36 Matching Annotations
  1. Oct 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
    1
    1. scibot 04 Oct 2024
      RRID:SCR_019318

      DOI: 10.1158/1535-7163.MCT-23-0564

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    ncbi.nlm.nih.gov/pmc/articles/PMC11443213/
  3. Sep 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A benzarone derivative inhibits EYA to suppress tumor growth in SHH medulloblastoma
    1
    1. scibot 25 Sep 2024
      RRID:SCR_019318

      DOI: 10.1158/0008-5472.CAN-22-3784

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    ncbi.nlm.nih.gov/pmc/articles/PMC10948029/
  5. aacrjournals.org aacrjournals.org
    Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma
    1
    1. scibot 17 Sep 2024
      RRID:SCR_019318

      DOI: 10.1158/0008-5472.CAN-22-3762

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    aacrjournals.org/cancerres/article/83/16/2704/728339/Drosophila-Screening-Identifies-Dual-Inhibition-of
  6. May 2024
  7. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
    1
    1. scibot 03 May 2024
      RRID:SCR_019318

      DOI: 10.7554/eLife.90683

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    elifesciences.org/articles/90683
  8. Apr 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription
    1
    1. scibot 11 Apr 2024
      RRID:SCR_019318

      DOI: 10.1371/journal.pbio.3002240

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    ncbi.nlm.nih.gov/pmc/articles/PMC11003700/
  10. Mar 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDK4/6-MEK inhibition in MPNSTs causes plasma cell infiltration, sensitization to PD-L1 blockade, and tumor regression
    1
    1. scibot 03 Mar 2024
      RRID:SCR_019318

      DOI: 10.1158/1078-0432.CCR-23-0749

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    ncbi.nlm.nih.gov/pmc/articles/PMC10528807/
  12. Oct 2023
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma
    1
    1. scibot 31 Oct 2023
      RRID:SCR_019318

      DOI: 10.3390/cancers15204911

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    ncbi.nlm.nih.gov/pmc/articles/PMC10605681/
  14. www.sciencedirect.com www.sciencedirect.com
    Synergistic antitumor efficacy of rMV-Hu191 and Olaparib in pancreatic cancer by generating oxidative DNA damage and ROS-dependent apoptosis
    1
    1. scibot 27 Oct 2023
      RRID:SCR_019318

      DOI: 10.1016/j.tranon.2023.101812

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    sciencedirect.com/science/article/pii/S1936523323001985
  15. dx.doi.org dx.doi.org
    Hyper-Dependence on NHEJ Enables Synergy Between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma
    1
    1. scibot 14 Oct 2023
      RRID:SCR_019318

      DOI: 10.1158/1078-0432.CCR-23-0998

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    dx.doi.org/10.1158/1078-0432.CCR-23-0998
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCN driven oncogenesis involves cooperation with WDR5 to activate canonical MYC targets and G9a to repress differentiation genes
    1
    1. scibot 12 Oct 2023
      RRID:SCR_019318

      DOI: 10.1101/2023.07.11.548643

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    ncbi.nlm.nih.gov/pmc/articles/PMC10541123/
  17. aacrjournals.org aacrjournals.org
    Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity.
    1
    1. scibot 07 Oct 2023
      RRID:SCR_019318

      DOI: 10.1158/2767-9764.CRC-23-0119

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    aacrjournals.org/cancerrescommun/article/3/10/2030/729478/Piperacetazine-Directly-Binds-to-the-PAX3-FOXO1
  18. 52.53.155.43 52.53.155.43
    Preprints202309.2164.v1-html.html
    1
    1. scibot 06 Oct 2023
      RRID:SCR_019318

      DOI: 10.20944/preprints202309.2164.v1

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    52.53.155.43/90a9b3d86bbedfe17ef71e7103069ab41e9b198e/Preprints202309.2164.v1-html.html
  19. Sep 2023
  20. academic.oup.com academic.oup.com
    bvad117-html.html
    2
    1. scibot 20 Sep 2023
      RRID:SCR_019318

      DOI: 10.1210/jendso/bvad117

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    2. scibot 20 Sep 2023
      RRID:SCR_019318

      DOI: 10.1210/jendso/bvad117

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    academic.oup.com/jes/article/7/10/bvad117/7274808
  21. Aug 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia
    1
    1. scibot 19 Aug 2023
      RRID:SCR_019318

      DOI: 10.1158/1078-0432.CCR-23-0415

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    ncbi.nlm.nih.gov/pmc/articles/PMC10425730/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
    1
    1. scibot 03 Aug 2023
      RRID:SCR_019318

      DOI: 10.1158/0008-5472.CAN-22-3173

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    ncbi.nlm.nih.gov/pmc/articles/PMC10391328/
  24. Jul 2023
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Caffeine supplementation and FOXM1 inhibition enhance the antitumor effect of statins in neuroblastoma
    1
    1. scibot 08 Jul 2023
      RRID:SCR_019318

      DOI: 10.1158/0008-5472.CAN-22-3450

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    ncbi.nlm.nih.gov/pmc/articles/PMC10320471/
  26. 52.53.155.43 52.53.155.43
    can-22-3173-html.html
    1
    1. scibot 08 Jul 2023
      RRID:SCR_019318

      DOI: 10.1158/0008-5472.can-22-3173

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    52.53.155.43/7a07162d3285902b20a1a359628fdd8826284ee8/can-22-3173-html.html
  27. Jun 2023
  28. 52.53.155.43 52.53.155.43
    can-22-3173-html.html
    1
    1. scibot 30 Jun 2023
      RRID:SCR_019318

      DOI: 10.1158/0008-5472.CAN-22-3173

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    52.53.155.43/7a07162d3285902b20a1a359628fdd8826284ee8/can-22-3173-html.html
  29. www.sciencedirect.com www.sciencedirect.com
    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
    1
    1. scibot 23 Jun 2023
      RRID:SCR_019318

      DOI: 10.1016/j.ccell.2023.06.001

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    sciencedirect.com/science/article/pii/S1535610823002088
  30. www.mdpi.com www.mdpi.com
    SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters
    1
    1. scibot 08 Jun 2023
      RRID:SCR_019318

      DOI: 10.3390/cancers15113043

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    mdpi.com/2072-6694/15/11/3043
  31. aacrjournals.org aacrjournals.org
    HAND2 assists MYCN enhancer invasion to regulate a noradrenergic neuroblastoma phenotype
    1
    1. scibot 03 Jun 2023
      RRID:SCR_019318

      DOI: 10.1158/0008-5472.CAN-22-2042

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    aacrjournals.org/cancerres/article/83/5/686/716682/HAND2-Assists-MYCN-Enhancer-Invasion-to-Regulate-a
  32. 52.53.155.43 52.53.155.43
    can-22-3450-html.html
    1
    1. scibot 01 Jun 2023
      RRID:SCR_019318

      DOI: 10.1158/0008-5472.can-22-3450

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    52.53.155.43/d74c78a2e62f04f8ffa00018470c131fb0d65945/can-22-3450-html.html
  33. May 2023
  34. www.nature.com www.nature.com
    Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype
    1
    1. scibot 18 May 2023
      RRID:SCR_019318

      DOI: 10.1038/s41416-023-02282-2

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    nature.com/articles/s41416-023-02282-2
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer
    1
    1. scibot 04 May 2023
      RRID:SCR_019318

      DOI: 10.1158/1078-0432.CCR-22-0669

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    ncbi.nlm.nih.gov/pmc/articles/PMC9633392/
  36. Apr 2023
  37. aacrjournals.org aacrjournals.org
    Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
    1
    1. scibot 21 Apr 2023
      RRID:SCR_019318

      DOI: 10.1158/2326-6066.CIR-22-0056

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    aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
    1
    1. scibot 21 Apr 2023
      RRID:SCR_019318

      DOI: 10.1158/1078-0432.CCR-22-3722

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    ncbi.nlm.nih.gov/pmc/articles/PMC10102849/
  39. www.sciencedirect.com www.sciencedirect.com
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
    1
    1. scibot 08 Apr 2023
      RRID:SCR_019318

      DOI: 10.1016/j.xcrm.2023.101007

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    sciencedirect.com/science/article/pii/S2666379123001179
  40. Feb 2023
  41. link.springer.com link.springer.com
    The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma
    1
    1. scibot 11 Feb 2023
      RRID:SCR_019318

      DOI: 10.1186/s13046-023-02615-2

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    link.springer.com/article/10.1186/s13046-023-02615-2
  42. Nov 2022
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
    1
    1. scibot 18 Nov 2022
      RRID:SCR_019318

      DOI: 10.1016/j.isci.2022.105458

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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC promotes tyrosine kinase inhibitor resistance in ROS1 fusion-positive lung cancer
    1
    1. scibot 09 Nov 2022
      RRID:SCR_019318

      DOI: 10.1158/1541-7786.MCR-22-0025

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    ncbi.nlm.nih.gov/pmc/articles/PMC9081178/
  45. Jul 2022
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NPC1 Confers Metabolic Flexibility in Triple Negative Breast Cancer
    1
    1. scibot 31 Jul 2022
      RRID:SCR_019318

      DOI: 10.3390/cancers14143543

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    ncbi.nlm.nih.gov/pmc/articles/PMC9319388/
  47. Jun 2022
  48. aacrjournals.org aacrjournals.org
    Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML
    1
    1. scibot 18 Jun 2022
      RRID:SCR_019318

      DOI: 10.1158/0008-5472.CAN-21-0548

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    aacrjournals.org/cancerres/article/82/11/2141/699099/Phosphorylation-of-SHP2-at-Tyr62-Enables-Acquired
  49. aacrjournals.org aacrjournals.org
    Porcupine inhibition disrupts mitochondrial function and homeostasis in WNT ligand-addicted pancreatic cancer
    1
    1. scibot 14 Jun 2022
      RRID:SCR_019318

      DOI: 10.1158/1535-7163.MCT-21-0623

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    aacrjournals.org/mct/article/21/6/936/699192/Porcupine-Inhibition-Disrupts-Mitochondrial
  50. Jan 2022
  51. www.sciencedirect.com www.sciencedirect.com
    AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia
    1
    1. scibot 05 Jan 2022
      RRID:SCR_019318

      DOI: 10.1016/j.celrep.2021.110197

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    sciencedirect.com/science/article/pii/S2211124721017010
  52. Jul 2021
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitro
    1
    1. scibot 08 Jul 2021
      RRID:SCR_019318

      DOI: 10.1111/bph.15418

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    ncbi.nlm.nih.gov/pmc/articles/PMC8251190/