Dosage and administration: The recommended starting dosage of mirtazapine is 15 mg/day for 4 days, then 30 mg/day for 10 days.
4 days is enough time to develop tolerance to the antihistamine sedation, but not to the adrenergic effects. Tolerance to yohimbine takes two weeks.
studies after administration during the day. Full daily doses of both drugs should be prescribed in nocturnal dosing regimens, and not in divided doses over the day, for avoiding excessive sedation and performance impairment.
A sound argument. This possibly could increase the antidepressant action as well.