Hypothesis

65 Matching Annotations

Oct 2025
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Long-read sequencing reveals extensive FMR1 somatic mosaicism in Fragile-X associated tremor/ataxia syndrome in human brain

1
1. scibot 23 Oct 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1101/2025.10.07.678589
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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biorxiv.org/content/10.1101/2025.10.07.678589v1
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Dexamethasone alters the cornea transcriptome to confer protection against ocular sulfur mustard exposure via regulating NFκB and TGFβ signaling in an in vivo rabbit model

1
1. scibot 07 Oct 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1007/s00204-025-04207-9
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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link.springer.com/article/10.1007/s00204-025-04207-9
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

MUC5B IPF Risk Variant Promotes a Muco-Secretory Phenotype and Loss of Small Airway Secretory Cells

1
1. scibot 16 Aug 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1164/rccm.202311-2111LE
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11351810/
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PARP1 and PARP2 are dispensable for DNA repair by microhomology-mediated end-joining during mitosis

1
1. scibot 11 Aug 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1101/2025.06.09.658719
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12259053/
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NKX2.2 and KLF4 cooperate to regulate α-cell identity

1
1. scibot 05 Aug 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1101/gad.352193.124
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11789634/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence

1
1. scibot 30 Jul 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1101/gad.352555.124
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12212003/
www.biorxiv.org www.biorxiv.org

Big1 is a cell cycle regulator linking cell size to basal body number

1
1. scibot 29 Jul 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1101/2025.07.24.666660
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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biorxiv.org/content/10.1101/2025.07.24.666660v1
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Immunosuppressive Tumor Microenvironment of Osteosarcoma

1
1. scibot 16 Jul 2025
  
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  RRID:SCR_021984
  
  DOI: 10.3390/cancers17132117
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12248827/
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Combining EHMT and PARP Inhibition: A Strategy to Diminish Therapy-Resistant Ovarian Cancer Tumor Growth while Stimulating Immune Activation

1
1. scibot 15 Jul 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1158/1535-7163.MCT-23-0613
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11543919/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

EHMT1/2 inhibition promotes regression of therapy-resistant ovarian cancer tumors in a CD8 T cell-dependent manner

1
1. scibot 11 Jun 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1158/1541-7786.MCR-24-0067
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11614706/
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Hypoxic pregnancy promotes fibrosis and increases stress metabolites in the ovine fetal liver

1
1. scibot 11 Jun 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1113/JP288724
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12126611/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Single-cell RNA sequencing reveals distinct senotypes and a quiescence-senescence continuum at the transcriptome level following chemotherapy

1
1. scibot 11 Jun 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1101/2025.05.13.653730
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12132365/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Deep mutationally scanned CHIKV E3/E2 virus library maps viral amino acid preferences and predicts viral escape mutants of neutralizing CHIKV antibodies

1
1. scibot 19 Apr 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1128/jvi.00081-25
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11998513/
Mar 2025
www.biorxiv.org www.biorxiv.org

Comparative multi-omics analysis uncovers contrasting molecular profiles of canine and human thyroid carcinomas

1
1. scibot 26 Mar 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1101/2025.03.14.643300
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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biorxiv.org/content/10.1101/2025.03.14.643300v1
Feb 2025
elifesciences.org elifesciences.org

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

1
1. scibot 11 Feb 2025
  
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  RRID:SCR_021984
  
  DOI: 10.7554/eLife.100197
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
  Curator: @scibot
  
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elifesciences.org/articles/100197
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A single-cell atlas of the Culex tarsalis midgut during West Nile virus infection

1
1. scibot 08 Feb 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1371/journal.ppat.1012855
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11793825/
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Single-cell multi-omics analysis identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma

7
1. scibot 07 Feb 2025
  
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  RRID:SCR_021984
  
  DOI: 10.21203/rs.3.rs-5522707/v1
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
  Curator: @scibot
  
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  RRID:SCR_021984
2. scibot 06 Feb 2025
  
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  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
3. scibot 05 Feb 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
4. scibot 04 Feb 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
5. scibot 03 Feb 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
6. scibot 02 Feb 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
7. scibot 01 Feb 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
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pmc.ncbi.nlm.nih.gov/articles/PMC11661367/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Single-cell multi-omics analysis identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma

8
1. scibot 31 Jan 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
2. scibot 30 Jan 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
3. scibot 29 Jan 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
4. scibot 28 Jan 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
5. scibot 27 Jan 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
6. scibot 26 Jan 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
7. scibot 25 Jan 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
8. scibot 24 Jan 2025
  
  in Public
  
  RRID:SCR_021984
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_021984
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pmc.ncbi.nlm.nih.gov/articles/PMC11661367/
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Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment

1
1. scibot 25 Jan 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1016/j.jlr.2024.100716
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11745954/
elifesciences.org elifesciences.org

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

1
1. scibot 24 Jan 2025
  
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  RRID:SCR_021984
  
  DOI: 10.7554/eLife.100197.2
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
  Curator: @scibot
  
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elifesciences.org/reviewed-preprints/100197
www.biorxiv.org www.biorxiv.org

Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence

1
1. scibot 24 Jan 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1101/2025.01.20.633996
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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biorxiv.org/content/10.1101/2025.01.20.633996v1
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Antigen experience history directs distinct functional states of CD8+ CAR T cells during the antileukemia response

1
1. scibot 16 Jan 2025
  
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  RRID:SCR_021984
  
  DOI: 10.1038/s41590-024-02034-1
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695263/
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Breast pericytes: a newly identified driver of tumor cell proliferation

1
1. scibot 04 Jan 2025
  
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  SCR_021984
  
  DOI: 10.3389/fonc.2024.1455484
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11685225/
Dec 2024
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Differential Effects of Extracellular Vesicles from Two Different Glioblastomas on Normal Human Brain Cells

1
1. scibot 22 Dec 2024
  
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  RRID:SCR_021984
  
  DOI: 10.3390/neurolint16060103
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11587087/
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Extracellular Vesicles from a Novel Chordoma Cell Line, ARF-8, Promote Tumorigenic Microenvironmental Changes When Incubated with the Parental Cells and with Human Osteoblasts

1
1. scibot 22 Dec 2024
  
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  RRID:SCR_021984
  
  DOI: 10.3390/ijms252312731
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11641215/
Nov 2024
pubs.acs.org pubs.acs.org

Discovery, Expression, and In Silico Safety Evaluation of Honey Truffle Sweetener, a Sweet Protein Derived from Mattirolomyces terfezioides and Produced by Heterologous Expression in Komagataella phaffii

1
1. scibot 29 Nov 2024
  
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  RRID: SCR_021984
  
  DOI: 10.1021/acs.jafc.4c04368
  
  Resource: University of Colorado Anschutz Medical Campus Cancer Center Genomics Shared Resource Core Facility (RRID:SCR_021984)
  
  Curator: @bandrow
  
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pubs.acs.org/doi/10.1021/acs.jafc.4c04368
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Pharmaceutical Attenuation Differs within Woodchip-Based Lignocellulose Bioreactors across Nitrate- and Sulfate-Reducing Conditions

1
1. scibot 23 Nov 2024
  
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  Genomics and Microarray Core, University of Colorado Anschutz Medical School (https://medschool.cuanschutz.edu/colorado-cancer-center/research/shared-resources/genomics)
  
  DOI: 10.1021/acsestwater.3c00030
  
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Granzyme F: Exhaustion Marker and Modulator of Chimeric Antigen Receptor T Cell–Mediated Cytotoxicity

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1. scibot 23 Nov 2024
  
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  DOI: 10.4049/jimmunol.2300334
  
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NKX2.2 and KLF4 cooperate to regulate α cell identity

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  DOI: 10.1101/2024.08.07.607083
  
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A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells

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  DOI: 10.1101/2024.04.08.588622
  
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Death and survival of gut CD4 T cells following HIV-1 infection ex vivo

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1. scibot 19 Nov 2024
  
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  DOI: 10.1093/pnasnexus/pgae486
  
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Oct 2024
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Ablation of hematopoietic stem cell derived adipocytes reduces tumor burden in syngeneic mouse models of high-grade serous carcinoma

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1. scibot 03 Oct 2024
  
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  DOI: 10.1101/2024.09.19.613924
  
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  DOI: 10.1101/2024.09.19.613924
  
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Discovery, Expression, and In Silico Safety Evaluation of Honey Truffle Sweetener, a Sweet Protein Derived from Mattirolomyces terfezioides and Produced by Heterologous Expression in Komagataella phaffii

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  DOI: 10.1021/acs.jafc.4c04368
  
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Maf expression in B cells restricts reactive plasmablast and germinal center B cell expansion

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  DOI: 10.1038/s41467-024-52224-6
  
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  DOI: 10.1038/s41467-024-52224-6
  
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Tumor intrinsic activity of Chromobox 2 (CBX2) remodels the tumor microenvironment in high grade serous carcinoma

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  DOI: 10.1158/2767-9764.CRC-24-0027
  
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Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment

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  DOI: 10.1101/2024.07.30.605803
  
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A single-cell atlas of the Culex tarsalis midgut during West Nile virus infection

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  DOI: 10.1101/2024.07.23.603613
  
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Directing B7-H3 chimeric antigen receptor T cell homing through IL-8 induces potent antitumor activity against pediatric sarcoma

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  RRID:SCR_021984
  
  DOI: 10.1136/jitc-2024-009221
  
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May 2024
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Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies

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1. scibot 30 May 2024
  
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  DOI: 10.1038/s41467-024-48653-y
  
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Feb 2024
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Microbiota-dependent indole production stimulates the development of collagen-induced arthritis in mice

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  DOI: 10.1172/JCI167671
  
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Jan 2024
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Antigen experience history directs distinct functional states of CD8+ CAR T cells during the anti-leukemia response

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  DOI: 10.21203/rs.3.rs-3712137/v1
  
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An intronic LINE-1 regulates IFNAR1 expression in human immune cells

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  DOI: 10.1186/s13100-023-00308-3
  
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EYA2 Tyrosine Phosphatase Inhibition Reduces MYC and Prevents Medulloblastoma Progression

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  DOI: 10.1093/neuonc/noad128
  
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Jul 2023
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noad128-html.html

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  DOI: 10.1093/neuonc/noad128
  
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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

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  DOI: 10.1101/2023.07.05.547813
  
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SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma

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  DOI: 10.1038/s41467-023-39945-w
  
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Jun 2023
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Murine Gammaherpesvirus 68 Efficiently Infects Myeloid Cells Resulting In An Atypical, Restricted Form Of Infection

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  DOI: 10.1101/2023.06.21.545948
  
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May 2023
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Low TCR Binding Strength Results in Increased Progenitor-like CD8+ Tumor-Infiltrating Lymphocytes

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  DOI: 10.1158/2326-6066.CIR-22-0761
  
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Apr 2023
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Combination CDC-like kinase inhibition (CLK)/Dual-specificity tyrosine-regulated kinase (DYRK) and taxane therapy in CTNNB1-mutated endometrial cancer

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  DOI: 10.1101/2023.04.04.535570
  
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Mar 2023
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Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models

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  DOI: 10.1101/2023.02.23.529773
  
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