- Apr 2016
To date 5'-cytosine methylation (5mC) has not been reported in Caenorhabditis elegans, and using ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) the existence of DNA methylation in T. spiralis was detected, making it the first 5mC reported in any species of nematode.
As a novel and potentially controversial finding, the huge amounts of supporting data are depositedhere to assist others to follow on and reproduce the results. This won the BMC Open Data Prize, as the judges were impressed by the numerous extra steps taken by the authors in optimizing the openness and easy accessibility of this data, and were keen to emphasize that the value of open data for such breakthrough science lies not only in providing a resource, but also in conferring transparency to unexpected conclusions that others will naturally wish to challenge. You can see more in the blog posting and interview with the authors here: http://blogs.biomedcentral.com/gigablog/2013/10/02/open-data-for-the-win/