1 Matching Annotations
- Nov 2020
EBF was much more potent than Pax5 in inducing B celldevelopment, as its expression in MPPs yielded at least 100-foldmore B lineage progeny than did expression of Pax5 (Fig. 3band data not shown). These data suggest that promotion of B cellgeneration from MPPs by EBF is not mediated solely throughactivation of Pax5 expression.
EBF expression represses and restricts alternative lineage genes, also help promote B cell independently of Pax 5.