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Structural basis of an endoplasmic reticulum EMC:Spf1 insertase–dislocase complex

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1. scibot 22 Oct 2026
  
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  RRID:SCR_025744
  
  DOI: 10.1038/s41594-026-01883-8
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13672079/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Multimodal substrate recruitment enables CTLHMKLN1 E3 ligase to target acetylated N-, C-, and internal degrons

1
1. scibot 22 Oct 2026
  
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  RRID:SCR_025744
  
  DOI: 10.1038/s41467-026-78311-4
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13676621/
Oct 2026
www.sciencedirect.com www.sciencedirect.com

A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability

1
1. scibot 15 Oct 2026
  
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  RRID:SCR_025744
  
  DOI: 10.1016/j.molcel.2026.09.023
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
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sciencedirect.com/science/article/pii/S1097276526006660
Jul 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Charged molecular glue discovery enabled by targeted degron display

1
1. scibot 14 Jul 2026
  
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  RRID:SCR_025744
  
  DOI: 10.1038/s41589-026-02182-5
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13355314/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Evolutionarily conserved spliceosome–exosome pathway in nuclear mRNA surveillance

1
1. scibot 03 Jul 2026
  
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  RRID:SCR_025744
  
  DOI: 10.1101/gad.353594.125
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13322074/
Apr 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation

1
1. scibot 18 Apr 2026
  
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  SCR_025744
  
  DOI: 10.1038/s41586-026-10232-0
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13083262/
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Direct coupling of the human nuclear exosome adaptors NEXT and PAXT with transcription termination and processing machineries

1
1. scibot 07 Feb 2026
  
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  RRID:SCR_025744
  
  DOI: 10.1093/nar/gkag088
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12873606/
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Feed-forward loops by NR5A2 ensure robust gene activation during pre-implantation development

1
1. scibot 30 Jan 2026
  
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  RRID:SCR_025744
  
  DOI: 10.1242/dev.205059
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12848575/
www.biorxiv.org www.biorxiv.org

The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation

1
1. scibot 16 Jan 2026
  
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  RRID:SCR_025744
  
  DOI: 10.64898/2026.01.05.697729
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
  Curator: @scibot
  
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biorxiv.org/content/10.64898/2026.01.05.697729v1
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

E2 variants for probing E3 ubiquitin ligase activities

1
1. scibot 06 Jan 2026
  
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  RRID:SCR_025744
  
  DOI: 10.1073/pnas.2524899122
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12773759/
Nov 2025
www.biorxiv.org www.biorxiv.org

Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1

1
1. scibot 18 Nov 2025
  
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  RRID:SCR_025744
  
  DOI: 10.1101/2025.11.14.688510
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
  Curator: @scibot
  
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biorxiv.org/content/10.1101/2025.11.14.688510v1
Oct 2025
www.sciencedirect.com www.sciencedirect.com

Molecular mechanisms governing the formation of distinct Upf1-containing complexes in yeast

1
1. scibot 11 Oct 2025
  
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  RRID:SCR_025744
  
  DOI: 10.1016/j.celrep.2025.116415
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2211124725011866
Aug 2025
www.biorxiv.org www.biorxiv.org

Structural basis of an EMC:Spf1 insertase-dislocase complex in the eukaryotic endoplasmic reticulum

1
1. scibot 13 Aug 2025
  
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  RRID:SCR_025744
  
  DOI: 10.1101/2025.08.07.669073
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_025744
  
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biorxiv.org/content/10.1101/2025.08.07.669073v1
www.nature.com www.nature.com

Structural analyses define the molecular basis of clusterin chaperone function

1
1. scibot 13 Aug 2025
  
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  RRID:SCR_025744
  
  DOI: 10.1038/s41594-025-01631-4
  
  Resource: Max Planck Institute of Biochemistry Cryo-EM Core Facility (RRID:SCR_025744)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_025744
  
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nature.com/articles/s41594-025-01631-4
May 2025
www.nature.com www.nature.com

TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains

1
1. scibot 29 May 2025
  
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  RRID:SCR_025744
  
  DOI: 10.1038/s41594-025-01561-1
  
  Resource: None
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_025744
  
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nature.com/articles/s41594-025-01561-1