49 Matching Annotations
  1. Oct 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cancer-associated fibroblasts expressing FSTL3 promote vasculogenic mimicry formation and drive colon cancer malignancy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12501291/
  3. Sep 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Direct co-targeting of Bcl-xL and Mcl-1 exhibits synergistic effects in AR-V7-expressing CRPC models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12368576/
  5. Jul 2025
  6. www.biorxiv.org www.biorxiv.org
    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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    biorxiv.org/content/10.1101/2025.06.27.662039v1
  7. 52.53.155.43 52.53.155.43
    1-s2.0-S0016508525057324-main-html.html
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    52.53.155.43/a363e4ae90be5a0c17cae72bbc9ca19379f34011/1-s2.0-S0016508525057324-main-html.html
  8. May 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312
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    pmc.ncbi.nlm.nih.gov/articles/PMC12076188/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SHMT inhibitor synergizes with 5-Fu to suppress gastric cancer via cell cycle arrest and chemoresistance alleviation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12064653/
  11. Apr 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11967718/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation–Induced Apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11964295/
  14. Mar 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial
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    pmc.ncbi.nlm.nih.gov/articles/PMC11911804/
  16. Feb 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11821485/
  18. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/f141eddf8d6ed9d4f64a9be0f6055059836b8d11/PDF-html.html
  19. www.biorxiv.org www.biorxiv.org
    Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma
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    biorxiv.org/content/10.1101/2025.01.28.635193v1
  20. Oct 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443213/
  22. Sep 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A benzarone derivative inhibits EYA to suppress tumor growth in SHH medulloblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10948029/
  24. aacrjournals.org aacrjournals.org
    Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma
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    aacrjournals.org/cancerres/article/83/16/2704/728339/Drosophila-Screening-Identifies-Dual-Inhibition-of
  25. May 2024
  26. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    elifesciences.org/articles/90683
  27. Apr 2024
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription
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    ncbi.nlm.nih.gov/pmc/articles/PMC11003700/
  29. Mar 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDK4/6-MEK inhibition in MPNSTs causes plasma cell infiltration, sensitization to PD-L1 blockade, and tumor regression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10528807/
  31. Oct 2023
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10605681/
  33. www.sciencedirect.com www.sciencedirect.com
    Synergistic antitumor efficacy of rMV-Hu191 and Olaparib in pancreatic cancer by generating oxidative DNA damage and ROS-dependent apoptosis
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    sciencedirect.com/science/article/pii/S1936523323001985
  34. dx.doi.org dx.doi.org
    Hyper-Dependence on NHEJ Enables Synergy Between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma
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    dx.doi.org/10.1158/1078-0432.CCR-23-0998
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCN driven oncogenesis involves cooperation with WDR5 to activate canonical MYC targets and G9a to repress differentiation genes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10541123/
  36. aacrjournals.org aacrjournals.org
    Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity.
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    aacrjournals.org/cancerrescommun/article/3/10/2030/729478/Piperacetazine-Directly-Binds-to-the-PAX3-FOXO1
  37. 52.53.155.43 52.53.155.43
    Preprints202309.2164.v1-html.html
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  38. Sep 2023
  39. academic.oup.com academic.oup.com
    bvad117-html.html
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    academic.oup.com/jes/article/7/10/bvad117/7274808
  40. Aug 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10425730/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10391328/
  43. Jul 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Caffeine supplementation and FOXM1 inhibition enhance the antitumor effect of statins in neuroblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10320471/
  45. 52.53.155.43 52.53.155.43
    can-22-3173-html.html
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  46. Jun 2023
  47. 52.53.155.43 52.53.155.43
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  48. www.sciencedirect.com www.sciencedirect.com
    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
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    sciencedirect.com/science/article/pii/S1535610823002088
  49. www.mdpi.com www.mdpi.com
    SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters
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    mdpi.com/2072-6694/15/11/3043
  50. aacrjournals.org aacrjournals.org
    HAND2 assists MYCN enhancer invasion to regulate a noradrenergic neuroblastoma phenotype
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    aacrjournals.org/cancerres/article/83/5/686/716682/HAND2-Assists-MYCN-Enhancer-Invasion-to-Regulate-a
  51. 52.53.155.43 52.53.155.43
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  52. May 2023
  53. www.nature.com www.nature.com
    Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype
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    nature.com/articles/s41416-023-02282-2
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9633392/
  55. Apr 2023
  56. aacrjournals.org aacrjournals.org
    Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
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    aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10102849/
  58. www.sciencedirect.com www.sciencedirect.com
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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    sciencedirect.com/science/article/pii/S2666379123001179
  59. Feb 2023
  60. link.springer.com link.springer.com
    The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma
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    link.springer.com/article/10.1186/s13046-023-02615-2
  61. Nov 2022
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC promotes tyrosine kinase inhibitor resistance in ROS1 fusion-positive lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9081178/
  64. Jul 2022
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NPC1 Confers Metabolic Flexibility in Triple Negative Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9319388/
  66. Jun 2022
  67. aacrjournals.org aacrjournals.org
    Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML
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    aacrjournals.org/cancerres/article/82/11/2141/699099/Phosphorylation-of-SHP2-at-Tyr62-Enables-Acquired
  68. aacrjournals.org aacrjournals.org
    Porcupine inhibition disrupts mitochondrial function and homeostasis in WNT ligand-addicted pancreatic cancer
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    aacrjournals.org/mct/article/21/6/936/699192/Porcupine-Inhibition-Disrupts-Mitochondrial
  69. Jan 2022
  70. www.sciencedirect.com www.sciencedirect.com
    AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2211124721017010
  71. Jul 2021
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitro
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    ncbi.nlm.nih.gov/pmc/articles/PMC8251190/