Blinatumomab activates T cells at picomolar concentrations, mimicking a natural MHC class I/peptide interaction with the T‐cell receptor. Expression of MHC class I and the presence of T‐cell receptor are not required for the redirected lysis, indicating that the effect of blinatumomab is independent of peptide antigen presentation and the presence of a T‐cell receptor.66 An advantage of this approach is that engaged T cells will be less susceptible to major immune escape mechanisms of tumor cells, thereby improving the effectiveness of T‐cell‐mediated killing.