This looks like great work, thanks for sharing this preprint.

We identified the use of ggplot2/seurat default colors as a significant accessibility barrier in the field of single-cell transcriptomics. I know several people interesting in the topic who will struggle to interpret some of the plots.

As a potential replacement, we created a tool that enables the generation of alternative color schemes

https://01a02046-79f7-61d5-c91b-740e77c7a252.share.connect.posit.cloud/?n=13&h_orbits=1.4&h1=170&h2=270&l_cycles=2.3&l1=45&l2=76&c1=90&delta_mode=add&delta_c=-49&c_mode=k&c_interval=7&divergent=0&palette_name=amir_intenso

(source code on Github: barfbow)

Thank you for your attention to this matter

Arnaud Martin, GWU