
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    ncbi.nlm.nih.gov/pmc/articles/PMC11130294/
  38. May 2024
  39. www.pnas.org www.pnas.org
    Molecular basis for antibody recognition of multiple drug–peptide/MHC complexes
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    pnas.org/doi/abs/10.1073/pnas.2319029121
  40. www.nature.com www.nature.com
    Structural basis of closed groove scrambling by a TMEM16 protein
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    nature.com/articles/s41594-024-01284-9
  41. Mar 2024
  42. www.nature.com www.nature.com
    Blueprinting extendable nanomaterials with standardized protein blocks
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    nature.com/articles/s41586-024-07188-4
  43. Feb 2024
  44. www.biorxiv.org www.biorxiv.org
    Conformational states of the microtubule nucleator, the γ-tubulin ring complex
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    biorxiv.org/content/10.1101/2023.12.19.572162v2
  45. link.springer.com link.springer.com
    Structural basis of pH-dependent activation in a CLC transporter
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    link.springer.com/article/10.1038/s41594-023-01210-5
  46. Jan 2024
  47. www.biorxiv.org www.biorxiv.org
    Conformational states of the microtubule nucleator, the γ-tubulin ring complex
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    biorxiv.org/content/10.1101/2023.12.19.572162v2
  48. www.science.org www.science.org
    Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1
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    science.org/doi/10.1126/sciadv.adg9832
  49. Sep 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis of closed groove scrambling by a TMEM16 protein
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    ncbi.nlm.nih.gov/pmc/articles/PMC10462188/
  51. www.nature.com www.nature.com
    Calcium-gated potassium channel blockade via membrane-facing fenestrations
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    nature.com/articles/s41589-023-01406-2
  52. Aug 2023
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fanzor is a eukaryotic programmable RNA-guided endonuclease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10432273/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis of closed groove scrambling by a TMEM16 protein
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    ncbi.nlm.nih.gov/pmc/articles/PMC10441378/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10411902/
  56. Jun 2023
  57. www.biorxiv.org www.biorxiv.org
    Blueprinting expandable nanomaterials with standardized protein building blocks
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    biorxiv.org/content/10.1101/2023.06.09.544258v1
  58. May 2023
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De novo design of energy transfer proteins housing excitonically coupled chlorophyll special pairs
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10153362/
  60. Apr 2023
  61. www.nature.com www.nature.com
    Control of transcription elongation and DNA repair by alarmone ppGpp
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    nature.com/articles/s41594-023-00948-2
  62. Mar 2023
  63. www.nature.com www.nature.com
    Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1
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    nature.com/articles/s41467-023-36765-w
  64. Feb 2023
  65. www.sciencedirect.com www.sciencedirect.com
    Measuring the effects of ice thickness on resolution in single particle cryo-EM
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    sciencedirect.com/science/article/pii/S2590152423000016
  66. Nov 2022
  67. www.nature.com www.nature.com
    Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel
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    nature.com/articles/s41467-022-34673-z
  68. www.nature.com www.nature.com
    Anionic lipids unlock the gates of select ion channels in the pacemaker family
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    nature.com/articles/s41594-022-00851-2
  69. www.jlr.org www.jlr.org
    Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency
    1
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    jlr.org/article/S0022-2275(22)00107-9/fulltext
  70. May 2022
  71. www.nature.com www.nature.com
    TMEM16 scramblases thin the membrane to enable lipid scrambling
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    nature.com/articles/s41467-022-30300-z