2 Matching Annotations
  1. Mar 2021
    1. Our primary aim was to generate a cohort large enough to examine the heritability of prognostic therapy outcomes. However, the meta-analysis estimate of SNP heritability was low and non-significant (h2SNP = 0.09, SE = 0.17). A sample size of 2724 has 80% and 99% power to detect a SNP-heritability of 33% and 50%, respectively94. To achieve 80% power to detect a heritability of 20%, a sample of 4500 individuals will be required. A meta-analysis of 2 799 individuals was sufficient to detect a significant heritability estimate for therapy outcome to antidepressant drugs (h2SNP = 0.42, SE = 0.18) and this was the first evidence of a genetic component for treatments outcome of any kind


    2. The meta-analysis sample (n = 2724) had 80% power to detect variants explaining 1.5% of the variance and 42% power to detect variants explaining 1% of the variance. Therefore, it is not especially surprising that we do not detect any variants at genome-wide significance. Typically, GWAS of psychological traits have required tens of thousands of participants to detect SNPs at genome-wide significance