As a journalist she worked on social issues ranging from the armed conflict in Colombia and sexual violence as a weapon of war to the global spread of cumbia music, and she was twice a winner of the Colombian National Journalism Award. Clare has directed several documentaries and doc series for TV channels. Clare is a founding member of Casatarantula and DOCCO Distribution and Promotion agency. Clare has been a tutor in CreaDoc-MiradasDoc (Spain) and teaches film in several universities. She is frequently invited as an advisor and as a jury in film funds.

Tajiri often focuses her inquiry on the representation of Asians and Asian-Americans in popular media. In Off Limits (1988), she critiques Hollywood's portrayal of the Vietnam War and Vietnamese people, juxtaposing fragments from Easy Rider with her own text to give voice to a Vietnamese character. In History and Memory (1990), Tajiri examines the construction of history and the manipulation of collective memory through a powerful pastiche of personal reminiscences and mass media images of the internment of Japanese-Americans during World War II.