111 Matching Annotations
  1. Aug 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAFV600E metastatic colorectal cancer
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    sciencedirect.com/science/article/pii/S153561082500340X
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    AI-driven multimodal algorithm predicts immunotherapy and targeted therapy outcomes in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S2666379125003726
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    Reconstructed cell-type-specific rhythms in human brain link Alzheimer’s pathology, circadian stress, and ribosomal disruption
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    sciencedirect.com/science/article/pii/S0896627325005173
  5. Jul 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human gut microbiome gene co-expression network reveals a loss in taxonomic and functional diversity in Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12289924/
  7. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225013914-main-html.html
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  8. www.biorxiv.org www.biorxiv.org
    A developmental program of early residency promotes the differentiation of divergent uterine NK cell subsets in humans
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    biorxiv.org/content/10.1101/2025.07.05.663267v1
  9. www.mdpi.com www.mdpi.com
    Clinical and Transcriptomic Characterization of Metastatic Hormone-Sensitive Prostate Cancer Patients with Low PTEN Expression
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    mdpi.com/1422-0067/26/13/6244
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain
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    pmc.ncbi.nlm.nih.gov/articles/PMC12232972/
  11. www.sciencedirect.com www.sciencedirect.com
    The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells
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    sciencedirect.com/science/article/pii/S1074761325002481
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining Non–small Cell Lung Cancer Tumor Microenvironment Changes at Primary and Acquired Immune Checkpoint Inhibitor Resistance Using Clinical and Real-World Data
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    pmc.ncbi.nlm.nih.gov/articles/PMC12207206/
  13. Jun 2025
  14. www.cell.com www.cell.com
    Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration
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    cell.com/developmental-cell/abstract/S1534-5807(25)00260-6
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    Transcription factor T-bet regulates the maintenance and differentiation potential of lymph node and lung effector memory B cell subsets
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    sciencedirect.com/science/article/pii/S1074761325002420
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    A hexamer tandem repeat RNA embedded within an SVA retrotransposon drives R-loop formation and neurodegeneration
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    sciencedirect.com/science/article/pii/S2211124725005832
  17. 52.53.155.43 52.53.155.43
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  19. May 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12068872/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clear-Cell Renal Cell Carcinoma Molecular Subtypes Differ by African and European Genetic Similarity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12044083/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Heterogeneous Responses to High-Dose Testosterone in Castration-Resistant Prostate Cancer Tumors with Mixed Rb-Proficient and Rb-Deficient Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046331/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetic Screen in a Pre-Clinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities
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    pmc.ncbi.nlm.nih.gov/articles/PMC11530313/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory
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    pmc.ncbi.nlm.nih.gov/articles/PMC12037779/
  25. Apr 2025
  26. www.nature.com www.nature.com
    α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells
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    nature.com/articles/s41556-025-01658-1
  27. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Comparative single-cell transcriptomic profiling of patient-derived renal carcinoma cells in cellular and animal models of kidney cancer
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    febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.70022
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clinical and Translational Results from PORTER, a Multicohort Phase I Platform Trial of Combination Immunotherapy in Metastatic Castration-Resistant Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11995007/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Global changes in Staphylococcus aureus virulence and metabolism during colonization of healthy skin
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    pmc.ncbi.nlm.nih.gov/articles/PMC11977313/
  30. www.sciencedirect.com www.sciencedirect.com
    A common ground: an in silico assessment of the sources of intrinsic ex vivo resistance to venetoclax in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2531137925000264
  31. aacrjournals.org aacrjournals.org
    Exploring B7-H4’s Role in Prostate Cancer Dormancy after Androgen Deprivation Therapy: Extracellular Matrix Interactions and Therapeutic Opportunities
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    aacrjournals.org/mcr/article/23/4/327/754237/Exploring-B7-H4-s-Role-in-Prostate-Cancer-Dormancy
  32. aacrjournals.org aacrjournals.org
    Phase 1/2 trial of XPO1 inhibitor selinexor plus docetaxel in previously treated, advanced KRAS mutant non-small cell lung cancer
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    aacrjournals.org/clincancerres/article/31/4/639/751730/Phase-I-II-Trial-of-Exportin-1-Inhibitor-Selinexor
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Early Neutrophil Activation in Psoriatic Skin at Relapse Following Dead Sea Climatotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11969059/
  34. Mar 2025
  35. elifesciences.org elifesciences.org
    Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease
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    elifesciences.org/reviewed-preprints/101035
  36. Feb 2025
  37. www.sciencedirect.com www.sciencedirect.com
    The endogenous antigen-specific CD8+ T cell repertoire is composed of unbiased and biased clonotypes with differential fate commitments
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    sciencedirect.com/science/article/pii/S1074761325000688
  38. 52.53.155.43 52.53.155.43
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  39. aacrjournals.org aacrjournals.org
    Epigenome reprogramming through H3K27 and H3K4 trimethylation as a resistance mechanism to DNA methylation inhibition in BRAFV600E-mutated colorectal cancer
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    aacrjournals.org/clincancerres/article/30/22/5166/749574/Epigenome-Reprogramming-Through-H3K27-and-H3K4
  40. aacrjournals.org aacrjournals.org
    Platinum-based chemotherapy induces opposing effects on immunotherapy response-related spatial and stromal biomarkers in the bladder cancer microenvironment
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    aacrjournals.org/clincancerres/article/30/18/4227/747456/Platinum-Based-Chemotherapy-Induces-Opposing
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    Using multiomic integration to improve blood biomarkers of major depressive disorder: a case-control study
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    sciencedirect.com/science/article/pii/S2352396425000131
  42. www.sciencedirect.com www.sciencedirect.com
    Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury
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    sciencedirect.com/science/article/pii/S2211124725000191
  43. Jan 2025
  44. link.springer.com link.springer.com
    Steatohepatitis-induced vascular niche alterations promote melanoma metastasis
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    link.springer.com/article/10.1186/s40170-025-00374-6
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    Cytoplasmic mRNA decay controlling inflammatory gene expression is determined by pre-mRNA fate decision
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    sciencedirect.com/science/article/pii/S1097276525000012
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aberrant Activation of Wound-Healing Programs within the Metastatic Niche Facilitates Lung Colonization by Osteosarcoma Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11739783/
  47. 52.53.155.43 52.53.155.43
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  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11734436/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Tumor Immune Microenvironment and Therapeutic Efficacy of Trastuzumab Deruxtecan in Gastric Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11729160/
  50. 52.53.155.43 52.53.155.43
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  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    JAK inhibition decreases the autoimmune burden in Down syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC11687933/
  52. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Nuclear respiratory factor-1 (NRF1) induction as a powerful strategy to deter mitochondrial dysfunction and senescence in mesenchymal stem cells
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    onlinelibrary.wiley.com/doi/10.1111/acel.14446
  53. 52.53.155.43 52.53.155.43
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  54. Dec 2024
  55. 52.53.155.43 52.53.155.43
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  56. www.sciencedirect.com www.sciencedirect.com
    Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients
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    sciencedirect.com/science/article/pii/S1550413124004509
  57. Nov 2024
  58. 52.53.155.43 52.53.155.43
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  59. Oct 2024
  60. aacrjournals.org aacrjournals.org
    NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs
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    aacrjournals.org/cancerimmunolres/article/12/10/1421/748722/NK-Receptor-Signaling-Lowers-TCR-Activation
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biomarker analyses investigating disease biology and associations with outcomes in the JAVELIN Merkel 200 trial of avelumab in metastatic Merkel cell carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443199/
  62. Sep 2024
  63. www.sciencedirect.com www.sciencedirect.com
    Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes
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    sciencedirect.com/science/article/pii/S0012160624002343
  64. May 2024
  65. www.cell.com www.cell.com
    The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects
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    cell.com/immunity/fulltext/S1074-7613(24)00231-0
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor niche network-defined subtypes predict immunotherapy response of esophageal squamous cell cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11089351/
  67. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    elifesciences.org/articles/90683
  68. Apr 2024
  69. www.sciencedirect.com www.sciencedirect.com
    ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection
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    sciencedirect.com/science/article/pii/S2211124724004844
  70. www.sciencedirect.com www.sciencedirect.com
    Generation of human cerebral organoids with a structured outer subventricular zone
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    sciencedirect.com/science/article/pii/S2211124724003590
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain
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    ncbi.nlm.nih.gov/pmc/articles/PMC10515776/
  72. Feb 2024
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10862846/
  74. www.sciencedirect.com www.sciencedirect.com
    Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease
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    sciencedirect.com/science/article/pii/S2211124724001128
  75. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Multi-organ single-cell RNA sequencing in mice reveals early hyperglycemia responses that converge on fibroblast dysregulation
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202302003R
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comparative transcriptomic analysis of bovine mesenchymal stromal cells reveals tissue-source and species-specific differences
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    ncbi.nlm.nih.gov/pmc/articles/PMC10838956/
  77. link.springer.com link.springer.com
    Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota
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    link.springer.com/article/10.1038/s41467-024-45336-6
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PD-1 blockade induces reactivation of non-productive T cell responses characterized by NF-kB signaling in patients with pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831338/
  79. Jan 2024
  80. www.sciencedirect.com www.sciencedirect.com
    Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation
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    sciencedirect.com/science/article/pii/S266637912300602X
  81. Dec 2023
  82. www.sciencedirect.com www.sciencedirect.com
    Remodeling of the human skeletal muscle proteome found after long-term endurance training but not after strength training
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    sciencedirect.com/science/article/pii/S2589004223027153
  83. 52.53.155.43 52.53.155.43
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  84. Nov 2023
  85. www.sciencedirect.com www.sciencedirect.com
    Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids
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    sciencedirect.com/science/article/pii/S2211124723013669
  86. www.sciencedirect.com www.sciencedirect.com
    Insulin receptor loss impairs mammary tumorigenesis in mice
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    sciencedirect.com/science/article/pii/S2211124723012639
  87. Oct 2023
  88. www.sciencedirect.com www.sciencedirect.com
    Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model
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    sciencedirect.com/science/article/pii/S221112472301344X
  89. 52.53.155.43 52.53.155.43
    CDK19 and CDK8 Mediator kinases drive androgen-independent in vivo growth of castration-resistant prostate cancer
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    52.53.155.43/9964c17a6d8fec4a6a270a6588b0b357cf73bf12/2023.08.08.552491v1.full-html.html
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses
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    ncbi.nlm.nih.gov/pmc/articles/PMC10551667/
  91. 52.53.155.43 52.53.155.43
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  92. Sep 2023
  93. www.sciencedirect.com www.sciencedirect.com
    Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice
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    sciencedirect.com/science/article/pii/S0896627323005858
  94. Aug 2023
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Down Syndrome is Associated with Altered Frequency and Functioning of Tracheal Multiciliated Cells, and Response to Influenza Virus Infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC10405068/
  96. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cooperative and competitive regulation of the astrocytic transcriptome by neurons and endothelial cells: Impact on astrocyte maturation
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15908
  97. Jul 2023
  98. www.biorxiv.org www.biorxiv.org
    Rgg2/Rgg3 quorum sensing is a determinant of Streptococcus pyogenes-host interactions in a murine intact skin infection model
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    biorxiv.org/content/10.1101/2023.07.14.549100v1
  99. www.biorxiv.org www.biorxiv.org
    Gestational diabetes augments group B Streptococcus perinatal infection through disruptions in maternal immunity and the vaginal microbiota
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    biorxiv.org/content/10.1101/2023.06.23.546252v1
  100. www.sciencedirect.com www.sciencedirect.com
    Global and tissue-specific aging effects on murine proteomes
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    sciencedirect.com/science/article/pii/S221112472300726X
  101. Jun 2023
  102. aacrjournals.org aacrjournals.org
    Comprehensive DNA methylation analysis indicates that pancreatic intraepithelial neoplasia lesions are acinar-derived and epigenetically primed for carcinogenesis
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    aacrjournals.org/cancerres/article/83/11/1905/726442/Comprehensive-DNA-Methylation-Analysis-Indicates
  103. May 2023
  104. www.nature.com www.nature.com
    Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation
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    nature.com/articles/s43018-023-00566-3
  105. Apr 2023
  106. www.biorxiv.org www.biorxiv.org
    Single cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, ageing and disease
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  107. Mar 2023
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  111. Feb 2023
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  113. Jan 2023
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  118. Dec 2022
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  121. Nov 2022
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  125. Oct 2022
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  127. Sep 2022
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    Biological misinterpretation of transcriptional signatures in tumor samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data
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  129. Jun 2022
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    Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
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    Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors
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  133. May 2022
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    Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease
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  136. Mar 2022
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  139. Feb 2022
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    Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
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    FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons
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  142. Nov 2021
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    Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice
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  144. Oct 2021
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  146. Sep 2021
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  148. Jun 2021
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    Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells
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